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3QGH
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Crystal structure of the hepatitis C virus NS5B RNA-dependent RNA polymerase genotype 1a complex with N-cyclopropyl-6-[(3R)-3-{[4-(trifluoromethoxy)benzyl]carbamoyl}-4-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazin-1-yl]pyridazine-3-carboxamide
Descriptor: N-cyclopropyl-6-[(3R)-3-{[4-(trifluoromethoxy)benzyl]carbamoyl}-4-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazin-1-yl]pyridazine-3-carboxamide, PHOSPHATE ION, RNA-directed RNA polymerase
Authors:Sheriff, S.
Deposit date:2011-01-24
Release date:2011-04-20
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Investigation of the mode of binding of a novel series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides to the hepatitis C virus polymerase.
Bioorg.Med.Chem.Lett., 21, 2011
3QIB
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BU of 3qib by Molmil
Crystal structure of the 2B4 TCR in complex with MCC/I-Ek
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2B4 beta chain, DI(HYDROXYETHYL)ETHER, ...
Authors:Ely, L.K, Newell, E.W, Davis, M.M, Garcia, K.C.
Deposit date:2011-01-26
Release date:2011-04-27
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis of specificity and cross-reactivity in T cell receptors specific for cytochrome c-I-E(k).
J.Immunol., 186, 2011
3QGI
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BU of 3qgi by Molmil
Crystal structure of the hepatitis C virus NS5B RNA-dependent RNA polymerase genotype 1a complex with N-[(2S)-butan-2-yl]-6-[(3R)-3-{[4-(trifluoromethoxy)benzyl]carbamoyl}-4-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazin-1-yl]pyridazine-3-carboxamide
Descriptor: GLYCEROL, N-[(2S)-butan-2-yl]-6-[(3R)-3-{[4-(trifluoromethoxy)benzyl]carbamoyl}-4-{[4-(trifluoromethoxy)phenyl]sulfonyl}piperazin-1-yl]pyridazine-3-carboxamide, RNA-directed RNA polymerase
Authors:Sheriff, S.
Deposit date:2011-01-24
Release date:2011-04-20
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Investigation of the mode of binding of a novel series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides to the hepatitis C virus polymerase.
Bioorg.Med.Chem.Lett., 21, 2011
3SS3
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BU of 3ss3 by Molmil
Crystal structure of mouse Glutaminase C, ligand-free form
Descriptor: CHLORIDE ION, Glutaminase C
Authors:Ambrosio, A.L.B, Dias, S.M.G, Cerione, R.A.
Deposit date:2011-07-07
Release date:2012-01-11
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism.
Proc.Natl.Acad.Sci.USA, 109, 2012
4G6A
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BU of 4g6a by Molmil
Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody AP33
Descriptor: AP33 Heavy Chain, AP33 Light chain, E2 peptide
Authors:Kong, L, Wilson, I.A, Law, M.
Deposit date:2012-07-18
Release date:2012-09-26
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:Structure of Hepatitis C Virus Envelope Glycoprotein E2 Antigenic Site 412 to 423 in Complex with Antibody AP33.
J.Virol., 86, 2012
3CZ6
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BU of 3cz6 by Molmil
Crystal Structure of the Rap1 C-terminus
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DNA-binding protein RAP1
Authors:Feeser, E.A, Wolberger, C.
Deposit date:2008-04-28
Release date:2008-05-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural and functional studies of the Rap1 C-terminus reveal novel separation-of-function mutants.
J.Mol.Biol., 380, 2008
1Q6A
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BU of 1q6a by Molmil
Solution Structure of the C-terminal Domain of Thermosynechococcus elongatus KaiA (ThKaiA180C); Averaged Minimized Structure
Descriptor: Circadian clock protein KaiA homolog
Authors:Vakonakis, I, Sun, J, Holzenburg, A, Golden, S.S, LiWang, A.C.
Deposit date:2003-08-13
Release date:2003-08-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR structure of the KaiC-interacting C-terminal domain of KaiA, a circadian clock protein: Implications for KaiA-KaiC interaction
Proc.Natl.Acad.Sci.USA, 101, 2004
2QZ6
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First crystal structure of a psychrophile class C beta-lactamase
Descriptor: Beta-lactamase
Authors:Michaux, C, Massant, J, Kerff, F, Charlier, P, Wouters, J.
Deposit date:2007-08-16
Release date:2008-03-18
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Crystal structure of a cold-adapted class C beta-lactamase
Febs J., 275, 2008
2EB1
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BU of 2eb1 by Molmil
Crystal Structure of the C-Terminal RNase III Domain of Human Dicer
Descriptor: Endoribonuclease Dicer, MAGNESIUM ION
Authors:Takeshita, D, Zenno, S, Lee, W.C, Nagata, K, Saigo, K, Tanokura, M.
Deposit date:2007-02-05
Release date:2007-11-06
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Homodimeric Structure and Double-stranded RNA Cleavage Activity of the C-terminal RNase III Domain of Human Dicer
J.Mol.Biol., 374, 2007
3SS5
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BU of 3ss5 by Molmil
Crystal structure of mouse Glutaminase C, L-glutamate-bound form
Descriptor: GLUTAMIC ACID, Glutaminase C
Authors:Ambrosio, A.L.B, Dias, S.M.G, Cerione, R.A.
Deposit date:2011-07-07
Release date:2012-01-11
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism.
Proc.Natl.Acad.Sci.USA, 109, 2012
1I2T
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BU of 1i2t by Molmil
X-RAY STRUCTURE OF THE HUMAN HYPERPLASTIC DISCS PROTEIN: AN ORTHOLOG OF THE C-TERMINAL DOMAIN OF POLY(A)-BINDING PROTEIN
Descriptor: HYD PROTEIN
Authors:Deo, R.C, Sonenberg, N, Burley, S.K.
Deposit date:2001-02-12
Release date:2001-04-18
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.04 Å)
Cite:X-ray structure of the human hyperplastic discs protein: an ortholog of the C-terminal domain of poly(A)-binding protein.
Proc.Natl.Acad.Sci.USA, 98, 2001
2C9X
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BU of 2c9x by Molmil
Sulfite dehydrogenase from Starkeya Novella Y236F mutant
Descriptor: (MOLYBDOPTERIN-S,S)-OXO-MOLYBDENUM, HEME C, SULFATE ION, ...
Authors:Bailey, S, Kappler, U, Feng, C, Honeychurch, M.J, Bernhardt, P, Tollin, G, Enemark, J.
Deposit date:2005-12-15
Release date:2006-08-16
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Kinetic and Structural Evidence for the Importance of Tyr236 for the Integrity of the Mo Active Site in a Bacterial Sulfite Dehydrogenase.
Biochemistry, 45, 2006
1RJH
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BU of 1rjh by Molmil
Structure of the Calcium Free Form of the C-type Lectin-like Domain of Tetranectin
Descriptor: Tetranectin
Authors:Nielbo, S, Thomsen, J.K, Graversen, J.H, Etzerodt, M, Poulsen, F.M, Thoegersen, H.C.
Deposit date:2003-11-19
Release date:2004-07-20
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Structure of the Plasminogen Kringle 4 Binding Calcium-Free Form of the C-Type Lectin-Like Domain of Tetranectin.
Biochemistry, 43, 2004
3PTD
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BU of 3ptd by Molmil
PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C MUTANT D274S
Descriptor: PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C
Authors:Heinz, D.W.
Deposit date:1997-07-17
Release date:1998-01-21
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Probing the roles of active site residues in phosphatidylinositol-specific phospholipase C from Bacillus cereus by site-directed mutagenesis.
Biochemistry, 36, 1997
3SS4
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BU of 3ss4 by Molmil
Crystal structure of mouse Glutaminase C, phosphate-bound form
Descriptor: Glutaminase C, PHOSPHATE ION
Authors:Ambrosio, A.L.B, Dias, S.M.G, Cerione, R.A.
Deposit date:2011-07-07
Release date:2012-01-11
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism.
Proc.Natl.Acad.Sci.USA, 109, 2012
1RFA
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BU of 1rfa by Molmil
NMR SOLUTION STRUCTURE OF THE RAS-BINDING DOMAIN OF C-RAF-1
Descriptor: RAF1
Authors:Emerson, S.D, Madison, V.S, Palermo, R.E, Waugh, D.S, Scheffler, J.E, Tsao, K.-L, Kiefer, S.E, Liu, S.P, Fry, D.C.
Deposit date:1995-04-26
Release date:1996-06-20
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Solution structure of the Ras-binding domain of c-Raf-1 and identification of its Ras interaction surface.
Biochemistry, 34, 1995
3RC4
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BU of 3rc4 by Molmil
Molecular mechanisms of viral and host-cell substrate recognition by HCV NS3/4A protease
Descriptor: NS3/4A Protease, Product TRIF, SULFATE ION, ...
Authors:Romano, K.P, Schiffer, C.A.
Deposit date:2011-03-30
Release date:2011-05-04
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Molecular mechanisms of viral and host cell substrate recognition by hepatitis C virus NS3/4A protease.
J.Virol., 85, 2011
2G15
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BU of 2g15 by Molmil
Structural Characterization of autoinhibited c-Met kinase
Descriptor: activated met oncogene
Authors:Wang, W, Marimuthu, A, Tsai, J, Kumar, A, Krupka, H.I, Zhang, C, Powell, B, Suzuki, Y, Nguyen, H, Tabrizizad, M, Luu, C, West, B.L.
Deposit date:2006-02-13
Release date:2006-03-21
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural characterization of autoinhibited c-Met kinase produced by coexpression in bacteria with phosphatase.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2JNF
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Solution structure of fly troponin C, isoform F1
Descriptor: Troponin C
Authors:De Nicola, G.F, Bullard, B, Pastore, A.
Deposit date:2007-01-18
Release date:2007-08-07
Last modified:2023-12-20
Method:SOLUTION NMR
Cite:The structure of lethocerus troponin C: insights into the mechanism of stretch activation in muscles
Structure, 15, 2007
2G01
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BU of 2g01 by Molmil
Pyrazoloquinolones as Novel, Selective JNK1 inhibitors
Descriptor: 6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE, C-jun-amino-terminal kinase-interacting protein 1, Mitogen-activated protein kinase 8, ...
Authors:Abad-Zapatero, C.
Deposit date:2006-02-10
Release date:2006-04-18
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Synthesis and SAR of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as novel, selective c-Jun N-terminal kinase inhibitors.
Bioorg.Med.Chem.Lett., 16, 2006
2JW8
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BU of 2jw8 by Molmil
Solution structure of stereo-array isotope labelled (SAIL) C-terminal dimerization domain of SARS coronavirus nucleocapsid protein
Descriptor: Nucleocapsid protein
Authors:Takeda, M, Chang, C, Ikeya, T, Guntert, P, Chang, Y, Hsu, Y, Huang, T, Kainosho, M.
Deposit date:2007-10-06
Release date:2008-08-26
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution structure of the c-terminal dimerization domain of SARS coronavirus nucleocapsid protein solved by the SAIL-NMR method
J.Mol.Biol., 380, 2008
4HEE
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BU of 4hee by Molmil
Crystal structure of PPARgamma in complex with compound 13
Descriptor: 5-benzyl-2-ethyl-3-{(1S)-5-[2-(1H-tetrazol-5-yl)phenyl]-2,3-dihydro-1H-inden-1-yl}-3,5-dihydro-4H-imidazo[4,5-c]pyridin-4-one, Nuclear receptor coactivator 1, Peroxisome proliferator-activated receptor gamma
Authors:Han, S.
Deposit date:2012-10-03
Release date:2013-08-21
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-gamma
Bioorg.Med.Chem.Lett., 23, 2013
1PL5
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BU of 1pl5 by Molmil
Crystal Structure Analysis of the Sir4p C-terminal Coiled Coil
Descriptor: Regulatory protein SIR4
Authors:Murphy, G.A, Spedale, E.J, Powell, S.T, Pillus, L, Schultz, S.C, Chen, L.
Deposit date:2003-06-06
Release date:2004-06-01
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Sir4 C-terminal coiled coil is required for telomeric and mating type silencing in Saccharomyces cerevisiae.
J.Mol.Biol., 334, 2003
1FMK
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BU of 1fmk by Molmil
CRYSTAL STRUCTURE OF HUMAN TYROSINE-PROTEIN KINASE C-SRC
Descriptor: TYROSINE-PROTEIN KINASE SRC
Authors:Xu, W, Harrison, S.C, Eck, M.J.
Deposit date:1997-01-24
Release date:1997-08-20
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Three-dimensional structure of the tyrosine kinase c-Src.
Nature, 385, 1997
2CE1
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BU of 2ce1 by Molmil
Structure of reduced Arabidopsis thaliana cytochrome 6A
Descriptor: CYTOCHROME C6, HEME C
Authors:Marcaida, M.J, Schlarb-Ridley, B.G, Worrall, J.A.R, Wastl, J, Evans, T.J, Bendall, D.S, Luisi, B.F, Howe, C.J.
Deposit date:2006-02-02
Release date:2006-07-05
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure of Cytochrome C(6A), a Novel Dithio-Cytochrome of Arabidopsis Thaliana, and its Reactivity with Plastocyanin: Implications for Function.
J.Mol.Biol., 360, 2006

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数据于2024-06-26公开中

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