5JEH

Human carbonic anhydrase II (L198A) complexed with benzo[d]thiazole-2-sulfonamide

Summary for 5JEH

• Entry DOI: 10.2210/pdb5jeh/pdb
• Related: 5JDV 5JE7 5JEG 5JEP 5JES 5JG3 5JG5
• Descriptor: Carbonic anhydrase 2, ZINC ION, 1,3-benzothiazole-2-sulfonamide, ... (4 entities in total)
• Functional Keywords: anhydrase, mutant, hydrophobic, lyase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm : P00918
• Total number of polymer chains: 1
• Total formula weight: 29379.46

Authors

Fox, J.M.,Kang, K.,Sastry, M.,Sherman, W.,Sankaran, B.,Zwart, P.H.,Whitesides, G.M. (deposition date: 2016-04-18, release date: 2017-01-11, Last modification date: 2023-09-27)

• Primary citation: Fox, J.M.,Kang, K.,Sastry, M.,Sherman, W.,Sankaran, B.,Zwart, P.H.,Whitesides, G.M.; Water-Restructuring Mutations Can Reverse the Thermodynamic Signature of Ligand Binding to Human Carbonic Anhydrase.; Angew. Chem. Int. Ed. Engl., 56:3833-3837, 2017; PubMed: 28252841; DOI: 10.1002/anie.201609409

Experimental method

X-RAY DIFFRACTION (1.13 Å)