PDB: 594 resultsInfo pagesStatus searchChemie searchBIRD

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5MTJ	Yes1-SH2 in complex with monobody Mb(Yes_1) Descriptor: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Monobody Mb(Yes_1), SULFATE ION, ... Authors: Sha, F, Kukenshoner, T, Koide, S, Hantschel, O. Deposit date: 2017-01-09 Release date: 2017-04-05 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.949 Å) Cite: Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies. J. Mol. Biol., 429, 2017
5MTM	Monobody Mb(Lck_3) bound to Lck-SH2 domain Descriptor: Monobody Mb(Lck_3), Tyrosine-protein kinase Lck, ZINC ION Authors: Pojer, F, Kukenshoner, T, Koide, S, Hantschel, O. Deposit date: 2017-01-10 Release date: 2017-04-05 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.405 Å) Cite: Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies. J. Mol. Biol., 429, 2017
5MTN	Monobody Mb(Lck_1) bound to Lck-Sh2 Descriptor: Monobody Mb(Lck_1), SULFATE ION, Tyrosine-protein kinase Lck Authors: Pojer, F, Kukenshoner, T, Koide, S, Hantschel, O. Deposit date: 2017-01-10 Release date: 2017-04-05 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies. J. Mol. Biol., 429, 2017
6E8H	Legionella Longbeachae LeSH (Llo2327) Descriptor: CHLORIDE ION, LeSH (Llo2327) Authors: Kaneko, T, Li, S.S.C. Deposit date: 2018-07-29 Release date: 2018-11-14 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.68 Å) Cite: Identification and characterization of a large family of superbinding bacterial SH2 domains. Nat Commun, 9, 2018
3EAZ	Crystal structure of SH2 domain of Human Csk (carboxyl-terminal src kinase), C122S mutant. Descriptor: Tyrosine-protein kinase CSK Authors: Liu, D, Seidel, R.D, Cowburn, D. Deposit date: 2008-08-26 Release date: 2009-11-10 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.31 Å) Cite: Combining biophysical methods to analyze the disulfide bond in SH2 domain of C-terminal Src kinase. Biophys Rep, 2, 2016
3C7I	X-RAY crystal structure of the complex between the grb2-sh2 domain and a flexible ligand, FPTVN. Descriptor: FORMIC ACID, Growth factor receptor-bound protein 2, N-{(2R)-4-(methylamino)-4-oxo-2-[4-(phosphonooxy)benzyl]butanoyl}-L-valyl-L-aspartamide Authors: Benfield, A.P, Martin, S.F. Deposit date: 2008-02-07 Release date: 2008-08-12 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Ligand Preorganization May be Accompanied by Entropic Penalties in Protein-Ligand Interactions. Angew.Chem.Int.Ed.Engl., 118, 2006
7SA7	Crystal structure of the apo SH2 domains of Syk Descriptor: Tyrosine-protein kinase SYK Authors: Hobbs, H.T, Badroos, J, Gee, C.L, Kuriyan, J. Deposit date: 2021-09-22 Release date: 2021-10-13 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Differences in the dynamics of the tandem-SH2 modules of the Syk and ZAP-70 tyrosine kinases. Protein Sci., 30, 2021
3IMJ	Crystal Structure of the Grb2 SH2 Domain in Complex with a Cyclopropyl-constrained Ac-pTyr-Ile-Asn-NH2 Tripeptide Mimic Descriptor: (1R,2S,3R,1S',1S")Phosphoric acid mono(4-{2-[1-(1,2-dicarbamoylethylcarbamoyl)-3-carbamoylpropylcarbamoyl]-3-methylcarbamoylcyclopropyl}phenyl) ester, Growth factor receptor-bound protein 2 Authors: Clements, J.H. Deposit date: 2009-08-10 Release date: 2009-11-17 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.02 Å) Cite: Thermodynamic and Structural Effects of Conformational Constraints in Protein-Ligand Interactions. Entropic Paradoxy Associated with Ligand Preorganization. J.Am.Chem.Soc., 131, 2009
3IN8	Crystal Structure of the Grb2 SH2 Domain in Complex with a Flexible Ac-pTyr-Ile-Asn-NH2 Tripeptide Mimic Descriptor: FORMIC ACID, Growth factor receptor-bound protein 2, N-{(2S)-4-(methylamino)-4-oxo-2-[4-(phosphonooxy)benzyl]butanoyl}-L-isoleucyl-L-aspartamide Authors: Benfield, A.P, Clements, J.H. Deposit date: 2009-08-11 Release date: 2009-11-17 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Thermodynamic and Structural Effects of Conformational Constraints in Protein-Ligand Interactions. Entropic Paradoxy Associated with Ligand Preorganization. J.Am.Chem.Soc., 131, 2009
7Q63	The tandem SH2 domains of SYK Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... Authors: Bradshaw, W.J, Katis, V.L, Chen, Z, Bountra, C, von Delft, F, Gileadi, O, Brennan, P.E. Deposit date: 2021-11-05 Release date: 2021-11-24 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.9 Å) Cite: The tandem SH2 domains of SYK To Be Published
7Q5W	The tandem SH2 domains of SYK with a bound TYROBP diphospho-ITAM peptide Descriptor: 1,2-ETHANEDIOL, 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, DI(HYDROXYETHYL)ETHER, ... Authors: Bradshaw, W.J, Katis, V.L, Chen, Z, Bountra, C, von Delft, F, Gileadi, O, Brennan, P.E. Deposit date: 2021-11-04 Release date: 2021-11-24 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.2 Å) Cite: The tandem SH2 domains of SYK To Be Published
3IN7	Crystal Structure of the Grb2 SH2 Domain in Complex with a Cyclopropyl-constrained Ac-pY-Q-N-NH2 Tripeptide Mimic Descriptor: Growth factor receptor-bound protein 2, N~2~-({(1R,2R,3S)-2-(methylcarbamoyl)-3-[4-(phosphonooxy)phenyl]cyclopropyl}carbonyl)-D-glutaminyl-D-aspartamide Authors: Clements, J.H. Deposit date: 2009-08-11 Release date: 2009-11-17 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Thermodynamic and Structural Effects of Conformational Constraints in Protein-Ligand Interactions. Entropic Paradoxy Associated with Ligand Preorganization. J.Am.Chem.Soc., 131, 2009
3IMD	Crystal Structure of the Grb2 SH2 Domain in Complex with a Flexible Ac-pY-Q-N-NH2 Tripeptide Mimic Descriptor: CHLORIDE ION, Growth factor receptor-bound protein 2, MAGNESIUM ION, ... Authors: Clements, J.H. Deposit date: 2009-08-10 Release date: 2009-11-17 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Thermodynamic and Structural Effects of Conformational Constraints in Protein-Ligand Interactions. Entropic Paradoxy Associated with Ligand Preorganization. J.Am.Chem.Soc., 131, 2009
7T1K	Crystal structure of a superbinder Fes SH2 domain (sFes1) in complex with a high affinity phosphopeptide Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, MALONATE ION, ... Authors: Martyn, G.D, Singer, A.U, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S. Deposit date: 2021-12-02 Release date: 2022-08-24 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.25 Å) Cite: Engineered SH2 Domains for Targeted Phosphoproteomics. Acs Chem.Biol., 17, 2022
7T1L	Crystal structure of a superbinder Fes SH2 domain (sFesS) in complex with a high affinity phosphopeptide Descriptor: CHLORIDE ION, SODIUM ION, Synthetic phosphotyrosine-containing Ezrin-derived peptide, ... Authors: Martyn, G.D, Singer, A.U, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S. Deposit date: 2021-12-02 Release date: 2022-08-24 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Engineered SH2 Domains for Targeted Phosphoproteomics. Acs Chem.Biol., 17, 2022
7T1U	Crystal structure of a superbinder Src SH2 domain (sSrcF) in complex with a high affinity phosphopeptide Descriptor: Proto-oncogene tyrosine-protein kinase Src, Synthetic phosphopeptide, ZINC ION Authors: Martyn, G.D, Singer, A.U, Manczyk, N, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S. Deposit date: 2021-12-02 Release date: 2022-08-24 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Engineered SH2 Domains for Targeted Phosphoproteomics. Acs Chem.Biol., 17, 2022
5JN0	CRK-II SH2 domain Descriptor: CHLORIDE ION, CRK-II SH2 domain Authors: Cho, J.-H. Deposit date: 2016-04-29 Release date: 2017-08-09 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.677 Å) Cite: CRK-II SH2 domain To Be Published
3KFJ	Crystal Structure of the Grb2 SH2 Domain in Complex with a Flexible Ac-pY-E-N-NH2 Tripeptide Mimic Descriptor: CHLORIDE ION, Growth factor receptor-bound protein 2, MAGNESIUM ION, ... Authors: Clements, J.H. Deposit date: 2009-10-27 Release date: 2010-03-02 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.02 Å) Cite: Thermodynamic and structural effects of conformational constraints in protein-ligand interactions. Entropic paradoxy associated with ligand preorganization. J.Am.Chem.Soc., 131, 2009
3K2M	Crystal Structure of Monobody HA4/Abl1 SH2 Domain Complex Descriptor: Monobody HA4, PHOSPHATE ION, Proto-oncogene tyrosine-protein kinase ABL1 Authors: Wojcik, J.B, Duguid, E. Deposit date: 2009-09-30 Release date: 2010-03-31 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.75 Å) Cite: A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain. Nat.Struct.Mol.Biol., 17, 2010
5KAZ	Human SH2D1B structure Descriptor: SH2 domain-containing protein 1B, SULFATE ION Authors: Taha, M, Nezerwa, E, Nam, H.-J. Deposit date: 2016-06-02 Release date: 2017-04-12 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.7 Å) Cite: The X-ray Crystallographic Structure of Human EAT2 (SH2D1B). Protein Pept. Lett., 23, 2016
6ICH	Grb2 SH2 domain in domain swapped dimer form Descriptor: Growth factor receptor-bound protein 2 Authors: Hosoe, Y, Numoto, N, Inaba, S, Ogawa, S, Morii, H, Abe, R, Ito, N, Oda, M. Deposit date: 2018-09-06 Release date: 2019-07-17 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural and functional properties of Grb2 SH2 dimer in CD28 binding. Biophys Physicobio., 16, 2019
5W3R	SH2B1 SH2 Domain Descriptor: PHENOL, PHOSPHATE ION, SH2B adapter protein 1 Authors: McKercher, M.A, Wuttke, D.S. Deposit date: 2017-06-08 Release date: 2017-11-22 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.386 Å) Cite: Diversity in peptide recognition by the SH2 domain of SH2B1. Proteins, 86, 2018
5CDW	Crystal Structure Analysis of a mutant Grb2 SH2 domain (W121G) with a pYVNV peptide Descriptor: Growth factor receptor-bound protein 2, SER-PTR-VAL-ASN-VAL-GLN Authors: Papaioannou, D, Geibel, S, Kunze, M, Kay, C, Waksman, G. Deposit date: 2015-07-05 Release date: 2016-05-25 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.602 Å) Cite: Structural and biophysical investigation of the interaction of a mutant Grb2 SH2 domain (W121G) with its cognate phosphopeptide. Protein Sci., 25, 2016
6HTF	Crystal structure of human Btk SH2 domain bound to rF10 repebody Descriptor: Tyrosine-protein kinase BTK, rF10 repebody Authors: Duarte, D.P, Pojer, F, Hantschel, O. Deposit date: 2018-10-04 Release date: 2020-05-20 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.102 Å) Cite: Btk SH2-kinase interface is critical for allosteric kinase activation and its targeting inhibits B-cell neoplasms. Nat Commun, 11, 2020
6WAY	C-terminal SH2 domain of p120RasGAP in complex with p190RhoGAP phosphotyrosine peptide Descriptor: Ras GTPase-activating protein 1, Rho GTPase-activating protein 35 Authors: Jaber Chehayeb, R, Wang, J, Stiegler, A.L, Boggon, T.J. Deposit date: 2020-03-26 Release date: 2020-06-17 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.5 Å) Cite: The GTPase-activating protein p120RasGAP has an evolutionarily conserved "FLVR-unique" SH2 domain. J.Biol.Chem., 295, 2020

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