2P33
Synthesis and SAR of Aminopyrimidines as Novel c-Jun N-Terminal Kinase (JNK) Inhibitors
Summary for 2P33
Entry DOI | 10.2210/pdb2p33/pdb |
Descriptor | c-Jun N-terminal kinase 3, 4-{[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino}-N-ethylpiperidine-1-carboxamide (3 entities in total) |
Functional Keywords | jnk3 kinase, inhibitor, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : P53779 |
Total number of polymer chains | 1 |
Total formula weight | 42515.62 |
Authors | Ceska, T.A.,Platt, A.,Fortunato, M.,Dickson, K.M.,Sharpe, A. (deposition date: 2007-03-08, release date: 2007-06-19, Last modification date: 2023-08-30) |
Primary citation | Alam, M.,Beevers, R.E.,Ceska, T.,Davenport, R.J.,Dickson, K.M.,Fortunato, M.,Gowers, L.,Haughan, A.F.,James, L.A.,Jones, M.W.,Kinsella, N.,Lowe, C.,Meissner, J.W.,Nicolas, A.L.,Perry, B.G.,Phillips, D.J.,Pitt, W.R.,Platt, A.,Ratcliffe, A.J.,Sharpe, A.,Tait, L.J. Synthesis and SAR of aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors Bioorg.Med.Chem.Lett., 17:3463-3467, 2007 Cited by PubMed: 17459703DOI: 10.1016/j.bmcl.2007.03.078 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
Download full validation report