3AVA
| Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site | Descriptor: | ACETIC ACID, CHLORIDE ION, Integrase, ... | Authors: | Peat, T.S, Deadman, J.J, Newman, J, Rhodes, D.I. | Deposit date: | 2011-03-02 | Release date: | 2012-01-18 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site. Chembiochem, 12, 2011
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3AVB
| Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site | Descriptor: | ACETIC ACID, CHLORIDE ION, Integrase, ... | Authors: | Peat, T.S, Deadman, J.J, Newman, J, Rhodes, D.I. | Deposit date: | 2011-03-02 | Release date: | 2012-01-18 | Last modified: | 2013-06-19 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site. Chembiochem, 12, 2011
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3AVC
| Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site | Descriptor: | ACETIC ACID, CHLORIDE ION, Integrase, ... | Authors: | Peat, T.S, Deadman, J.J, Newman, J, Rhodes, D.I. | Deposit date: | 2011-03-02 | Release date: | 2012-01-18 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site. Chembiochem, 12, 2011
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3AVF
| Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site | Descriptor: | ACETIC ACID, CHLORIDE ION, Integrase, ... | Authors: | Peat, T.S, Deadman, J.J, Newman, J, Rhodes, D.I. | Deposit date: | 2011-03-05 | Release date: | 2012-01-18 | Last modified: | 2013-06-19 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site. Chembiochem, 12, 2011
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3AVG
| Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site | Descriptor: | ACETIC ACID, CHLORIDE ION, Integrase, ... | Authors: | Peat, T.S, Deadman, J.J, Newman, J, Rhodes, D.I. | Deposit date: | 2011-03-05 | Release date: | 2012-01-18 | Last modified: | 2013-06-19 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site. Chembiochem, 12, 2011
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3AVH
| Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site | Descriptor: | ACETIC ACID, CHLORIDE ION, Integrase, ... | Authors: | Peat, T.S, Deadman, J.J, Newman, J, Rhodes, D.I. | Deposit date: | 2011-03-05 | Release date: | 2012-01-18 | Last modified: | 2013-06-19 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site. Chembiochem, 12, 2011
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3AVI
| Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site | Descriptor: | ACETIC ACID, CHLORIDE ION, Integrase, ... | Authors: | Peat, T.S, Deadman, J.J, Newman, J, Rhodes, D.I. | Deposit date: | 2011-03-05 | Release date: | 2012-02-15 | Last modified: | 2013-06-19 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site. Chembiochem, 12, 2011
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3AVJ
| Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site | Descriptor: | ACETIC ACID, CHLORIDE ION, Integrase, ... | Authors: | Peat, T.S, Deadman, J.J, Newman, J, Rhodes, D.I. | Deposit date: | 2011-03-05 | Release date: | 2012-01-18 | Last modified: | 2013-06-19 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site. Chembiochem, 12, 2011
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3AVK
| Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site | Descriptor: | ACETIC ACID, CHLORIDE ION, Integrase, ... | Authors: | Peat, T.S, Deadman, J.J, Newman, J, Rhodes, D.I. | Deposit date: | 2011-03-05 | Release date: | 2012-01-18 | Last modified: | 2013-06-19 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site. Chembiochem, 12, 2011
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3AVL
| Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site | Descriptor: | ACETIC ACID, CHLORIDE ION, Integrase, ... | Authors: | Peat, T.S, Deadman, J.J, Newman, J, Rhodes, D.I. | Deposit date: | 2011-03-05 | Release date: | 2012-01-18 | Last modified: | 2013-06-19 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site. Chembiochem, 12, 2011
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3AVM
| Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site | Descriptor: | ACETIC ACID, CHLORIDE ION, Integrase, ... | Authors: | Peat, T.S, Deadman, J.J, Newman, J, Rhodes, D.I. | Deposit date: | 2011-03-05 | Release date: | 2012-01-18 | Last modified: | 2013-06-19 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site. Chembiochem, 12, 2011
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3AVN
| Crystal structures of novel allosteric peptide inhibitors of HIV integrase in the LEDGF binding site | Descriptor: | ACETIC ACID, CHLORIDE ION, Integrase, ... | Authors: | Peat, T.S, Deadman, J.J, Newman, J, Rhodes, D.I. | Deposit date: | 2011-03-05 | Release date: | 2012-01-18 | Last modified: | 2013-06-19 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site. Chembiochem, 12, 2011
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3DLR
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3F9K
| Two domain fragment of HIV-2 integrase in complex with LEDGF IBD | Descriptor: | Integrase, MAGNESIUM ION, PC4 and SFRS1-interacting protein, ... | Authors: | Hare, S, Cherepanov, P. | Deposit date: | 2008-11-14 | Release date: | 2009-01-20 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | A novel co-crystal structure affords the design of gain-of-function lentiviral integrase mutants in the presence of modified PSIP1/LEDGF/p75 Plos Pathog., 5, 2009
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3HPG
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3HPH
| Closed tetramer of Visna virus integrase (residues 1-219) in complex with LEDGF IBD | Descriptor: | GLYCEROL, Integrase, PC4 and SFRS1-interacting protein, ... | Authors: | Hare, S, Wang, J, Cherepanov, P. | Deposit date: | 2009-06-04 | Release date: | 2009-07-28 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.64 Å) | Cite: | Structural basis for functional tetramerization of lentiviral integrase Plos Pathog., 5, 2009
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3JCA
| Core model of the Mouse Mammary Tumor Virus intasome | Descriptor: | 5'-D(*AP*AP*TP*GP*CP*CP*GP*CP*AP*GP*TP*CP*GP*GP*CP*CP*GP*AP*CP*CP*TP*G)-3', 5'-D(*CP*AP*GP*GP*TP*CP*GP*GP*CP*CP*GP*AP*CP*TP*GP*CP*GP*GP*CP*A)-3', Integrase, ... | Authors: | Lyumkis, D.L, Ballandras-Colas, A, Brown, M, Cook, N.J, Dewdney, T.G, Demeler, B, Cherepanov, P, Engelman, A.N. | Deposit date: | 2015-11-24 | Release date: | 2016-02-17 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (4.8 Å) | Cite: | Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function. Nature, 530, 2016
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3KKR
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3KKS
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3L2Q
| Crystal structure of the Prototype Foamy Virus (PFV) intasome in apo form | Descriptor: | 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*TP*GP*TP*A)-3', 5'-D(*TP*AP*CP*AP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3', GLYCEROL, ... | Authors: | Hare, S, Gupta, S.S, Cherepanov, P. | Deposit date: | 2009-12-15 | Release date: | 2010-02-09 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | Retroviral intasome assembly and inhibition of DNA strand transfer Nature, 464, 2010
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3L2R
| Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium | Descriptor: | 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*TP*GP*TP*A)-3', 5'-D(*TP*AP*CP*AP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3', AMMONIUM ION, ... | Authors: | Hare, S, Gupta, S.S, Cherepanov, P. | Deposit date: | 2009-12-15 | Release date: | 2010-02-09 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.88 Å) | Cite: | Retroviral intasome assembly and inhibition of DNA strand transfer Nature, 464, 2010
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3L2U
| Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with magnesium and GS9137 (Elvitegravir) | Descriptor: | 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*TP*GP*TP*A)-3', 5'-D(*TP*AP*CP*AP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3', 6-(3-chloro-2-fluorobenzyl)-1-[(1S)-1-(hydroxymethyl)-2-methylpropyl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, ... | Authors: | Hare, S, Gupta, S.S, Cherepanov, P. | Deposit date: | 2009-12-15 | Release date: | 2010-02-09 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Retroviral intasome assembly and inhibition of DNA strand transfer Nature, 464, 2010
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3L2V
| Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with manganese and MK0518 (Raltegravir) | Descriptor: | 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*TP*GP*TP*A)-3', 5'-D(*TP*AP*CP*AP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3', AMMONIUM ION, ... | Authors: | Hare, S, Gupta, S.S, Cherepanov, P. | Deposit date: | 2009-12-15 | Release date: | 2010-02-09 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Retroviral intasome assembly and inhibition of DNA strand transfer Nature, 464, 2010
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3L2W
| Crystal structure of the Prototype Foamy Virus (PFV) intasome in complex with manganese and GS9137 (Elvitegravir) | Descriptor: | 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*TP*GP*TP*A)-3', 5'-D(*TP*AP*CP*AP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3', 6-(3-chloro-2-fluorobenzyl)-1-[(1S)-1-(hydroxymethyl)-2-methylpropyl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, ... | Authors: | Hare, S, Gupta, S.S, Cherepanov, P. | Deposit date: | 2009-12-15 | Release date: | 2010-02-09 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Retroviral intasome assembly and inhibition of DNA strand transfer Nature, 464, 2010
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3L3U
| Crystal structure of the HIV-1 integrase core domain to 1.4A | Descriptor: | POL polyprotein, SULFATE ION | Authors: | Wielens, J, Chalmers, D.K, Scanlon, M.J, Parker, M.W. | Deposit date: | 2009-12-17 | Release date: | 2010-03-31 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Crystal structure of the HIV-1 integrase core domain in complex with sucrose reveals details of an allosteric inhibitory binding site. Febs Lett., 584, 2010
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