PDB: 23765 resultsInfo pagesStatus searchChemie searchBIRD

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4Z70	Crystal structure of inorganic pyrophosphatase from Mycobacterium tuberculosis in complex with Ca ions Descriptor: CALCIUM ION, Inorganic pyrophosphatase Authors: Pratt, A.C, Biswas, T, Tsodikov, O.V. Deposit date: 2015-04-06 Release date: 2015-08-26 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Structural and computational dissection of the catalytic mechanism of the inorganic pyrophosphatase from Mycobacterium tuberculosis. J.Struct.Biol., 192, 2015
6D2S	Mycobacterium tuberculosis transcriptional regulator Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, CHLORIDE ION, ... Authors: Tang, S, Sacchettini, J. Deposit date: 2018-04-13 Release date: 2019-04-17 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.819 Å) Cite: Structural and functional insight into the Mycobacterium tuberculosis protein PrpR reveals a novel type of transcription factor. Nucleic Acids Res., 47, 2019
4XT7	Crystal structure of Rv2671 from Mycobacterium tuberculosis in complex with NADP+ and trimethoprim Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: Sacchettini, J.C, Cheng, Y.S, TB Structural Genomics Consortium (TBSGC) Deposit date: 2015-01-23 Release date: 2016-02-24 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance. Biochemistry, 55, 2016
6D4K	Crystal structure of L,D-transpeptidase 3 from Mycobacterium tuberculosis at 1.32 A resolution Descriptor: CALCIUM ION, Probable L,D-transpeptidase 3 Authors: Libreros, G.A, Dias, M.V.B. Deposit date: 2018-04-18 Release date: 2019-02-27 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.32 Å) Cite: Structural Basis for the Interaction and Processing of beta-Lactam Antibiotics by l,d-Transpeptidase 3 (LdtMt3) from Mycobacterium tuberculosis. ACS Infect Dis, 5, 2019
6D51	Crystal structure of L,D-transpeptidase 3 from Mycobacterium tuberculosis in complex with a faropenem-derived adduct Descriptor: ACETYL GROUP, CALCIUM ION, Probable L,D-transpeptidase 3 Authors: Libreros, G.A, Dias, M.V.B. Deposit date: 2018-04-19 Release date: 2019-02-27 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.83 Å) Cite: Structural Basis for the Interaction and Processing of beta-Lactam Antibiotics by l,d-Transpeptidase 3 (LdtMt3) from Mycobacterium tuberculosis. ACS Infect Dis, 5, 2019
6D5A	Crystal structure of L,D-transpeptidase 5 from Mycobacterium tuberculosis in apo form Descriptor: L,D-transpeptidase 5, TETRAETHYLENE GLYCOL Authors: Libreros, G.A, Dias, M.V. Deposit date: 2018-04-19 Release date: 2019-02-27 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.622 Å) Cite: Structural Basis for the Interaction and Processing of beta-Lactam Antibiotics by l,d-Transpeptidase 3 (LdtMt3) from Mycobacterium tuberculosis. ACS Infect Dis, 5, 2019
4XEW	Crystal structure of 7,8-diaminopelargonic acid synthase (BioA) from Mycobacterium tuberculosis, complexed with a HTS lead compound Descriptor: 6-(2-fluorophenyl)[1,3]dioxolo[4,5-g]quinolin-8(5H)-one, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, PYRIDOXAL-5'-PHOSPHATE Authors: Finzel, B.C, Dai, R. Deposit date: 2014-12-25 Release date: 2015-07-08 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.47 Å) Cite: Fragment-Based Exploration of Binding Site Flexibility in Mycobacterium tuberculosis BioA. J.Med.Chem., 58, 2015
4XRB	Crystal structure of Rv2671 from Mycobacterium tuberculosis Descriptor: DI(HYDROXYETHYL)ETHER, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, RV2671 Authors: Cheng, Y.S, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) Deposit date: 2015-01-20 Release date: 2016-02-24 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance. Biochemistry, 55, 2016
4XT6	Crystal structure of Rv2671 from Mycobacterium tuberculosis in complex with the tetrahydropteridine ring of tetrahydrofolate (THF) Descriptor: (6S)-2-amino-6-methyl-5,6,7,8-tetrahydropteridin-4(3H)-one, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Rv2671 Authors: Sacchettini, J.C, Cheng, Y.S, TB Structural Genomics Consortium (TBSGC) Deposit date: 2015-01-23 Release date: 2016-02-24 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance. Biochemistry, 55, 2016
4XT5	Crystal structure of Rv2671 from Mycobacterium tuberculosis in complex with NADP+ Descriptor: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Rv2671 Authors: Sacchettini, J.C, Cheng, Y.S, TB Structural Genomics Consortium (TBSGC) Deposit date: 2015-01-22 Release date: 2016-02-24 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.13 Å) Cite: Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance. Biochemistry, 55, 2016
4Z74	Crystal structure of inorganic pyrophosphatase from Mycobacterium tuberculosis in complex with inorganic pyrophosphate Descriptor: CALCIUM ION, Inorganic pyrophosphatase, PYROPHOSPHATE 2- Authors: Pratt, A.C, Biswas, T, Tsodikov, O.V. Deposit date: 2015-04-06 Release date: 2015-08-26 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Structural and computational dissection of the catalytic mechanism of the inorganic pyrophosphatase from Mycobacterium tuberculosis. J.Struct.Biol., 192, 2015
4Z71	Crystal structure of inorganic pyrophosphatase from Mycobacterium tuberculosis in complex with Mg ions Descriptor: Inorganic pyrophosphatase, MAGNESIUM ION Authors: Pratt, A.C, Biswas, T, Tsodikov, O.V. Deposit date: 2015-04-06 Release date: 2015-08-26 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Structural and computational dissection of the catalytic mechanism of the inorganic pyrophosphatase from Mycobacterium tuberculosis. J.Struct.Biol., 192, 2015
6CCD	The crystal structure of Mycobacterium tuberculosis Rv1747 FHA-1 Descriptor: ABC transporter ATP-binding/permease protein Rv1747, SULFATE ION Authors: Gay, L.M, Gee, C.L, Alber, T. Deposit date: 2018-02-06 Release date: 2018-06-20 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Biophysical Characterization of the Tandem FHA Domain Regulatory Module from the Mycobacterium tuberculosis ABC Transporter Rv1747. Structure, 26, 2018
6DVH	Lactate Monooxygenase from Mycobacterium smegmatis - C203A mutant Descriptor: FLAVIN MONONUCLEOTIDE, Lactate 2-monooxygenase, SULFATE ION Authors: Kean, K.M, Karplus, P.A. Deposit date: 2018-06-23 Release date: 2018-10-03 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structure and role for active site lid of lactate monooxygenase from Mycobacterium smegmatis. Protein Sci., 28, 2019
4G3T	Mycobacterium smegmatis DprE1 - hexagonal crystal form Descriptor: oxidoreductase DprE1 Authors: Li, H, Jogl, G. Deposit date: 2012-07-15 Release date: 2012-12-05 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.346 Å) Cite: Crystal structure of decaprenylphosphoryl-beta- D-ribose 2'-epimerase from Mycobacterium smegmatis. Proteins, 81, 2013
6CYY	Mycobacterium tuberculosis transcriptional regulator Descriptor: COENZYME A, HTH-type transcriptional regulator PrpR, IRON/SULFUR CLUSTER Authors: Tang, S, Sacchettini, J. Deposit date: 2018-04-07 Release date: 2019-04-17 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.506 Å) Cite: Structural and functional insight into the Mycobacterium tuberculosis protein PrpR reveals a novel type of transcription factor. Nucleic Acids Res., 47, 2019
4QII	Crystal Structure of type II MenB from Mycobacteria tuberculosis Descriptor: 1,4-Dihydroxy-2-naphthoyl-CoA synthase, Salicylyl CoA, TRIETHYLENE GLYCOL Authors: Song, H.G, Tse, Y.S, Sung, H.P, Guo, Z.H. Deposit date: 2014-05-31 Release date: 2014-11-19 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.64 Å) Cite: Ligand-dependent active-site closure revealed in the crystal structure of Mycobacterium tuberculosis MenB complexed with product analogues Acta Crystallogr.,Sect.D, 70, 2014
4QIJ	Crystal structure of MenB from Mycobacteria tuberculosis in complex with 1-HNA-CoA Descriptor: 1,4-Dihydroxy-2-naphthoyl-CoA synthase, 1-hydroxy-2-naphthoyl-CoA Authors: Song, H.G, Sung, H.P, Tse, Y.S, Guo, Z.H. Deposit date: 2014-05-31 Release date: 2014-11-19 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Ligand-dependent active-site closure revealed in the crystal structure of Mycobacterium tuberculosis MenB complexed with product analogues Acta Crystallogr.,Sect.D, 70, 2014
4WYG	Crystal structure of 7,8-diaminopelargonic acid synthase (BioA) from Mycobacterium tuberculosis complexed with a fragment hit Descriptor: 1,2-ETHANEDIOL, 1-{4-[(4-chloro-1H-pyrazol-1-yl)methyl]phenyl}methanamine, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... Authors: Dai, R, Finzel, B.C. Deposit date: 2014-11-17 Release date: 2015-07-08 Last modified: 2025-04-02 Method: X-RAY DIFFRACTION (1.62 Å) Cite: Fragment-Based Exploration of Binding Site Flexibility in Mycobacterium tuberculosis BioA. J.Med.Chem., 58, 2015
2XC3	X-ray structure of Mycobacterium tuberculosis cyp125 bound to the reverse type I inhibitor Descriptor: NALPHA-[(TRANS-4-METHYLCYCLOHEXYL)CARBONYL]-N-PYRIDIN-4-YL-D-TRYPTOPHANAMIDE, PROTOPORPHYRIN IX CONTAINING FE, PUTATIVE CYTOCHROME P450 125 Authors: Ouellet, H, Kells, P.M, Ortiz de Montellano, P.R, Podust, L.M. Deposit date: 2010-04-16 Release date: 2010-11-10 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Reverse Type I Inhibitor of Mycobacteriumtuberculosis Cyp125A1. Bioorg.Med.Chem.Lett., 21, 2011
4WYF	Crystal structure of 7,8-diaminopelargonic acid synthase (BioA) from Mycobacterium tuberculosis, complexed with a DSF fragment hit Descriptor: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, N-(1-oxo-1H-inden-5-yl)acetamide, PYRIDOXAL-5'-PHOSPHATE Authors: Barry, C.F, Dai, R. Deposit date: 2014-11-17 Release date: 2015-07-08 Last modified: 2025-04-02 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Fragment-Based Exploration of Binding Site Flexibility in Mycobacterium tuberculosis BioA. J.Med.Chem., 58, 2015
6CAH	NMR-based structure of the FHA-2 domain from Mycobacterium tuberculosis ABC transporter Rv1747 Descriptor: ABC transporter ATP-binding/permease protein Rv1747 Authors: Heinkel, F, Okon, M, Gsponer, J, McIntosh, L.P. Deposit date: 2018-01-30 Release date: 2018-06-20 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Biophysical Characterization of the Tandem FHA Domain Regulatory Module from the Mycobacterium tuberculosis ABC Transporter Rv1747. Structure, 26, 2018
4WYD	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase from Mycobacterium tuberculosis complexed with a fragment from DSF screening Descriptor: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, ... Authors: Dai, R, Finzel, B.C, Geders, T.W. Deposit date: 2014-11-17 Release date: 2015-07-15 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Fragment-Based Exploration of Binding Site Flexibility in Mycobacterium tuberculosis BioA. J.Med.Chem., 58, 2015
4X0E	Structure of M. tuberculosis nicotinate mono nucleotide adenylyltransferase Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Probable nicotinate-nucleotide adenylyltransferase, SULFATE ION Authors: Zuccola, H.J, Ostermna, A.L. Deposit date: 2014-11-21 Release date: 2015-01-28 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.41 Å) Cite: Mycobacterial nicotinate mononucleotide adenylyltransferase: structure, mechanism, and implications for drug discovery. J. Biol. Chem., 290, 2015
6EDZ	Crystal structure of Mycobacterium tuberculosis ICL2 in complex with acetyl-CoA, form I Descriptor: ACETYL COENZYME *A, Isocitrate lyase 2 Authors: Bashiri, G, Bhusal, R, Leung, I. Deposit date: 2018-08-12 Release date: 2019-08-14 Last modified: 2025-04-02 Method: X-RAY DIFFRACTION (2.67 Å) Cite: Acetyl-CoA-mediated activation of Mycobacterium tuberculosis isocitrate lyase 2. Nat Commun, 10, 2019

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