8CXN
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8CXK
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![BU of 8cxk by Molmil](/molmil-images/mine/8cxk) | Structure of the C. elegans HIM-3 R93Y mutant | Descriptor: | HORMA domain-containing protein | Authors: | Ego, K.M, Russo, A, Giacopazzi, S, Deshong, A, Menon, M, Ortiz, V, Bhalla, N, Corbett, K.D. | Deposit date: | 2022-05-21 | Release date: | 2023-05-17 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | The conserved AAA ATPase PCH-2 distributes its regulation of meiotic prophase events through multiple meiotic HORMADs in C. elegans. Plos Genet., 19, 2023
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8CXJ
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8CX9
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![BU of 8cx9 by Molmil](/molmil-images/mine/8cx9) | Structure of the SARS-COV2 PLpro (C111S) in complex with a dimeric Ubv that inhibits activity by an unusual allosteric mechanism | Descriptor: | BROMIDE ION, CHLORIDE ION, Papain-like protease nsp3, ... | Authors: | Singer, A.U, Slater, C.L, Patel, A, Russel, R, Mark, B.L, Sidhu, S.S. | Deposit date: | 2022-05-20 | Release date: | 2023-01-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Ubiquitin variants potently inhibit SARS-CoV-2 PLpro and viral replication via a novel site distal to the protease active site. Plos Pathog., 18, 2022
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8CX4
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![BU of 8cx4 by Molmil](/molmil-images/mine/8cx4) | TCR-antigen complex AS8.4-YEIH-HLA*B27 | Descriptor: | AS8.4a, AS8.4b, Beta-2-microglobulin, ... | Authors: | Yang, X, Jude, K.M, Garcia, K.C. | Deposit date: | 2022-05-19 | Release date: | 2022-12-07 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides. Nature, 612, 2022
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8CX3
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![BU of 8cx3 by Molmil](/molmil-images/mine/8cx3) | Crystal structure of full-length mesothelin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | Authors: | Zhan, J, Esser, L, Xia, D. | Deposit date: | 2022-05-19 | Release date: | 2023-02-01 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3.609 Å) | Cite: | Structures of Cancer Antigen Mesothelin and Its Complexes with Therapeutic Antibodies. Cancer Res Commun, 3, 2023
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8CWV
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8CWU
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8CWT
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8CWR
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8CWP
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![BU of 8cwp by Molmil](/molmil-images/mine/8cwp) | X-ray crystal structure of NTHi Protein D bound to a putative glycerol moiety | Descriptor: | GLYCEROL, Glycerophosphoryl diester phosphodiesterase, SODIUM ION | Authors: | Jones, S.P, Cook, K.H, Holmquist, M.L, Almekinder, L, DeLaney, A, Labbe, N, Perdue, J, Jackson, N, Charles, R, Pichichero, M, Kaur, R, Michel, L, Gleghorn, M.L. | Deposit date: | 2022-05-19 | Release date: | 2022-09-28 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Vaccine target and carrier molecule nontypeable Haemophilus influenzae protein D dimerizes like the close Escherichia coli GlpQ homolog but unlike other known homolog dimers. Proteins, 91, 2023
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8CWK
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8CWJ
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8CW2
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![BU of 8cw2 by Molmil](/molmil-images/mine/8cw2) | Crystal structure of TDP1 complexed with compound XZ760 | Descriptor: | 1,2-ETHANEDIOL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, 4-({(4R)-7-phenyl-2-[4-(2-{[4-(pyridin-2-yl)phenyl]methoxy}ethyl)phenyl]imidazo[1,2-a]pyridin-3-yl}amino)benzene-1,2-dicarboxylic acid, ... | Authors: | Lountos, G.T, Zhao, X.Z, Wang, W, Kiselev, E, Tropea, J.E, Needle, D, Pommier, Y, Burke, T.R. | Deposit date: | 2022-05-18 | Release date: | 2023-04-12 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.811 Å) | Cite: | Identification of multidentate tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors that simultaneously access the DNA, protein and catalytic-binding sites by oxime diversification. Rsc Chem Biol, 4, 2023
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8CVT
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![BU of 8cvt by Molmil](/molmil-images/mine/8cvt) | Human 19S-20S proteasome, state SD2 | Descriptor: | 26S protease regulatory subunit 10B, 26S protease regulatory subunit 8, 26S proteasome complex subunit SEM1, ... | Authors: | Zhao, J. | Deposit date: | 2022-05-18 | Release date: | 2022-11-02 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural insights into the human PA28-20S proteasome enabled by efficient tagging and purification of endogenous proteins. Proc.Natl.Acad.Sci.USA, 119, 2022
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8CVQ
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![BU of 8cvq by Molmil](/molmil-images/mine/8cvq) | Crystal structure of TDP1 complexed with compound XZ761 | Descriptor: | 1,2-ETHANEDIOL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, 4-{[(4S)-2,7-diphenylimidazo[1,2-a]pyridin-3-yl]amino}benzene-1,2-dicarboxylic acid, ... | Authors: | Lountos, G.T, Zhao, X.Z, Wang, W, Kiselev, E, Tropea, J.E, Needle, D, Pommier, Y, Burke, T.R. | Deposit date: | 2022-05-18 | Release date: | 2023-04-12 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Identification of multidentate tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors that simultaneously access the DNA, protein and catalytic-binding sites by oxime diversification. Rsc Chem Biol, 4, 2023
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8CVH
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![BU of 8cvh by Molmil](/molmil-images/mine/8cvh) | Structure of L289F Hyoscyamine 6-beta Hydroxylase in complex with vanadyl, succinate, and 6-OH-hyoscyamine | Descriptor: | (1R,3S,5R,6S)-6-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-yl (2S)-3-hydroxy-2-phenylpropanoate, 1,2-ETHANEDIOL, FORMIC ACID, ... | Authors: | Wenger, E.W, Boal, A.K, Bollinger, J.M, Krebs, C. | Deposit date: | 2022-05-18 | Release date: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Structure of the L289F H6H cyclization ferryl-mimicking complex To Be Published
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8CVG
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![BU of 8cvg by Molmil](/molmil-images/mine/8cvg) | Structure of L289F Hyoscyamine 6-beta Hydroxylase in complex with iron, 2-oxoglutarate, and 6-OH-hyoscyamine | Descriptor: | (1R,3S,5R,6S)-6-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-yl (2S)-3-hydroxy-2-phenylpropanoate, 1,2-ETHANEDIOL, 2-OXOGLUTARIC ACID, ... | Authors: | Wenger, E.W, Boal, A.K, Bollinger, J.M, Krebs, C. | Deposit date: | 2022-05-18 | Release date: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Structure of the L289F H6H cyclization reactant complex To Be Published
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8CVF
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![BU of 8cvf by Molmil](/molmil-images/mine/8cvf) | Structure of L289F Hyoscyamine 6-beta Hydroxylase in complex with vanadyl, succinate, and hyoscyamine | Descriptor: | 1,2-ETHANEDIOL, FORMIC ACID, Hyoscyamine 6-beta-hydroxylase, ... | Authors: | Wenger, E.W, Boal, A.K, Bollinger, J.M, Krebs, C. | Deposit date: | 2022-05-18 | Release date: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.532 Å) | Cite: | Structure of the L289F H6H ferryl-mimicking complex To Be Published
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8CVE
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![BU of 8cve by Molmil](/molmil-images/mine/8cve) | Structure of L289F Hyoscyamine 6-beta Hydroxylase in complex with iron, 2-oxoglutarate, and hyoscyamine | Descriptor: | 1,2-ETHANEDIOL, 2-OXOGLUTARIC ACID, FE (II) ION, ... | Authors: | Wenger, E.W, Boal, A.K, Bollinger, J.M, Krebs, C. | Deposit date: | 2022-05-18 | Release date: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | Structure of the L289F H6H hydroxylation reactant complex To Be Published
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8CVD
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![BU of 8cvd by Molmil](/molmil-images/mine/8cvd) | Structure of Hyoscyamine 6-beta Hydroxylase in complex with iron, succinate, and scopolamine | Descriptor: | (1R,2R,4S,5S,7s)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0~2,4~]nonan-7-yl (2S)-3-hydroxy-2-phenylpropanoate, 1,2-ETHANEDIOL, FE (II) ION, ... | Authors: | Wenger, E.W, Boal, A.K, Bollinger, J.M, Krebs, C. | Deposit date: | 2022-05-18 | Release date: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.717 Å) | Cite: | Structure of the H6H cyclization product complex To Be Published
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8CVC
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![BU of 8cvc by Molmil](/molmil-images/mine/8cvc) | Structure of Hyoscyamine 6-beta Hydroxylase in complex with vanadyl, succinate, and 6-OH-hyoscyamine | Descriptor: | (1R,3S,5R,6S)-6-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-yl (2S)-3-hydroxy-2-phenylpropanoate, 1,2-ETHANEDIOL, FORMIC ACID, ... | Authors: | Wenger, E.W, Boal, A.K, Bollinger, J.M, Krebs, C. | Deposit date: | 2022-05-18 | Release date: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.791 Å) | Cite: | Structure mimicking the H6H cyclization ferryl complex To Be Published
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8CVB
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![BU of 8cvb by Molmil](/molmil-images/mine/8cvb) | Structure of Hyoscyamine 6-beta Hydroxylase in complex with iron, 2-oxoglutarate, and 6-OH-hyoscyamine | Descriptor: | (1R,3S,5R,6S)-6-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-yl (2S)-3-hydroxy-2-phenylpropanoate, 1,2-ETHANEDIOL, 2-OXOGLUTARIC ACID, ... | Authors: | Wenger, E.W, Boal, A.K, Bollinger, J.M, Krebs, C. | Deposit date: | 2022-05-18 | Release date: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.532 Å) | Cite: | Structure of the H6H cyclization reactant complex To Be Published
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8CVA
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![BU of 8cva by Molmil](/molmil-images/mine/8cva) | Structure of Hyoscyamine 6-beta Hydroxylase in complex with iron, succinate, and 6-OH-hyoscyamine | Descriptor: | (1R,3S,5R,6S)-6-hydroxy-8-methyl-8-azabicyclo[3.2.1]octan-3-yl (2S)-3-hydroxy-2-phenylpropanoate, 1,2-ETHANEDIOL, FE (II) ION, ... | Authors: | Wenger, E.W, Boal, A.K, Bollinger, J.M, Krebs, C. | Deposit date: | 2022-05-18 | Release date: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.581 Å) | Cite: | Structure of the H6H hydroxylation product complex To Be Published
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8CV9
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![BU of 8cv9 by Molmil](/molmil-images/mine/8cv9) | Structure of Hyoscyamine 6-beta Hydroxylase in complex with vanadyl, succinate, and hyoscyamine | Descriptor: | 1,2-ETHANEDIOL, FORMIC ACID, Hyoscyamine 6-beta-hydroxylase, ... | Authors: | Wenger, E.W, Boal, A.K, Bollinger, J.M, Krebs, C. | Deposit date: | 2022-05-18 | Release date: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Structure of the H6H hydroxylation reactant complex To Be Published
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