9B9H
 
 | | Crystal structure of the ternary complex of DCAF1 and WDR5 with PROTAC, OICR-40333 | | Descriptor: | DDB1- and CUL4-associated factor 1, N-{(1P)-5'-({(17E)-18-[(3P)-4-{[(1S)-3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl]carbamoyl}-3-(4-chloro-2-fluorophenyl)-1H-pyrrol-2-yl]-16-oxo-3,6,9,12-tetraoxa-15-azaoctadec-17-en-1-yl}carbamoyl)-2'-fluoro-4-[(3R,5S)-3,4,5-trimethylpiperazin-1-yl][1,1'-biphenyl]-3-yl}-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide, WD repeat-containing protein 5 | | Authors: | Mabanglo, M.F, Wilson, B.J, Alvarez, H.G, Hoffer, L, Al-awar, R, Vedadi, M. | | Deposit date: | 2024-04-02 | | Release date: | 2024-11-06 | | Last modified: | 2024-12-04 | | Method: | X-RAY DIFFRACTION (2.06 Å) | | Cite: | Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity.
Nat Commun, 15, 2024
|
|
9B9W
 | | Crystal structure of the ternary complex of DCAF1 and WDR5 with PROTAC, OICR-40792 | | Descriptor: | (4P)-N-[(1R)-3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl]-4-(4-chloro-2-fluorophenyl)-5-[(25E)-1-{(1P)-6-fluoro-3'-[4-fluoro-2-(trifluoromethyl)benzamido]-4'-[(3R,5S)-3,4,5-trimethylpiperazin-1-yl][1,1'-biphenyl]-3-yl}-1,24-dioxo-5,8,11,14,17,20-hexaoxa-2,23-diazahexacos-25-en-26-yl]-1H-pyrrole-3-carboxamide, DDB1- and CUL4-associated factor 1, WD repeat-containing protein 5 | | Authors: | Mabanglo, M.F, Wilson, B.J, Mamai, A, Hoffer, L, Al-awar, R, Vedadi, M. | | Deposit date: | 2024-04-03 | | Release date: | 2024-11-06 | | Last modified: | 2024-12-04 | | Method: | X-RAY DIFFRACTION (1.92 Å) | | Cite: | Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity.
Nat Commun, 15, 2024
|
|
9B9T
 | | Crystal structure of the ternary complex of DCAF1 and WDR5 with PROTAC, OICR-40407 | | Descriptor: | DDB1- and CUL4-associated factor 1, N-{(1P)-5'-[(17-{(4P)-4-[(2P)-4-{[(1R)-3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl]carbamoyl}-3-(4-chloro-2-fluorophenyl)-1H-pyrrol-2-yl]-1H-pyrazol-1-yl}-16-oxo-3,6,9,12-tetraoxa-15-azaheptadecan-1-yl)carbamoyl]-2'-fluoro-4-[(3R,5S)-3,4,5-trimethylpiperazin-1-yl][1,1'-biphenyl]-3-yl}-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide, WD repeat-containing protein 5 | | Authors: | Mabanglo, M.F, Wilson, B.J, Krausser, C, Hoffer, L, Al-awar, R, Vedadi, M. | | Deposit date: | 2024-04-03 | | Release date: | 2024-11-06 | | Last modified: | 2024-12-04 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity.
Nat Commun, 15, 2024
|
|
9BA2
 | | Crystal structure of the binary complex of DCAF1 and WDR5 | | Descriptor: | DDB1- and CUL4-associated factor 1, IMIDAZOLE, WD repeat-containing protein 5 | | Authors: | Mabanglo, M.F, Wilson, B.J, Srivastava, S, Al-awar, R, Vedadi, M. | | Deposit date: | 2024-04-03 | | Release date: | 2024-11-06 | | Last modified: | 2024-12-04 | | Method: | X-RAY DIFFRACTION (2.97 Å) | | Cite: | Crystal structures of DCAF1-PROTAC-WDR5 ternary complexes provide insight into DCAF1 substrate specificity.
Nat Commun, 15, 2024
|
|
1YYN
 | | A common binding site for disialyllactose and a tri-peptide in the C-fragment of tetanus neurotoxin | | Descriptor: | N-acetyl-alpha-neuraminic acid-(2-8)-N-acetyl-alpha-neuraminic acid-(2-3)-alpha-D-galactopyranose-(1-4)-beta-D-glucopyranose, Tetanus toxin | | Authors: | Seetharaman, J, Eswaramoorthy, S, Kumaran, D, Swaminathan, S. | | Deposit date: | 2005-02-25 | | Release date: | 2005-03-15 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Common binding site for disialyllactose and tri-peptide in C-fragment of tetanus neurotoxin
Proteins, 61, 2005
|
|
6TWM
 | | Product bound structure of the Ectoine utilization protein EutE (DoeB) from Ruegeria pomeroyi | | Descriptor: | 2,4-DIAMINOBUTYRIC ACID, ACETATE ION, N-acetyl-L-2,4-diaminobutyric acid deacetylase, ... | | Authors: | Mais, C.-N, Altegoer, F, Bange, G. | | Deposit date: | 2020-01-13 | | Release date: | 2020-05-20 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Degradation of the microbial stress protectants and chemical chaperones ectoine and hydroxyectoine by a bacterial hydrolase-deacetylase complex.
J.Biol.Chem., 295, 2020
|
|
6UH7
 | | EV-A71 strain 11316 complexed with MADAL compound 30 | | Descriptor: | SPHINGOSINE, VP1, VP2, ... | | Authors: | Lee, H, Hafenstein, S. | | Deposit date: | 2019-09-26 | | Release date: | 2019-12-18 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (2.87 Å) | | Cite: | Scaffold Simplification Strategy Leads to a Novel Generation of Dual Human Immunodeficiency Virus and Enterovirus-A71 Entry Inhibitors.
J.Med.Chem., 63, 2020
|
|
2AFJ
 | | SPRY domain-containing SOCS box protein 2 (SSB-2) | | Descriptor: | gene rich cluster, C9 gene | | Authors: | Masters, S.L, Yao, S, Willson, T.A, Zhang, J.G, Palmer, K.R, Smith, B.J, Babon, J.J, Nicola, N.A, Norton, R.S, Nicholson, S.E. | | Deposit date: | 2005-07-26 | | Release date: | 2006-01-03 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | The SPRY domain of SSB-2 adopts a novel fold that presents conserved Par-4-binding residues
Nat.Struct.Mol.Biol., 13, 2006
|
|
3DRG
 | | Lactococcal OppA complexed with bradykinin in the closed conformation | | Descriptor: | Bradykinin, CHLORIDE ION, Oligopeptide-binding protein oppA | | Authors: | Berntsson, R.P.-A, Doeven, M.K, Duurkens, R.H, Sengupta, D, Marrink, S.-J, Thunnissen, A.-M, Poolman, B, Slotboom, D.-J. | | Deposit date: | 2008-07-11 | | Release date: | 2009-03-31 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | The structural basis for peptide selection by the transport receptor OppA
Embo J., 28, 2009
|
|
1UNC
 | | Solution structure of the human villin C-terminal headpiece subdomain | | Descriptor: | VILLIN 1 | | Authors: | Vermeulen, W, Van Troys, M, Vanhaesebrouck, P, Verschueren, M, Fant, F, Ampe, C, Martins, J, Borremans, F. | | Deposit date: | 2003-09-09 | | Release date: | 2004-07-15 | | Last modified: | 2024-11-13 | | Method: | SOLUTION NMR | | Cite: | Solution Structures of the C-Terminal Headpiece Subdomains of Human Villin and Advillin, Evaluation of Headpiece F-Actin-Binding Requirements
Protein Sci., 13, 2004
|
|
2AFX
 | | Crystal structure of human glutaminyl cyclase in complex with 1-benzylimidazole | | Descriptor: | 1-BENZYL-1H-IMIDAZOLE, Glutaminyl-peptide cyclotransferase, SULFATE ION, ... | | Authors: | Huang, K.F, Liu, Y.L, Cheng, W.J, Ko, T.P, Wang, A.H.J. | | Deposit date: | 2005-07-26 | | Release date: | 2005-08-23 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.64 Å) | | Cite: | Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation
Proc.Natl.Acad.Sci.Usa, 102, 2005
|
|
9B65
 | | Biased agonist bound CB1-Gi structure | | Descriptor: | Cannabinoid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Rangari, V.A, O'Brien, E.S, Kobilka, B.K, Krishna Kumar, K, Majumdar, S. | | Deposit date: | 2024-03-23 | | Release date: | 2025-03-05 | | Last modified: | 2025-04-16 | | Method: | ELECTRON MICROSCOPY (3.03 Å) | | Cite: | A cryptic pocket in CB1 drives peripheral and functional selectivity.
Nature, 640, 2025
|
|
3DL8
 | | Structure of the complex of aquifex aeolicus SecYEG and bacillus subtilis SecA | | Descriptor: | Preprotein translocase subunit secY, Protein translocase subunit secA, Protein-export membrane protein secG, ... | | Authors: | Nam, Y, Zimmer, J, Rapoport, T.A. | | Deposit date: | 2008-06-26 | | Release date: | 2008-12-02 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (7.5 Å) | | Cite: | Structure of a complex of the ATPase SecA and the protein-translocation channel.
Nature, 455, 2008
|
|
9B54
 | | Biased agonist bound CB1-Gi structure | | Descriptor: | Cannabinoid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Rangari, V.A, O'Brien, E.S, Kobilka, B.K, Krishna Kumar, K, Majumdar, S. | | Deposit date: | 2024-03-22 | | Release date: | 2025-03-05 | | Last modified: | 2025-04-16 | | Method: | ELECTRON MICROSCOPY (2.86 Å) | | Cite: | A cryptic pocket in CB1 drives peripheral and functional selectivity.
Nature, 640, 2025
|
|
9B1Y
 | | WT strain WT mycobacterial ribosome | | Descriptor: | 16S rRNA, 23S rRNA, 23S rRNA fragment, ... | | Authors: | Chen, Y, Young, I.D, Fraser, J.S, Javid, B. | | Deposit date: | 2024-03-14 | | Release date: | 2025-03-26 | | Method: | ELECTRON MICROSCOPY (2.47 Å) | | Cite: | Ribosomal RNA methylation by GidB is a capacitor for discrimination of mischarged tRNA
To be published
|
|
9B5Y
 | | Cryo-EM structure of the LAPTH-bound PTH1R in complex with Gq | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q), ... | | Authors: | Zhang, X, Liu, H, Zhang, C, Vilardaga, J.-P. | | Deposit date: | 2024-03-22 | | Release date: | 2025-03-19 | | Last modified: | 2025-06-04 | | Method: | ELECTRON MICROSCOPY (3.49 Å) | | Cite: | Allosteric mechanism in the distinctive coupling of G q and G s to the parathyroid hormone type 1 receptor.
Proc.Natl.Acad.Sci.USA, 122, 2025
|
|
3DRK
 | | Crystal structure of Lactococcal OppA co-crystallized with Neuropeptide S in an open conformation | | Descriptor: | Neuropeptide S, Oligopeptide-binding protein oppA | | Authors: | Berntsson, R.P.-A, Doeven, M.K, Duurkens, R.H, Sengupta, D, Marrink, S.-J, Thunnissen, A.-M, Poolman, B, Slotboom, D.-J. | | Deposit date: | 2008-07-11 | | Release date: | 2009-03-31 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The structural basis for peptide selection by the transport receptor OppA
Embo J., 28, 2009
|
|
9BLW
 | | Human amylin1 Receptor in complex with Gs and Cagrilintide backbone (non-acylated) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cagrilintide backbone (non-acylated), Calcitonin receptor, ... | | Authors: | Cao, J, Belousoff, M.J, Sexton, P.M, Wootten, D.L. | | Deposit date: | 2024-05-01 | | Release date: | 2025-04-16 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Human amylin1 Receptor in complex with Gs and Cagrilintide backbone (non-acylated)
To Be Published
|
|
9BLC
 | | Human Calcitonin Receptor in Complex with Gs and Cagrilintide Backbone (non-acylated) in CT-like conformation | | Descriptor: | Cagrilintide backbone (non-acylated), Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Cao, J, Belousoff, M.J, Wootten, D.L, Sexton, P.M. | | Deposit date: | 2024-04-30 | | Release date: | 2025-04-16 | | Last modified: | 2025-05-28 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Human Calcitonin Receptor in Complex with Gs and Cagrilintide Backbone (non-acylated) in CT-like conformation
To Be Published
|
|
9BUE
 | | Human calcitonin Receptor in complex with Gs and cagrilintide in the CT-like conformation (repeat) | | Descriptor: | Cagrilintide, Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Cao, J, Belousoff, M.J, Johnson, R.M, Sexton, P.M, Wootten, D.L. | | Deposit date: | 2024-05-16 | | Release date: | 2025-04-16 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Human Amylin1 Receptor in complex with Gs and cagrilintide
To Be Published
|
|
9BTW
 | | Human Amylin3 Receptor in complex with Gs and cagrilintide | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cagrilintide, Calcitonin receptor, ... | | Authors: | Cao, J, Belousoff, M.J, Johnson, R.M, Sexton, P.M, Wootten, D.L. | | Deposit date: | 2024-05-15 | | Release date: | 2025-04-16 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Human Amylin3 Receptor in complex with Gs and cagrilintide
To Be Published
|
|
3DIN
 | | Crystal structure of the protein-translocation complex formed by the SecY channel and the SecA ATPase | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | | Authors: | Zimmer, J, Nam, Y, Rapoport, T.A. | | Deposit date: | 2008-06-20 | | Release date: | 2008-10-07 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (4.5 Å) | | Cite: | Structure of a complex of the ATPase SecA and the protein-translocation channel.
Nature, 455, 2008
|
|
9BLB
 | | Human Calcitonin Receptor in Complex with Gs and Cagrilintide Backbone (non-acylated) in bypass conformation | | Descriptor: | Cagrilintide backbone (non-acylated), Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Cao, J, Belousoff, M.J, Wootten, D.L, Sexton, P.M. | | Deposit date: | 2024-04-30 | | Release date: | 2025-04-16 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Human Calcitonin Receptor in Complex with Gs and Cagrilintide Backbone (non-acylated) in bypass conformation
To Be Published
|
|
9BUB
 | | Human calcitonin Receptor in complex with Gs and cagrilintide in the bypass conformation | | Descriptor: | (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, Cagrilintide, Calcitonin receptor, ... | | Authors: | Cao, J, Belousoff, M.J, Johnson, R.M, Sexton, P.M, Wootten, D.L. | | Deposit date: | 2024-05-16 | | Release date: | 2025-04-23 | | Last modified: | 2025-04-30 | | Method: | ELECTRON MICROSCOPY (2.3 Å) | | Cite: | Structural and dynamic features of cagrilintide binding to calcitonin and amylin receptors.
Nat Commun, 16, 2025
|
|
6U61
 | | BRD2-BD1 in complex with the cyclic peptide 3.1_3 | | Descriptor: | Bromodomain-containing protein 2, ZINC ION, cyclic peptide 3.1_3 | | Authors: | Patel, K, Walshe, J.L, Walport, L.J, Mackay, J.P. | | Deposit date: | 2019-08-28 | | Release date: | 2020-08-19 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.29 Å) | | Cite: | Cyclic peptides can engage a single binding pocket through highly divergent modes.
Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
