6TMO
Structure determination of an enhanced affinity TCR, a24b17, in complex with HLA-A*02:01 presenting a MART-1 peptide, EAAGIGILTV
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | MHC class I antigen | polymer | 276 | 31951.3 | 1 | UniProt (A0A5B8RNS7) Pfam (PF00129) Pfam (PF07654) | Homo sapiens (Human) | |
| 2 | B (B) | Beta-2-microglobulin | polymer | 100 | 11879.4 | 1 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (Human) | |
| 3 | C (C) | EAAGIGILTV | polymer | 10 | 943.1 | 1 | UniProt (by SIFTS) (Q16655) | Homo sapiens | |
| 4 | D (D) | Alpha chain of engineered high affinity T-cell receptor | polymer | 197 | 21887.1 | 1 | Homo sapiens | ||
| 5 | E (E) | Beta chain of high affinity engineered T-cell receptor | polymer | 244 | 27391.5 | 1 | Homo sapiens | ||
| 6 | F, G, H, R, T (A, D, E) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 7 | I, J, K, L, P... (A, B, D, E) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 7 | Chemie (EDO) | |||
| 8 | M, N, Q, V, W (A, B, E) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 9 | O, X, Y (A, E) | TRIS(HYDROXYETHYL)AMINOMETHANE | non-polymer | 163.2 | 3 | Chemie (TAM) | |||
| 10 | AA, BA, CA, DA, Z (B, C, D, E, A) | water | water | 18.0 | 388 | Chemie (HOH) |
Sequence modifications
B: 1 - 99 (UniProt: P61769)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 94052.3 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 1864.9 | |
| All* | Total formula weight | 95917.2 |
