4HXD
 
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3S4S
 | | Crystal structure of CD4 mutant bound to HLA-DR1 | | Descriptor: | GLYCEROL, HLA class II histocompatibility antigen, DR alpha chain, ... | | Authors: | Li, Y. | | Deposit date: | 2011-05-20 | | Release date: | 2011-09-21 | | Last modified: | 2017-11-08 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex.
Proc.Natl.Acad.Sci.USA, 108, 2011
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4HXP
 | | Brd4 Bromodomain 1 complex with 4-(2-OXO-1,3-OXAZOLIDIN-3-YL)BENZAMIDE inhibitor | | Descriptor: | 4-(2-oxo-1,3-oxazolidin-3-yl)benzamide, Bromodomain-containing protein 4 | | Authors: | Chen, T.T, Cao, D.Y, Chen, W.Y, Xiong, B, Shen, J.K, Xu, Y.C. | | Deposit date: | 2012-11-12 | | Release date: | 2013-04-03 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.73 Å) | | Cite: | Fragment-Based Drug Discovery of 2-Thiazolidinones as Inhibitors of the Histone Reader BRD4 Bromodomain.
J.Med.Chem., 56, 2013
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3CTT
 | | Crystal complex of N-terminal Human Maltase-Glucoamylase with Casuarine | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CASUARINE, GLYCEROL, ... | | Authors: | Sim, L, Rose, D.R. | | Deposit date: | 2008-04-14 | | Release date: | 2009-02-24 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Total syntheses of casuarine and its 6-O-alpha-glucoside: complementary inhibition towards glycoside hydrolases of the GH31 and GH37 families
Chemistry, 15, 2009
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3SMP
 | | Monoclinic crystal structure of human pantothenate kinase 1 alpha | | Descriptor: | ACETYL COENZYME *A, ARSENIC, CHLORIDE ION, ... | | Authors: | Guan, X, Tempel, W, Hong, B, Wernimont, A.K, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Park, H, Structural Genomics Consortium (SGC) | | Deposit date: | 2011-06-28 | | Release date: | 2011-07-20 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Monoclinic crystal structure of human pantothenate kinase 1 alpha
to be published
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3CUF
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3SNH
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3S71
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3S7T
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4I08
 | | Crystal structure of beta-ketoacyl-acyl carrier protein reductase (FabG) from Vibrio cholerae in complex with NADPH | | Descriptor: | 1,2-ETHANEDIOL, 3-oxoacyl-[acyl-carrier-protein] reductase FabG, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | Authors: | Hou, J, Chruszcz, M, Zheng, H, Osinski, T, Anderson, W.F, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2012-11-16 | | Release date: | 2012-12-12 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.063 Å) | | Cite: | Dissecting the Structural Elements for the Activation of beta-Ketoacyl-(Acyl Carrier Protein) Reductase from Vibrio cholerae.
J.Bacteriol., 198, 2015
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4EWH
 | | Co-crystal structure of ACK1 with inhibitor | | Descriptor: | 6-{4-[2-(dimethylamino)ethoxy]phenyl}-N-(1,3-dithiolan-2-ylmethyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Activated CDC42 kinase 1 | | Authors: | Liu, J, Walker, N, Wang, Z. | | Deposit date: | 2012-04-27 | | Release date: | 2012-09-19 | | Last modified: | 2012-10-31 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Synthesis and optimization of substituted furo[2,3-d]-pyrimidin-4-amines and 7H-pyrrolo[2,3-d]pyrimidin-4-amines as ACK1 inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
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4I18
 | | Crystal structure of human prolactin receptor complexed with Fab fragment | | Descriptor: | ACETATE ION, CALCIUM ION, GLYCEROL, ... | | Authors: | Duguid, E.M, Mukherjee, S, Kouadio, J.L. | | Deposit date: | 2012-11-20 | | Release date: | 2013-11-20 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3.238 Å) | | Cite: | Engineering synthetic antibody binders for allosteric inhibition of prolactin receptor signaling.
Cell Commun Signal, 13, 2015
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3S91
 | | Crystal Structure of the first bromodomain of human BRD3 in complex with the inhibitor JQ1 | | Descriptor: | (6S)-6-(2-tert-butoxy-2-oxoethyl)-4-(4-chlorophenyl)-2,3,9-trimethyl-6,7-dihydrothieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-10-ium, Bromodomain-containing protein 3, ISOPROPYL ALCOHOL | | Authors: | Filippakopoulos, P, Picaud, S, Qi, J, Keates, T, Felletar, I, Fedorov, O, Muniz, J, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Bradner, J.E, Knapp, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2011-05-31 | | Release date: | 2011-06-29 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.06 Å) | | Cite: | Crystal Structure of the first bromodomain of human BRD3 in complex with the inhibitor JQ1
To be Published
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4I36
 | | Crystal Structure of the Bacillus stearothermophilus Phosphofructokinase Mutant D12A | | Descriptor: | 6-phosphofructokinase | | Authors: | Mosser, R, Reddy, M, Bruning, J.B, Sacchettini, J.C, Reinhart, G.D. | | Deposit date: | 2012-11-25 | | Release date: | 2013-07-31 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Redefining the Role of the Quaternary Shift in Bacillus stearothermophilus Phosphofructokinase.
Biochemistry, 52, 2013
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4EDT
 | | The structure of the S. aureus DnaG RNA Polymerase Domain bound to ppGpp and Manganese | | Descriptor: | BENZAMIDINE, DNA primase, GUANOSINE-5',3'-TETRAPHOSPHATE, ... | | Authors: | Rymer, R.U, Solorio, F.A, Chu, C, Corn, J.E, Wang, J.D, Berger, J.M. | | Deposit date: | 2012-03-27 | | Release date: | 2012-07-25 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.005 Å) | | Cite: | Binding Mechanism of Metal-NTP Substrates and Stringent-Response Alarmones to Bacterial DnaG-Type Primases.
Structure, 20, 2012
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3SB8
 | | Cu-mediated Dimer of T4 Lysozyme D61H/K65H by Synthetic Symmetrization | | Descriptor: | COPPER (II) ION, Lysozyme | | Authors: | Soriaga, A.B, Laganowsky, A, Zhao, M, Sawaya, M.R, Cascio, D, Yeates, T.O. | | Deposit date: | 2011-06-03 | | Release date: | 2011-09-21 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | An approach to crystallizing proteins by metal-mediated synthetic symmetrization.
Protein Sci., 20, 2011
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3DKB
 | | Crystal Structure of A20, 2.5 angstrom | | Descriptor: | Tumor necrosis factor, alpha-induced protein 3 | | Authors: | Lin, S.-C, Chung, J.Y, Lo, Y.-C, Wu, H. | | Deposit date: | 2008-06-24 | | Release date: | 2008-07-08 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Molecular basis for the unique deubiquitinating activity of the NF-kappaB inhibitor A20
J.Mol.Biol., 376, 2008
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4I5U
 | | Crystal structure of a fungal chimeric cellobiohydrolase Cel6A | | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, Chimeric cel6A, ... | | Authors: | Arnold, F.H, Wu, I. | | Deposit date: | 2012-11-29 | | Release date: | 2013-04-03 | | Last modified: | 2017-08-09 | | Method: | X-RAY DIFFRACTION (1.22 Å) | | Cite: | Engineered thermostable fungal Cel6A and Cel7A cellobiohydrolases hydrolyze cellulose efficiently at elevated temperatures.
Biotechnol.Bioeng., 110, 2013
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3DLT
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3DMK
 | | Crystal structure of Down Syndrome Cell Adhesion Molecule (DSCAM) isoform 1.30.30, N-terminal eight Ig domains | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Down Syndrome Cell Adhesion Molecule (DSCAM) isoform 1.30.30, ... | | Authors: | Sawaya, M.R, Wojtowicz, W.M, Eisenberg, D, Zipursky, S.L. | | Deposit date: | 2008-07-01 | | Release date: | 2008-10-07 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (4.19 Å) | | Cite: | A double S shape provides the structural basis for the extraordinary binding specificity of Dscam isoforms.
Cell(Cambridge,Mass.), 134, 2008
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4I92
 | | Structure of the BSK8 kinase domain | | Descriptor: | CHLORIDE ION, Probable serine/threonine-protein kinase At5g41260 | | Authors: | Gruetter, C, Rauh, D. | | Deposit date: | 2012-12-04 | | Release date: | 2013-08-14 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structural Characterization of the RLCK Family Member BSK8: A Pseudokinase with an Unprecedented Architecture
J.Mol.Biol., 425, 2013
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3SEK
 | | Crystal Structure of the Myostatin:Follistatin-like 3 Complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Follistatin-related protein 3, Growth/differentiation factor 8 | | Authors: | Cash, J.N, Thompson, T.B. | | Deposit date: | 2011-06-10 | | Release date: | 2011-11-02 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.401 Å) | | Cite: | Structure of myostatinfollistatin-like 3: N-terminal domains of follistatin-type molecules exhibit alternate modes of binding.
J.Biol.Chem., 287, 2012
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3SEY
 | | Zn-mediated Polymer of Maltose-binding Protein A216H/K220H by Synthetic Symmetrization (Form II) | | Descriptor: | ACETATE ION, GLYCEROL, Maltose-binding periplasmic protein, ... | | Authors: | Zhao, M, Soriaga, A.B, Laganowsky, A, Sawaya, M.R, Cascio, D, Yeates, T.O. | | Deposit date: | 2011-06-11 | | Release date: | 2011-09-21 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | An approach to crystallizing proteins by metal-mediated synthetic symmetrization.
Protein Sci., 20, 2011
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4I79
 | | Crystal structure of human NUP43 | | Descriptor: | Nucleoporin Nup43, UNKNOWN ATOM OR ION, floating chain, ... | | Authors: | Xu, C, Tempel, W, Li, Z, He, H, Wernimont, A.K, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | Deposit date: | 2012-11-30 | | Release date: | 2013-02-27 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Crystal structure of human nuclear pore complex component NUP43.
Febs Lett., 589, 2015
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3SER
 | | Zn-mediated Polymer of Maltose-binding Protein K26H/K30H by Synthetic Symmetrization | | Descriptor: | CALCIUM ION, CHLORIDE ION, Maltose-binding periplasmic protein, ... | | Authors: | Zhao, M, Soriaga, A.B, Laganowsky, A, Sawaya, M.R, Cascio, D, Yeates, T.O. | | Deposit date: | 2011-06-11 | | Release date: | 2011-09-21 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | An approach to crystallizing proteins by metal-mediated synthetic symmetrization.
Protein Sci., 20, 2011
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