8VSC
 
 | L-TGF-b1/GARP | Descriptor: | Transforming growth factor beta activator LRRC32, Transforming growth factor beta-1 proprotein | Authors: | Jin, M, Cheng, Y, Nishimura, S.L. | Deposit date: | 2024-01-23 | Release date: | 2024-09-11 | Last modified: | 2024-11-20 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Dynamic allostery drives autocrine and paracrine TGF-beta signaling. Cell, 187, 2024
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8VSB
 
 | L-TGF-b3/GARP | Descriptor: | Transforming growth factor beta activator LRRC32, Transforming growth factor beta-3 proprotein | Authors: | Jin, M, Cheng, Y, Nishimura, S.L. | Deposit date: | 2024-01-23 | Release date: | 2024-09-11 | Last modified: | 2024-11-20 | Method: | ELECTRON MICROSCOPY (2.93 Å) | Cite: | Dynamic allostery drives autocrine and paracrine TGF-beta signaling. Cell, 187, 2024
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3G3B
 
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1M10
 
 | Crystal structure of the complex of Glycoprotein Ib alpha and the von Willebrand Factor A1 Domain | Descriptor: | Glycoprotein Ib alpha, von Willebrand Factor | Authors: | Huizinga, E.G, Tsuji, S, Romijn, R.A.P, Schiphorst, M.E, de Groot, P.G, Sixma, J.J, Gros, P. | Deposit date: | 2002-06-16 | Release date: | 2002-08-28 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain. Science, 297, 2002
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1XWD
 
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1P8V
 
 | CRYSTAL STRUCTURE OF THE COMPLEX OF PLATELET RECEPTOR GPIB-ALPHA AND ALPHA-THROMBIN AT 2.6A | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIISOPROPYL PHOSPHONATE, ... | Authors: | Dumas, J.J, Kumar, R, Seehra, J, Somers, W.S, Mosyak, L. | Deposit date: | 2003-05-07 | Release date: | 2003-07-22 | Last modified: | 2024-12-25 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal Structure of the GpIbalpha-Thrombin Complex Essential for Platelet Aggregation Science, 301, 2003
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1OOK
 
 | Crystal Structure of the Complex of Platelet Receptor GPIb-alpha and Human alpha-Thrombin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Human Alpha Thrombin, ... | Authors: | Varughese, K.I, Celikel, R, Ruggeri, Z.M. | Deposit date: | 2003-03-03 | Release date: | 2003-07-22 | Last modified: | 2024-10-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Modulation of alpha-thrombin function by distinct interactions with platelet
glycoprotein Ibalpha Science, 301, 2003
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8WVV
 
 | Cryo-EM structure of LGR4 in state I | Descriptor: | Leucine-rich repeat-containing G-protein coupled receptor 4 | Authors: | Lin, C, Chang, Z. | Deposit date: | 2023-10-24 | Release date: | 2024-10-30 | Last modified: | 2025-06-25 | Method: | ELECTRON MICROSCOPY (3.35 Å) | Cite: | Cryo-EM structure of LGR4 in state I To Be Published
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8WVW
 
 | Cryo-EM structure of LGR4 in state II | Descriptor: | Leucine-rich repeat-containing G-protein coupled receptor 4 | Authors: | Lin, C, Chang, Z. | Deposit date: | 2023-10-24 | Release date: | 2024-10-30 | Last modified: | 2025-06-18 | Method: | ELECTRON MICROSCOPY (3.53 Å) | Cite: | Cryo-EM structure of LGR4 in state I To Be Published
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8XUM
 
 | Structure of LGR4 with RSPO2 | Descriptor: | Leucine-rich repeat-containing G-protein coupled receptor 4, MB52, R-spondin-2 | Authors: | Wang, L, Geng, Y. | Deposit date: | 2024-01-13 | Release date: | 2025-01-15 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | structure of LGR4 with RSPO2 To Be Published
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8XT9
 
 | structure of LGR4 | Descriptor: | Leucine-rich repeat-containing G-protein coupled receptor 4, MB52 | Authors: | Wang, L, Geng, Y. | Deposit date: | 2024-01-10 | Release date: | 2025-01-15 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | structure of LGR4 To Be Published
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8Y69
 
 | LGR4-RSPO2-ZNRF3 (2:2:2) | Descriptor: | CHOLESTEROL, E3 ubiquitin-protein ligase ZNRF3, Leucine-rich repeat-containing G-protein coupled receptor 4, ... | Authors: | Wang, L, Geng, Y. | Deposit date: | 2024-02-02 | Release date: | 2024-12-04 | Last modified: | 2025-06-18 | Method: | ELECTRON MICROSCOPY (3.38 Å) | Cite: | Structural insights into the LGR4-RSPO2-ZNRF3 complexes regulating WNT/ beta-catenin signaling. Nat Commun, 16, 2025
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8XFP
 
 | the pentamerA complex of LGR4-RSPO2-ZNRF3(delta RING) | Descriptor: | E3 ubiquitin-protein ligase ZNRF3, Leucine-rich repeat-containing G-protein coupled receptor 4, R-spondin-2, ... | Authors: | Geng, Y, Wang, L. | Deposit date: | 2023-12-14 | Release date: | 2024-12-04 | Last modified: | 2025-06-18 | Method: | ELECTRON MICROSCOPY (3.21 Å) | Cite: | Structural insights into the LGR4-RSPO2-ZNRF3 complexes regulating WNT/ beta-catenin signaling. Nat Commun, 16, 2025
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8XFS
 
 | LGR4-RSPO2-ZNRF3 RING domain (1:2:2) | Descriptor: | E3 ubiquitin-protein ligase ZNRF3, Leucine-rich repeat-containing G-protein coupled receptor 4, R-spondin-2, ... | Authors: | Lu, W, Yong, G. | Deposit date: | 2023-12-14 | Release date: | 2024-12-04 | Last modified: | 2025-06-18 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural insights into the LGR4-RSPO2-ZNRF3 complexes regulating WNT/ beta-catenin signaling. Nat Commun, 16, 2025
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8XFT
 
 | LGR4-RSPO2-ZNRF3(1:1:1) | Descriptor: | E3 ubiquitin-protein ligase ZNRF3, Leucine-rich repeat-containing G-protein coupled receptor 4, MB52, ... | Authors: | Lu, W, Yong, G. | Deposit date: | 2023-12-14 | Release date: | 2024-12-04 | Last modified: | 2025-06-18 | Method: | ELECTRON MICROSCOPY (3.24 Å) | Cite: | Structural insights into the LGR4-RSPO2-ZNRF3 complexes regulating WNT/ beta-catenin signaling. Nat Commun, 16, 2025
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4AY9
 
 | Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FOLLICLE-STIMULATING HORMONE RECEPTOR, FOLLITROPIN SUBUNIT BETA, ... | Authors: | Jiang, X, Liu, H, Chen, X, He, X. | Deposit date: | 2012-06-19 | Release date: | 2012-08-08 | Last modified: | 2024-10-23 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of Follicle-Stimulating Hormone in Complex with the Entire Ectodomain of its Receptor. Proc.Natl.Acad.Sci.USA, 109, 2012
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4C2A
 
 | Crystal Structure of High-Affinity von Willebrand Factor A1 domain with R1306Q and I1309V Mutations in Complex with High Affinity GPIb alpha | Descriptor: | ACETATE ION, CACODYLATE ION, CALCIUM ION, ... | Authors: | Blenner, M.A, Dong, X, Springer, T.A. | Deposit date: | 2013-08-16 | Release date: | 2014-01-08 | Last modified: | 2024-10-23 | Method: | X-RAY DIFFRACTION (2.081 Å) | Cite: | Towards the Structural Basis of Regulation of Von Willebrand Factor Binding to Glycoprotein Ib J.Biol.Chem., 289, 2014
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4C2B
 
 | Crystal Structure of High-Affinity von Willebrand Factor A1 domain with Disulfide Mutation in Complex with High Affinity GPIb alpha | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, PLATELET GLYCOPROTEIN IB ALPHA CHAIN, ... | Authors: | Blenner, M.A, Dong, X, Springer, T.A. | Deposit date: | 2013-08-16 | Release date: | 2014-01-08 | Last modified: | 2024-11-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Towards the Structural Basis of Regulation of Von Willebrand Factor Binding to Glycoprotein Ib J.Biol.Chem., 289, 2014
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