8POR

Crystal structure of wolbachia leucyl-tRNA synthetase editing domain bound to cmpd6-AMP adduct

Summary for 8POR

• Entry DOI: 10.2210/pdb8por/pdb
• Related: 8POQ
• Descriptor: Leucine--tRNA ligase, SULFATE ION, [(1~{R},5~{S},6~{R},8~{R},9'~{S})-9'-(aminomethyl)-8-(6-aminopurin-9-yl)-2'-bromanyl-5'-[3-oxidanylidene-3-(1,3-thiazol-2-ylamino)propoxy]spiro[2,4,7-trioxa-3-boranuidabicyclo[3.3.0]octane-3,7'-8-oxa-7-boranuidabicyclo[4.3.0]nona-1(6),2,4-triene]-6-yl]methyl dihydrogen phosphate, ... (6 entities in total)
• Functional Keywords: leucine trna ligase, atp binding protein, trna aminoacylation for protein translation, cytosolic reaction catalysed: atp + l-leucine + trna(leu) = amp + diphosphate + l-leucyl-trna(leu), ligase
• Biological source: Wolbachia endosymbiont strain TRS of Brugia malayi
• Total number of polymer chains: 1
• Total formula weight: 21265.01

Authors

Palencia, A.,Lukarska, M. (deposition date: 2023-07-05, release date: 2024-06-12)

• Primary citation: Palencia, A.,Hoffmann, G.,Lukarska, M.,Clare, R.,Ward, S.,Taylor, M.A.,Ringkjobing Jensen, M.; Targeting A Microbiota Wolbachian Aminoacyl-tRNA Synthetase To Block Its Pathogenic Host; Science Advances, 2024

Experimental method

X-RAY DIFFRACTION (1.85 Å)