1VCC

AMINO TERMINAL 9KDA DOMAIN OF VACCINIA VIRUS DNA TOPOISOMERASE I RESIDUES 1-77, EXPERIMENTAL ELECTRON DENSITY FOR RESIDUES 1-77

Summary for 1VCC

Entry DOI	10.2210/pdb1vcc/pdb
Descriptor	DNA TOPOISOMERASE I (2 entities in total)
Functional Keywords	dna binding
Biological source	Vaccinia virus
Total number of polymer chains	1
Total formula weight	9066.25
Authors	Sharma, A.,Hanai, R.,Mondragon, A. (deposition date: 1995-10-02, release date: 1996-03-08, Last modification date: 2024-02-14)
Primary citation	Sharma, A.,Hanai, R.,Mondragon, A. Crystal structure of the amino-terminal fragment of vaccinia virus DNA topoisomerase I at 1.6 A resolution. Structure, 2:767-777, 1994 Cited by PubMed Abstract: Vaccinia virus, a cytoplasmically-replicating poxvirus, encodes a type I DNA topoisomerase that is biochemically similar to eukaryotic-like DNA topoisomerases I, and which has been widely studied as a model topoisomerase. It is the smallest topoisomerase known and is unusual in that it is resistant to the potent chemotherapeutic agent camptothecin. PubMed: 7994576 DOI: 10.1016/S0969-2126(94)00077-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation