6CQ2

Crystal structure of Mycobacterium tuberculosis Topoisomerase I in complex with oligonucleotide MTS2-12 and Magnesium

Summary for 6CQ2

• Entry DOI: 10.2210/pdb6cq2/pdb
• Related: 5D5H
• Descriptor: DNA topoisomerase 1, DNA (5'-D(P*TP*TP*CP*CP*GP*CP*TP*TP*GP*A)-3'), MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: mycobacterium tuberculosis, topoisomerase i, co-crystallization, complex with oligonucleotide and magnesium, isomerase, isomerase-dna complex, isomerase/dna
• Biological source: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv); More
• Total number of polymer chains: 2
• Total formula weight: 81944.24

Authors

Cao, N.,Thirunavukkaraus, A.,Tan, K.,Tse-Dinh, Y.-C. (deposition date: 2018-03-14, release date: 2018-05-30, Last modification date: 2024-03-13)

• Primary citation: Cao, N.,Tan, K.,Annamalai, T.,Joachimiak, A.,Tse-Dinh, Y.C.; Investigating mycobacterial topoisomerase I mechanism from the analysis of metal and DNA substrate interactions at the active site.; Nucleic Acids Res., 46:7296-7308, 2018; PubMed: 29905859; DOI: 10.1093/nar/gky492

Experimental method

X-RAY DIFFRACTION (3.004 Å)