Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003916 | molecular_function | DNA topoisomerase activity |
| A | 0003917 | molecular_function | DNA topoisomerase type I (single strand cut, ATP-independent) activity |
| A | 0006265 | biological_process | DNA topological change |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 801 |
| Chain | Residue |
| A | GLU24 |
| A | ASP111 |
| A | HOH903 |
| B | DC6 |
| B | DT7 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue MG A 802 |
| Chain | Residue |
| A | GLU296 |
| A | HIS492 |
| A | HOH902 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue MG A 803 |
| Chain | Residue |
| A | ASP507 |
| A | HIS509 |
| A | ASP220 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue MG A 804 |
| Chain | Residue |
| A | GLU589 |
| A | GLU598 |
| A | HIS613 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 A 805 |
| Chain | Residue |
| A | GLY112 |
| A | HIS139 |
| A | GLN386 |
| A | HIS389 |
Functional Information from PROSITE/UniProt
| site_id | PS00396 |
| Number of Residues | 15 |
| Details | TOPO_IA_1 Topoisomerase (Topo) IA-type active site signature. QrLYEngy.........ITYmRTD |
| Chain | Residue | Details |
| A | GLN332-ASP346 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 124 |
| Details | Domain: {"description":"Toprim","evidences":[{"source":"HAMAP-Rule","id":"MF_00952","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | Region: {"description":"Interaction with DNA","evidences":[{"source":"HAMAP-Rule","id":"MF_00952","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"O-(5'-phospho-DNA)-tyrosine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU01383","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00952","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Site: {"description":"Interaction with DNA","evidences":[{"source":"HAMAP-Rule","id":"MF_00952","evidenceCode":"ECO:0000255"}]} |
