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6KSD
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BU of 6ksd by Molmil
Structural basis for domain rotation during adenylation of active site K123 and fragment library screening against NAD+ -dependent DNA ligase from Mycobacterium tuberculosis
Descriptor: BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, DNA ligase A, SULFATE ION
Authors:Ramachandran, R, Shukla, A, Afsar, M.
Deposit date:2019-08-23
Release date:2020-08-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Salt bridges at the subdomain interfaces of the adenylation domain and active-site residues of Mycobacterium tuberculosis NAD + -dependent DNA ligase A (MtbLigA) are important for the initial steps of nick-sealing activity.
Acta Crystallogr D Struct Biol, 77, 2021
6KSC
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BU of 6ksc by Molmil
Structural basis for domain rotation during adenylation of active site K123 and fragment library screening against NAD+ -dependent DNA ligase from Mycobacterium tuberculosis
Descriptor: ADENOSINE MONOPHOSPHATE, DNA ligase A, SULFATE ION
Authors:Ramachandran, R, Shukla, A, Afsar, M.
Deposit date:2019-08-23
Release date:2020-08-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Salt bridges at the subdomain interfaces of the adenylation domain and active-site residues of Mycobacterium tuberculosis NAD + -dependent DNA ligase A (MtbLigA) are important for the initial steps of nick-sealing activity.
Acta Crystallogr D Struct Biol, 77, 2021
8IJ1
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BU of 8ij1 by Molmil
Protomer 1 and 2 of the asymmetry trimer of the Cul2-Rbx1-EloBC-FEM1B ubiquitin ligase complex
Descriptor: Cullin-2, E3 ubiquitin-protein ligase RBX1, Elongin-B, ...
Authors:Dai, Z, Liang, L, Yin, Y.X.
Deposit date:2023-02-24
Release date:2024-02-28
Last modified:2024-04-03
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structural insights into the ubiquitylation strategy of the oligomeric CRL2 FEM1B E3 ubiquitin ligase.
Embo J., 43, 2024
3Q4L
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BU of 3q4l by Molmil
Structure of a small peptide ligand bound to E.coli DNA sliding clamp
Descriptor: DNA polymerase III subunit beta, SODIUM ION, peptide ligand
Authors:Wolff, P, Olieric, V, Briand, J.P, Chaloin, O, Dejaegere, A, Dumas, P, Ennifar, E, Guichard, G, Wagner, J, Burnouf, D.
Deposit date:2010-12-23
Release date:2011-12-28
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure-based design of short peptide ligands binding onto the E. coli processivity ring.
J.Med.Chem., 54, 2011
8KHP
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BU of 8khp by Molmil
CULLIN3-KLHL22-RBX1 E3 ligase
Descriptor: Cullin-3, E3 ubiquitin-protein ligase RBX1, Kelch-like protein 22
Authors:Su, M.-Y, Su, M.-Y.
Deposit date:2023-08-22
Release date:2023-12-13
Method:ELECTRON MICROSCOPY (3.67 Å)
Cite:Cryo-EM structure of the KLHL22 E3 ligase bound to an oligomeric metabolic enzyme.
Structure, 31, 2023
9J8E
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BU of 9j8e by Molmil
Structural insights into BirA from Haemophilus influenzae, a bifunctional protein as a biotin protein ligase and a transcriptional repressor
Descriptor: BIOTINYL-5-AMP, Bifunctional ligase/repressor BirA
Authors:Lee, J.Y, Jeong, K.H, Son, S.B, Ko, J.H.
Deposit date:2024-08-21
Release date:2024-09-11
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural insights into BirA from Haemophilus influenzae, a bifunctional protein as a biotin protein ligase and a transcriptional repressor.
Biochem.Biophys.Res.Commun., 733, 2024
4I1H
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BU of 4i1h by Molmil
Structure of Parkin E3 ligase
Descriptor: E3 ubiquitin-protein ligase parkin, ZINC ION
Authors:Lougheed, J.C, Brecht, E, Yao, N.H.
Deposit date:2012-11-20
Release date:2013-06-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases.
Nat Commun, 4, 2013
1S68
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BU of 1s68 by Molmil
Structure and Mechanism of RNA Ligase
Descriptor: ADENOSINE MONOPHOSPHATE, RNA Ligase 2
Authors:Ho, C.K, Wang, L.K, Lima, C.D, Shuman, S.
Deposit date:2004-01-22
Release date:2004-02-24
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure and mechanism of RNA ligase.
Structure, 12, 2004
4C5A
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BU of 4c5a by Molmil
The X-ray crystal structures of D-alanyl-D-alanine ligase in complex ADP and D-cycloserine phosphate
Descriptor: ADENOSINE-5'-DIPHOSPHATE, D-ALANINE--D-ALANINE LIGASE, GLYCEROL, ...
Authors:Batson, S, Majce, V, Lloyd, A.J, Rea, D, Fishwick, C.W.G, Simmons, K.J, Fulop, V, Roper, D.I.
Deposit date:2013-09-10
Release date:2015-01-21
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine.
Nat Commun, 8, 2017
8JE1
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BU of 8je1 by Molmil
An asymmetry dimer of the Cul2-Rbx1-EloBC-FEM1B ubiquitin ligase complexed with BEX2
Descriptor: Cullin-2, E3 ubiquitin-protein ligase RBX1, Elongin-B, ...
Authors:Dai, Z, Liang, L, Yin, Y.X.
Deposit date:2023-05-15
Release date:2024-02-28
Last modified:2024-04-03
Method:ELECTRON MICROSCOPY (3.95 Å)
Cite:Structural insights into the ubiquitylation strategy of the oligomeric CRL2 FEM1B E3 ubiquitin ligase.
Embo J., 43, 2024
5O6C
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BU of 5o6c by Molmil
Crystal Structure of a threonine-selective RCR E3 ligase
Descriptor: E3 ubiquitin-protein ligase MYCBP2, ZINC ION
Authors:Pao, K.-C, Rafie, K.Z, van Aalten, D, Virdee, S.
Deposit date:2017-06-06
Release date:2018-04-18
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.
Nature, 556, 2018
4C5B
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BU of 4c5b by Molmil
The X-ray crystal structure of D-alanyl-D-alanine ligase in complex with ATP and D-ala-D-ala
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CARBONATE ION, D-ALANINE, ...
Authors:Batson, S, Majce, V, Lloyd, A.J, Rea, D, Fishwick, C.W.G, Simmons, K.J, Fulop, V, Roper, D.I.
Deposit date:2013-09-10
Release date:2015-01-21
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine.
Nat Commun, 8, 2017
4C5C
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BU of 4c5c by Molmil
The X-ray crystal structure of D-alanyl-D-alanine ligase in complex with ADP and D-ala-D-ala
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, D-ALANINE, D-ALANINE--D-ALANINE LIGASE, ...
Authors:Batson, S, Majce, V, Lloyd, A.J, Rea, D, Fishwick, C.W.G, Simmons, K.J, Fulop, V, Roper, D.I.
Deposit date:2013-09-10
Release date:2015-01-21
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine.
Nat Commun, 8, 2017
2OOB
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BU of 2oob by Molmil
crystal structure of the UBA domain from Cbl-b ubiquitin ligase in complex with ubiquitin
Descriptor: E3 ubiquitin-protein ligase CBL-B, Ubiquitin
Authors:Kozlov, G, Gehring, K.
Deposit date:2007-01-25
Release date:2007-02-06
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for ubiquitin-mediated dimerization and activation of the ubiquitin protein ligase Cbl-b.
Mol.Cell, 27, 2007
4XOM
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BU of 4xom by Molmil
Coenzyme F420:L-glutamate ligase (FbiB) from Mycobacterium tuberculosis (C-terminal domain).
Descriptor: Coenzyme F420:L-glutamate ligase, SULFATE ION
Authors:Rehan, A.M, Bashiri, G, Baker, H.M, Baker, E.N, Squire, C.J.
Deposit date:2015-01-16
Release date:2016-02-17
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Elongation of the Poly-gamma-glutamate Tail of F420 Requires Both Domains of the F420: gamma-Glutamyl Ligase (FbiB) of Mycobacterium tuberculosis.
J.Biol.Chem., 291, 2016
2C5U
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BU of 2c5u by Molmil
T4 RNA Ligase (Rnl1) Crystal Structure
Descriptor: CALCIUM ION, CHLORIDE ION, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ...
Authors:El Omari, K, Ren, J, Bird, L.E, Bona, M.K, Klarmann, G, LeGrice, S.F.J, Stammers, D.K.
Deposit date:2005-11-01
Release date:2005-11-04
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Molecular Architecture and Ligand Recognition Determinants for T4 RNA Ligase
J.Biol.Chem., 281, 2006
1DGS
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BU of 1dgs by Molmil
CRYSTAL STRUCTURE OF NAD+-DEPENDENT DNA LIGASE FROM T. FILIFORMIS
Descriptor: ADENOSINE MONOPHOSPHATE, DNA LIGASE, ZINC ION
Authors:Lee, J.Y, Chang, C, Song, H.K, Kwon, S.T, Suh, S.W.
Deposit date:1999-11-25
Release date:2000-11-27
Last modified:2024-12-25
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of NAD(+)-dependent DNA ligase: modular architecture and functional implications.
EMBO J., 19, 2000
6J1Y
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BU of 6j1y by Molmil
Semi-open conformation E3 ligase
Descriptor: GLYCEROL, NEDD4-like E3 ubiquitin-protein ligase WWP1
Authors:Liu, Z.H.
Deposit date:2018-12-30
Release date:2019-07-24
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases.
Nat Commun, 10, 2019
8E0Q
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BU of 8e0q by Molmil
Structure of the human UBR5 HECT-type E3 ubiquitin ligase in a C2 symmetric dimeric form
Descriptor: E3 ubiquitin-protein ligase UBR5, ZINC ION
Authors:Wang, F, He, Q, Lin, G, Li, H.
Deposit date:2022-08-09
Release date:2023-04-19
Last modified:2025-05-21
Method:ELECTRON MICROSCOPY (2.66 Å)
Cite:Structure of the human UBR5 E3 ubiquitin ligase.
Structure, 31, 2023
4R9M
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BU of 4r9m by Molmil
Crystal structure of spermidine N-acetyltransferase from Escherichia coli
Descriptor: MAGNESIUM ION, Spermidine N(1)-acetyltransferase
Authors:Filippova, E.V, Minasov, G, Kiryukhina, O, Shuvalova, L, Grimshaw, S, Wolfe, A.J, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2014-09-05
Release date:2014-11-05
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Analysis of crystalline and solution states of ligand-free spermidine N-acetyltransferase (SpeG) from Escherichia coli.
Acta Crystallogr D Struct Biol, 75, 2019
6GMO
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BU of 6gmo by Molmil
Plant glutamate cysteine ligase (GCL) in complex with non-reducing GSH (GSM)
Descriptor: ACETATE ION, GLYCEROL, Glutamate--cysteine ligase, ...
Authors:Lenherr, E.D.
Deposit date:2018-05-27
Release date:2019-06-19
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Plant glutathione biosynthesis revisited: redox-mediated activation of glutamylcysteine ligase does not require homo-dimerization.
Biochem.J., 476, 2019
8EWI
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BU of 8ewi by Molmil
Structure of the human UBR5 HECT-type E3 ubiquitin ligase in a tetrameric form
Descriptor: E3 ubiquitin-protein ligase UBR5, ZINC ION
Authors:Wang, F, He, Q, Lin, G, Li, H.
Deposit date:2022-10-23
Release date:2023-04-19
Last modified:2025-06-04
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure of the human UBR5 E3 ubiquitin ligase.
Structure, 31, 2023
3OEM
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BU of 3oem by Molmil
Crystal structure of GluN2D ligand-binding core in complex with N-methyl-D-aspartate
Descriptor: Glutamate [NMDA] receptor subunit epsilon-4, N-methyl-D-aspartic acid
Authors:Simorowski, N, Furukawa, H.
Deposit date:2010-08-12
Release date:2011-05-11
Last modified:2025-03-26
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors.
Nat Commun, 2, 2011
7P3B
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BU of 7p3b by Molmil
Human RNA ligase RTCB in complex with GMP and Co(II)
Descriptor: ACETATE ION, COBALT (II) ION, FORMIC ACID, ...
Authors:Kroupova, A, Ackle, F, Jinek, M.
Deposit date:2021-07-07
Release date:2021-12-22
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular architecture of the human tRNA ligase complex.
Elife, 10, 2021
4RFW
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BU of 4rfw by Molmil
Crystal structure of human retinoid X Receptor alpha-ligand binding domain complex with 9cUAB70 and the coactivator peptide GRIP-1
Descriptor: (2E,4E,6Z,8E)-3,7-dimethyl-8-(6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-ylidene)octa-2,4,6-trienoic acid, Nuclear receptor coactivator 2, Retinoic acid receptor RXR-alpha
Authors:Xia, G, Muccio, D.D, Smith, C.D.
Deposit date:2014-09-28
Release date:2015-09-16
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Conformationally Defined Rexinoids and Their Efficacy in the Prevention of Mammary Cancers.
J.Med.Chem., 58, 2015

238582

数据于2025-07-09公开中

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