5UMZ
 
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5D5K
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3UL1
 | | Mouse importin alpha: nucleoplasmin cNLS peptide complex | | Descriptor: | Importin subunit alpha-2, Nucleoplasmin | | Authors: | Marfori, M, Forwood, J.K, Lonhienne, T.G, Kobe, B. | | Deposit date: | 2011-11-10 | | Release date: | 2012-10-03 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural Basis of High-Affinity Nuclear Localization Signal Interactions with Importin-alpha
Traffic, 13, 2012
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5HUW
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7RFZ
 | | Importin alpha 2 in complex with MERS ORF4B NLS peptide | | Descriptor: | Importin subunit alpha-1, ORF4b | | Authors: | Munasinghe, T.S, Tsimbalyuk, S, Roby, J.A, Aragao, D, Forwood, J.K. | | Deposit date: | 2021-07-14 | | Release date: | 2021-07-28 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity.
Nat Commun, 13, 2022
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4U5U
 | | IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR | | Descriptor: | Importin subunit alpha-1, N~2~-[3-(pyridin-3-yl)benzyl]-L-lysinamide | | Authors: | Stewart, M, Valkov, E, Holvey, R.S. | | Deposit date: | 2014-07-25 | | Release date: | 2015-05-13 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.96 Å) | | Cite: | Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design.
Chemmedchem, 10, 2015
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7JK7
 | | Crystal structure of Importin alpha 2 in complex with LSD1 NLS S111E mutant | | Descriptor: | GLYCEROL, Importin subunit alpha-1, Lysine-specific histone demethylase 1A | | Authors: | Tu, W.J, McCuaig, R, Tan, A.H.Y, Hardy, K, Seddiki, N, Ali, S, Dahlstron, J.E, Bean, E.G, Dunn, J, Forwood, J.K, Tsimbalyuk, S, Smith, K.M, Yip, D, Malik, L, Prasana, T, Milburn, P, Rao, S. | | Deposit date: | 2020-07-27 | | Release date: | 2020-08-05 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.96 Å) | | Cite: | Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch.
Front Immunol, 11, 2020
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4U5V
 | | IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR | | Descriptor: | Importin subunit alpha-1, N~2~-{[5-(pyridin-3-yl)thiophen-2-yl]methyl}-L-lysinamide | | Authors: | Stewart, M, Valkov, E, Holvey, R.S. | | Deposit date: | 2014-07-25 | | Release date: | 2015-05-13 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.968 Å) | | Cite: | Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design.
Chemmedchem, 10, 2015
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5HUY
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5W4F
 | | Importin binding to pol Mu NLS peptide | | Descriptor: | DNA-directed DNA/RNA polymerase mu, GLYCEROL, Importin subunit alpha-1 | | Authors: | Pedersen, L.C, London, R.E. | | Deposit date: | 2017-06-10 | | Release date: | 2018-06-13 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.984 Å) | | Cite: | Variations in nuclear localization strategies among pol X family enzymes.
Traffic, 2018
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6P6E
 | | Structure of Mouse Importin alpha - PAC3 NLS peptide complex | | Descriptor: | Importin subunit alpha-1, PAC3 NLS | | Authors: | Bernardes, N.E, Silva, T.D, Fukuda, C.A, Oliveira, H.C, Fontes, M.R.M. | | Deposit date: | 2019-06-03 | | Release date: | 2020-01-29 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Comparative study of the interactions between fungal transcription factor nuclear localization sequences with mammalian and fungal importin-alpha.
Sci Rep, 10, 2020
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7UMI
 | | Importin a1 bound to Cp183-CTD | | Descriptor: | HBV-NLS, Importin subunit alpha-1 | | Authors: | Yang, R, Cingolani, G. | | Deposit date: | 2022-04-07 | | Release date: | 2023-10-25 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Structural basis for nuclear import of hepatitis B virus (HBV) nucleocapsid core.
Sci Adv, 10, 2024
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5B6G
 | | Protein-protein interaction | | Descriptor: | Adenomatous polyposis coli protein, GLYCEROL, PHQ-ALA-GLY-GLU-ALA-XYC-TYR-GLU, ... | | Authors: | Zhao, Y, Jiang, H, Yang, X, Jiang, F, Song, K, Zhang, J. | | Deposit date: | 2016-05-27 | | Release date: | 2017-05-31 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.
Nat. Chem. Biol., 13, 2017
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4BQK
 | | rice importin_alpha : VirD2NLS complex | | Descriptor: | DI(HYDROXYETHYL)ETHER, IMPORTIN SUBUNIT ALPHA-1A, T-DNA BORDER ENDONUCLEASE VIRD2 | | Authors: | Chang, C.-W, Counago, R.M, Williams, S.J, Kobe, B. | | Deposit date: | 2013-05-31 | | Release date: | 2014-02-19 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.997 Å) | | Cite: | Structural Basis of Interaction of Bipartite Nuclear Localization Signal from Agrobacterium Vird2 with Rice Importin-Alpha
Mol.Plant, 7, 2014
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3UL0
 | | Mouse importin alpha: mouse CBP80Y8D cNLS complex | | Descriptor: | Importin subunit alpha-2, Nuclear cap-binding protein subunit 1 | | Authors: | Marfori, M, Forwood, J.K, Lonhienne, T.G, Kobe, B. | | Deposit date: | 2011-11-10 | | Release date: | 2012-10-03 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural Basis of High-Affinity Nuclear Localization Signal Interactions with Importin-alpha
Traffic, 13, 2012
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4U5O
 | | IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR | | Descriptor: | Importin subunit alpha-1, N~2~-[4-(pyridin-3-yl)benzyl]-D-lysinamide | | Authors: | Stewart, M, Valkov, E, Holvey, R.S. | | Deposit date: | 2014-07-25 | | Release date: | 2015-05-13 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design.
Chemmedchem, 10, 2015
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8TUQ
 | | STL Polyomavirus LTA NLS bound to importin alpha 2 | | Descriptor: | Importin subunit alpha-1, Large T antigen | | Authors: | Donnelly, C.M, Cross, E.M, Forwood, J.K, Alvisi, G. | | Deposit date: | 2023-08-17 | | Release date: | 2024-02-07 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin alpha-dependent nuclear localization signals.
Protein Sci., 33, 2024
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7RG0
 | | Importin alpha2 in complex with MERS ORF4B R24A mutant | | Descriptor: | Importin subunit alpha-1, ORF4b | | Authors: | Munasinghe, T.S, Tsimbalyuk, S, Roby, J.A, Aragao, D, Forwood, J.K. | | Deposit date: | 2021-07-14 | | Release date: | 2021-07-28 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity.
Nat Commun, 13, 2022
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7RG3
 | | Importin alpha2 in complex with MERS ORF4B R37A mutant | | Descriptor: | Importin subunit alpha-1, ORF4b | | Authors: | Munasinghe, T.S, Tsimbalyuk, S, Roby, J.A, Aragao, D, Forwood, J.K. | | Deposit date: | 2021-07-14 | | Release date: | 2021-08-25 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity.
Nat Commun, 13, 2022
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7RG2
 | | Importin alpha2 in complex with MERS ORF4B R33A mutant | | Descriptor: | Importin subunit alpha-1, ORF4b | | Authors: | Munasinghe, T.S, Tsimbalyuk, S, Roby, J.A, Aragao, D, Forwood, J.K. | | Deposit date: | 2021-07-14 | | Release date: | 2021-08-25 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity.
Nat Commun, 13, 2022
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5WUM
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5SVZ
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3OQS
 | | Crystal structure of importin-alpha bound to a CLIC4 NLS peptide | | Descriptor: | Importin subunit alpha-2, peptide of Chloride intracellular channel protein 4 | | Authors: | Mynott, A.V, Brown, L.J, Harrop, S.J, Curmi, P.M.G. | | Deposit date: | 2010-09-03 | | Release date: | 2011-07-27 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal structure of importin-alpha bound to a peptide bearing the nuclear localisation signal from chloride intracellular channel protein 4
Febs J., 278, 2011
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8QXW
 | | HCMV DNA polymerase processivity factor UL44 unphosphorylated NLS 410-433 bound to mouse importin alpha 2 | | Descriptor: | DNA polymerase processivity factor, Importin subunit alpha-1 | | Authors: | Cross, E.M, Marin, O, Ariawan, D, Aragao, D, Cozza, G, Di Iorio, E, Forwood, J.K, Alvisi, G. | | Deposit date: | 2023-10-25 | | Release date: | 2023-11-08 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural determinants of phosphorylation-dependent nuclear transport of HCMV DNA polymerase processivity factor UL44.
Febs Lett., 598, 2024
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1WA5
 | | Structure of the Cse1:Imp-alpha:RanGTP complex | | Descriptor: | GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, Importin alpha re-exporter, ... | | Authors: | Stewart, M. | | Deposit date: | 2004-10-23 | | Release date: | 2004-12-13 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural basis for the assembly of a nuclear export complex.
Nature, 432, 2004
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