PDB: 226262 resultsInfo pagesStatus searchChemie searchBIRD

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9C8U	Human PRC2 - RvLEAM (short) (1:6 molar ratio), cross-linked 10 min Descriptor: Isoform 2 of Histone-lysine N-methyltransferase EZH2, Polycomb protein EED, Polycomb protein SUZ12, ... Authors: Abe, K.M, Li, G, He, Q, Grant, T, Lim, C. Deposit date: 2024-06-13 Release date: 2024-09-04 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Human PRC2 - RvLEAM (short) (1:6 molar ratio), cross-linked 10 min To Be Published
9C8S	CryoEM structure of Cryptococcus neoformans H99 Acetyl-CoA Synthetase in complex with adenosine-5'-ethylphosphate Descriptor: 5'-O-[(S)-ethoxy(hydroxy)phosphoryl]adenosine, Acetyl-coenzyme A synthetase Authors: Xu, Z, Schnicker, N.J, Jezeski, A.J, Krysan, D.J. Deposit date: 2024-06-12 Release date: 2024-07-03 Method: ELECTRON MICROSCOPY (2.37 Å) Cite: CryoEM structure of Cryptococcus neoformans H99 Acetyl-CoA Synthetase in complex with adenosine-5'-ethylphosphate To Be Published
9C8R	CryoEM structure of Apo Cryptococcus neoformans H99 Acetyl-CoA Synthetase Descriptor: Acetyl-coenzyme A synthetase Authors: Xu, Z, Schnicker, N.J, Jezeski, A.J, Krysan, D.J. Deposit date: 2024-06-12 Release date: 2024-07-03 Method: ELECTRON MICROSCOPY (2.83 Å) Cite: CryoEM structure of Apo Cryptococcus neoformans H99 Acetyl-CoA Synthetase To Be Published
9C8Q	Co-structure of Main Protease of SARS-CoV-2 (COVID-19) with covalent inhibitor Descriptor: (7P,8S)-3-cyclohexyl-7-(3-methylpyridin-2-yl)pyrazolo[1,5-a]pyrimidine, 3C-like proteinase nsp5 Authors: Knapp, M.S, Ornelas, E. Deposit date: 2024-06-12 Release date: 2024-10-16 Method: X-RAY DIFFRACTION (1.692 Å) Cite: Identification of Potent, Broad-Spectrum Coronavirus Main Protease Inhibitors for Pandemic Preparedness. J.Med.Chem., 2024
9C8P	High-resolution structure of cytochrome c peroxidase from yeast at ambient temperature and 3.0 kbar Descriptor: Cytochrome c peroxidase, mitochondrial, PROTOPORPHYRIN IX CONTAINING FE Authors: Zawistowski, R.K, Crane, B.R. Deposit date: 2024-06-12 Release date: 2024-10-16 Method: X-RAY DIFFRACTION (2.31 Å) Cite: Differential responses in the core, active site and peripheral regions of cytochrome c peroxidase to extreme pressure and temperature. J.Mol.Biol., 2024
9C8O	High-resolution structure of cytochrome c peroxidase from yeast at ambient temperature and 1.5 kbar Descriptor: Cytochrome c peroxidase, mitochondrial, PEROXIDE ION, ... Authors: Zawistowski, R.K, Crane, B.R. Deposit date: 2024-06-12 Release date: 2024-10-16 Method: X-RAY DIFFRACTION (2.31 Å) Cite: Differential responses in the core, active site and peripheral regions of cytochrome c peroxidase to extreme pressure and temperature. J.Mol.Biol., 2024
9C8M	High-resolution structure of cytochrome c peroxidase from yeast under cryogenic conditions and ambient pressure Descriptor: Cytochrome c peroxidase, mitochondrial, PROTOPORPHYRIN IX CONTAINING FE Authors: Zawistowski, R.K, Crane, B.R. Deposit date: 2024-06-12 Release date: 2024-10-16 Method: X-RAY DIFFRACTION (1.78 Å) Cite: Differential responses in the core, active site and peripheral regions of cytochrome c peroxidase to extreme pressure and temperature. J.Mol.Biol., 2024
9C8L	High-resolution structure of cytochrome c peroxidase from yeast at ambient temperature and ambient pressure Descriptor: Cytochrome c peroxidase, mitochondrial, PROTOPORPHYRIN IX CONTAINING FE Authors: Zawistowski, R.K, Crane, B.R. Deposit date: 2024-06-12 Release date: 2024-10-16 Method: X-RAY DIFFRACTION (1.54 Å) Cite: Differential responses in the core, active site and peripheral regions of cytochrome c peroxidase to extreme pressure and temperature. J.Mol.Biol., 2024
9C8J	X-ray crystal structure of AmpC beta-lactamase with inhibitor Descriptor: AmpC Beta-lactamase, N-(1-acetyl-2,3-dihydro-1H-indol-4-yl)-3-chloro-2-hydroxybenzene-1-sulfonamide Authors: Liu, F, Shoichet, B.K. Deposit date: 2024-06-12 Release date: 2024-06-19 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Improved correlations with score, hit-rate, and affinity as docking library and testing scale increase To Be Published
9C89	Crystal structure of outer membrane lipoprotein carrier protein (LolA) from Ehrlichia chaffeensis Descriptor: CHLORIDE ION, GLYCEROL, Outer membrane lipoprotein carrier protein LolA, ... Authors: Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2024-06-12 Release date: 2024-06-19 Method: X-RAY DIFFRACTION (3 Å) Cite: Crystal structure of outer membrane lipoprotein carrier protein (LolA) from Ehrlichia chaffeensis To be published
9C88	Cryo-EM Structure of a Proteolytic ClpXP AAA+ Machine Translocating a Portion of a Branched-Degron DHFR Substrate Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpX, ... Authors: Ghanbarpour, A, Sauer, R.T, Davis, J.H. Deposit date: 2024-06-12 Release date: 2024-10-16 Method: ELECTRON MICROSCOPY (2.6 Å) Cite: Cryo-EM structure of a fully-engaged DHFR-ssrA substrate and the AAA+ ClpXP protease To Be Published
9C87	Cryo-EM Structure of a Proteolytic ClpXP AAA+ Machine Poised to Unfold a Linear-Degron DHFR-ssrA Substrate Bound with MTX Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpX, ... Authors: Ghanbarpour, A, Sauer, R.T, Davis, J.H. Deposit date: 2024-06-12 Release date: 2024-10-16 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Cryo-EM Structure of a Proteolytic ClpXP AAA+ Machine Poised to Unfold a Linear-Degron DHFR-ssrA Substrate Bound with MTX To Be Published
9C84	X-ray crystal structure of AmpC beta-lactamase with inhibitor Descriptor: 3,5-dichloro-N-(8-fluoroisoquinolin-5-yl)-2-hydroxybenzene-1-sulfonamide, AmpC Beta-lactamase Authors: Liu, F, Shoichet, B.K. Deposit date: 2024-06-12 Release date: 2024-06-19 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Improved correlations with score, hit-rate, and affinity as docking library and testing scale increase To Be Published
9C83	X-ray crystal structure of AmpC beta-lactamase with inhibitor Descriptor: AmpC Beta-lactamase, N-[(3M)-3-(5-chloro-1,2,3-thiadiazol-4-yl)phenyl]-5-methyl-3-oxo-2,3-dihydro-1,2-oxazole-4-sulfonamide Authors: Liu, F, Shoichet, B.K. Deposit date: 2024-06-11 Release date: 2024-06-19 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Improved correlations with score, hit-rate, and affinity as docking library and testing scale increase To Be Published
9C82	Structure of human ULK1C:PI3KC3-C1 supercomplex Descriptor: Beclin 1-associated autophagy-related key regulator, Beclin-1, Phosphatidylinositol 3-kinase catalytic subunit type 3, ... Authors: Chen, M, Hurley, J.H. Deposit date: 2024-06-11 Release date: 2024-07-03 Method: ELECTRON MICROSCOPY (6.84 Å) Cite: Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex bioRxiv, 2023
9C81	X-ray crystal structure of AmpC beta-lactamase with inhibitor Descriptor: (2R)-2-phenoxy-3-{[(1S,2S,4S)-spiro[bicyclo[2.2.1]heptane-7,1'-cyclopropane]-2-carbonyl]amino}propanoic acid, AmpC Beta-lactamase Authors: Liu, F, Shoichet, B.K, Bassim, V. Deposit date: 2024-06-11 Release date: 2024-06-19 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Improved correlations with score, hit-rate, and affinity as docking library and testing scale increase To Be Published
9C80	Co-structure of SARS-CoV-2 (COVID-19 with covalent inhibitor Descriptor: (5R,7S,8R)-7-(2-fluorophenyl)-3-[(2-fluorophenyl)carbamoyl]-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-5-carboxylic acid, 3C-like proteinase nsp5 Authors: Ornelas, E, Knapp, M.S. Deposit date: 2024-06-11 Release date: 2024-10-16 Method: X-RAY DIFFRACTION (1.77 Å) Cite: Identification of Potent, Broad-Spectrum Coronavirus Main Protease Inhibitors for Pandemic Preparedness. J.Med.Chem., 2024
9C7W	human OC43 Main Protease (1-303) in complex with potent inhibitor Descriptor: (8S)-3-(4,4-difluorocyclohexyl)-5-(pyrimidin-2-yl)pyrazolo[1,5-a]pyrimidine, ORF1ab polyprotein Authors: Tang, J.Y, Knapp, M.S. Deposit date: 2024-06-11 Release date: 2024-10-16 Method: X-RAY DIFFRACTION (2.08 Å) Cite: Identification of Potent, Broad-Spectrum Coronavirus Main Protease Inhibitors for Pandemic Preparedness. J.Med.Chem., 2024
9C7V	Structure of the human BOS:human EMC complex in GDN Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BOS complex subunit NOMO2, ... Authors: Nguyen, V.N, Tomaleri, G.P, Voorhees, R.M. Deposit date: 2024-06-11 Release date: 2024-08-21 Last modified: 2024-09-25 Method: ELECTRON MICROSCOPY (6.6 Å) Cite: Role of a holo-insertase complex in the biogenesis of biophysically diverse ER membrane proteins. Mol.Cell, 84, 2024
9C7U	Structure of the human truncated BOS complex in GDN Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, BOS complex subunit NOMO2, Nicalin, ... Authors: Nguyen, V.N, Tomaleri, G.P, Voorhees, R.M. Deposit date: 2024-06-11 Release date: 2024-08-21 Last modified: 2024-10-16 Method: ELECTRON MICROSCOPY (3.65 Å) Cite: Role of a holo-insertase complex in the biogenesis of biophysically diverse ER membrane proteins. Mol.Cell, 84, 2024
9C7B	Crystal structure of R150H neurodevelopmental disease-associated U2AF2 variant Descriptor: DNA/RNA (5'-R(P*UP*U)-D(P*U)-R(P*UP*U)-D(P*(BRU))-R(P*CP*C)-3'), Splicing factor U2AF 65 kDa subunit Authors: Maji, D, Jenkins, J.L, Kielkopf, C.L. Deposit date: 2024-06-10 Release date: 2024-10-02 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Recurrent neurodevelopmentally-associated variants of the pre-mRNA splicing factor U2AF2 alter RNA binding affinities and interactions To Be Published
9C7A	Crystal structure of R149W neurodevelopmental disease-associated U2AF2 variant Descriptor: DNA/RNA (5'-R(P*UP*U)-D(P*U)-R(P*UP*U)-D(P*(BRU))-R(P*CP*C)-3'), GLYCEROL, SODIUM ION, ... Authors: Maji, D, Jenkins, J.L, Kielkopf, C.L. Deposit date: 2024-06-10 Release date: 2024-10-02 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Recurrent neurodevelopmentally-associated variants of the pre-mRNA splicing factor U2AF2 alter RNA binding affinities and interactions To Be Published
9C74	superfolder Green Fluorescent Protein with meta-nitro-tyrosine incorporated at position 66 Descriptor: Green fluorescent protein, SODIUM ION Authors: Phillips-Piro, C.M, Broughton, D.P. Deposit date: 2024-06-10 Release date: 2024-10-16 Method: X-RAY DIFFRACTION (1.51 Å) Cite: Modulating the pH Dependent Photophysical Properties of Green Fluorescent Protein Rsc Adv, 2024
9C6X	Crystal Structure of a single chain trimer composed of HLA-B*39:01 Y84C variant, beta-2microglobulin, and NRVMLPKAA peptide from NLRP2 Descriptor: 1,2-ETHANEDIOL, 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, NACHT, ... Authors: Sharma, R, Amdare, N.P, Celikgil, A, Garforth, S.J, DiLorenzo, T.P, Almo, S.C, Ghosh, A. Deposit date: 2024-06-09 Release date: 2024-09-04 Last modified: 2024-10-02 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural and biochemical analysis of highly similar HLA-B allotypes differentially associated with type 1 diabetes. J.Biol.Chem., 300, 2024
9C6W	Crystal Structure of a single chain trimer composed of HLA-B*39:06 Y84C variant, beta-2microglobulin, and NRVMLPKAA peptide from NLRP2 (2 molecules/asymmetric unit) Descriptor: 1,2-ETHANEDIOL, 3,6,9,12,15-PENTAOXAHEPTADECANE, CHLORIDE ION, ... Authors: Sharma, R, Amdare, N.P, Celikgil, A, Garforth, S.J, DiLorenzo, T.P, Almo, S.C, Ghosh, A. Deposit date: 2024-06-09 Release date: 2024-09-04 Last modified: 2024-10-02 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structural and biochemical analysis of highly similar HLA-B allotypes differentially associated with type 1 diabetes. J.Biol.Chem., 300, 2024

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