2OP3
| The structure of cathepsin S with a novel 2-arylphenoxyacetaldehyde inhibitor derived by the Substrate Activity Screening (SAS) method | Descriptor: | 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL, 2-[(2',3',4'-TRIFLUOROBIPHENYL-2-YL)OXY]ETHANOL, Cathepsin S, ... | Authors: | Spraggon, G, Inagaki, H, Tsuruoka, H, Hornsby, M, Lesley, S.A, Ellman, J.A. | Deposit date: | 2007-01-26 | Release date: | 2007-05-22 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Characterization and optimization of selective, nonpeptidic inhibitors of cathepsin S with an unprecedented binding mode. J.Med.Chem., 50, 2007
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4F5O
| Open ternary complex of R283K DNA polymerase beta with a one metal bound dCTP analog | Descriptor: | 2'-deoxy-5'-O-[(S)-{difluoro[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}(hydroxy)phosphoryl]cytidine, DNA (5'-D(*CP*CP*GP*AP*CP*(8OG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ... | Authors: | Freudenthal, B.D, Beard, W.A, Wilson, S.H. | Deposit date: | 2012-05-13 | Release date: | 2012-12-12 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structures of dNTP Intermediate States during DNA Polymerase Active Site Assembly. Structure, 20, 2012
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5CHG
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4OYT
| Crystal structure of ternary complex of Plasmodium vivax SHMT with D-serine and folinic acid | Descriptor: | (2R)-2-[(E)-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]-3-oxidanyl-propanoic acid, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLYCEROL, ... | Authors: | Chitnumsub, P, Jaruwat, A, Leartsakulpanich, U. | Deposit date: | 2014-02-13 | Release date: | 2014-12-10 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structures of Plasmodium vivax serine hydroxymethyltransferase: implications for ligand-binding specificity and functional control. Acta Crystallogr.,Sect.D, 70, 2014
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1KUY
| X-ray Crystallographic Studies of Serotonin N-acetyltransferase Catalysis and Inhibition | Descriptor: | COA-S-ACETYL TRYPTAMINE, Serotonin N-acetyltransferase | Authors: | Wolf, E, De Angelis, J, Khalil, E.M, Cole, P.A, Burley, S.K. | Deposit date: | 2002-01-22 | Release date: | 2002-03-22 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | X-ray crystallographic studies of serotonin N-acetyltransferase catalysis and inhibition. J.Mol.Biol., 317, 2002
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2FCR
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5ET5
| Human muscle fructose-1,6-bisphosphatase in active R-state | Descriptor: | Fructose-1,6-bisphosphatase isozyme 2 | Authors: | Barciszewski, J, Wisniewski, J, Kolodziejczyk, R, Dzugaj, A, Jaskolski, M, Rakus, D. | Deposit date: | 2015-11-17 | Release date: | 2016-04-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | T-to-R switch of muscle fructose-1,6-bisphosphatase involves fundamental changes of secondary and quaternary structure. Acta Crystallogr D Struct Biol, 72, 2016
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5ET8
| Human muscle fructose-1,6-bisphosphatase in active R-state in complex with fructose-6-phosphate | Descriptor: | 6-O-phosphono-beta-D-fructofuranose, Fructose-1,6-bisphosphatase isozyme 2 | Authors: | Barciszewski, J, Wisniewski, J, Kolodziejczyk, R, Dzugaj, A, Jaskolski, M, Rakus, D. | Deposit date: | 2015-11-17 | Release date: | 2016-11-23 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | T-to-R switch of muscle FBPase involves extreme changes of secondary and quaternary structure To Be Published
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5ET6
| Human muscle fructose-1,6-bisphosphatase in inactive T-state in complex with AMP | Descriptor: | ADENOSINE MONOPHOSPHATE, Fructose-1,6-bisphosphatase isozyme 2 | Authors: | Barciszewski, J, Wisniewski, J, Kolodziejczyk, R, Dzugaj, A, Jaskolski, M, Rakus, D. | Deposit date: | 2015-11-17 | Release date: | 2016-04-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.845 Å) | Cite: | T-to-R switch of muscle fructose-1,6-bisphosphatase involves fundamental changes of secondary and quaternary structure. Acta Crystallogr D Struct Biol, 72, 2016
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5ET7
| Human muscle fructose-1,6-bisphosphatase in inactive T-state | Descriptor: | Fructose-1,6-bisphosphatase isozyme 2 | Authors: | Barciszewski, J, Wisniewski, J, Kolodziejczyk, R, Dzugaj, A, Jaskolski, M, Rakus, D. | Deposit date: | 2015-11-17 | Release date: | 2016-04-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.989 Å) | Cite: | T-to-R switch of muscle fructose-1,6-bisphosphatase involves fundamental changes of secondary and quaternary structure. Acta Crystallogr D Struct Biol, 72, 2016
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4F5Q
| Closed ternary complex of R283K DNA polymerase beta | Descriptor: | 2'-deoxy-5'-O-[(S)-{difluoro[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}(hydroxy)phosphoryl]cytidine, DNA (5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(P*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), ... | Authors: | Freudenthal, B.D, Beard, W.A, Wilson, S.H. | Deposit date: | 2012-05-13 | Release date: | 2012-12-12 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structures of dNTP Intermediate States during DNA Polymerase Active Site Assembly. Structure, 20, 2012
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4F5N
| Open ternary complex of R283K DNA polymerase beta with a metal free dCTP analog | Descriptor: | 2'-deoxy-5'-O-[(S)-{difluoro[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}(hydroxy)phosphoryl]cytidine, DNA (5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), ... | Authors: | Freudenthal, B.D, Beard, W.A, Wilson, S.H. | Deposit date: | 2012-05-13 | Release date: | 2012-12-12 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structures of dNTP Intermediate States during DNA Polymerase Active Site Assembly. Structure, 20, 2012
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4F5R
| Open and closed ternary complex of R283K DNA polymerase beta with a dCTP analog in the same asymmetric unit | Descriptor: | 2'-deoxy-5'-O-[(S)-{difluoro[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}(hydroxy)phosphoryl]cytidine, DNA (5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), ... | Authors: | Freudenthal, B.D, Beard, W.A, Wilson, S.H. | Deposit date: | 2012-05-13 | Release date: | 2012-12-12 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structures of dNTP Intermediate States during DNA Polymerase Active Site Assembly. Structure, 20, 2012
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4F5P
| Open ternary mismatch complex of R283K DNA polymerase beta with a dATP analog | Descriptor: | 2'-deoxy-5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]adenosine, DNA (5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), ... | Authors: | Freudenthal, B.D, Beard, W.A, Wilson, S.H. | Deposit date: | 2012-05-13 | Release date: | 2012-12-12 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structures of dNTP Intermediate States during DNA Polymerase Active Site Assembly. Structure, 20, 2012
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5ANR
| Structure of a human 4E-T - DDX6 - CNOT1 complex | Descriptor: | CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TRANSPORTER, PROBABLE ATP-DEPENDENT RNA HELICASE DDX6 | Authors: | Basquin, J, Oezguer, S, Conti, E. | Deposit date: | 2015-09-08 | Release date: | 2015-10-21 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.102 Å) | Cite: | Structure of a Human 4E-T/Ddx6/Cnot1 Complex Reveals the Different Interplay of Ddx6-Binding Proteins with the Ccr4-not Complex. Cell Rep., 13, 2015
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5X16
| Sirt6 apo structure | Descriptor: | GLYCEROL, NAD-dependent protein deacetylase sirtuin-6, TERTIARY-BUTYL ALCOHOL, ... | Authors: | Zhang, J, Huang, Z, Song, K. | Deposit date: | 2017-01-24 | Release date: | 2018-07-04 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Sirt6 apo structure To Be Published
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4FJU
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1NTN
| THE CRYSTAL STRUCTURE OF NEUROTOXIN-I FROM NAJA NAJA OXIANA AT 1.9 ANGSTROMS RESOLUTION | Descriptor: | NEUROTOXIN I | Authors: | Mikhailov, A.M, Nickitenko, A.V, Vainshtein, B.K, Betzel, C, Wilson, K. | Deposit date: | 1994-09-26 | Release date: | 1995-05-08 | Last modified: | 2017-11-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Three-dimensional structure of neurotoxin-1 from Naja naja oxiana venom at 1.9 A resolution. Febs Lett., 320, 1993
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1KUX
| X-ray Crystallographic Studies of Serotonin N-acetyltransferase Catalysis and Inhibition | Descriptor: | COA-S-TRIMETHYLENE-ACETYL-TRYPTAMINE, Serotonin N-acetyltransferase | Authors: | Wolf, E, De Angelis, J, Khalil, E.M, Cole, P.A, Burley, S.K. | Deposit date: | 2002-01-22 | Release date: | 2002-03-22 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | X-ray crystallographic studies of serotonin N-acetyltransferase catalysis and inhibition. J.Mol.Biol., 317, 2002
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3QSM
| Crystal structure for the MSOX.chloride binary complex | Descriptor: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, Monomeric sarcosine oxidase | Authors: | Kommoju, P, Chen, Z, Bruckner, R.C, Mathews, F.S, Jorns, M.S. | Deposit date: | 2011-02-21 | Release date: | 2011-06-01 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Probing oxygen activation sites in two flavoprotein oxidases using chloride as an oxygen surrogate. Biochemistry, 50, 2011
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1B14
| Alcohol Dehydrogenase from Drosophila Lebanonensis Binary Complex with NAD+ | Descriptor: | ALCOHOL DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Benach, J, Atrian, S, Gonzalez-Duarte, R, Ladenstein, R. | Deposit date: | 1998-11-25 | Release date: | 1999-11-26 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The catalytic reaction and inhibition mechanism of Drosophila alcohol dehydrogenase: observation of an enzyme-bound NAD-ketone adduct at 1.4 A resolution by X-ray crystallography. J.Mol.Biol., 289, 1999
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3AJR
| Crystal structure of L-3-Hydroxynorvaline bound L-Threonine dehydrogenase (Y137F) from Hyperthermophilic Archaeon Thermoplasma volcanium | Descriptor: | (3R)-3-hydroxy-L-norvaline, (4S)-2-METHYL-2,4-PENTANEDIOL, NDP-sugar epimerase, ... | Authors: | Yoneda, K, Sakuraba, H, Ohshima, T. | Deposit date: | 2010-06-14 | Release date: | 2011-06-15 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Crystal Structure of Binary and Ternary Complexes of Archaeal UDP-galactose 4-Epimerase-like L-Threonine Dehydrogenase from Thermoplasma volcanium. J.Biol.Chem., 287, 2012
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3RVD
| Crystal structure of the binary complex, obtained by soaking, of photosyntetic a4 glyceraldehyde 3-phosphate dehydrogenase (gapdh) with cp12-2, both from arabidopsis thaliana. | Descriptor: | Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | Authors: | Fermani, S, Thumiger, A, Falini, G, Marri, L, Sparla, F, Trost, P. | Deposit date: | 2011-05-06 | Release date: | 2012-04-25 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Conformational Selection and Folding-upon-binding of Intrinsically Disordered Protein CP12 Regulate Photosynthetic Enzymes Assembly. J.Biol.Chem., 287, 2012
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2KTM
| Solution NMR structure of H2H3 domain of ovine prion protein (residues 167-234) | Descriptor: | Major prion protein | Authors: | Pastore, A, Adrover, M, Pauwels, K, de Chiara, C, Prigent, S, Rezeai, H. | Deposit date: | 2010-02-04 | Release date: | 2010-04-07 | Last modified: | 2021-11-10 | Method: | SOLUTION NMR | Cite: | Prion fibrillization is mediated by a native structural element that comprises helices H2 and H3. J.Biol.Chem., 285, 2010
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1K9B
| Crystal structure of the bifunctional soybean Bowman-Birk inhibitor at 0.28 nm resolution. Structural peculiarities in a folded protein conformation | Descriptor: | BOWMAN-BIRK TYPE PROTEINASE INHIBITOR | Authors: | Voss, R.H, Ermler, U, Essen, L.O, Wenzl, G, Kim, Y.M, Flecker, P. | Deposit date: | 2001-10-29 | Release date: | 2001-11-16 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of the bifunctional soybean Bowman-Birk inhibitor at 0.28-nm resolution. Structural peculiarities in a folded protein conformation. Eur.J.Biochem., 242, 1996
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