PDB: 230764 resultsInfo pagesStatus searchChemie searchBIRD

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3F66	Human c-Met Kinase in complex with quinoxaline inhibitor Descriptor: 3-[3-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)quinoxalin-5-yl]phenol, GAMMA-BUTYROLACTONE, Hepatocyte growth factor receptor, ... Authors: Meier, C, Ceska, T. Deposit date: 2008-11-05 Release date: 2008-12-23 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Discovery of a novel series of quinoxalines as inhibitors of c-Met kinase. Bioorg.Med.Chem.Lett., 19, 2009
1BZ2	STABILIZATION OF THE ANTICODON STEM-LOOP OF TRNALYS,3 BY AN A+C BASE PAIR AND BY PSEUDOURIDINE, NMR, 1 STRUCTURE Descriptor: TRNA Authors: Durant, P.C, Davis, D.R. Deposit date: 1998-11-05 Release date: 1999-04-27 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Stabilization of the anticodon stem-loop of tRNALys,3 by an A+-C base-pair and by pseudouridine. J.Mol.Biol., 285, 1999
1BZT	STABILIZATION OF THE ANTICODON STEM-LOOP OF TRNALYS,3 BY AN A+C BASE PAIR AND BY PSEUDOURIDINE, NMR, 1 STRUCTURE Descriptor: TRNA Authors: Durant, P.C, Davis, D.R. Deposit date: 1998-11-05 Release date: 1999-04-27 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Stabilization of the anticodon stem-loop of tRNALys,3 by an A+-C base-pair and by pseudouridine. J.Mol.Biol., 285, 1999
6OSL	Cryo-EM structure of the N-terminally acetylated C-terminal Alpha-synuclein truncation Ac1-122 Descriptor: Alpha-synuclein Authors: Ni, X, McGlinchey, R.P, Jiang, J, Lee, J.C. Deposit date: 2019-05-01 Release date: 2019-09-25 Last modified: 2025-06-04 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structural Insights into alpha-Synuclein Fibril Polymorphism: Effects of Parkinson's Disease-Related C-Terminal Truncations. J.Mol.Biol., 431, 2019
6PTD	PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C MUTANT H32L Descriptor: PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C Authors: Heinz, D.W. Deposit date: 1997-07-18 Release date: 1998-01-21 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Probing the roles of active site residues in phosphatidylinositol-specific phospholipase C from Bacillus cereus by site-directed mutagenesis. Biochemistry, 36, 1997
7VBT	Crystal structure of RIOK2 in complex with CQ211 Descriptor: 8-(6-methoxypyridin-3-yl)-1-[4-piperazin-1-yl-3-(trifluoromethyl)phenyl]-5H-[1,2,3]triazolo[4,5-c]quinolin-4-one, Serine/threonine-protein kinase RIO2 Authors: Zhu, C, Zhang, Z.M. Deposit date: 2021-09-01 Release date: 2022-07-06 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.54001474 Å) Cite: Discovery of 8-(6-Methoxypyridin-3-yl)-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)-1,5-dihydro- 4H -[1,2,3]triazolo[4,5- c ]quinolin-4-one (CQ211) as a Highly Potent and Selective RIOK2 Inhibitor. J.Med.Chem., 65, 2022
100D	CRYSTAL STRUCTURE OF THE HIGHLY DISTORTED CHIMERIC DECAMER R(C)D(CGGCGCCG)R(G)-SPERMINE COMPLEX-SPERMINE BINDING TO PHOSPHATE ONLY AND MINOR GROOVE TERTIARY BASE-PAIRING Descriptor: DNA/RNA (5'-R(*CP*)-D(*CP*GP*GP*CP*GP*CP*CP*GP*)-R(*G)-3'), SPERMINE Authors: Ban, C, Ramakrishnan, B, Sundaralingam, M. Deposit date: 1994-12-05 Release date: 1995-03-31 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of the highly distorted chimeric decamer r(C)d(CGGCGCCG)r(G).spermine complex--spermine binding to phosphate only and minor groove tertiary base-pairing. Nucleic Acids Res., 22, 1994
5EQS	Crystal structure of a genotype 1a/3a chimeric HCV NS3/4A protease in complex with Asunaprevir Descriptor: N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-[(7-chloro-4-methoxyisoquinolin-1-yl)oxy]-N-{(1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethenylcyclopropyl}-L-prolinamide, NS3 protease, ZINC ION Authors: Soumana, D, Yilmaz, N.K, Ali, A, Prachanronarong, K.L, Schiffer, C.A. Deposit date: 2015-11-13 Release date: 2016-11-23 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.839 Å) Cite: Molecular and Dynamic Mechanism Underlying Drug Resistance in Genotype 3 Hepatitis C NS3/4A Protease. J.Am.Chem.Soc., 138, 2016
6UYD	Structure of Hepatitis C Virus Envelope Glycoprotein E2mc3-v1 redesigned core from genotype 1a bound to broadly neutralizing antibody AR3C Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein E2, ... Authors: Tzarum, N, Wilson, I.A, Zhu, J. Deposit date: 2019-11-13 Release date: 2020-04-22 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (1.897 Å) Cite: Proof of concept for rational design of hepatitis C virus E2 core nanoparticle vaccines. Sci Adv, 6, 2020
6FZV	Crystal structure of the metalloproteinase enhancer PCPE-1 bound to the procollagen C propeptide trimer (short) Descriptor: CALCIUM ION, CHLORIDE ION, CITRATE ANION, ... Authors: Pulido, D, Hohenester, E. Deposit date: 2018-03-15 Release date: 2018-07-04 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural Basis for the Acceleration of Procollagen Processing by Procollagen C-Proteinase Enhancer-1. Structure, 26, 2018
6UYG	Structure of Hepatitis C Virus Envelope Glycoprotein E2c3 core from genotype 6a bound to broadly neutralizing antibody AR3A and non neutralizing antibody E1 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein E2, ... Authors: Tzarum, N, Wilson, I.A, Zhu, J. Deposit date: 2019-11-13 Release date: 2020-04-22 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (3.375 Å) Cite: Proof of concept for rational design of hepatitis C virus E2 core nanoparticle vaccines. Sci Adv, 6, 2020
8GTH	Crystal strucuture of cyt c551 from anoxygenic phototrophic bacterium Roseiflexus castenholzii Descriptor: Cytochrome c class I, HEME C Authors: Min, Z.Z, Meng, H.L, Xu, X.L. Deposit date: 2022-09-08 Release date: 2023-09-13 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (3.1 Å) Cite: A cytochrome c 551 mediates the cyclic electron transport chain of the anoxygenic phototrophic bacterium Roseiflexus castenholzii. Plant Commun., 5, 2024
6VIZ	BRD4_Bromodomain1 complex with pyrrolopyridone compound 27 Descriptor: 4-[2-(2,6-dimethylphenoxy)-5-(ethylsulfonyl)phenyl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide, Bromodomain-containing protein 4 Authors: Longenecker, K.L, Park, C.H, Qiu, W. Deposit date: 2020-01-14 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.391 Å) Cite: Discovery ofN-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain. J.Med.Chem., 63, 2020
6VIW	BRD4_Bromodomain1 complex with pyrrolopyridone compound 18 Descriptor: 4-[2-(2,4-difluorophenoxy)-5-(methylsulfonyl)phenyl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide, Bromodomain-containing protein 4 Authors: Longenecker, K.L, Park, C.H, Qiu, W. Deposit date: 2020-01-14 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.429 Å) Cite: Discovery ofN-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain. J.Med.Chem., 63, 2020
6OSM	Cryo-EM structure of the N-terminally acetylated C-terminal Alpha-synuclein truncation Ac1-103 Descriptor: Alpha-synuclein Authors: Xiaodan, N, Ryan, P.M, Jiansen, J, Jennifer, C.L. Deposit date: 2019-05-01 Release date: 2019-09-25 Last modified: 2025-06-04 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structural Insights into alpha-Synuclein Fibril Polymorphism: Effects of Parkinson's Disease-Related C-Terminal Truncations. J.Mol.Biol., 431, 2019
6NZT	Crystal structure of HCV NS3/4A protease in complex with voxilaprevir Descriptor: HCV NS3/4A protease, SULFATE ION, Voxilaprevir, ... Authors: Appleby, T.C, Taylor, J.G. Deposit date: 2019-02-14 Release date: 2019-07-10 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi®. Bioorg.Med.Chem.Lett., 29, 2019
8G9T	Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications Descriptor: AcrIC9, Cas11, Cas5, ... Authors: Hu, C, Nam, K.H, Ke, A. Deposit date: 2023-02-22 Release date: 2024-03-06 Last modified: 2025-05-21 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications. Mol.Cell, 84, 2024
8GAF	Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications Descriptor: Cas11, Cas5, Cas7, ... Authors: Hu, C, Nam, K.H, Ke, A. Deposit date: 2023-02-22 Release date: 2024-03-06 Method: ELECTRON MICROSCOPY (3.64 Å) Cite: Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications. Mol.Cell, 84, 2024
8GAM	Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications Descriptor: Cas11, Cas5, Cas7, ... Authors: Hu, C, Nam, K.H, Ke, A. Deposit date: 2023-02-23 Release date: 2024-03-06 Method: ELECTRON MICROSCOPY (3.46 Å) Cite: Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications. Mol.Cell, 84, 2024
7VU7	The Solution structure of the C-terminal domain from flagelliform spidroin Descriptor: Flagelliform fibroin Authors: Fan, J.S, Yang, D. Deposit date: 2021-11-01 Release date: 2022-04-06 Last modified: 2024-11-13 Method: SOLUTION NMR Cite: C-Terminal Domains of Spider Silk Proteins Having Divergent Structures but Conserved Functional Roles. Biomacromolecules, 23, 2022
4WHT	Structure of the Hepatitis C virus envelope glycoprotein E2 antigenic region 412-423 bound to the broadly neutralizing antibody 3/11, P1 crystal form Descriptor: Epitope peptide, Heavy chain of the Fab fragment derived from neutralizing antibody 3/11, Light chain of the Fab fragment derived from neutralizing antibody 3/11 Authors: Krey, T, Rey, F.A. Deposit date: 2014-09-23 Release date: 2014-12-17 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (2.22 Å) Cite: Structural flexibility of a conserved antigenic region in hepatitis C virus glycoprotein e2 recognized by broadly neutralizing antibodies. J.Virol., 89, 2015
6VIX	BRD4_Bromodomain2 complex with pyrrolopyridone compound 18 Descriptor: 4-[2-(2,4-difluorophenoxy)-5-(methylsulfonyl)phenyl]-N-ethyl-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide, Bromodomain-containing protein 4 Authors: Longenecker, K.L, Park, C.H, Qiu, W. Deposit date: 2020-01-14 Release date: 2020-05-06 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.116 Å) Cite: Discovery ofN-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain. J.Med.Chem., 63, 2020
6UYM	Structure of Hepatitis C Virus Envelope Glycoprotein E2mc3-v6 redesigned core from genotype 1a bound to broadly neutralizing antibody AR3C Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein E2, ... Authors: Tzarum, N, Wilson, I.A, Zhu, J. Deposit date: 2019-11-13 Release date: 2020-04-22 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.848 Å) Cite: Proof of concept for rational design of hepatitis C virus E2 core nanoparticle vaccines. Sci Adv, 6, 2020
5ED7	Crystal Structure of HSV-1 UL21 C-terminal Domain Descriptor: CHLORIDE ION, Tegument protein UL21 Authors: Metrick, C.M, Heldwein, E.E. Deposit date: 2015-10-20 Release date: 2016-04-20 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.72 Å) Cite: Novel Structure and Unexpected RNA-Binding Ability of the C-Terminal Domain of Herpes Simplex Virus 1 Tegument Protein UL21. J.Virol., 90, 2016
6GD8	Cytochrome c in complex with Sulfonato-calix[8]arene, P31 form Descriptor: Cytochrome c iso-1, HEME C, sulfonato-calix[8]arene Authors: Rennie, M.L, Fox, G.C, Crowley, P.B. Deposit date: 2018-04-23 Release date: 2018-08-29 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Auto-regulated Protein Assembly on a Supramolecular Scaffold. Angew. Chem. Int. Ed. Engl., 57, 2018

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