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7PMK
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BU of 7pmk by Molmil
S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation I)
Descriptor: Cell division control protein 45,Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA helicase, ...
Authors:Jenkyn-Bedford, M, Yeeles, J.T.P, Deegan, T.D.
Deposit date:2021-09-02
Release date:2021-11-10
Last modified:2022-02-02
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:A conserved mechanism for regulating replisome disassembly in eukaryotes.
Nature, 600, 2021
7PMN
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BU of 7pmn by Molmil
S. cerevisiae replisome-SCF(Dia2) complex bound to double-stranded DNA (conformation II)
Descriptor: Cell division control protein 45,Cell division control protein 45, Chromosome segregation in meiosis protein 3, DNA polymerase alpha-binding protein, ...
Authors:Jenkyn-Bedford, M, Yeeles, J.T.P, Deegan, T.D.
Deposit date:2021-09-02
Release date:2021-11-10
Last modified:2022-01-26
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:A conserved mechanism for regulating replisome disassembly in eukaryotes.
Nature, 600, 2021
7PLO
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BU of 7plo by Molmil
H. sapiens replisome-CUL2/LRR1 complex
Descriptor: Cell division control protein 45 homolog, Claspin, Cullin-2, ...
Authors:Jones, M.J, Yeeles, J.T.P, Deegan, T.D, Jenkyn-Bedford, M.
Deposit date:2021-09-01
Release date:2021-11-10
Last modified:2023-10-18
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:A conserved mechanism for regulating replisome disassembly in eukaryotes.
Nature, 600, 2021
7S0T
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BU of 7s0t by Molmil
Structure of DNA polymerase zeta with mismatched DNA
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (30-MER), ...
Authors:Malik, R, Ubarretxena, I.B, Aggarwal, A.K.
Deposit date:2021-08-31
Release date:2022-03-09
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.05 Å)
Cite:Cryo-EM structure of translesion DNA synthesis polymerase zeta with a base pair mismatch.
Nat Commun, 13, 2022
7PFO
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BU of 7pfo by Molmil
Core human replisome
Descriptor: Cell division control protein 45 homolog, Claspin, DNA polymerase epsilon catalytic subunit A, ...
Authors:Jones, M.J, Yeeles, J.T.P.
Deposit date:2021-08-11
Release date:2021-11-10
Last modified:2023-10-18
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure of a human replisome shows the organisation and interactions of a DNA replication machine.
Embo J., 40, 2021
7RSR
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BU of 7rsr by Molmil
Kod-RI incorporating PMT, n+2
Descriptor: DNA polymerase, Primer, Template
Authors:Hajjar, M, Chim, N, Chaput, J.C.
Deposit date:2021-08-11
Release date:2022-08-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Crystallographic analysis of engineered polymerases synthesizing phosphonomethylthreosyl nucleic acid.
Nucleic Acids Res., 50, 2022
7RSS
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BU of 7rss by Molmil
Kod-RI incorporating DNA, n+2
Descriptor: DNA polymerase, Primer, Template
Authors:Hajjar, M, Chim, N, Chaput, J.C.
Deposit date:2021-08-11
Release date:2022-08-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Crystallographic analysis of engineered polymerases synthesizing phosphonomethylthreosyl nucleic acid.
Nucleic Acids Res., 50, 2022
7RSU
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BU of 7rsu by Molmil
TNA polymerase, n+2 product
Descriptor: DNA polymerase, Primer, Template
Authors:Maola, V, Chaput, J, Chim, N.
Deposit date:2021-08-11
Release date:2021-10-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Synthesis and Polymerase Recognition of Threose Nucleic Acid Triphosphates Equipped with Diverse Chemical Functionalities.
J.Am.Chem.Soc., 143, 2021
7F4Y
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BU of 7f4y by Molmil
Crystal structure of replisomal dimer of DNA polymerase from bacteriophage RB69 with DNA duplexes
Descriptor: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*GP*AP*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*C)-3'), ...
Authors:Youn, H.-S, Park, J, An, J.Y, Lee, Y, Eom, S.H, Wang, J.
Deposit date:2021-06-21
Release date:2021-07-14
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of New Binary and Ternary DNA Polymerase Complexes From Bacteriophage RB69.
Front Mol Biosci, 8, 2021
7OPL
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BU of 7opl by Molmil
CryoEM structure of DNA Polymerase alpha - primase bound to SARS CoV nsp1
Descriptor: DNA polymerase alpha catalytic subunit, DNA polymerase alpha subunit B, DNA primase large subunit, ...
Authors:Kilkenny, M.L, Pellegrini, L.
Deposit date:2021-06-01
Release date:2021-11-10
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (4.12 Å)
Cite:Structural basis for the interaction of SARS-CoV-2 virulence factor nsp1 with DNA polymerase alpha-primase.
Protein Sci., 31, 2022
7N2M
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BU of 7n2m by Molmil
Crystal structure of DNA polymerase alpha catalytic core in complex with dCTP and template/primer having T-C mismatch at the post-insertion site
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*T*AP*GP*TP*CP*GP*CP*TP*CP*CP*AP*GP*GP*C)-3'), DNA polymerase alpha catalytic subunit, ...
Authors:Tahirov, T.H, Baranovskiy, A.G, Babayeva, N.D.
Deposit date:2021-05-29
Release date:2022-04-20
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural and functional insight into mismatch extension by human DNA polymerase alpha.
Proc.Natl.Acad.Sci.USA, 119, 2022
7OMG
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BU of 7omg by Molmil
Crystal structure of KOD DNA Polymerase in a ternary complex with an Uracil containing template
Descriptor: 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, ...
Authors:Betz, K, Kropp, H.M, Diederichs, K, Marx, A.
Deposit date:2021-05-22
Release date:2021-10-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Basis for The Recognition of Deaminated Nucleobases by An Archaeal DNA Polymerase.
Chembiochem, 22, 2021
7OM3
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BU of 7om3 by Molmil
Crystal structure of KOD DNA Polymerase in a binary complex with Hypoxanthine containing template
Descriptor: 1,2-ETHANEDIOL, 21nt Template, BROMIDE ION, ...
Authors:Betz, K, Kropp, H.M, Diederichs, K, Marx, A.
Deposit date:2021-05-21
Release date:2021-10-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Structural Basis for The Recognition of Deaminated Nucleobases by An Archaeal DNA Polymerase.
Chembiochem, 22, 2021
7OMB
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BU of 7omb by Molmil
Crystal structure of KOD DNA Polymerase in a ternary complex with a p/t duplex containing an extended 5' single stranded template overhang
Descriptor: 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA polymerase, ...
Authors:Betz, K, Kropp, H.M, Diederichs, K, Marx, A.
Deposit date:2021-05-21
Release date:2021-10-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Structural Basis for The Recognition of Deaminated Nucleobases by An Archaeal DNA Polymerase.
Chembiochem, 22, 2021
7LXD
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BU of 7lxd by Molmil
Structure of yeast DNA Polymerase Zeta (apo)
Descriptor: DNA polymerase delta small subunit, DNA polymerase delta subunit 3, DNA polymerase zeta catalytic subunit, ...
Authors:Truong, C.D, Craig, T.A, Cui, G, Botuyan, M.V, Serkasevich, R.A, Chan, K.-Y, Mer, G, Chiu, P.-L, Kumar, R.
Deposit date:2021-03-03
Release date:2021-06-30
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (4.11 Å)
Cite:Cryo-EM reveals conformational flexibility in apo DNA polymerase zeta.
J.Biol.Chem., 297, 2021
7LUF
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BU of 7luf by Molmil
HSV1 polymerase ternary complex with dsDNA and PNU-183792
Descriptor: DNA (5'-D(*CP*GP*AP*TP*CP*CP*TP*TP*CP*CP*CP*CP*TP*AP*C)-3'), DNA (5'-D(P*AP*TP*GP*GP*TP*AP*GP*GP*GP*GP*AP*AP*GP*GP*AP*TP*CP*G)-3'), DNA polymerase, ...
Authors:Hayes, R.P, Klein, D.
Deposit date:2021-02-22
Release date:2021-04-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structural understanding of non-nucleoside inhibition in an elongating herpesvirus polymerase.
Nat Commun, 12, 2021
7B0H
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BU of 7b0h by Molmil
TgoT_6G12 Ternary complex
Descriptor: DNA (5'-D(P*AP*AP*CP*GP*GP*CP*AP*AP*AP*TP*GP*CP*G)-3'), DNA (5'-D(P*CP*GP*CP*AP*TP*T)-3'), DNA polymerase, ...
Authors:Samson, C, Legrand, P, Tekpinar, M, Rozenski, J, Abramov, M, Holliger, P, Pinheiro, V, Herdewijn, P, Delarue, M.
Deposit date:2020-11-19
Release date:2021-01-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structural Studies of HNA Substrate Specificity in Mutants of an Archaeal DNA Polymerase Obtained by Directed Evolution.
Biomolecules, 10, 2020
7B0G
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BU of 7b0g by Molmil
TgoT_6G12 binary with 2 hCTPs
Descriptor: CYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(P*AP*TP*TP*GP*GP*CP*TP*GP*CP*CP*CP*TP*CP*C)-3'), DNA (5'-D(P*GP*GP*AP*GP*GP*GP*CP*AP*GP*()P*())-3'), ...
Authors:Samson, C, Legrand, P, Tekpinar, M, Rozenski, J, Abramov, M, Holliger, P, Pinheiro, V, Herdewijn, P, Delarue, M.
Deposit date:2020-11-19
Release date:2020-12-30
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Studies of HNA Substrate Specificity in Mutants of an Archaeal DNA Polymerase Obtained by Directed Evolution.
Biomolecules, 10, 2020
7B0F
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BU of 7b0f by Molmil
TgoT_6G12 Binary complex
Descriptor: DNA (5'-D(P*AP*AP*CP*GP*GP*CP*TP*AP*AP*TP*GP*CP*G)-3'), DNA (5'-D(P*CP*GP*CP*AP*TP*T)-3'), DNA polymerase, ...
Authors:Samson, C, Legrand, P, Tekpinar, M, Rozenski, J, Abramov, M, Holliger, P, Pinheiro, V, Herdewijn, P, Delarue, M.
Deposit date:2020-11-19
Release date:2020-12-30
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.797 Å)
Cite:Structural Studies of HNA Substrate Specificity in Mutants of an Archaeal DNA Polymerase Obtained by Directed Evolution.
Biomolecules, 10, 2020
7B08
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BU of 7b08 by Molmil
TgoT apo
Descriptor: DNA polymerase, THYMIDINE-5'-TRIPHOSPHATE, TRIETHYLENE GLYCOL
Authors:Samson, C, Legrand, P, Tekpinar, M, Rozenski, J, Abramov, M, Holliger, P, Pinheiro, V, Herdewijn, P, Delarue, M.
Deposit date:2020-11-18
Release date:2020-12-30
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.394 Å)
Cite:Structural Studies of HNA Substrate Specificity in Mutants of an Archaeal DNA Polymerase Obtained by Directed Evolution.
Biomolecules, 10, 2020
7B07
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BU of 7b07 by Molmil
TgoT_6G12 apo
Descriptor: CALCIUM ION, DNA polymerase
Authors:Samson, C, Legrand, P, Tekpinar, M, Rozenski, J, Abramov, M, Holliger, P, Pinheiro, V, Herdewijn, P, Delarue, M.
Deposit date:2020-11-18
Release date:2020-12-30
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.099 Å)
Cite:Structural Studies of HNA Substrate Specificity in Mutants of an Archaeal DNA Polymerase Obtained by Directed Evolution.
Biomolecules, 10, 2020
7B06
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BU of 7b06 by Molmil
TgoT_RT521 apo
Descriptor: DNA polymerase
Authors:Samson, C, Legrand, P, Tekpinar, M, Rozenski, J, Abramov, M, Holliger, P, Pinheiro, V, Herdewijn, P, Delarue, M.
Deposit date:2020-11-18
Release date:2020-12-30
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.349 Å)
Cite:Structural Studies of HNA Substrate Specificity in Mutants of an Archaeal DNA Polymerase Obtained by Directed Evolution.
Biomolecules, 10, 2020
7KC0
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BU of 7kc0 by Molmil
Structure of the Saccharomyces cerevisiae replicative polymerase delta in complex with a primer/template and the PCNA clamp
Descriptor: 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, DNA (25-MER), DNA (5'-D(P*AP*TP*GP*AP*CP*CP*AP*TP*GP*AP*TP*TP*AP*CP*GP*AP*AP*TP*TP*GP*C)-3'), ...
Authors:Zheng, F, Georgescu, R, Li, H, O'Donnell, M.E.
Deposit date:2020-10-04
Release date:2020-12-02
Last modified:2020-12-16
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure of eukaryotic DNA polymerase delta bound to the PCNA clamp while encircling DNA.
Proc.Natl.Acad.Sci.USA, 117, 2020
6WYA
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BU of 6wya by Molmil
RTX (Reverse Transcription Xenopolymerase) in complex with a DNA duplex and dAMPNPP
Descriptor: 1,2-ETHANEDIOL, 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Choi, W.S, He, P, Pothukuchy, A, Gollihar, J, Ellington, A.D, Yang, W.
Deposit date:2020-05-12
Release date:2020-08-19
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:How a B family DNA polymerase has been evolved to copy RNA.
Proc.Natl.Acad.Sci.USA, 117, 2020
6WYB
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BU of 6wyb by Molmil
RTX (Reverse Transcription Xenopolymerase) in complex with an RNA/DNA hybrid
Descriptor: 1,2-ETHANEDIOL, 3,3',3''-phosphanetriyltripropanoic acid, DNA polymerase, ...
Authors:Choi, W.S, He, P, Pothukuchy, A, Gollihar, J, Ellington, A.D, Yang, W.
Deposit date:2020-05-12
Release date:2020-08-19
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:How a B family DNA polymerase has been evolved to copy RNA.
Proc.Natl.Acad.Sci.USA, 117, 2020

221051

数据于2024-06-12公开中

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