Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

6RLT
DownloadVisualize
BU of 6rlt by Molmil
Trypanosoma brucei Seryl-tRNA Synthetase in Complex with 5'-O-(N-(L-seryl)-Sulfamoyl)uridine
Descriptor: 5'-O-(N-(L-seryl)-Sulfamoyl)uridine, GLYCEROL, MALONATE ION, ...
Authors:Pang, L, De Graef, S, Strelkov, S.V, Weeks, S.D.
Deposit date:2019-05-02
Release date:2020-01-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases.
Acs Chem.Biol., 15, 2020
4JC4
DownloadVisualize
BU of 4jc4 by Molmil
Crystal structure of Peptidyl-tRNA hydrolase from Pseudomonas aeruginosa at 2.25 angstrom resolution
Descriptor: GLYCEROL, Peptidyl-tRNA hydrolase
Authors:Singh, A, Kumar, A, Sinha, M, Bhushan, A, Kaur, P, Sharma, S, Arora, A, Singh, T.P.
Deposit date:2013-02-21
Release date:2013-04-03
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural and binding studies of peptidyl-tRNA hydrolase from Pseudomonas aeruginosa provide a platform for the structure-based inhibitor design against peptidyl-tRNA hydrolase
Biochem.J., 463, 2014
3AII
DownloadVisualize
BU of 3aii by Molmil
Archaeal non-discriminating glutamyl-tRNA synthetase from Methanothermobacter thermautotrophicus
Descriptor: 1,2-ETHANEDIOL, ACETIC ACID, CALCIUM ION, ...
Authors:Nureki, O, Ishitani, R.
Deposit date:2010-05-14
Release date:2010-08-04
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure of an archaeal non-discriminating glutamyl-tRNA synthetase: a missing link in the evolution of Gln-tRNAGln formation
Nucleic Acids Res., 2010
3A31
DownloadVisualize
BU of 3a31 by Molmil
Crystal structure of putative threonyl-tRNA synthetase ThrRS-1 from Aeropyrum pernix (selenomethionine derivative)
Descriptor: Probable threonyl-tRNA synthetase 1, SULFATE ION, ZINC ION
Authors:Shimizu, S, Juan, E.C.M, Miyashita, Y, Sato, Y, Hoque, M.M, Suzuki, K, Yogiashi, M, Tsunoda, M, Dock-Bregeon, A.-C, Moras, D, Sekiguchi, T, Takenaka, A.
Deposit date:2009-06-07
Release date:2009-10-27
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Two complementary enzymes for threonylation of tRNA in crenarchaeota: crystal structure of Aeropyrum pernix threonyl-tRNA synthetase lacking a cis-editing domain
J.Mol.Biol., 394, 2009
3A32
DownloadVisualize
BU of 3a32 by Molmil
Crystal structure of putative threonyl-tRNA synthetase ThrRS-1 from Aeropyrum pernix
Descriptor: Probable threonyl-tRNA synthetase 1, SULFATE ION, ZINC ION
Authors:Shimizu, S, Juan, E.C.M, Miyashita, Y, Sato, Y, Hoque, M.M, Suzuki, K, Yogiashi, M, Tsunoda, M, Dock-Bregeon, A.-C, Moras, D, Sekiguchi, T, Takenaka, A.
Deposit date:2009-06-07
Release date:2009-10-27
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Two complementary enzymes for threonylation of tRNA in crenarchaeota: crystal structure of Aeropyrum pernix threonyl-tRNA synthetase lacking a cis-editing domain
J.Mol.Biol., 394, 2009
3A04
DownloadVisualize
BU of 3a04 by Molmil
Crystal structure of tryptophanyl-tRNA synthetase from hyperthermophilic archaeon, Aeropyrum pernix K1
Descriptor: CADMIUM ION, IRON/SULFUR CLUSTER, Tryptophanyl-tRNA synthetase
Authors:Tsuchiya, W, Fujimoto, Z, Hasegawa, T.
Deposit date:2009-03-02
Release date:2010-03-09
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Crystal structure of tryptophanyl-tRNA synthetase from hyperthermophilic archaeon, Aeropyrum pernix K1
To be Published
3A05
DownloadVisualize
BU of 3a05 by Molmil
Crystal structure of tryptophanyl-tRNA synthetase from hyperthermophilic archaeon, Aeropyrum pernix K1 complex with tryptophan
Descriptor: CADMIUM ION, IRON/SULFUR CLUSTER, TRYPTOPHAN, ...
Authors:Tsuchiya, W, Fujimoto, Z, Hasegawa, T.
Deposit date:2009-03-02
Release date:2010-03-09
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of tryptophanyl-tRNA synthetase from hyperthermophilic archaeon, Aeropyrum pernix K1
To be Published
1TKG
DownloadVisualize
BU of 1tkg by Molmil
Crystal structure of the editing domain of threonyl-tRNA synthetase complexed with an analog of seryladenylate
Descriptor: 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, Threonyl-tRNA synthetase
Authors:Dock-Bregeon, A.C, Rees, B, Torres-Larios, A, Bey, G, Caillet, J, Moras, D.
Deposit date:2004-06-08
Release date:2004-11-30
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Achieving Error-Free Translation; The Mechanism of Proofreading of Threonyl-tRNA Synthetase at Atomic Resolution.
Mol.Cell, 16, 2004
4KZ2
DownloadVisualize
BU of 4kz2 by Molmil
Crystal Structure of phi29 pRNA 3WJ Core
Descriptor: MANGANESE (II) ION, phi29 pRNA 3WJ core RNA 16 mer, phi29 pRNA 3WJ core RNA 18 mer, ...
Authors:Zhang, H, Endrizzi, J.A, Shu, Y, Haque, F, Sauter, C, Guo, P, Chi, Y.-I.
Deposit date:2013-05-29
Release date:2013-10-16
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Crystal structure of 3WJ core revealing divalent ion-promoted thermostability and assembly of the Phi29 hexameric motor pRNA.
Rna, 19, 2013
4RMF
DownloadVisualize
BU of 4rmf by Molmil
Biochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug target
Descriptor: 2,2-bis(hydroxymethyl)propane-1,3-diol, Aspartate--tRNA(Asp/Asn) ligase, FORMIC ACID
Authors:Cox, J.A.G, Gurcha, S.S, Veeraraghavan, U, Besra, G.S, Futterer, K.
Deposit date:2014-10-21
Release date:2014-11-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Biochemical and Structural Characterization of Mycobacterial Aspartyl-tRNA Synthetase AspS, a Promising TB Drug Target.
Plos One, 9, 2014
4NCX
DownloadVisualize
BU of 4ncx by Molmil
Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline--tRNA ligase) from Plasmodium falciparum 3D7
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Proline--tRNA ligase
Authors:Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2013-10-25
Release date:2014-10-29
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase.
Acs Infect Dis., 3, 2017
3VQX
DownloadVisualize
BU of 3vqx by Molmil
Crystal structure of the catalytic domain of pyrrolysyl-tRNA synthetase in triclinic crystal form
Descriptor: ADENOSINE MONOPHOSPHATE, PHOSPHATE ION, Pyrrolysine--tRNA ligase, ...
Authors:Yanagisawa, T, Sumida, T, Ishii, R, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2012-04-02
Release date:2013-01-02
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A novel crystal form of pyrrolysyl-tRNA synthetase reveals the pre- and post-aminoacyl-tRNA synthesis conformational states of the adenylate and aminoacyl moieties and an asparagine residue in the catalytic site
Acta Crystallogr.,Sect.D, 69, 2013
3VQW
DownloadVisualize
BU of 3vqw by Molmil
Crystal structure of the SeMet substituted catalytic domain of pyrrolysyl-tRNA synthetase
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Pyrrolysine--tRNA ligase
Authors:Yanagisawa, T, Sumida, T, Ishii, R, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2012-04-01
Release date:2013-01-02
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A novel crystal form of pyrrolysyl-tRNA synthetase reveals the pre- and post-aminoacyl-tRNA synthesis conformational states of the adenylate and aminoacyl moieties and an asparagine residue in the catalytic site
Acta Crystallogr.,Sect.D, 69, 2013
3VQY
DownloadVisualize
BU of 3vqy by Molmil
Crystal structure of the catalytic domain of pyrrolysyl-tRNA synthetase in complex with BocLys and AMPPNP (form 2)
Descriptor: MAGNESIUM ION, N~6~-(tert-butoxycarbonyl)-L-lysine, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Yanagisawa, T, Sumida, T, Ishii, R, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2012-04-02
Release date:2013-01-02
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A novel crystal form of pyrrolysyl-tRNA synthetase reveals the pre- and post-aminoacyl-tRNA synthesis conformational states of the adenylate and aminoacyl moieties and an asparagine residue in the catalytic site
Acta Crystallogr.,Sect.D, 69, 2013
8POR
DownloadVisualize
BU of 8por by Molmil
Crystal structure of wolbachia leucyl-tRNA synthetase editing domain bound to cmpd6-AMP adduct
Descriptor: 1,2-ETHANEDIOL, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Leucine--tRNA ligase, ...
Authors:Palencia, A, Lukarska, M.
Deposit date:2023-07-05
Release date:2024-06-12
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Targeting a microbiota Wolbachian aminoacyl-tRNA synthetase to block its pathogenic host.
Sci Adv, 10, 2024
3VQV
DownloadVisualize
BU of 3vqv by Molmil
Crystal structure of the catalytic domain of pyrrolysyl-tRNA synthetase in complex with AMPPNP (re-refined)
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Pyrrolysine--tRNA ligase
Authors:Yanagisawa, T, Sumida, T, Ishii, R, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2012-04-01
Release date:2013-01-02
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A novel crystal form of pyrrolysyl-tRNA synthetase reveals the pre- and post-aminoacyl-tRNA synthesis conformational states of the adenylate and aminoacyl moieties and an asparagine residue in the catalytic site
Acta Crystallogr.,Sect.D, 69, 2013
4N7R
DownloadVisualize
BU of 4n7r by Molmil
Crystal structure of Arabidopsis glutamyl-tRNA reductase in complex with its binding protein
Descriptor: Genomic DNA, chromosome 3, P1 clone: MXL8, ...
Authors:Zhao, A, Fang, Y, Lin, Y, Gong, W, Liu, L.
Deposit date:2013-10-16
Release date:2014-05-14
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.802 Å)
Cite:Crystal structure of Arabidopsis glutamyl-tRNA reductase in complex with its stimulator protein
Proc.Natl.Acad.Sci.USA, 111, 2014
5USF
DownloadVisualize
BU of 5usf by Molmil
Leishmania donovani tyrosyl-tRNA synthetase in complex with nanobody and inhibitor
Descriptor: 5'-O-[N-(L-TYROSYL)SULFAMOYL]ADENOSINE, Immunoglobulin heavy chain variable region, Tyrosyl-tRNA synthetase, ...
Authors:Barros-Alvarez, X, Hol, W.G.J.
Deposit date:2017-02-13
Release date:2017-05-17
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts.
Biochimie, 138, 2017
1MKH
DownloadVisualize
BU of 1mkh by Molmil
C-terminal domain of methionyl-tRNA synthetase from Pyrococcus abyssi
Descriptor: C-terminal domain of Methionyl-tRNA synthetase
Authors:Crepin, T, Schmitt, E, Blanquet, S, Mechulam, Y.
Deposit date:2002-08-29
Release date:2003-02-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Structure and function of the C-terminal domain of methionyl-tRNA synthetase
Biochemistry, 41, 2002
5V49
DownloadVisualize
BU of 5v49 by Molmil
Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor (Chem 1917)
Descriptor: GLYCEROL, METHIONINE, Methionyl-tRNA synthetase, ...
Authors:Barros-Alvarez, X, Hol, W.G.J.
Deposit date:2017-03-08
Release date:2017-07-26
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Optimization of a binding fragment targeting the "enlarged methionine pocket" leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
1N3L
DownloadVisualize
BU of 1n3l by Molmil
Crystal structure of a human aminoacyl-tRNA synthetase cytokine
Descriptor: GLYCEROL, SULFATE ION, tyrosyl-tRNA synthetase
Authors:Yang, X.-L, Skene, R.J, McRee, D.E, Schimmel, P.
Deposit date:2002-10-28
Release date:2002-11-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:Crystal structure of a human aminoacyl-tRNA synthetase cytokine
Proc.Natl.Acad.Sci.USA, 99, 2002
5XIF
DownloadVisualize
BU of 5xif by Molmil
Crystal Structure of Prolyl-tRNA Synthetase (PRS) from Toxoplasma gondii
Descriptor: CHLORIDE ION, Prolyl-tRNA synthetase (ProRS)
Authors:Jain, V, Manickam, Y, Sharma, A.
Deposit date:2017-04-26
Release date:2018-03-07
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5XIQ
DownloadVisualize
BU of 5xiq by Molmil
Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with Halofuginone
Descriptor: 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Jain, V, Manickam, Y, Sharma, A.
Deposit date:2017-04-26
Release date:2018-03-07
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5XIL
DownloadVisualize
BU of 5xil by Molmil
Crystal Structure of Leishmania major Prolyl-tRNA Synthetase (LmPRS)
Descriptor: ACETATE ION, MAGNESIUM ION, Putative prolyl-tRNA synthetase, ...
Authors:Jain, V, Manickam, Y, Sharma, A.
Deposit date:2017-04-26
Release date:2018-03-07
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017
5XII
DownloadVisualize
BU of 5xii by Molmil
Crystal Structure of Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in complex with inhibitor 6
Descriptor: 1,2-ETHANEDIOL, 6-chloranyl-7-fluoranyl-3-[3-[(2R)-3-oxidanylidenepiperidin-2-yl]propyl]quinazolin-4-one, CHLORIDE ION, ...
Authors:Jain, V, Manickam, Y, Sharma, A.
Deposit date:2017-04-26
Release date:2018-03-07
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis
Structure, 25, 2017

238582

数据于2025-07-09公开中

PDB statisticsPDBj update infoContact PDBjnumon