PDB: 52540 resultsInfo pagesStatus searchChemie searchBIRD

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3V7N	Crystal structure of Threonine synthase (thrC) from from Burkholderia thailandensis Descriptor: 1,2-ETHANEDIOL, BORIC ACID, MALONIC ACID, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2011-12-21 Release date: 2012-01-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Combining functional and structural genomics to sample the essential Burkholderia structome. Plos One, 8, 2013
3V9P	Crystal structure of Thymidylate kinase from Burkholderia thailandensis Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2011-12-27 Release date: 2012-01-25 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Combining functional and structural genomics to sample the essential Burkholderia structome. Plos One, 8, 2013
5OKN	Crystal structure of human SHIP2 Phosphatase-C2 D607A mutant Descriptor: 1,2-ETHANEDIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MAGNESIUM ION, ... Authors: Le Coq, J, Lietha, D. Deposit date: 2017-07-25 Release date: 2017-08-23 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Structural basis for interdomain communication in SHIP2 providing high phosphatase activity. Elife, 6, 2017
8EEC	Crystal structure of HPK1 citron-homology domain Descriptor: Isoform 2 of Mitogen-activated protein kinase kinase kinase kinase 1, PHOSPHATE ION Authors: Wu, P, Lehoux, I, Wang, W. Deposit date: 2022-09-06 Release date: 2024-03-27 Method: X-RAY DIFFRACTION (2.5 Å) Cite: HPK1 Citron Homology Domain Serves as a Scaffold to Promote Phosphorylation of SLP76 To Be Published
6Y0Q	Alpha-ketoglutarate-dependent dioxygenase AlkB in complex with Fe, AKG and methylated DNA under anaerobic environment using FT-SSX methods Descriptor: 2-OXOGLUTARIC ACID, Alpha-ketoglutarate-dependent dioxygenase AlkB, FE (III) ION, ... Authors: Rabe, P, Beale, J.H, Lang, P.A, Dirr, A.S, Leissing, T.M, Butryn, A, Aller, P, Kamps, J.J.A.G, Axford, D, McDonough, M.A, Orville, A.M, Owen, R, Schofield, C.J. Deposit date: 2020-02-10 Release date: 2020-09-09 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Anaerobic fixed-target serial crystallography. Iucrj, 7, 2020
3VHN	Y61G mutant of Cellulase 12A from thermotoga maritima Descriptor: Endo-1,4-beta-glucanase, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose Authors: Cheng, Y.-S, Ko, T.-P, Guo, R.-T, Liu, J.-R. Deposit date: 2011-08-30 Release date: 2012-07-11 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Enhanced activity of Thermotoga maritima cellulase 12A by mutating a unique surface loop Appl.Microbiol.Biotechnol., 95, 2012
3VGL	Crystal structure of a ROK family glucokinase from Streptomyces griseus in complex with glucose and AMPPNP Descriptor: Glucokinase, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SODIUM ION, ... Authors: Miyazono, K, Tabei, N, Morita, S, Ohnishi, Y, Horinouchi, S, Tanokura, M. Deposit date: 2011-08-15 Release date: 2011-12-07 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Substrate recognition mechanism and substrate-dependent conformational changes of an ROK family glucokinase from Streptomyces griseus J.Bacteriol., 194, 2012
5BQI	Discovery of a Potent and Selective mPGES-1 Inhibitor for the Treatment of Pain Descriptor: (2-hydroxyethoxy)acetaldehyde, 2-(difluoromethyl)-5-{[(2-methylpropanoyl)amino]methyl}-N-{5-methyl-4-[4-(trifluoromethyl)phenyl]-1H-imidazol-2-yl}pyridine-3-carboxamide, GLUTATHIONE, ... Authors: Fisher, M.J, Schiffler, M.A, Kuklish, S.L, Antonysamy, S, Luz, J.G. Deposit date: 2015-05-29 Release date: 2016-04-13 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.88 Å) Cite: Discovery and Characterization of 2-Acylaminoimidazole Microsomal Prostaglandin E Synthase-1 Inhibitors. J.Med.Chem., 59, 2016
5FP7	Crystal structure of human KDM4D in complex with 3-4-methylthiophen-2- yl methylaminopyridine-4-carboxylic acid Descriptor: 3-(4-phenylbutanoylamino)pyridine-4-carboxylic acid, FE (II) ION, GLYCEROL, ... Authors: Chung, C. Deposit date: 2015-11-27 Release date: 2016-11-09 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2 Å) Cite: Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives. J. Med. Chem., 59, 2016
5FPB	Crystal structure of human KDM4D in complex with 2-1H-pyrazol-4-yloxy- 3H,4H-pyrido-3,4-d-pyrimidin-4-one Descriptor: 2-(1H-pyrazol-4-yloxy)-3H-pyrido[3,4-d]pyrimidin-4-one, COBALT (II) ION, LYSINE-SPECIFIC DEMETHYLASE 4D, ... Authors: Chung, C. Deposit date: 2015-11-27 Release date: 2016-01-27 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.91 Å) Cite: Cell Penetrant Inhibitors of the Kdm4 and Kdm5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-Pyridine Carboxylate Derivatives. J.Med.Chem., 59, 2016
5BZU	Crystal structure of the RNA-binding domain of yeast Puf5p bound to AAT2 RNA Descriptor: Suppressor protein MPT5, UGUAAUA Authors: Qiu, C, Hall, T.M.T. Deposit date: 2015-06-11 Release date: 2015-09-23 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.501 Å) Cite: RNA regulatory networks diversified through curvature of the PUF protein scaffold. Nat Commun, 6, 2015
3WCB	The complex structure of TcSQS with ligand, BPH1237 Descriptor: Farnesyltransferase, putative, hydrogen [(1R)-2-(3-decyl-1H-imidazol-3-ium-1-yl)-1-hydroxy-1-phosphonoethyl]phosphonate Authors: Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T. Deposit date: 2013-05-27 Release date: 2014-06-18 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (3 Å) Cite: Squalene synthase as a target for Chagas disease therapeutics. Plos Pathog., 10, 2014
3WCL	The complex structure of HsSQS wtih ligand,BPH1344 Descriptor: Squalene synthase, hydrogen [(1R)-2-(3-pentadecyl-1H-imidazol-3-ium-1-yl)-1-phosphonoethyl]phosphonate Authors: Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T. Deposit date: 2013-05-28 Release date: 2014-06-18 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.24 Å) Cite: Squalene synthase as a target for Chagas disease therapeutics. Plos Pathog., 10, 2014
3WCI	The complex structure of HsSQS wtih ligand,BPH1325 Descriptor: Squalene synthase, hydrogen [(1R)-1-hydroxy-2-(3-pentadecyl-1H-imidazol-3-ium-1-yl)-1-phosphonoethyl]phosphonate Authors: Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T. Deposit date: 2013-05-27 Release date: 2014-06-18 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Squalene synthase as a target for Chagas disease therapeutics. Plos Pathog., 10, 2014
5FYX	Crystal structure of Drosophila NCS-1 bound to penothiazine FD16 Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, FREQUENIN 2, ... Authors: Martinez-Gonzalez, L, Chaves-Sanjuan, A, Infantes, L, Sanchez-Barrena, M.J. Deposit date: 2016-03-10 Release date: 2017-01-25 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Interference of the complex between NCS-1 and Ric8a with phenothiazines regulates synaptic function and is an approach for fragile X syndrome. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
3WCH	The complex structure of HsSQS wtih ligand BPH1237 Descriptor: Squalene synthase, hydrogen [(1R)-2-(3-decyl-1H-imidazol-3-ium-1-yl)-1-hydroxy-1-phosphonoethyl]phosphonate Authors: Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T. Deposit date: 2013-05-27 Release date: 2014-06-18 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Squalene synthase as a target for Chagas disease therapeutics. Plos Pathog., 10, 2014
2JC2	The crystal structure of the natural F112L human sorcin mutant Descriptor: SORCIN, SULFATE ION Authors: Franceschini, S, Ilari, A, Colotti, G, Chiancone, E. Deposit date: 2006-12-19 Release date: 2007-08-28 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Molecular Basis for the Impaired Function of the Natural F112L Sorcin Mutant: X-Ray Crystal Structure, Calcium Affinity, and Interaction with Annexin Vii and the Ryanodine Receptor. Faseb J., 22, 2008
2JC3	Structure of O-Acetylserine Sulfhydrylase B from Salmonella Typhimurium Descriptor: O-ACETYLSERINE SULFHYDRYLASE B, PYRIDOXAL-5'-PHOSPHATE Authors: Chattopadhyay, A, Rabeh, W.M, Speroni, F, Meier, M, Ivaninskii, S, Mozzarelli, A, Burkhard, P, Cook, P.F. Deposit date: 2006-12-19 Release date: 2007-01-23 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structure, Mechanism, and Conformational Dynamics of O-Acetylserine Sulfhydrylase from Salmonella Typhimurium: Comparison of a and B Isozymes. Biochemistry, 46, 2007
3WCD	The complex structure of HsSQS wtih ligand, WC-9 Descriptor: 2-(4-phenoxyphenoxy)ethyl thiocyanate, Squalene synthase Authors: Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T. Deposit date: 2013-05-27 Release date: 2014-06-18 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Squalene synthase as a target for Chagas disease therapeutics. Plos Pathog., 10, 2014
5BZ1	Crystal structure of the RNA-binding domain of yeast Puf5p bound to MFA2 RNA Descriptor: RNA (5'-R(*UP*GP*UP*AP*UP*UP*UP*GP*UP*A)-3'), Suppressor protein MPT5 Authors: Qiu, C, Hall, T.M.T. Deposit date: 2015-06-11 Release date: 2015-09-23 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.15 Å) Cite: RNA regulatory networks diversified through curvature of the PUF protein scaffold. Nat Commun, 6, 2015
3WC9	The complex structure of HsSQS wtih ligand, FSPP Descriptor: S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE, Squalene synthase Authors: Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T. Deposit date: 2013-05-26 Release date: 2014-06-18 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.82 Å) Cite: Squalene synthase as a target for Chagas disease therapeutics. Plos Pathog., 10, 2014
2I5W	Structure of hOGG1 crosslinked to DNA sampling a normal G adjacent to an oxoG Descriptor: 5'-D(*GP*GP*TP*AP*GP*AP*CP*CP*TP*GP*GP*A)-3', 5'-D(P*CP*CP*AP*GP*(G42)P*TP*CP*TP*AP*C)-3', CALCIUM ION, ... Authors: Banerjee, A, Verdine, G.L. Deposit date: 2006-08-26 Release date: 2006-10-17 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.6 Å) Cite: A nucleobase lesion remodels the interaction of its normal neighbor in a DNA glycosylase complex. Proc.Natl.Acad.Sci.Usa, 103, 2006
3WCE	The complex structure of TcSQS with ligand, ER119884 Descriptor: (3R)-3-{[2-benzyl-6-(3-methoxypropoxy)pyridin-3-yl]ethynyl}-1-azabicyclo[2.2.2]octan-3-ol, Farnesyltransferase, putative Authors: Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T. Deposit date: 2013-05-27 Release date: 2014-06-18 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Squalene synthase as a target for Chagas disease therapeutics. Plos Pathog., 10, 2014
5OKO	Crystal structure of human SHIP2 Phosphatase-C2 double mutant F593D/L597D Descriptor: 1,2-ETHANEDIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 Authors: Le Coq, J, Lietha, D. Deposit date: 2017-07-25 Release date: 2017-08-23 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.94 Å) Cite: Structural basis for interdomain communication in SHIP2 providing high phosphatase activity. Elife, 6, 2017
3WCM	The complex structure of HsSQS wtih ligand, ER119884 Descriptor: (3R)-3-{[2-benzyl-6-(3-methoxypropoxy)pyridin-3-yl]ethynyl}-1-azabicyclo[2.2.2]octan-3-ol, Squalene synthase Authors: Shang, N, Li, Q, Ko, T.P, Chan, H.C, Huang, C.H, Ren, F, Zheng, Y, Zhu, Z, Chen, C.C, Guo, R.T. Deposit date: 2013-05-28 Release date: 2014-06-18 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.06 Å) Cite: Squalene synthase as a target for Chagas disease therapeutics. Plos Pathog., 10, 2014

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