6CQ2
Crystal structure of Mycobacterium tuberculosis Topoisomerase I in complex with oligonucleotide MTS2-12 and Magnesium
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA topoisomerase 1 | polymer | 706 | 77843.5 | 1 | UniProt (P9WG49) Pfam (PF01751) Pfam (PF01131) Pfam (PF13368) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | DNA topoisomerase I,Omega-protein,Relaxing enzyme,Swivelase,Untwisting enzyme |
| 2 | B (B) | DNA (5'-D(P*TP*TP*CP*CP*GP*CP*TP*TP*GP*A)-3') | polymer | 13 | 3908.5 | 1 | Mycobacterium tuberculosis H37Rv | ||
| 3 | C, D, E, F (A) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 4 | G (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 5 | H, I (A, B) | water | water | 18.0 | 14 | Chemie (HOH) |
Sequence modifications
A: 2 - 704 (UniProt: P9WG49)
| PDB | External Database | Details |
|---|---|---|
| Ser -1 | - | expression tag |
| Asn 0 | - | expression tag |
| Ala 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 81752.0 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 192.2 | |
| All* | Total formula weight | 81944.2 |
