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1A41	TYPE 1-TOPOISOMERASE CATALYTIC FRAGMENT FROM VACCINIA VIRUS Descriptor: SULFATE ION, TOPOISOMERASE I Authors: Cheng, C, Kussie, P, Pavletich, N, Shuman, S. Deposit date: 1998-02-10 Release date: 1999-06-01 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Conservation of structure and mechanism between eukaryotic topoisomerase I and site-specific recombinases. Cell(Cambridge,Mass.), 92, 1998
1VCC	AMINO TERMINAL 9KDA DOMAIN OF VACCINIA VIRUS DNA TOPOISOMERASE I RESIDUES 1-77, EXPERIMENTAL ELECTRON DENSITY FOR RESIDUES 1-77 Descriptor: DNA TOPOISOMERASE I Authors: Sharma, A, Hanai, R, Mondragon, A. Deposit date: 1995-10-02 Release date: 1996-03-08 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Crystal structure of the amino-terminal fragment of vaccinia virus DNA topoisomerase I at 1.6 A resolution. Structure, 2, 1994
1YUA	C-TERMINAL DOMAIN OF ESCHERICHIA COLI TOPOISOMERASE I Descriptor: TOPOISOMERASE I Authors: Yu, L, Zhu, C.-X, Tse-Dinh, Y.-C, Fesik, S.W. Deposit date: 1995-03-02 Release date: 1996-03-08 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: Solution structure of the C-terminal single-stranded DNA-binding domain of Escherichia coli topoisomerase I. Biochemistry, 34, 1995
2GAI	Structure of Full Length Topoisomerase I from Thermotoga maritima in triclinic crystal form Descriptor: DNA topoisomerase I Authors: Hansen, G. Deposit date: 2006-03-08 Release date: 2006-04-25 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal Structure of Full Length Topoisomerase I from Thermotoga maritima J.Mol.Biol., 358, 2006
2GAJ	Structure of Full Length Topoisomerase I from Thermotoga maritima in monoclinic crystal form Descriptor: DNA topoisomerase I Authors: Hansen, G. Deposit date: 2006-03-09 Release date: 2006-04-25 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Crystal Structure of Full Length Topoisomerase I from Thermotoga maritima J.Mol.Biol., 358, 2006
1MW8	Crystal Structure of a Complex between H365R mutant of 67 kDA N-terminal fragment of E. coli DNA Topoisomerase I and 5'-ACTTCGGGATG-3' Descriptor: 5'-D(*AP*CP*TP*TP*CP*GP*GP*GP*AP*TP*G)-3', DNA Topoisomerase I, SULFATE ION, ... Authors: Perry, K, Mondragon, A. Deposit date: 2002-09-27 Release date: 2003-10-14 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structure of a Complex between E. coli DNA Topoisomerase I and Single-Stranded DNA. Structure, 11, 2003
1LPQ	Human DNA Topoisomerase I (70 Kda) In Non-Covalent Complex With A 22 Base Pair DNA Duplex Containing an 8-oxoG Lesion Descriptor: 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*(8OG)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*CP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', DNA topoisomerase I Authors: Lesher, D.T, Pommier, Y, Stewart, L, Redinbo, M.R. Deposit date: 2002-05-08 Release date: 2002-08-16 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (3.14 Å) Cite: 8-Oxoguanine rearranges the active site of human topoisomerase I Proc.Natl.Acad.Sci.USA, 99, 2002
1MW9	Crystal Structure of H365R mutant of 67 kDA N-terminal fragment of E. coli DNA Topoisomerase I Descriptor: DNA Topoisomerase I, SULFATE ION Authors: Perry, K, Mondragon, A. Deposit date: 2002-09-27 Release date: 2003-10-14 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.67 Å) Cite: Structure of a Complex between E. coli DNA Topoisomerase I and Single-Stranded DNA. Structure, 11, 2003
6CQI	2.42A Crystal structure of Mycobacterium tuberculosis Topoisomerase I in complex with an oligonucleotide MTS2-11 Descriptor: ACETATE ION, DNA (5'-D(P*TP*TP*CP*CP*GP*CP*TP*TP*GP*A)-3'), DNA topoisomerase 1, ... Authors: Cao, N, Thirunavukkarasu, A, Tan, K, Tse-Dinh, Y.-C. Deposit date: 2018-03-15 Release date: 2018-05-30 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.42 Å) Cite: Investigating mycobacterial topoisomerase I mechanism from the analysis of metal and DNA substrate interactions at the active site. Nucleic Acids Res., 46, 2018
6CQ2	Crystal structure of Mycobacterium tuberculosis Topoisomerase I in complex with oligonucleotide MTS2-12 and Magnesium Descriptor: DNA (5'-D(P*TP*TP*CP*CP*GP*CP*TP*TP*GP*A)-3'), DNA topoisomerase 1, MAGNESIUM ION, ... Authors: Cao, N, Thirunavukkaraus, A, Tan, K, Tse-Dinh, Y.-C. Deposit date: 2018-03-14 Release date: 2018-05-30 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (3.004 Å) Cite: Investigating mycobacterial topoisomerase I mechanism from the analysis of metal and DNA substrate interactions at the active site. Nucleic Acids Res., 46, 2018
1CY0	COMPLEX OF E.COLI DNA TOPOISOMERASE I WITH 3'-5'-ADENOSINE DIPHOSPHATE Descriptor: ADENOSINE-3'-5'-DIPHOSPHATE, DNA TOPOISOMERASE I Authors: Feinberg, H, Changela, A, Mondragon, A. Deposit date: 1999-08-31 Release date: 2000-03-08 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Protein-nucleotide interactions in E. coli DNA topoisomerase I. Nat.Struct.Biol., 6, 1999
1ECL	AMINO TERMINAL 67KDA DOMAIN OF ESCHERICHIA COLI DNA TOPOISOMERASE I (RESIDUES 2-590 OF MATURE PROTEIN) CLONING ARTIFACT ADDS TWO RESIDUES TO THE AMINO-TERMINUS WHICH WERE NOT OBSERVED IN THE EXPERIMENTAL ELECTRON DENSITY (GLY-2, SER-1). Descriptor: ESCHERICHIA COLI TOPOISOMERASE I Authors: Lima, C.D, Wang, J.C, Mondragon, A. Deposit date: 1995-05-05 Release date: 1995-07-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Three-dimensional structure of the 67K N-terminal fragment of E. coli DNA topoisomerase I. Nature, 367, 1994
1EJ9	CRYSTAL STRUCTURE OF HUMAN TOPOISOMERASE I DNA COMPLEX Descriptor: DNA (5'-D(*C*AP*AP*AP*AP*AP*GP*AP*CP*TP*CP*AP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3'), DNA (5'-D(*C*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*TP*GP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3'), DNA TOPOISOMERASE I Authors: Redinbo, M.R, Champoux, J.J, Hol, W.G. Deposit date: 2000-03-01 Release date: 2000-08-03 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Novel insights into catalytic mechanism from a crystal structure of human topoisomerase I in complex with DNA. Biochemistry, 39, 2000
1CY7	COMPLEX OF E.COLI DNA TOPOISOMERASE I WITH 5'-THYMIDINE MONOPHOSPHATE Descriptor: DNA TOPOISOMERASE I, PHOSPHATE ION, THYMIDINE-5'-PHOSPHATE Authors: Feinberg, H, Changela, A, Mondragon, A. Deposit date: 1999-08-31 Release date: 2000-03-08 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Protein-nucleotide interactions in E. coli DNA topoisomerase I. Nat.Struct.Biol., 6, 1999
1CY4	COMPLEX OF E.COLI DNA TOPOISOMERASE I WITH 5'pTpTpTp3' Descriptor: DNA TOPOISOMERASE I, PHOSPHATE ION, THYMIDINE-5'-PHOSPHATE Authors: Feinberg, H, Changela, A, Mondragon, A. Deposit date: 1999-08-31 Release date: 2000-03-08 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Protein-nucleotide interactions in E. coli DNA topoisomerase I. Nat.Struct.Biol., 6, 1999
1CY1	COMPLEX OF E.COLI DNA TOPOISOMERASE I WITH 5'PTPTPT Descriptor: DNA TOPOISOMERASE I, PHOSPHATE ION, THYMIDINE-3',5'-DIPHOSPHATE, ... Authors: Feinberg, H, Changela, A, Mondragon, A. Deposit date: 1999-08-31 Release date: 2000-03-03 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Protein-nucleotide interactions in E. coli DNA topoisomerase I. Nat.Struct.Biol., 6, 1999
1CY2	COMPLEX OF E.COLI DNA TOPOISOMERASE I WITH TPTPTP3' Descriptor: DNA TOPOISOMERASE I, PHOSPHATE ION, THYMIDINE-5'-PHOSPHATE Authors: Feinberg, H, Changela, A, Mondragon, A. Deposit date: 1999-08-31 Release date: 2000-03-08 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Protein-nucleotide interactions in E. coli DNA topoisomerase I. Nat.Struct.Biol., 6, 1999
1CY8	COMPLEX OF E.COLI DNA TOPOISOMERASE I WITH 5'-THYMIDINE MONOPHOSPHATE AND 3'-THYMIDINE MONOPHOSPHATE Descriptor: DNA TOPOISOMERASE I, PHOSPHATE ION, THYMIDINE-3'-PHOSPHATE, ... Authors: Feinberg, H, Changela, A, Mondragon, A. Deposit date: 1999-08-31 Release date: 2000-03-08 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Protein-nucleotide interactions in E. coli DNA topoisomerase I. Nat.Struct.Biol., 6, 1999
1CYY	CRYSTAL STRUCTURE OF THE 30 KDA FRAGMENT OF E. COLI DNA TOPOISOMERASE I. HEXAGONAL FORM Descriptor: DNA TOPOISOMERASE I, ZINC ION Authors: Feinberg, H, Lima, C, Mondragon, A. Deposit date: 1999-08-31 Release date: 2000-03-08 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Conformational changes in E. coli DNA topoisomerase I. Nat.Struct.Biol., 6, 1999
1CY6	COMPLEX OF E.COLI DNA TOPOISOMERASE I WITH 3' THYMIDINE MONOPHOSPHATE Descriptor: DNA TOPOISOMERASE I, PHOSPHATE ION, THYMIDINE-3'-PHOSPHATE Authors: Feinberg, H, Changela, A, Mondragon, A. Deposit date: 1999-08-31 Release date: 2000-03-08 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Protein-nucleotide interactions in E. coli DNA topoisomerase I. Nat.Struct.Biol., 6, 1999
1CY9	CRYSTAL STRUCTURE OF THE 30 KDA FRAGMENT OF E. COLI DNA TOPOISOMERASE I. MONOCLINIC FORM Descriptor: DNA TOPOISOMERASE I Authors: Feinberg, H, Lima, C, Mondragon, A. Deposit date: 1999-08-31 Release date: 2000-03-08 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Conformational changes in E. coli DNA topoisomerase I. Nat.Struct.Biol., 6, 1999
2B9S	Crystal Structure of heterodimeric L. donovani topoisomerase I-vanadate-DNA complex Descriptor: 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*TP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', 5'-D(*AP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', ... Authors: Davies, D.R, Hol, W.G.J. Deposit date: 2005-10-12 Release date: 2006-01-17 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2.27 Å) Cite: The Structure of the Transition State of the Heterodimeric Topoisomerase I of Leishmania donovani as a Vanadate Complex with Nicked DNA. J.Mol.Biol., 357, 2006
3I93	Crystal structure of Mycobacterium tuberculosis dUTPase STOP138T mutant Descriptor: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Deoxyuridine 5'-triphosphate nucleotidohydrolase, ... Authors: Leveles, I, Harmat, V, Lopata, A, Toth, J, Vertessy, B.G. Deposit date: 2009-07-10 Release date: 2009-11-24 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Direct contacts between conserved motifs of different subunits provide major contribution to active site organization in human and mycobacterial dUTPases. Febs Lett., 584, 2010
8CW2	Crystal structure of TDP1 complexed with compound XZ760 Descriptor: 1,2-ETHANEDIOL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, 4-({(4R)-7-phenyl-2-[4-(2-{[4-(pyridin-2-yl)phenyl]methoxy}ethyl)phenyl]imidazo[1,2-a]pyridin-3-yl}amino)benzene-1,2-dicarboxylic acid, ... Authors: Lountos, G.T, Zhao, X.Z, Wang, W, Kiselev, E, Tropea, J.E, Needle, D, Pommier, Y, Burke, T.R. Deposit date: 2022-05-18 Release date: 2023-04-12 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.811 Å) Cite: Identification of multidentate tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors that simultaneously access the DNA, protein and catalytic-binding sites by oxime diversification. Rsc Chem Biol, 4, 2023
8CVQ	Crystal structure of TDP1 complexed with compound XZ761 Descriptor: 1,2-ETHANEDIOL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, 4-{[(4S)-2,7-diphenylimidazo[1,2-a]pyridin-3-yl]amino}benzene-1,2-dicarboxylic acid, ... Authors: Lountos, G.T, Zhao, X.Z, Wang, W, Kiselev, E, Tropea, J.E, Needle, D, Pommier, Y, Burke, T.R. Deposit date: 2022-05-18 Release date: 2023-04-12 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Identification of multidentate tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors that simultaneously access the DNA, protein and catalytic-binding sites by oxime diversification. Rsc Chem Biol, 4, 2023

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