7ZUP
| Human PRMT5:MEP50 structure with Fragment (Example 18) and MTA Bound | Descriptor: | 3-ethylimidazo[4,5-b]pyridin-2-amine, 5'-DEOXY-5'-METHYLTHIOADENOSINE, GLYCEROL, ... | Authors: | Ahmad, M.U, Koelmel, W, Arkhipova, V, Lawson, J.D, Smith, C.R, Gunn, R.J. | Deposit date: | 2022-05-12 | Release date: | 2022-10-19 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. Rsc Med Chem, 13, 2022
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7ZVU
| HUMAN PRMT5:MEP50 Crystal Structure With MTA and Fragment Bound | Descriptor: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, GLYCEROL, Methylosome protein 50, ... | Authors: | Ahmad, M.U, Koelmel, W, Arkhipova, V, Lawson, J.D, Smith, C.R, Gunn, R.J. | Deposit date: | 2022-05-17 | Release date: | 2022-10-19 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Fragment optimization and elaboration strategies - the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits. Rsc Med Chem, 13, 2022
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8AE6
| Cryo-EM structure of the SEA complex wing (SEACIT) | Descriptor: | Maintenance of telomere capping protein 5, Nitrogen permease regulator 2, Nitrogen permease regulator 3, ... | Authors: | Tafur, L, Loewith, R. | Deposit date: | 2022-07-12 | Release date: | 2022-11-02 | Last modified: | 2023-05-10 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Cryo-EM structure of the SEA complex. Nature, 611, 2022
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8ADL
| Cryo-EM structure of the SEA complex | Descriptor: | Maintenance of telomere capping protein 5, Nitrogen permease regulator 2, Nitrogen permease regulator 3, ... | Authors: | Tafur, L, Loewith, R. | Deposit date: | 2022-07-08 | Release date: | 2022-11-02 | Last modified: | 2023-05-10 | Method: | ELECTRON MICROSCOPY (2.95 Å) | Cite: | Cryo-EM structure of the SEA complex. Nature, 611, 2022
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8AJN
| Structure of the human DDB1-DCAF12 complex | Descriptor: | DDB1- and CUL4-associated factor 12, DNA damage-binding protein 1 | Authors: | Pla-Prats, C, Cavadini, S, Kempf, G, Thoma, N.H. | Deposit date: | 2022-07-28 | Release date: | 2022-11-09 | Last modified: | 2023-05-24 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Recognition of the CCT5 di-Glu degron by CRL4 DCAF12 is dependent on TRiC assembly. Embo J., 42, 2023
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8ASW
| Cryo-EM structure of yeast Elp123 in complex with alanine tRNA | Descriptor: | 5'-DEOXYADENOSINE, Alanine tRNA, Elongator complex protein 1, ... | Authors: | Jaciuk, M, Scherf, D, Kaszuba, K, Gaik, M, Koscielniak, A, Krutyholowa, R, Rawski, M, Indyka, P, Biela, A, Dobosz, D, Lin, T.-Y, Abbassi, N, Hammermeister, A, Chramiec-Glabik, A, Kosinski, J, Schaffrath, R, Glatt, S. | Deposit date: | 2022-08-21 | Release date: | 2022-12-07 | Last modified: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (3.96 Å) | Cite: | Cryo-EM structure of the fully assembled Elongator complex. Nucleic Acids Res., 51, 2023
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8AVG
| Cryo-EM structure of mouse Elp123 with bound SAM | Descriptor: | Elongator complex protein 1, Elongator complex protein 2, Elongator complex protein 3, ... | Authors: | Jaciuk, M, Scherf, D, Kaszuba, K, Gaik, M, Koscielniak, A, Krutyholowa, R, Rawski, M, Indyka, P, Biela, A, Dobosz, D, Lin, T.-Y, Abbassi, N, Hammermeister, A, Chramiec-Glabik, A, Kosinski, J, Schaffrath, R, Glatt, S. | Deposit date: | 2022-08-26 | Release date: | 2022-12-07 | Last modified: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (4.01 Å) | Cite: | Cryo-EM structure of the fully assembled Elongator complex. Nucleic Acids Res., 51, 2023
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8ASV
| Cryo-EM structure of yeast Elongator complex | Descriptor: | Elongator complex protein 1, Elongator complex protein 2, Elongator complex protein 3, ... | Authors: | Jaciuk, M, Scherf, D, Kaszuba, K, Gaik, M, Koscielniak, A, Krutyholowa, R, Rawski, M, Indyka, P, Biela, A, Dobosz, D, Lin, T.-Y, Abbassi, N, Hammermeister, A, Chramiec-Glabik, A, Kosinski, J, Schaffrath, R, Glatt, S. | Deposit date: | 2022-08-21 | Release date: | 2022-12-07 | Last modified: | 2023-03-29 | Method: | ELECTRON MICROSCOPY (4.35 Å) | Cite: | Cryo-EM structure of the fully assembled Elongator complex. Nucleic Acids Res., 51, 2023
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8AFQ
| Tube assembly of Atg18-PR72AA | Descriptor: | Autophagy-related protein 18 | Authors: | Mann, D, Fromm, S, Martinez-Sanchez, A, Gopaldass, N, Mayer, A, Sachse, C. | Deposit date: | 2022-07-18 | Release date: | 2023-11-01 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Atg18 oligomer organization in assembled tubes and on lipid membrane scaffolds. Nat Commun, 14, 2023
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8AFW
| Tube assembly of Atg18-WT | Descriptor: | Autophagy-related protein 18 | Authors: | Mann, D, Fromm, S, Martinez-Sanchez, A, Gopaldass, N, Mayer, A, Sachse, C. | Deposit date: | 2022-07-18 | Release date: | 2023-11-01 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Atg18 oligomer organization in assembled tubes and on lipid membrane scaffolds. Nat Commun, 14, 2023
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8AFY
| Subtomogram average of membrane-bound Atg18 oligomers | Descriptor: | Autophagy-related protein 18 | Authors: | Mann, D, Fromm, S, Martinez-Sanchez, A, Gopaldass, N, Mayer, A, Sachse, C. | Deposit date: | 2022-07-18 | Release date: | 2023-11-01 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (26 Å) | Cite: | Atg18 oligomer organization in assembled tubes and on lipid membrane scaffolds. Nat Commun, 14, 2023
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8AFX
| Single particle structure of Atg18-WT | Descriptor: | Autophagy-related protein 18 | Authors: | Mann, D, Fromm, S, Martinez-Sanchez, A, Gopaldass, N, Mayer, A, Sachse, C. | Deposit date: | 2022-07-18 | Release date: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (4.8 Å) | Cite: | Cryo-EM structures of Atg18 oligomers reveal a tilted structural scaffold for Atg2 at the isolation membrane To Be Published
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8BBF
| Structure of the IFT-A complex; IFT-A1 module | Descriptor: | Intraflagellar transport protein 122 homolog, Intraflagellar transport protein 140 homolog, WD repeat-containing protein 19 | Authors: | Hesketh, S.J, Mukhopadhyay, A.G, Nakamura, D, Toropova, K, Roberts, A.J. | Deposit date: | 2022-10-12 | Release date: | 2022-12-07 | Last modified: | 2023-01-04 | Method: | ELECTRON MICROSCOPY (8 Å) | Cite: | IFT-A structure reveals carriages for membrane protein transport into cilia. Cell, 185, 2022
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8BBG
| Structure of the IFT-A complex; anterograde IFT-A train model | Descriptor: | Intraflagellar transport protein 122 homolog, Intraflagellar transport protein 140 homolog, Intraflagellar transport protein 43 homolog, ... | Authors: | Hesketh, S.J, Mukhopadhyay, A.G, Nakamura, D, Toropova, K, Roberts, A.J. | Deposit date: | 2022-10-12 | Release date: | 2022-12-21 | Last modified: | 2023-01-04 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | IFT-A structure reveals carriages for membrane protein transport into cilia. Cell, 185, 2022
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8BBE
| Structure of the IFT-A complex; IFT-A2 module | Descriptor: | Intraflagellar transport protein 122 homolog, Intraflagellar transport protein 43 homolog, SNAP-tag,Tetratricopeptide repeat protein 21B, ... | Authors: | Hesketh, S.J, Mukhopadhyay, A.G, Nakamura, D, Toropova, K, Roberts, A.J. | Deposit date: | 2022-10-12 | Release date: | 2022-12-21 | Last modified: | 2023-01-04 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | IFT-A structure reveals carriages for membrane protein transport into cilia. Cell, 185, 2022
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8F5P
| Structure of Leishmania tarentolae IFT-A (state 2) | Descriptor: | Intraflagellar transport protein 122 homolog, Intraflagellar transport protein 122B, putative, ... | Authors: | Zhou, H, Brown, A. | Deposit date: | 2022-11-14 | Release date: | 2022-12-21 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Mechanism of IFT-A polymerization into trains for ciliary transport. Cell, 185, 2022
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8F5O
| Structure of Leishmania tarentolae IFT-A (state 1) | Descriptor: | Intraflagellar transport protein 122 homolog, Intraflagellar transport protein 122B, putative, ... | Authors: | Zhou, H, Brown, A. | Deposit date: | 2022-11-14 | Release date: | 2022-12-21 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Mechanism of IFT-A polymerization into trains for ciliary transport. Cell, 185, 2022
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8F76
| Human olfactory receptor OR51E2 bound to propionate in complex with miniGs399 | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | Authors: | Billesboelle, C.B, Manglik, A. | Deposit date: | 2022-11-18 | Release date: | 2023-03-22 | Last modified: | 2023-04-05 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of odorant recognition by a human odorant receptor. Nature, 615, 2023
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8FGW
| Human IFT-A complex structures provide molecular insights into ciliary transport | Descriptor: | Intraflagellar transport protein 122 homolog, Intraflagellar transport protein 140 homolog, Intraflagellar transport protein 43 homolog, ... | Authors: | Jiang, M, Palicharla, V.R, Miller, D, Hwang, S.H, Zhu, H, Hixson, P, Mukhopadhyay, S, Sun, J. | Deposit date: | 2022-12-12 | Release date: | 2023-02-22 | Last modified: | 2023-04-12 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Human IFT-A complex structures provide molecular insights into ciliary transport. Cell Res., 33, 2023
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8FH3
| Human IFT-A complex structures provide molecular insights into ciliary transport | Descriptor: | Intraflagellar transport protein 122 homolog, Intraflagellar transport protein 140 homolog, Tubby-related protein 3, ... | Authors: | Jiang, M, Palicharla, V.R, Miller, D, Hwang, S.H, Zhu, H, Hixson, P, Mukhopadhyay, S, Sun, J. | Deposit date: | 2022-12-13 | Release date: | 2023-02-22 | Last modified: | 2023-04-12 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Human IFT-A complex structures provide molecular insights into ciliary transport. Cell Res., 33, 2023
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8G1U
| Structure of the methylosome-Lsm10/11 complex | Descriptor: | ADENOSINE, Methylosome protein 50, Methylosome subunit pICln, ... | Authors: | Lin, M, Paige, A, Tong, L. | Deposit date: | 2023-02-03 | Release date: | 2023-08-23 | Last modified: | 2023-10-25 | Method: | ELECTRON MICROSCOPY (2.83 Å) | Cite: | In vitro methylation of the U7 snRNP subunits Lsm11 and SmE by the PRMT5/MEP50/pICln methylosome. Rna, 29, 2023
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8FYH
| G4 RNA-mediated PRC2 dimer | Descriptor: | G4 RNA, Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH2, ... | Authors: | Song, J, Kasinath, V. | Deposit date: | 2023-01-26 | Release date: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis for inactivation of PRC2 by G-quadruplex RNA. Science, 381, 2023
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8GQE
| Crystal structure of the W285A mutant of UVR8 in complex with RUP2 | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Ultraviolet-B receptor UVR8, WD repeat-containing protein RUP2 | Authors: | Wang, Y.D, Wang, L.X, Guan, Z.Y, chang, H.F, Yin, P. | Deposit date: | 2022-08-30 | Release date: | 2022-09-14 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | RUP2 facilitates UVR8 redimerization via two interfaces. Plant Commun., 4, 2023
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8FDT
| Engineered human dynein motor domain in the microtubule-unbound state with LIS1 complex in the buffer containing ATP-Vi | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1,Serine--tRNA ligase, ... | Authors: | Ton, W, Wang, Y, Chai, P. | Deposit date: | 2022-12-04 | Release date: | 2023-06-21 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport. Nat.Struct.Mol.Biol., 30, 2023
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8FDU
| Engineered human dynein motor domain in the microtubule-unbound state with LIS1 complex in the buffer containing ATP-Vi (local refined on AAA3-AAA5 and LIS1) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Cytoplasmic dynein 1 heavy chain 1,Serine--tRNA ligase, Platelet-activating factor acetylhydrolase IB subunit beta,Platelet-activating factor acetylhydrolase IB subunit beta,human LIS1 protein with a SNAP tag | Authors: | Ton, W, Wang, Y, Chai, P. | Deposit date: | 2022-12-04 | Release date: | 2023-06-21 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Microtubule-binding-induced allostery triggers LIS1 dissociation from dynein prior to cargo transport. Nat.Struct.Mol.Biol., 30, 2023
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