8CX3

Crystal structure of full-length mesothelin

Summary for 8CX3

• Entry DOI: 10.2210/pdb8cx3/pdb
• Descriptor: Isoform 4 of Mesothelin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: mesothelin, cell adhesion
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 6
• Total formula weight: 214873.41

Authors

Zhan, J.,Esser, L.,Xia, D. (deposition date: 2022-05-19, release date: 2023-02-01, Last modification date: 2023-10-25)

• Primary citation: Zhan, J.,Lin, D.,Watson, N.,Esser, L.,Tang, W.K.,Zhang, A.,Liu, X.,Hassan, R.,Gleinich, A.,Shajahan, A.,Azadi, P.,Pastan, I.,Xia, D.; Structures of Cancer Antigen Mesothelin and Its Complexes with Therapeutic Antibodies.; Cancer Res Commun, 3:175-191, 2023; PubMed: 36968141; DOI: 10.1158/2767-9764.CRC-22-0306

Experimental method

X-RAY DIFFRACTION (3.609 Å)