8CX3

Crystal structure of full-length mesothelin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	Isoform 4 of Mesothelin	polymer	312	35261.2	6	UniProt (Q13421) Pfam (PF06060) In PDB	Homo sapiens (human)	CAK1 antigen,Pre-pro-megakaryocyte-potentiating factor
2	G	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
3	H	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	1	In PDB GlyTouCan (G15407YE)
4	A, B, C, E	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)
5	A, B, C, D, E...	PHOSPHATE ION	non-polymer		95.0	10	Chemie (PO4)
6	F, A, B, C, D	GLYCEROL	non-polymer		92.1	5	Chemie (GOL)

Sequence modifications

A, B, C, D, E, F: 296 - 600 (UniProt: Q13421)

PDB	External Database	Details
Met 295	-	initiating methionine
Val 593	Met 592	conflict
His 601	-	expression tag
His 602	-	expression tag
His 603	-	expression tag
His 604	-	expression tag
His 605	-	expression tag
His 606	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	211567.5
Branched	Number of molecules	2
	Total formula weight	1010.9
Non-Polymers*	Number of molecules	19
	Total formula weight	2295.0
All*	Total formula weight	214873.4

*Water molecules are not included.