8BC8
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![BU of 8bc8 by Molmil](/molmil-images/mine/8bc8) | Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and compound 18 | Descriptor: | 1,2-ETHANEDIOL, 3-azanyl-4-oxidanyl-benzenesulfonamide, Pre-mRNA-processing-splicing factor 8, ... | Authors: | Vester, K, Loll, B, Wahl, M.C. | Deposit date: | 2022-10-15 | Release date: | 2023-03-08 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | Conformation-dependent ligand hot spots in the spliceosomal RNA helicase BRR2. Acta Crystallogr D Struct Biol, 79, 2023
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6HMO
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8BWF
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![BU of 8bwf by Molmil](/molmil-images/mine/8bwf) | PTBP1 RRM1 bound to an allosteric inhibitor | Descriptor: | AMINO GROUP, GLYCEROL, Ligand, ... | Authors: | Schmeing, S, Vetter, I, t Hart, P, Gasper, R. | Deposit date: | 2022-12-06 | Release date: | 2023-10-11 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Rationally designed stapled peptides allosterically inhibit PTBP1-RNA-binding. Chem Sci, 14, 2023
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1JFZ
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5APM
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![BU of 5apm by Molmil](/molmil-images/mine/5apm) | Multiple capsid-stabilizing protein-RNA and protein-protein interactions revealed in a high-resolution structure of an emerging picornavirus causing neonatal sepsis | Descriptor: | VP0, VP1, VP3 | Authors: | Shakeel, S, Westerhuis, B.M, Domanska, A, Koning, R.I, Matadeen, R, Koster, A.J, Bakker, A.Q, Beaumont, T, Wolthers, K.C, Butcher, S.J. | Deposit date: | 2015-09-17 | Release date: | 2016-07-27 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Multiple Capsid-Stabilizing Interactions Revealed in a High-Resolution Structure of an Emerging Picornavirus Causing Neonatal Sepsis Nat.Commun., 7, 2016
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3HJY
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![BU of 3hjy by Molmil](/molmil-images/mine/3hjy) | Structure of a functional ribonucleoprotein pseudouridine synthase bound to a substrate RNA | Descriptor: | 5'-R(*GP*GP*AP*GP*CP*GP*UP*GP*CP*GP*GP*UP*UP*U)-3', 5'-R(*GP*GP*GP*CP*UP*CP*CP*GP*GP*AP*AP*AP*CP*CP*GP*CP*GP*GP*CP*GP*C)-3', RNA (25-MER), ... | Authors: | Liang, B, Zhou, J, Kahen, E, Terns, R.M, Terns, M.P, Li, H. | Deposit date: | 2009-05-22 | Release date: | 2009-06-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.65 Å) | Cite: | Structure of a functional ribonucleoprotein pseudouridine synthase bound to a substrate RNA Nat.Struct.Mol.Biol., 16, 2009
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5FW1
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![BU of 5fw1 by Molmil](/molmil-images/mine/5fw1) | Crystal structure of SpyCas9 variant VQR bound to sgRNA and TGAG PAM target DNA | Descriptor: | CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, NON-TARGET DNA STRAND, ... | Authors: | Anders, C, Bargsten, K, Jinek, M. | Deposit date: | 2016-02-11 | Release date: | 2016-04-20 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.499 Å) | Cite: | Structural Plasticity of Pam Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9. Mol.Cell, 61, 2016
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6NME
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![BU of 6nme by Molmil](/molmil-images/mine/6nme) | Structure of LbCas12a-crRNA | Descriptor: | Cpf1, MAGNESIUM ION, crRNA | Authors: | Chang, L, Li, Z, Zhang, H. | Deposit date: | 2019-01-10 | Release date: | 2019-06-12 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (5.67 Å) | Cite: | Structural Basis for the Inhibition of CRISPR-Cas12a by Anti-CRISPR Proteins. Cell Host Microbe, 25, 2019
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8DP3
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5WTY
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![BU of 5wty by Molmil](/molmil-images/mine/5wty) | Structure of Nop9 RNA complex | Descriptor: | Nucleolar protein 9, RNA (5'-R(*AP*AP*AP*GP*GP*AP*AP*UP*UP*GP*AP*CP*GP*GP*AP*AP*GP*G)-3') | Authors: | Ye, K, Wang, B. | Deposit date: | 2016-12-15 | Release date: | 2017-01-25 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.785 Å) | Cite: | Nop9 binds the central pseudoknot region of 18S rRNA Nucleic Acids Res., 45, 2017
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6VEM
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![BU of 6vem by Molmil](/molmil-images/mine/6vem) | Structure of RNA octamer | Descriptor: | COBALT HEXAMMINE(III), Modified Octamer RNA | Authors: | Pallan, P.S, Egli, M. | Deposit date: | 2020-01-02 | Release date: | 2020-11-18 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Synthesis, chirality-dependent conformational and biological properties of siRNAs containing 5'-(R)- and 5'-(S)-C-methyl-guanosine. Nucleic Acids Res., 48, 2020
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2VUM
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![BU of 2vum by Molmil](/molmil-images/mine/2vum) | Alpha-amanitin inhibited complete RNA polymerase II elongation complex | Descriptor: | 5'-D(*AP*AP*AP*CP*TP*AP*CP*TP*TP*GP *AP*GP*CP*T)-3', 5'-D(*AP*GP*CP*TP*CP*AP*AP*GP*TP*AP *GP*TP*TP*AP*CP*GP*CP*CP*BRUP*GP*GP*TP*CP*AP*TP*T)-3', 5'-R(*AP*AP*AP*GP*AP*CP*CP*AP*GP*GP*C)-3', ... | Authors: | Brueckner, F, Cramer, P. | Deposit date: | 2008-05-27 | Release date: | 2008-06-17 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Structural Basis of Transcription Inhibition by Alpha-Amanitin and Implications for RNA Polymerase II Translocation. Nat.Struct.Mol.Biol., 15, 2008
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1KNZ
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![BU of 1knz by Molmil](/molmil-images/mine/1knz) | Recognition of the rotavirus mRNA 3' consensus by an asymmetric NSP3 homodimer | Descriptor: | 5'-R(*UP*GP*AP*CP*C)-3', Nonstructural RNA-binding Protein 34 | Authors: | Deo, R.C, Groft, C.M, Rajashankar, K.R, Burley, S.K. | Deposit date: | 2001-12-19 | Release date: | 2002-01-17 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Recognition of the rotavirus mRNA 3' consensus by an asymmetric NSP3 homodimer. Cell(Cambridge,Mass.), 108, 2002
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6EVK
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4Q94
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![BU of 4q94 by Molmil](/molmil-images/mine/4q94) | human RPRD1B CID in complex with a RPB1-CTD derived Ser2 phosphorylated peptide | Descriptor: | Regulation of nuclear pre-mRNA domain-containing protein 1B, SULFATE ION, UNKNOWN ATOM OR ION, ... | Authors: | Ni, Z, Xu, C, Tempel, W, El Bakkouri, M, Loppnau, P, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Greenblatt, J.F, Structural Genomics Consortium (SGC) | Deposit date: | 2014-04-29 | Release date: | 2014-06-18 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation. Nat.Struct.Mol.Biol., 21, 2014
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2ESE
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![BU of 2ese by Molmil](/molmil-images/mine/2ese) | Structure of the SAM domain of Vts1p in complex with RNA | Descriptor: | 5'-R(*GP*GP*AP*GP*AP*GP*GP*CP*UP*CP*UP*GP*GP*CP*AP*GP*CP*UP*UP*UP*UP*CP*C)-3', Vts1p | Authors: | Allain, F.H.T. | Deposit date: | 2005-10-26 | Release date: | 2006-01-24 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Shape-specific recognition in the structure of the Vts1p SAM domain with RNA. Nat.Struct.Mol.Biol., 13, 2006
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8TJQ
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8TJU
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![BU of 8tju by Molmil](/molmil-images/mine/8tju) | Tetrahymena Ribozyme scaffolded TABV xrRNA | Descriptor: | DNA/RNA (416-MER), MAGNESIUM ION | Authors: | Langeberg, C.J, Kieft, J.S. | Deposit date: | 2023-07-24 | Release date: | 2023-11-01 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (3.46 Å) | Cite: | A generalizable scaffold-based approach for structure determination of RNAs by cryo-EM. Nucleic Acids Res., 51, 2023
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3EWS
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![BU of 3ews by Molmil](/molmil-images/mine/3ews) | Human DEAD-box RNA-helicase DDX19 in complex with ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DDX19B | Authors: | Lehtio, l, Karlberg, t, Andersson, j, Arrowsmith, c.h, Berglund, h, Bountra, c, Collins, r, Dahlgren, l.g, Edwards, a.m, Flodin, s, Flores, a, Graslund, s, Hammarstrom, m, Johansson, a, Johansson, i, Kotenyova, t, Moche, m, Nilsson, m.e, Nordlund, p, Nyman, t, Olesen, k, Persson, c, Sagemark, j, Thorsell, a.g, Tresaugues, l, Van den berg, s, Weigelt, j, Welin, m, Wikstrom, m, Wisniewska, m, Schueler, h, Structural Genomics Consortium (SGC) | Deposit date: | 2008-10-16 | Release date: | 2008-11-04 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The DEXD/H-box RNA Helicase DDX19 Is Regulated by an {alpha}-Helical Switch. J.Biol.Chem., 284, 2009
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6NOD
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![BU of 6nod by Molmil](/molmil-images/mine/6nod) | Crystal structure of C. elegans PUF-8 in complex with RNA | Descriptor: | PUF (Pumilio/FBF) domain-containing, RNA (5'-R(P*UP*GP*UP*AP*UP*AP*UP*A)-3') | Authors: | Wang, Y, McCann, K.L, Qiu, C, Hall, T.M.T. | Deposit date: | 2019-01-16 | Release date: | 2019-01-30 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.547 Å) | Cite: | Engineering a conserved RNA regulatory protein repurposes its biological function in vivo . Elife, 8, 2019
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8G1S
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![BU of 8g1s by Molmil](/molmil-images/mine/8g1s) | Cryo-EM structure of 3DVA component 1 of Escherichia coli que-PEC (paused elongation complex) RNA Polymerase minus preQ1 ligand | Descriptor: | DNA (31-MER), DNA (39-MER), DNA-directed RNA polymerase subunit alpha, ... | Authors: | Porta, J.C, Chauvier, A, Deb, I, Ellinger, E, Frank, A.T, Meze, K, Ohi, M.D, Walter, N.G. | Deposit date: | 2023-02-02 | Release date: | 2023-06-21 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural basis for control of bacterial RNA polymerase pausing by a riboswitch and its ligand. Nat.Struct.Mol.Biol., 30, 2023
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2ZM5
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![BU of 2zm5 by Molmil](/molmil-images/mine/2zm5) | Crystal structure of tRNA modification enzyme MiaA in the complex with tRNA(Phe) | Descriptor: | MAGNESIUM ION, tRNA delta(2)-isopentenylpyrophosphate transferase, tRNA(Phe) | Authors: | Sakai, J, Yao, M, Chimnaronk, S, Tanaka, I. | Deposit date: | 2008-04-11 | Release date: | 2009-04-14 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Snapshots of dynamics in synthesizing N(6)-isopentenyladenosine at the tRNA anticodon Biochemistry, 48, 2009
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3AX1
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7OGN
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![BU of 7ogn by Molmil](/molmil-images/mine/7ogn) | Crystal structure of T2R-TTL -mebendazole complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, CHLORIDE ION, ... | Authors: | Oliva, M.A, Bonato, F, Diaz, J.F. | Deposit date: | 2021-05-07 | Release date: | 2022-04-06 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Effect of Clinically Used Microtubule Targeting Drugs on Viral Infection and Transport Function. Int J Mol Sci, 23, 2022
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6D8F
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![BU of 6d8f by Molmil](/molmil-images/mine/6d8f) | RsAgo Ternary Complex with Guide RNA and Target DNA Containing T-T Bulge Within the Seed Segment | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, DNA (5'-D(P*TP*CP*GP*TP*CP*AP*CP*CP*TP*GP*TP*GP*CP*AP*GP*TP*TP*TP*AP*AP*C)-3'), ... | Authors: | Liu, Y, Esyunina, D, Olovnikov, I, Teplova, M, Patel, D.J. | Deposit date: | 2018-04-26 | Release date: | 2018-07-25 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Accommodation of Helical Imperfections in Rhodobacter sphaeroides Argonaute Ternary Complexes with Guide RNA and Target DNA. Cell Rep, 24, 2018
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