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5U8C
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BU of 5u8c by Molmil
CRYSTAL STRUCTURE OF GLUN1/GLUN2A LIGAND-BINDING DOMAIN IN COMPLEX WITH GLYCINE AND NVP-AAM077
Descriptor: GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2A, GLYCEROL, ...
Authors:Romero-Hernandez, A, Furukawa, H.
Deposit date:2016-12-14
Release date:2017-05-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.598 Å)
Cite:Novel Mode of Antagonist Binding in NMDA Receptors Revealed by the Crystal Structure of the GluN1-GluN2A Ligand-Binding Domain Complexed to NVP-AAM077.
Mol. Pharmacol., 92, 2017
5TP9
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BU of 5tp9 by Molmil
Structure of the human GluN1/GluN2A LBD in complex with compound 2 (GNE9178)
Descriptor: 7-{[5-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-N-ethyl-2-methyl-5-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-3-carboxamide, ACETATE ION, CALCIUM ION, ...
Authors:Wallweber, H.J.A, Lupardus, P.J.
Deposit date:2016-10-20
Release date:2016-11-30
Last modified:2017-02-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile.
ACS Med Chem Lett, 8, 2017
5TPA
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BU of 5tpa by Molmil
Structure of the human GluN1/GluN2A LBD in complex with compound 9 (GNE3500)
Descriptor: (1R,2R)-2-(2-{[5-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-7-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-6-yl)cyclopropane-1-carbonitrile, GLUTAMIC ACID, GLYCINE, ...
Authors:Wallweber, H.J.A, Lupardus, P.J.
Deposit date:2016-10-20
Release date:2016-11-30
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile.
ACS Med Chem Lett, 8, 2017
5ZG3
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BU of 5zg3 by Molmil
Crystal structure of the GluA2o LBD in complex with glutamate and TAK-137
Descriptor: 9-(4-phenoxyphenyl)-3,4-dihydro-2H-2lambda~6~-pyrido[2,1-c][1,2,4]thiadiazine-2,2-dione, ACETATE ION, GLUTAMIC ACID, ...
Authors:Sogabe, S, Igaki, S, Hirokawa, A, Zama, Y, Lane, W, Snell, G.
Deposit date:2018-03-07
Release date:2019-01-16
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window.
Neuropsychopharmacology, 44, 2019
5CBR
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BU of 5cbr by Molmil
Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (S)-2-amino-3-(3,4-dichloro-5-(5-hydroxypyridin-3-yl)phenyl)propanoic acid at 2.0A resolution
Descriptor: 3,4-dichloro-5-(5-hydroxypyridin-3-yl)-L-phenylalanine, ACETATE ION, GLYCEROL, ...
Authors:Frydenvang, K, Kastrup, J.S.
Deposit date:2015-07-01
Release date:2015-12-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.996 Å)
Cite:Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors.
J.Med.Chem., 59, 2016
5CC2
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BU of 5cc2 by Molmil
STRUCTURE OF THE LIGAND-BINDING DOMAIN OF THE IONOTROPIC GLUTAMATE RECEPTOR-LIKE GLUD2 IN COMPLEX WITH 7-CKA
Descriptor: 7-Chlorokynurenic acid, CHLORIDE ION, GLYCEROL, ...
Authors:Naur, P, Gajhede, M, Kastrup, J.S.
Deposit date:2015-07-01
Release date:2015-12-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors.
Mol.Pharmacol., 89, 2016
5ZG1
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BU of 5zg1 by Molmil
Crystal structure of the GluA2o LBD in complex with glutamate and Compound-2
Descriptor: 9-(4-~{tert}-butylphenyl)-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide, GLUTAMIC ACID, GLYCEROL, ...
Authors:Sogabe, S, Igaki, S, Hirokawa, A, Zama, Y, Lane, W, Snell, G.
Deposit date:2018-03-07
Release date:2019-01-16
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window.
Neuropsychopharmacology, 44, 2019
5ZG2
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BU of 5zg2 by Molmil
Crystal structure of the GluA2o LBD in complex with ZK200775 and Compound-2
Descriptor: 9-(4-~{tert}-butylphenyl)-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide, ACETATE ION, GLYCEROL, ...
Authors:Sogabe, S, Igaki, S, Hirokawa, A, Zama, Y, Lane, W, Snell, G.
Deposit date:2018-03-07
Release date:2019-01-16
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window.
Neuropsychopharmacology, 44, 2019
5CBS
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BU of 5cbs by Molmil
Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (R)-2-amino-3-(3'-hydroxybiphenyl-3-yl)propanoic acid at 1.8A resolution
Descriptor: (R)-2-amino-3-(3'-hydroxybiphenyl-3-yl)propanoic acid, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:Frydenvang, K, Kastrup, J.S.
Deposit date:2015-07-01
Release date:2015-12-30
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.801 Å)
Cite:Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors.
J.Med.Chem., 59, 2016
5CMM
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BU of 5cmm by Molmil
Crystal structure of the GluK2EM LBD dimer assembly complex with 2S,4R-4-methylglutamate
Descriptor: 2S,4R-4-METHYLGLUTAMATE, Glutamate receptor ionotropic, kainate 2
Authors:Chittori, S, Mayer, M.L.
Deposit date:2015-07-16
Release date:2016-07-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.271 Å)
Cite:Structural basis of kainate subtype glutamate receptor desensitization.
Nature, 537, 2016
2I3V
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BU of 2i3v by Molmil
Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of G725C mutant
Descriptor: GLUTAMIC ACID, Glutamate receptor 2, ZINC ION
Authors:Armstrong, N, Jasti, J, Beich-Frandsen, M, Gouaux, E.
Deposit date:2006-08-21
Release date:2006-10-17
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Measurement of Conformational Changes accompanying Desensitization in an Ionotropic Glutamate Receptor.
Cell(Cambridge,Mass.), 127, 2006
5ZG0
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BU of 5zg0 by Molmil
Crystal structure of the GluA2o LBD in complex with glutamate and Compound-1
Descriptor: 9-{4-[(propan-2-yl)oxy]phenyl}-3,4-dihydro-2H-2lambda~6~-pyrido[2,1-c][1,2,4]thiadiazine-2,2-dione, ACETATE ION, GLUTAMIC ACID, ...
Authors:Sogabe, S, Igaki, S, Hirokawa, A, Zama, Y, Lane, W, Snell, G.
Deposit date:2018-03-07
Release date:2019-01-16
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window.
Neuropsychopharmacology, 44, 2019
2I0C
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BU of 2i0c by Molmil
Crystal structure of the GluR6 ligand binding core dimer crosslinked by disulfide bonds between Y490C and L752C at 2.25 Angstroms Resolution
Descriptor: GLUTAMIC ACID, Glutamate receptor, ionotropic kainate 2
Authors:Mayer, M.L.
Deposit date:2006-08-10
Release date:2006-11-21
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Conformational restriction blocks glutamate receptor desensitization.
Nat.Struct.Mol.Biol., 13, 2006
2I0B
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BU of 2i0b by Molmil
Crystal structure of the GluR6 ligand binding core ELKQ mutant dimer at 1.96 Angstroms Resolution
Descriptor: GLUTAMIC ACID, Glutamate receptor, ionotropic kainate 2, ...
Authors:Mayer, M.L.
Deposit date:2006-08-10
Release date:2006-11-21
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Conformational restriction blocks glutamate receptor desensitization.
Nat.Struct.Mol.Biol., 13, 2006
2I3W
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BU of 2i3w by Molmil
Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of S729C mutant
Descriptor: GLUTAMATE RECEPTOR SUBUNIT 2, GLUTAMIC ACID
Authors:Armstrong, N, Jasti, J, Beich-Frandsen, M, Gouaux, E.
Deposit date:2006-08-21
Release date:2006-10-17
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Measurement of Conformational Changes accompanying Desensitization in an Ionotropic Glutamate Receptor.
Cell(Cambridge,Mass.), 127, 2006
2F36
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BU of 2f36 by Molmil
Crystal Structure of the GluR5 Ligand Binding Core Dimer with Glutamate At 2.1 Angstroms Resolution
Descriptor: GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 1, GLUTAMIC ACID, ...
Authors:Mayer, M.L.
Deposit date:2005-11-18
Release date:2006-04-04
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists.
J.Neurosci., 26, 2006
2CMO
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BU of 2cmo by Molmil
The structure of a mixed glur2 ligand-binding core dimer in complex with (s)-glutamate and the antagonist (s)-ns1209
Descriptor: 2-({[(3E)-5-{4-[(DIMETHYLAMINO)(DIHYDROXY)-LAMBDA~4~-SULFANYL]PHENYL}-8-METHYL-2-OXO-6,7,8,9-TETRAHYDRO-1H-PYRROLO[3,2-H]ISOQUINOLIN-3(2H)-YLIDENE]AMINO}OXY)-4-HYDROXYBUTANOIC ACID, GLUTAMATE RECEPTOR 2, GLUTAMIC ACID, ...
Authors:Kasper, C, Pickering, D.S, Mirza, O, Olsen, L, Kristensen, A.S, Greenwood, J.R, Liljefors, T, Schousboe, A, Watjen, F, Gajhede, M, Sigurskjold, B.W, Kastrup, J.S.
Deposit date:2006-05-11
Release date:2006-06-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:The Structure of a Mixed Glur2 Ligand-Binding Core Dimer in Complex with (S)-Glutamate and the Antagonist (S)-Ns1209.
J.Mol.Biol., 357, 2006
2F34
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BU of 2f34 by Molmil
Crystal Structure of the GluR5 Ligand Binding Core Dimer with UBP310 At 1.74 Angstroms Resolution
Descriptor: (S)-1-(2-AMINO-2-CARBOXYETHYL)-3(2-CARBOXYTHIOPHENE-3-YL-METHYL)-5-METHYLPYRIMIDINE-2,4-DIONE, CHLORIDE ION, GLUTAMATE RECEPTOR, ...
Authors:Mayer, M.L.
Deposit date:2005-11-18
Release date:2006-04-04
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists.
J.Neurosci., 26, 2006
2F35
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BU of 2f35 by Molmil
Crystal Structure of the GluR5 Ligand Binding Core with UBP302 At 1.87 Angstroms Resolution
Descriptor: (S)-1-(2-AMINO-2-CARBOXYETHYL)-3-(2-CARBOXYBENZYL)PYRIMIDINE-2,4-DIONE, CHLORIDE ION, GLUTAMATE RECEPTOR, ...
Authors:Mayer, M.L.
Deposit date:2005-11-18
Release date:2006-04-04
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists.
J.Neurosci., 26, 2006
2GFE
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BU of 2gfe by Molmil
Crystal structure of the GluR2 A476E S673D Ligand Binding Core Mutant at 1.54 Angstroms Resolution
Descriptor: GLUTAMIC ACID, Glutamate receptor 2, ZINC ION
Authors:Mayer, M.L.
Deposit date:2006-03-21
Release date:2006-08-22
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Interdomain interactions in AMPA and kainate receptors regulate affinity for glutamate.
J.Neurosci., 26, 2006
4YU0
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BU of 4yu0 by Molmil
Crystal structure of a tetramer of GluA2 TR mutant ligand binding domains bound with glutamate at 1.26 Angstrom resolution
Descriptor: DI(HYDROXYETHYL)ETHER, GLUTAMIC ACID, Glutamate receptor 2,Glutamate receptor 2, ...
Authors:Chebli, M, Salazar, H, Baranovic, J, Carbone, A.L, Ghisi, V, Faelber, K, Lau, A.Y, Daumke, O, Plested, A.J.R.
Deposit date:2015-03-18
Release date:2016-01-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.26 Å)
Cite:Crystal structure of the tetrameric GluA2 ligand-binding domain in complex with glutamate at 1.26 Angstroms resolution
To Be Published
4BDL
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BU of 4bdl by Molmil
Crystal structure of the GluK2 K531A LBD dimer in complex with glutamate
Descriptor: GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 2, GLUTAMIC ACID, ...
Authors:Nayeem, N, Mayans, O, Green, T.
Deposit date:2012-10-05
Release date:2013-04-10
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Correlating Efficacy and Desensitization with Gluk2 Ligand-Binding Domain Movements.
Open Biol., 3, 2013
4BDO
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BU of 4bdo by Molmil
Crystal structure of the GluK2 K531A-T779G LBD dimer in complex with kainate
Descriptor: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 2, ...
Authors:Nayeem, N, Mayans, O, Green, T.
Deposit date:2012-10-05
Release date:2013-04-10
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Correlating Efficacy and Desensitization with Gluk2 Ligand-Binding Domain Movements.
Open Biol., 3, 2013
4BDM
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BU of 4bdm by Molmil
Crystal structure of the GluK2 K531A LBD dimer in complex with kainate
Descriptor: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, GLUTAMATE RECEPTOR, IONOTROPIC KAINATE 2
Authors:Nayeem, N, Mayans, O, Green, T.
Deposit date:2012-10-05
Release date:2013-04-10
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Correlating Efficacy and Desensitization with Gluk2 Ligand-Binding Domain Movements.
Open Biol., 3, 2013
4YMB
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BU of 4ymb by Molmil
Structure of the ligand-binding domain of GluK1 in complex with the antagonist CNG10111
Descriptor: (3R,4S)-3-(3-carboxyphenyl)-4-propyl-L-proline, 1,2-ETHANEDIOL, ACETATE ION, ...
Authors:Moller, C, Tapken, D, Kastrup, J.S, Frydenvang, K.
Deposit date:2015-03-06
Release date:2015-08-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structure-Activity Relationship Study of Ionotropic Glutamate Receptor Antagonist (2S,3R)-3-(3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid.
J.Med.Chem., 58, 2015

221371

数据于2024-06-19公开中

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