3ZU5

Structure of the enoyl-ACP reductase FabV from Yersinia pestis with the cofactor NADH and the 2-pyridone inhibitor PT173

Summary for 3ZU5

• Entry DOI: 10.2210/pdb3zu5/pdb
• Related: 3ZU2 3ZU3 3ZU4
• Descriptor: PUTATIVE REDUCTASE YPO4104/Y4119/YP_4011, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 1-(3-amino-2-methylbenzyl)-4-hexylpyridin-2(1H)-one, ... (5 entities in total)
• Functional Keywords: oxidoreductase, fatty acid biosynthesis ii, short-chain dehydrogenase reductase superfamily, structure-based drug design
• Biological source: YERSINIA PESTIS
• Total number of polymer chains: 1
• Total formula weight: 45019.47

Authors

Hirschbeck, M.W.,Kuper, J.,Tonge, P.J.,Kisker, C. (deposition date: 2011-07-13, release date: 2012-01-18, Last modification date: 2017-07-05)

• Primary citation: Hirschbeck, M.W.,Kuper, J.,Lu, H.,Liu, N.,Neckles, C.,Shah, S.,Wagner, S.,Sotriffer, C.A.,Tonge, P.J.,Kisker, C.; Structure of the Yersinia Pestis Fabv Enoyl-Acp Reductase and its Interaction with Two 2-Pyridone Inhibitors; Structure, 20:89-, 2012; PubMed: 22244758; DOI: 10.1016/J.STR.2011.07.019

Experimental method

X-RAY DIFFRACTION (2 Å)