4IBJ
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![BU of 4ibj by Molmil](/molmil-images/mine/4ibj) | Ebola virus VP35 bound to small molecule | Descriptor: | 3-{(5S)-3-hydroxy-2-oxo-4-[3-(trifluoromethyl)benzoyl]-5-[3-(trifluoromethyl)phenyl]-2,5-dihydro-1H-pyrrol-1-yl}benzoic acid, Polymerase cofactor VP35 | Authors: | Brown, C.S, Leung, D.W, Xu, W, Borek, D.M, Otwinowski, Z, Ramanan, P, Stubbs, A.J, Peterson, D.S, Binning, J.M, Amarasinghe, G.K. | Deposit date: | 2012-12-08 | Release date: | 2014-03-19 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity. J.Mol.Biol., 426, 2014
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4IBI
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![BU of 4ibi by Molmil](/molmil-images/mine/4ibi) | Ebola virus VP35 bound to small molecule | Descriptor: | 3-{(2S)-2-(7-chloro-1,3-benzodioxol-5-yl)-4-hydroxy-5-oxo-3-[3-(trifluoromethyl)benzoyl]-2,5-dihydro-1H-pyrrol-1-yl}benzoic acid, Polymerase cofactor VP35 | Authors: | Brown, C.S, Leung, D.W, Xu, W, Borek, D.M, Otwinowski, Z, Ramanan, P, Stubbs, A.J, Peterson, D.S, Binning, J.M, Amarasinghe, G.K. | Deposit date: | 2012-12-08 | Release date: | 2014-03-19 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.473 Å) | Cite: | In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity. J.Mol.Biol., 426, 2014
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3ITV
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![BU of 3itv by Molmil](/molmil-images/mine/3itv) | Crystal structure of Pseudomonas stutzeri L-rhamnose isomerase mutant S329K in complex with D-psicose | Descriptor: | D-psicose, L-rhamnose isomerase, MANGANESE (II) ION | Authors: | Yoshida, H, Yamaji, M, Ishii, T, Izumori, K, Kamitori, S. | Deposit date: | 2009-08-28 | Release date: | 2010-02-02 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Catalytic reaction mechanism of Pseudomonas stutzeri l-rhamnose isomerase deduced from X-ray structures Febs J., 277, 2010
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4IBE
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![BU of 4ibe by Molmil](/molmil-images/mine/4ibe) | Ebola virus VP35 bound to small molecule | Descriptor: | 5-[(2R)-3-benzoyl-2-(4-bromothiophen-2-yl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl]-2-chlorobenzoic acid, GLYCEROL, Polymerase cofactor VP35 | Authors: | Brown, C.S, Leung, D.W, Xu, W, Borek, D.M, Otwinowski, Z, Ramanan, P, Stubbs, A.J, Peterson, D.S, Binning, J.M, Amarasinghe, G.K, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2012-12-08 | Release date: | 2014-03-19 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity. J.Mol.Biol., 426, 2014
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1PQN
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![BU of 1pqn by Molmil](/molmil-images/mine/1pqn) | dominant negative human hDim1 (hDim1 1-128) | Descriptor: | Spliceosomal U5 snRNP-specific 15 kDa protein | Authors: | Zhang, Y.Z, Cheng, H, Gould, K.L, Golemis, E.A, Roder, H. | Deposit date: | 2003-06-18 | Release date: | 2003-08-26 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure, stability and function of hDim1 investigated by NMR, circular
dichroism and mutational analysis Biochemistry, 42, 2003
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4IBF
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![BU of 4ibf by Molmil](/molmil-images/mine/4ibf) | Ebola virus VP35 bound to small molecule | Descriptor: | (4-{(2R)-2-(4-bromothiophen-2-yl)-3-[(5-chlorothiophen-2-yl)carbonyl]-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl}phenyl)acetic acid, Polymerase cofactor VP35 | Authors: | Brown, C.S, Leung, D.W, Xu, W, Borek, D.M, Otwinowski, Z, Ramanan, P, Stubbs, A.J, Peterson, D.S, Binning, J.M, Amarasinghe, G.K, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2012-12-08 | Release date: | 2014-03-19 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.291 Å) | Cite: | In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity. J.Mol.Biol., 426, 2014
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3J6J
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![BU of 3j6j by Molmil](/molmil-images/mine/3j6j) | 3.6 Angstrom resolution MAVS filament generated from helical reconstruction | Descriptor: | Mitochondrial antiviral-signaling protein | Authors: | Wu, B, Peisley, A, Li, Z, Egelman, E, Walz, T, Penczek, P, Hur, S. | Deposit date: | 2014-03-13 | Release date: | 2014-07-30 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.64 Å) | Cite: | Molecular Imprinting as a Signal-Activation Mechanism of the Viral RNA Sensor RIG-I. Mol.Cell, 55, 2014
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3CM3
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![BU of 3cm3 by Molmil](/molmil-images/mine/3cm3) | |
1X8E
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![BU of 1x8e by Molmil](/molmil-images/mine/1x8e) | Crystal structure of Pyrococcus furiosus phosphoglucose isomerase free enzyme | Descriptor: | Glucose-6-phosphate isomerase | Authors: | Berrisford, J.M, Akerboom, J, Brouns, S, Sedelnikova, S.E, Turnbull, A.P, van der Oost, J, Salmon, L, Hardre, R, Murray, I.A, Blackburn, G.M, Rice, D.W, Baker, P.J. | Deposit date: | 2004-08-18 | Release date: | 2004-10-12 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The structures of inhibitor complexes of Pyrococcus furiosus phosphoglucose isomerase provide insights into substrate binding and catalysis. J.Mol.Biol., 343, 2004
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3J5Q
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![BU of 3j5q by Molmil](/molmil-images/mine/3j5q) | Structure of TRPV1 ion channel in complex with DkTx and RTX determined by single particle electron cryo-microscopy | Descriptor: | Kappa-theraphotoxin-Cg1a 1, Transient receptor potential cation channel subfamily V member 1 | Authors: | Liao, M, Cao, E, Julius, D, Cheng, Y. | Deposit date: | 2013-10-28 | Release date: | 2013-12-04 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | TRPV1 structures in distinct conformations reveal activation mechanisms. Nature, 504, 2013
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6FAX
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![BU of 6fax by Molmil](/molmil-images/mine/6fax) | Complex of Human CD40 Ectodomain with Lob 7.4 Fab | Descriptor: | Lob 7.4 heavy chain, Lob 7.4 light chain, Tumor necrosis factor receptor superfamily member 5 | Authors: | Orr, C.M, Tews, I, Pearson, A.R. | Deposit date: | 2017-12-18 | Release date: | 2018-02-07 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.99 Å) | Cite: | Complex Interplay between Epitope Specificity and Isotype Dictates the Biological Activity of Anti-human CD40 Antibodies. Cancer Cell, 33, 2018
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3ZU3
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![BU of 3zu3 by Molmil](/molmil-images/mine/3zu3) | Structure of the enoyl-ACP reductase FabV from Yersinia pestis with the cofactor NADH (MR, cleaved Histag) | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, GLYCEROL, PUTATIVE REDUCTASE YPO4104/Y4119/YP_4011, ... | Authors: | Hirschbeck, M.W, Kuper, J, Kisker, C. | Deposit date: | 2011-07-13 | Release date: | 2012-01-18 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.802 Å) | Cite: | Structure of the Yersinia Pestis Fabv Enoyl-Acp Reductase and its Interaction with Two 2-Pyridone Inhibitors Structure, 20, 2012
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3ZGP
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![BU of 3zgp by Molmil](/molmil-images/mine/3zgp) | NMR structure of the catalytic domain from E. faecium L,D- transpeptidase acylated by ertapenem | Descriptor: | (4R,5S)-3-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, ERFK/YBIS/YCFS/YNHG | Authors: | Lecoq, L, Triboulet, S, Dubee, V, Bougault, C, Hugonnet, J.E, Arthur, M, Simorre, J.P. | Deposit date: | 2012-12-18 | Release date: | 2013-04-24 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | The Structure of Enterococcus Faecium L,D---Transpeptidase Acylated by Ertapenem Provides Insight Into the Inactivation Mechanism. Acs Chem.Biol., 8, 2013
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3ZQQ
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![BU of 3zqq by Molmil](/molmil-images/mine/3zqq) | Crystal structure of the full-length small terminase from a SPP1-like bacteriophage | Descriptor: | TERMINASE SMALL SUBUNIT | Authors: | Buttner, C.R, Chechik, M, Ortiz-Lombardia, M, Smits, C, Chechik, V, Jeschke, G, Dykeman, E, Benini, S, Alonso, J.C, Antson, A.A. | Deposit date: | 2011-06-10 | Release date: | 2011-12-28 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | Structural Basis for DNA Recognition and Loading Into a Viral Packaging Motor. Proc.Natl.Acad.Sci.USA, 109, 2012
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6G0A
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![BU of 6g0a by Molmil](/molmil-images/mine/6g0a) | |
3ZQP
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![BU of 3zqp by Molmil](/molmil-images/mine/3zqp) | Crystal structure of the small terminase oligomerization domain from a SPP1-like bacteriophage | Descriptor: | TERMINASE SMALL SUBUNIT | Authors: | Buttner, C.R, Chechik, M, Ortiz-Lombardia, M, Smits, C, Chechik, V, Jeschke, G, Dykeman, E, Benini, S, Alonso, J.C, Antson, A.A. | Deposit date: | 2011-06-10 | Release date: | 2011-12-28 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural Basis for DNA Recognition and Loading Into a Viral Packaging Motor. Proc.Natl.Acad.Sci.USA, 109, 2012
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3ZU5
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![BU of 3zu5 by Molmil](/molmil-images/mine/3zu5) | Structure of the enoyl-ACP reductase FabV from Yersinia pestis with the cofactor NADH and the 2-pyridone inhibitor PT173 | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 1-(3-amino-2-methylbenzyl)-4-hexylpyridin-2(1H)-one, PUTATIVE REDUCTASE YPO4104/Y4119/YP_4011, ... | Authors: | Hirschbeck, M.W, Kuper, J, Tonge, P.J, Kisker, C. | Deposit date: | 2011-07-13 | Release date: | 2012-01-18 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of the Yersinia Pestis Fabv Enoyl-Acp Reductase and its Interaction with Two 2-Pyridone Inhibitors Structure, 20, 2012
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3ZU4
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![BU of 3zu4 by Molmil](/molmil-images/mine/3zu4) | Structure of the enoyl-ACP reductase FabV from Yersinia pestis with the cofactor NADH and the 2-pyridone inhibitor PT172 | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 1-(2-CHLOROBENZYL)-4-HEXYLPYRIDIN-2(1H)-ONE, PUTATIVE REDUCTASE YPO4104/Y4119/YP_4011, ... | Authors: | Hirschbeck, M.W, Kuper, J, Tonge, P.J, Kisker, C. | Deposit date: | 2011-07-13 | Release date: | 2012-01-18 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Structure of the Yersinia Pestis Fabv Enoyl-Acp Reductase and its Interaction with Two 2-Pyridone Inhibitors Structure, 20, 2012
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5BQX
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![BU of 5bqx by Molmil](/molmil-images/mine/5bqx) | Crystal structure of human STING in complex with 3'2'-cGAMP | Descriptor: | 3'2'-cGAMP, Stimulator of interferon genes protein | Authors: | Wu, J, Zhang, X, Chen, Z.J, Chen, C. | Deposit date: | 2015-05-29 | Release date: | 2015-06-24 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Molecular basis for the specific recognition of the metazoan cyclic GMP-AMP by the innate immune adaptor protein STING. Proc.Natl.Acad.Sci.USA, 112, 2015
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4AP9
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![BU of 4ap9 by Molmil](/molmil-images/mine/4ap9) | Crystal structure of phosphoserine phosphatase from T. onnurineus in complex with NDSB-201 | Descriptor: | 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, PHOSPHOSERINE PHOSPHATASE | Authors: | Jung, T.-Y, Kim, Y.-S, Song, H.-N, Woo, E. | Deposit date: | 2012-03-31 | Release date: | 2012-12-26 | Last modified: | 2013-04-17 | Method: | X-RAY DIFFRACTION (1.783 Å) | Cite: | Identification of a Novel Ligand Binding Site in Phosphoserine Phosphatase from the Hyperthermophilic Archaeon Thermococcus Onnurineus. Proteins, 81, 2013
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4AR7
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![BU of 4ar7 by Molmil](/molmil-images/mine/4ar7) | X-ray structure of the cyan fluorescent protein mTurquoise | Descriptor: | GREEN FLUORESCENT PROTEIN | Authors: | von Stetten, D, Noirclerc-Savoye, M, Goedhart, J, Gadella, T.W.J, Royant, A. | Deposit date: | 2012-04-21 | Release date: | 2012-08-08 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.23 Å) | Cite: | Structure of a Fluorescent Protein from Aequorea Victoria Bearing the Obligate-Monomer Mutation A206K. Acta Crystallogr.,Sect.F, 68, 2012
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1YB6
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![BU of 1yb6 by Molmil](/molmil-images/mine/1yb6) | |
1Y0K
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![BU of 1y0k by Molmil](/molmil-images/mine/1y0k) | Structure of Protein of Unknown Function PA4535 from Pseudomonas aeruginosa strain PAO1, Monooxygenase Superfamily | Descriptor: | hypothetical protein PA4535 | Authors: | Nocek, B.P, Evdokimova, E, Savchenko, A, Edwards, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2004-11-15 | Release date: | 2005-01-18 | Last modified: | 2014-11-26 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | 1.75 A Crystal Structure of the Hypothetical Protein Pa4535 from Pseudomonas Aeruginosa To be Published
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1YB7
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![BU of 1yb7 by Molmil](/molmil-images/mine/1yb7) | Hydroxynitrile lyase from hevea brasiliensis in complex with 2,3-dimethyl-2-hydroxy-butyronitrile | Descriptor: | (S)-2-HYDROXY-2,3-DIMETHYLBUTANENITRILE, (S)-acetone-cyanohydrin lyase, SULFATE ION | Authors: | Gruber, K, Gartler, G, Kratky, C. | Deposit date: | 2004-12-20 | Release date: | 2005-12-20 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Structural determinants of the enantioselectivity of the hydroxynitrile lyase from Hevea brasiliensis J.Biotechnol., 129, 2007
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3ZU2
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![BU of 3zu2 by Molmil](/molmil-images/mine/3zu2) | Structure of the enoyl-ACP reductase FabV from Yersinia pestis with the cofactor NADH (SIRAS) | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, PUTATIVE REDUCTASE YPO4104/Y4119/YP_4011, SODIUM ION | Authors: | Hirschbeck, M.W, Kuper, J, Kisker, C. | Deposit date: | 2011-07-13 | Release date: | 2012-01-18 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of the Yersinia Pestis Fabv Enoyl-Acp Reductase and its Interaction with Two 2-Pyridone Inhibitors Structure, 20, 2012
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