5IBK
| Skp1-F-box in complex with a ubiquitin variant | Descriptor: | F-box/WD repeat-containing protein 7, Polyubiquitin-B, S-phase kinase-associated protein 1,S-phase kinase-associated protein 1 | Authors: | Orlicky, S, Sicheri, F. | Deposit date: | 2016-02-22 | Release date: | 2016-03-30 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.503 Å) | Cite: | Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1-F-box interface. Proc.Natl.Acad.Sci.USA, 113, 2016
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5Y9W
| Crystal 1 for AtLURE1.2-AtPRK6LRR | Descriptor: | Pollen receptor-like kinase 6, Protein LURE 1.2, SULFATE ION | Authors: | Chai, J, Zhang, X. | Deposit date: | 2017-08-28 | Release date: | 2017-12-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.847 Å) | Cite: | Structural basis for receptor recognition of pollen tube attraction peptides. Nat Commun, 8, 2017
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1R8G
| Structure and function of YbdK | Descriptor: | Hypothetical protein ybdK | Authors: | Lehmann, C, Doseeva, V, Pullalarevu, S, Krajewski, W, Howard, A, Herzberg, O, Structure 2 Function Project (S2F) | Deposit date: | 2003-10-24 | Release date: | 2004-08-17 | Last modified: | 2021-07-28 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | YbdK is a carboxylate-amine ligase with a gamma-glutamyl:Cysteine ligase activity: crystal structure and enzymatic assays PROTEINS: STRUCT.,FUNCT.,GENET., 56, 2004
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1GFD
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4XOY
| Crystal structure of ERK2 in complex with an inhibitor | Descriptor: | 2-amino-1,9-dihydro-6H-purine-6-thione, Mitogen-activated protein kinase 1, SULFATE ION | Authors: | Gelin, M, Allemand, F, Labesse, G, Guichou, J.F. | Deposit date: | 2015-01-16 | Release date: | 2015-08-12 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography. Acta Crystallogr.,Sect.D, 71, 2015
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5YAH
| Crystal 2 for AtLURE1.2-AtPRK6LRR | Descriptor: | Pollen receptor-like kinase 6, Protein LURE 1.2 | Authors: | Chai, J, Zhang, X. | Deposit date: | 2017-08-31 | Release date: | 2018-04-11 | Method: | X-RAY DIFFRACTION (2.104 Å) | Cite: | Structural basis for receptor recognition of pollen tube attraction peptides. Nat Commun, 8, 2017
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5YEM
| CATPO mutant - T188F | Descriptor: | CALCIUM ION, Catalase, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Yuzugullu Karakus, Y, Balci, S, Goc, G, Pearson, A.R, Yorke, B. | Deposit date: | 2017-09-18 | Release date: | 2018-07-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | Investigation of how gate residues in the main channel affect the catalytic activity of Scytalidium thermophilum catalase. Acta Crystallogr D Struct Biol, 80, 2024
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4XP0
| Crystal structure of ERK2 in complex with an inhibitor | Descriptor: | 1H-pyrrolo[2,3-b]pyridine-3-carbonitrile, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ... | Authors: | Gelin, M, Allemand, F, Labesse, G, Guichou, J.F. | Deposit date: | 2015-01-16 | Release date: | 2015-08-12 | Last modified: | 2017-09-06 | Method: | X-RAY DIFFRACTION (1.46 Å) | Cite: | Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography. Acta Crystallogr.,Sect.D, 71, 2015
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4XRJ
| Crystal structure of ERK2 in complex with an inhibitor | Descriptor: | Mitogen-activated protein kinase 1, N~1~-[3-(benzyloxy)benzyl]-1H-tetrazole-1,5-diamine, SULFATE ION | Authors: | Gelin, M, Allemand, F, Labesse, G, Guichou, J.F. | Deposit date: | 2015-01-21 | Release date: | 2015-08-12 | Last modified: | 2015-08-19 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Combining `dry' co-crystallization and in situ diffraction to facilitate ligand screening by X-ray crystallography. Acta Crystallogr.,Sect.D, 71, 2015
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1E0O
| CRYSTAL STRUCTURE OF A TERNARY FGF1-FGFR2-HEPARIN COMPLEX | Descriptor: | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, FIBROBLAST GROWTH FACTOR 1, FIBROBLAST GROWTH FACTOR RECEPTOR 2, ... | Authors: | Pellegrini, L, Burke, D.F, von Delft, F, Mulloy, B, Blundell, T.L. | Deposit date: | 2000-04-03 | Release date: | 2000-10-23 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal Structure of Fibroblast Growth Factor Receptor Ectodomain Bound to Ligand and Heparin Nature, 407, 2000
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2N0W
| Mdmx-SJ212 | Descriptor: | 4-({(4S,5R)-4-(5-bromo-2-fluorophenyl)-5-(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one, Protein Mdm4 | Authors: | Grace, C.R, Kriwacki, R.W. | Deposit date: | 2015-03-17 | Release date: | 2016-01-27 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Monitoring Ligand-Induced Protein Ordering in Drug Discovery. J.Mol.Biol., 428, 2016
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2N06
| Mdmx-298 | Descriptor: | 4-[[(4S,5R)-5-(4-chlorophenyl)-4-(3-methoxyphenyl)-2-(4-methoxy-2-propan-2-yloxy-phenyl)-4,5-dihydroimidazol-1-yl]carbonyl]piperazin-2-one, Protein Mdm4 | Authors: | Grace, C.R, Kriwacki, R.W. | Deposit date: | 2015-03-04 | Release date: | 2016-01-27 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Monitoring Ligand-Induced Protein Ordering in Drug Discovery. J.Mol.Biol., 428, 2016
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1KM3
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2MVU
| Solution Structure of the 3,7-dioxo-octyl Actinorhodin Acyl Carrier Protein from Streptomyces coelicolor | Descriptor: | Actinorhodin polyketide synthase acyl carrier protein, N~3~-{(2S)-4-[(dihydroxyphosphanyl)oxy]-2-hydroxy-3,3-dimethylbutanoyl}-N-{2-[(3,7-dioxooctyl)sulfanyl]ethyl}-beta-alaninamide | Authors: | Dong, X, Bailey, C, Williams, C, Crosby, J, Simpson, T.J, Willis, C.L, Crump, M.P. | Deposit date: | 2014-10-15 | Release date: | 2015-10-21 | Method: | SOLUTION NMR | Cite: | ACP-ligand recognition: Selection of derivatized aromatic biosynthetic intermediates To be Published
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3MI2
| Crystal structure of human orotidine-5'-monophosphate decarboxylase complexed with pyrazofurin monophosphate | Descriptor: | (1S)-1,4-anhydro-1-(5-carbamoyl-4-hydroxy-1H-pyrazol-3-yl)-5-O-phosphono-D-ribitol, Uridine 5'-monophosphate synthase | Authors: | Liu, Y, To, T, Kotra, L.P, Pai, E.F. | Deposit date: | 2010-04-09 | Release date: | 2010-05-26 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Structural determinants for the inhibitory ligands of orotidine-5'-monophosphate decarboxylase. Bioorg.Med.Chem., 18, 2010
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7V0J
| Crystal structure of a CelR catalytic domain active site mutant with bound cellobiose product | Descriptor: | CALCIUM ION, Glucanase, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose | Authors: | Bingman, C.A, Kuch, N, Kutsche, M.E, Parker, A, Smith, R.W, Fox, B.G. | Deposit date: | 2022-05-10 | Release date: | 2023-04-05 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Contribution of calcium ligands in substrate binding and product release in the Acetovibrio thermocellus glycoside hydrolase family 9 cellulase CelR. J.Biol.Chem., 299, 2023
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4FEN
| Crystal structure of the A24U/U25A/A46G mutant xpt-pbuX guanine riboswitch aptamer domain in complex with hypoxanthine | Descriptor: | A24U/U25A/A46G mutant of the B. subtilis xpt-pbuX guanine riboswitch aptamer domain, ACETATE ION, COBALT HEXAMMINE(III), ... | Authors: | Stoddard, C.D, Trausch, J.J, Widmann, J, Marcano, J, Knight, R, Batey, R.T. | Deposit date: | 2012-05-30 | Release date: | 2013-02-27 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Nucleotides Adjacent to the Ligand-Binding Pocket are Linked to Activity Tuning in the Purine Riboswitch. J.Mol.Biol., 425, 2013
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7UNP
| Crystal structure of the CelR catalytic domain and CBM3c | Descriptor: | CALCIUM ION, Glucanase | Authors: | Bingman, C.A, Kuch, N, Kutsche, M.E, Parker, A, Smith, R.W, Fox, B.G. | Deposit date: | 2022-04-11 | Release date: | 2023-04-05 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Contribution of calcium ligands in substrate binding and product release in the Acetovibrio thermocellus glycoside hydrolase family 9 cellulase CelR. J.Biol.Chem., 299, 2023
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3WX2
| Mouse Cereblon thalidomide binding domain, native | Descriptor: | Protein cereblon, SULFATE ION, ZINC ION | Authors: | Mori, T, Ito, T, Hirano, Y, Yamaguchi, Y, Handa, H, Hakoshima, T. | Deposit date: | 2014-07-10 | Release date: | 2014-08-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs Nat.Struct.Mol.Biol., 21, 2014
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7V0I
| Crystal structure of a CelR catalytic domain active site mutant with bound cellohexaose substrate | Descriptor: | CALCIUM ION, Glucanase, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose | Authors: | Bingman, C.A, Kuch, N, Kutsche, M.E, Parker, A, Smith, R.W, Fox, B.G. | Deposit date: | 2022-05-10 | Release date: | 2023-04-05 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Contribution of calcium ligands in substrate binding and product release in the Acetovibrio thermocellus glycoside hydrolase family 9 cellulase CelR. J.Biol.Chem., 299, 2023
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2N14
| Mdmx-295 | Descriptor: | 4-({(4S,5R)-4-(3-chlorophenyl)-5-(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one, Protein Mdm4 | Authors: | Grace, C.R, Kriwacki, R.W. | Deposit date: | 2015-03-20 | Release date: | 2016-01-27 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Monitoring Ligand-Induced Protein Ordering in Drug Discovery. J.Mol.Biol., 428, 2016
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1KJL
| High Resolution X-Ray Structure of Human Galectin-3 in complex with LacNAc | Descriptor: | BROMIDE ION, CHLORIDE ION, Galectin-3, ... | Authors: | Sorme, P, Arnoux, P, Kahl-Knutsson, B, Leffler, H, Rini, J.M, Nilsson, U.J. | Deposit date: | 2001-12-04 | Release date: | 2005-04-12 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structural and thermodynamic studies on cation-Pi interactions in lectin-ligand complexes: high-affinity galectin-3 inhibitors through fine-tuning of an arginine-arene interaction. J.Am.Chem.Soc., 127, 2005
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1KLY
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1KM4
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3WX1
| Mouse Cereblon thalidomide binding domain, selenomethionine derivative | Descriptor: | Protein cereblon, SULFATE ION, ZINC ION | Authors: | Mori, T, Ito, T, Hirano, Y, Yamaguchi, Y, Handa, H, Hakoshima, T. | Deposit date: | 2014-07-10 | Release date: | 2014-08-06 | Last modified: | 2014-09-17 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs Nat.Struct.Mol.Biol., 21, 2014
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