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1W87
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BU of 1w87 by Molmil
FERREDOXIN-NADP REDUCTASE (MUTATION: Y 303 W) COMPLEXED WITH NADP BY COCRYSTALLIZATION
Descriptor: FERREDOXIN-NADP REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Hermoso, J.A, Perez-Dorado, I, Maya, C.
Deposit date:2004-09-16
Release date:2005-10-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:C-Terminal Tyrosine of Ferredoxin-Nadp(+) Reductase in Hydride Transfer Processes with Nad(P)(+)/H.
Biochemistry, 44, 2005
2P59
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Crystal Structure of Hepatitis C Virus NS3.4A protease
Descriptor: (2S,3AS,7AS)-1-[(2S)-2-{[(2S)-2-CYCLOHEXYL-2-({[(2R)-4-NITRO-2H-PYRROL-2-YL]CARBONYL}AMINO)ACETYL]AMINO}-3,3-DIMETHYLBUTANOYL]-N-{(1S)-1-[(1R)-2-(CYCLOPROPYLAMINO)-1-HYDROXY-2-OXOETHYL]BUTYL}OCTAHYDRO-1H-INDOLE-2-CARBOXAMIDE, NS3, peptide
Authors:Perni, R.B, Wei, Y.
Deposit date:2007-03-14
Release date:2008-02-05
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Inhibitors of hepatitis C virus NS3.4A protease. Effect of P4 capping groups on inhibitory potency and pharmacokinetics.
Bioorg.Med.Chem.Lett., 17, 2007
1W35
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FERREDOXIN-NADP+ REDUCTASE (MUTATION: Y 303 W)
Descriptor: FERREDOXIN-NADP+ REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION
Authors:Hermoso, J.A, Perez-Dorado, I, Medina, M, Julvez, M.M, Sanz-Aparicio, J, Gomez-Moreno, C.
Deposit date:2004-07-13
Release date:2005-07-26
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:C-Terminal Tyrosine of Ferredoxin-Nadp(+) Reductase in Hydride Transfer Processes with Nad(P)(+)/H.
Biochemistry, 44, 2005
3P8O
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BU of 3p8o by Molmil
Crystal structure of HCV NS3/NS4A protease complexed with des-bromine analogue of BI 201335
Descriptor: HCV non-structural protein 4A, HCV serine protease NS3, N-[(cyclopentyloxy)carbonyl]-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-carboxy-2-ethenylcyclopropyl]-4-[(7-methoxy-2-{2-[(2-methylpropanoyl)amino]-1,3-thiazol-4-yl}quinolin-4-yl)oxy]-L-prolinamide, ...
Authors:Lemke, C.T.
Deposit date:2010-10-14
Release date:2011-01-26
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Combined X-ray, NMR, and kinetic analyses reveal uncommon binding characteristics of the hepatitis C virus NS3-NS4A protease inhibitor BI 201335.
J.Biol.Chem., 286, 2011
2GIW
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BU of 2giw by Molmil
SOLUTION STRUCTURE OF REDUCED HORSE HEART CYTOCHROME C, NMR, 40 STRUCTURES
Descriptor: CYTOCHROME C, HEME C
Authors:Banci, L, Bertini, I, Huber, J.G, Spyroulias, G.A, Turano, P.
Deposit date:1998-06-25
Release date:1998-12-09
Last modified:2024-10-09
Method:SOLUTION NMR
Cite:Solution structure of reduced horse heart cytochrome c.
J.Biol.Inorg.Chem., 4, 1999
3BUW
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BU of 3buw by Molmil
Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Syk
Descriptor: 13-meric peptide from Tyrosine-protein kinase SYK, E3 ubiquitin-protein ligase CBL
Authors:Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J.
Deposit date:2008-01-03
Release date:2008-02-26
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Embo J., 27, 2008
3Q7U
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BU of 3q7u by Molmil
Structure of Mtb 2-C-methyl-D-erythritol 4-phosphate cytidyltransferase (IspD) complexed with CTP
Descriptor: 2-C-methyl-D-erythritol 4-phosphate cytidyltransferase, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Reddy, M.C.M, Bruning, J.B, Thurman, C, Ioerger, T.R, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-01-05
Release date:2011-05-04
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of Mycobacterium tuberculosis 2-C-methyl-D-erythritol 4-phosphate cytidyltransferase (IspD): a candidate antitubercular drug target
Proteins, 2011
1UPK
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BU of 1upk by Molmil
Crystal structure of MO25 in complex with a C-terminal peptide of STRAD
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, MO25 PROTEIN, STE-20 RELATED ADAPTOR
Authors:Milburn, C.C, Boudeau, J, Deak, M, Alessi, D.R, Van Aalten, D.M.F.
Deposit date:2003-10-07
Release date:2004-01-22
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structure of Mo25 Alpha in Complex with the C-Terminus of the Pseudo Kinase Ste-20 Related Adaptor (Strad)
Nat.Struct.Mol.Biol., 11, 2004
3BUN
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BU of 3bun by Molmil
Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Sprouty4
Descriptor: 13-meric peptide from Protein sprouty homolog 4, E3 ubiquitin-protein ligase CBL
Authors:Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J.
Deposit date:2008-01-03
Release date:2008-02-26
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Embo J., 27, 2008
1MV3
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BU of 1mv3 by Molmil
NMR STRUCTURE OF THE TUMOR SUPPRESSOR BIN1: ALTERNATIVE SPLICING IN MELANOMA AND INTERACTION WITH C-MYC
Descriptor: Myc box dependent interacting protein 1
Authors:Pineda-Lucena, A, Arrowsmith, C.H.
Deposit date:2002-09-24
Release date:2003-09-30
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:A structure-based model of the c-Myc/Bin1 protein interaction shows alternative splicing of Bin1 and c-Myc phosphorylation are key binding determinants.
J.Mol.Biol., 351, 2005
3BUO
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BU of 3buo by Molmil
Crystal structure of c-Cbl-TKB domain complexed with its binding motif in EGF receptor'
Descriptor: 13-meric peptide from Epidermal growth factor receptor, E3 ubiquitin-protein ligase CBL
Authors:Ng, C, Jackson, R.A, Buschdorf, J.P, Sun, Q, Guy, G.R, Sivaraman, J.
Deposit date:2008-01-03
Release date:2008-02-26
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Embo J., 27, 2008
3P8N
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BU of 3p8n by Molmil
Crystal structure of HCV NS3/NS4A protease complexed with BI 201335
Descriptor: HCV non-structural protein 4A, HCV serine protease NS3, N-[(cyclopentyloxy)carbonyl]-3-methyl-L-valyl-(4R)-4-[(8-bromo-7-methoxy-2-{2-[(2-methylpropanoyl)amino]-1,3-thiazol-4-yl}quinolin-4-yl)oxy]-N-[(1R,2S)-1-carboxy-2-ethenylcyclopropyl]-L-prolinamide, ...
Authors:Lemke, C.T.
Deposit date:2010-10-14
Release date:2011-01-26
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Combined X-ray, NMR, and kinetic analyses reveal uncommon binding characteristics of the hepatitis C virus NS3-NS4A protease inhibitor BI 201335.
J.Biol.Chem., 286, 2011
4JQ0
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BU of 4jq0 by Molmil
Voltage-gated sodium channel 1.5 C-terminal domain in complex with FGF12B and Ca2+/calmodulin
Descriptor: CALCIUM ION, Calmodulin, Fibroblast growth factor 12, ...
Authors:Wang, C, Chung, B.C, Yan, H, Wang, H.G, Lee, S.Y, Pitt, G.S.
Deposit date:2013-03-19
Release date:2014-05-21
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.84 Å)
Cite:Structural analyses of Ca(2+)/CaM interaction with NaV channel C-termini reveal mechanisms of calcium-dependent regulation.
Nat Commun, 5, 2014
1T45
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BU of 1t45 by Molmil
STRUCTURAL BASIS FOR THE AUTOINHIBITION AND STI-571 INHIBITION OF C-KIT TYROSINE KINASE
Descriptor: Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Authors:Mol, C.D, Dougan, D.R, Schneider, T.R, Skene, R.J, Kraus, M.L, Scheibe, D.N, Snell, G.P, Zou, H, Sang, B.C, Wilson, K.P.
Deposit date:2004-04-28
Release date:2004-06-15
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinase.
J.Biol.Chem., 279, 2004
1TN3
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BU of 1tn3 by Molmil
THE C-TYPE LECTIN CARBOHYDRATE RECOGNITION DOMAIN OF HUMAN TETRANECTIN
Descriptor: CALCIUM ION, ETHANOL, SULFATE ION, ...
Authors:Kastrup, J.S, Nielsen, B.B, Rasmussen, H, Holtet, T.L, Graversen, J.H, Etzerodt, M, Thoegersen, H.C, Larsen, I.K.
Deposit date:1997-11-06
Release date:1998-05-06
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the C-type lectin carbohydrate recognition domain of human tetranectin.
Acta Crystallogr.,Sect.D, 54, 1998
2ZJO
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BU of 2zjo by Molmil
Crystal structure of hepatitis C virus NS3 helicase with a novel inhibitor
Descriptor: Genome polyprotein, N-[4-(BIS{4-[(3-SULFOPHENYL)AMINO]PHENYL}METHYLENE)CYCLOHEXA-2,5-DIEN-1-YLIDENE]-4-SULFOBENZENAMINIUM
Authors:Liaw, S.H, Chen, S.J, Hu, C.Y, Chi, W.K, Chu, I.D, Hwang, L.H, Chern, J.W, Chen, D.S.
Deposit date:2008-03-07
Release date:2009-03-10
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-Based Discovery of Triphenylmethane Derivatives as Novel Inhibitors of Hepatitis C Virus Helicase
To be Published
1CRH
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BU of 1crh by Molmil
THE ROLE OF A CONSERVED INTERNAL WATER MOLECULE AND ITS ASSOCIATED HYDROGEN BOND NETWORK IN CYTOCHROME C
Descriptor: CYTOCHROME C, HEME C, SULFATE ION
Authors:Berghuis, A.M, Brayer, G.D.
Deposit date:1993-08-06
Release date:1994-01-31
Last modified:2025-03-26
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The role of a conserved internal water molecule and its associated hydrogen bond network in cytochrome c.
J.Mol.Biol., 236, 1994
1CRG
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BU of 1crg by Molmil
THE ROLE OF A CONSERVED INTERNAL WATER MOLECULE AND ITS ASSOCIATED HYDROGEN BOND NETWORK IN CYTOCHROME C
Descriptor: CYTOCHROME C, HEME C, SULFATE ION
Authors:Berghuis, A.M, Brayer, G.D.
Deposit date:1993-08-06
Release date:1994-01-31
Last modified:2025-03-26
Method:X-RAY DIFFRACTION (2 Å)
Cite:The role of a conserved internal water molecule and its associated hydrogen bond network in cytochrome c.
J.Mol.Biol., 236, 1994
2P33
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BU of 2p33 by Molmil
Synthesis and SAR of Aminopyrimidines as Novel c-Jun N-Terminal Kinase (JNK) Inhibitors
Descriptor: 4-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-N-ethylpiperidine-1-carboxamide, c-Jun N-terminal kinase 3
Authors:Ceska, T.A, Platt, A, Fortunato, M, Dickson, K.M, Sharpe, A.
Deposit date:2007-03-08
Release date:2007-06-19
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Synthesis and SAR of aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors
Bioorg.Med.Chem.Lett., 17, 2007
1DII
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BU of 1dii by Molmil
CRYSTAL STRUCTURE OF P-CRESOL METHYLHYDROXYLASE AT 2.5 A RESOLUTION
Descriptor: CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, HEME C, ...
Authors:Cunane, L.M, Chen, Z.W, Shamala, N, Mathews, F.S, Cronin, C.N, McIntire, W.S.
Deposit date:1999-11-29
Release date:1999-12-08
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of the flavocytochrome p-cresol methylhydroxylase and its enzyme-substrate complex: gated substrate entry and proton relays support the proposed catalytic mechanism.
J.Mol.Biol., 295, 2000
3OP0
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BU of 3op0 by Molmil
Crystal structure of Cbl-c (Cbl-3) TKB domain in complex with EGFR pY1069 peptide
Descriptor: Epidermal growth factor receptor, NICKEL (II) ION, SODIUM ION, ...
Authors:Chaikuad, A, Guo, K, Cooper, C.D.O, Ayinampudi, V, Krojer, T, Ugochukwu, E, Muniz, J.R.C, Vollmar, M, Canning, P, von Delft, F, Arrowsmith, C.H, Weigelt, J, Edwards, A.M, Bountra, C, Bullock, A, Structural Genomics Consortium (SGC)
Deposit date:2010-08-31
Release date:2010-10-20
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Crystal structure of Cbl-c (Cbl-3) TKB domain in complex with EGFR pY1069 peptide
To be Published
1RZQ
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BU of 1rzq by Molmil
Crystal Structure of C-Terminal Despentapeptide Nitrite Reductase from Achromobacter Cycloclastes at pH5.0
Descriptor: ACETIC ACID, COPPER (II) ION, Copper-containing nitrite reductase, ...
Authors:Li, H.T, Wang, C, Chang, T, Chang, W.C, Liu, M.Y, Le Gall, J, Gui, L.L, Zhang, J.P, An, X.M, Chang, W.R.
Deposit date:2003-12-26
Release date:2004-03-30
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:pH-profile crystal structure studies of C-terminal despentapeptide nitrite reductase from Achromobacter cycloclastes
Biochem.Biophys.Res.Commun., 316, 2004
1CGN
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BU of 1cgn by Molmil
CYTOCHROME C'
Descriptor: CYTOCHROME C, HEME C
Authors:Dobbs, A.J, Faber, H.R, Anderson, B.F, Baker, E.N.
Deposit date:1995-05-01
Release date:1995-07-31
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Three-dimensional structure of cytochrome c' from two Alcaligenes species and the implications for four-helix bundle structures.
Acta Crystallogr.,Sect.D, 52, 1996
1CRJ
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BU of 1crj by Molmil
THE ROLE OF A CONSERVED INTERNAL WATER MOLECULE AND ITS ASSOCIATED HYDROGEN BOND NETWORK IN CYTOCHROME C
Descriptor: CYTOCHROME C, HEME C, SULFATE ION
Authors:Berghuis, A.M, Brayer, G.D.
Deposit date:1993-08-06
Release date:1994-01-31
Last modified:2025-03-26
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:The role of a conserved internal water molecule and its associated hydrogen bond network in cytochrome c.
J.Mol.Biol., 236, 1994
1CTY
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BU of 1cty by Molmil
MUTATION OF TYROSINE-67 IN CYTOCHROME C SIGNIFICANTLY ALTERS THE LOCAL HEME ENVIRONMENT
Descriptor: CYTOCHROME C, HEME C, SULFATE ION
Authors:Berghuis, A.M, Brayer, G.D.
Deposit date:1993-02-15
Release date:1993-07-15
Last modified:2025-03-26
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Mutation of tyrosine-67 to phenylalanine in cytochrome c significantly alters the local heme environment.
J.Mol.Biol., 235, 1994

238582

数据于2025-07-09公开中

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