5JGS
Human carbonic anhydrase II (F131Y/L198A) complexed with benzo[d]thiazole-2-sulfonamide
Summary for 5JGS
Entry DOI | 10.2210/pdb5jgs/pdb |
Descriptor | Carbonic anhydrase 2, 1,3-benzothiazole-2-sulfonamide, ZINC ION, ... (4 entities in total) |
Functional Keywords | anhydrase, mutant, water, hydrophobic, lyase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : P00918 |
Total number of polymer chains | 1 |
Total formula weight | 29400.50 |
Authors | Fox, J.M.,Kang, K.,Sastry, M.,Sherman, W.,Sankaran, B.,Zwart, P.H.,Whitesides, G.M. (deposition date: 2016-04-20, release date: 2017-01-11, Last modification date: 2023-09-27) |
Primary citation | Fox, J.M.,Kang, K.,Sastry, M.,Sherman, W.,Sankaran, B.,Zwart, P.H.,Whitesides, G.M. Water-Restructuring Mutations Can Reverse the Thermodynamic Signature of Ligand Binding to Human Carbonic Anhydrase. Angew. Chem. Int. Ed. Engl., 56:3833-3837, 2017 Cited by PubMed: 28252841DOI: 10.1002/anie.201609409 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.11 Å) |
Structure validation
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