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8BHD
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BU of 8bhd by Molmil
N-terminal domain of Plasmodium berghei glutamyl-tRNA synthetase (Tbxo4 derivative crystal structure)
Descriptor: GLYCEROL, Glutamate--tRNA ligase, SULFATE ION, ...
Authors:Benas, P, Jaramillo Ponce, J.R, Legrand, P, Frugier, M, Sauter, C.
Deposit date:2022-10-31
Release date:2023-01-25
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (3.17 Å)
Cite:Solution X-ray scattering highlights discrepancies in Plasmodium multi-aminoacyl-tRNA synthetase complexes.
Protein Sci., 32, 2023
9QRP
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BU of 9qrp by Molmil
Thermus thermophilus seryl-tRNA synthetase bound to tRNA(ser)(GGA) and seryl-adenylate analogue.
Descriptor: 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, MANGANESE (II) ION, SULFATE ION, ...
Authors:Cusack, S.
Deposit date:2025-04-04
Release date:2025-05-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The crystal structure of the ternary complex of T.thermophilus seryl-tRNA synthetase with tRNA(Ser) and a seryl-adenylate analogue reveals a conformational switch in the active site.
EMBO J, 15, 1996
9LS8
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BU of 9ls8 by Molmil
Crystal structure of peptidyl-tRNA hydrolase from Enterococcus faecium at 1.22 A
Descriptor: 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, Peptidyl-tRNA hydrolase, ...
Authors:Pandey, R, Zohib, M, Arora, A.
Deposit date:2025-02-04
Release date:2025-02-19
Method:X-RAY DIFFRACTION (1.22 Å)
Cite:Characterization of structure of peptidyl-tRNA hydrolase from Enterococcus faecium and its inhibition by a pyrrolinone compound.
Int J Biol Macromol, 275, 2024
8T8B
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BU of 8t8b by Molmil
Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site formyl-MAI-tripeptidyl-tRNA analog ACCA-IAMf at 2.65A resolution
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ...
Authors:Thaler, J, Syroegin, E.A, Breuker, K, Polikanov, Y.S, Micura, R.
Deposit date:2023-06-22
Release date:2023-07-19
Last modified:2025-03-19
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Practical Synthesis of N -Formylmethionylated Peptidyl-tRNA Mimics.
Acs Chem.Biol., 18, 2023
8T8C
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BU of 8t8c by Molmil
Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site formyl-MFI-tripeptidyl-tRNA analog ACCA-IFMf at 2.60A resolution
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ...
Authors:Thaler, J, Syroegin, E.A, Breuker, K, Polikanov, Y.S, Micura, R.
Deposit date:2023-06-22
Release date:2023-07-19
Last modified:2025-03-19
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Practical Synthesis of N -Formylmethionylated Peptidyl-tRNA Mimics.
Acs Chem.Biol., 18, 2023
8AP4
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BU of 8ap4 by Molmil
Structure of Escherischia coli heat shock protein Hsp15 in complex with ribosomal 50S subunits bearing peptidyl-tRNA
Descriptor: 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ...
Authors:Safdari, H.A, Wilson, D.N.
Deposit date:2022-08-09
Release date:2022-11-16
Last modified:2025-03-12
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure of Escherichia coli heat shock protein Hsp15 in complex with the ribosomal 50S subunit bearing peptidyl-tRNA.
Nucleic Acids Res., 50, 2022
7XPL
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BU of 7xpl by Molmil
Crystal structure of a C/D-free RNA-guided RNA 2'-O-methyltransferase
Descriptor: BMG3 RNA strand A, BMG3 RNA strand B, C/D box methylation guide ribonucleoprotein complex aNOP56 subunit, ...
Authors:Wang, J, Ye, K.
Deposit date:2022-05-04
Release date:2022-10-05
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.213 Å)
Cite:Methylation guide RNAs without box C/D motifs.
Rna, 28, 2022
5I8Q
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BU of 5i8q by Molmil
S. cerevisiae Prp43 in complex with RNA and ADPNP
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43, ...
Authors:He, Y, Nielsen, K.H, Andersen, G.R.
Deposit date:2016-02-19
Release date:2017-02-01
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Structure of the DEAH/RHA ATPase Prp43p bound to RNA implicates a pair of hairpins and motif Va in translocation along RNA.
RNA, 23, 2017
6D90
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BU of 6d90 by Molmil
Mammalian 80S ribosome with a double translocated CrPV-IRES, P-site tRNA and eRF1.
Descriptor: 18S rRNA, 28S rRNA, 40S ribosomal protein S12, ...
Authors:Pisareva, V.P, Pisarev, A.V, Fernandez, I.S.
Deposit date:2018-04-27
Release date:2018-06-06
Last modified:2024-12-25
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Dual tRNA mimicry in the Cricket Paralysis Virus IRES uncovers an unexpected similarity with the Hepatitis C Virus IRES.
Elife, 7, 2018
8HMY
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BU of 8hmy by Molmil
Cryo-EM structure of the human pre-catalytic TSEN/pre-tRNA complex
Descriptor: Chromosome 1 open reading frame 19, isoform CRA_a, MAGNESIUM ION, ...
Authors:Zhang, X, Yang, F, Zhan, X, Shi, Y.
Deposit date:2022-12-06
Release date:2023-04-19
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (2.94 Å)
Cite:Structural basis of pre-tRNA intron removal by human tRNA splicing endonuclease.
Mol.Cell, 83, 2023
8HMZ
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BU of 8hmz by Molmil
Cryo-EM structure of the human post-catalytic TSEN/pre-tRNA complex
Descriptor: Chromosome 1 open reading frame 19, isoform CRA_a, MAGNESIUM ION, ...
Authors:Zhang, X, Yang, F, Zhan, X, Shi, Y.
Deposit date:2022-12-06
Release date:2023-04-19
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis of pre-tRNA intron removal by human tRNA splicing endonuclease.
Mol.Cell, 83, 2023
6D9J
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BU of 6d9j by Molmil
Mammalian 80S ribosome with a double translocated CrPV-IRES, P-sitetRNA and eRF1.
Descriptor: 18S rRNA, 28S rRNA, 40S ribosomal protein S12, ...
Authors:Pisareva, V.P, Pisarev, A.V, Fernandez, I.S.
Deposit date:2018-04-30
Release date:2018-06-06
Last modified:2024-12-25
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Dual tRNA mimicry in the Cricket Paralysis Virus IRES uncovers an unexpected similarity with the Hepatitis C Virus IRES.
Elife, 7, 2018
3EP2
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BU of 3ep2 by Molmil
Model of Phe-tRNA(Phe) in the ribosomal pre-accommodated state revealed by cryo-EM
Descriptor: 30S ribosomal protein S12, 50S ribosomal protein L11, Elongation factor Tu, ...
Authors:Frank, J, Li, W, Agirrezabala, X.
Deposit date:2008-09-29
Release date:2008-12-16
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (9 Å)
Cite:Recognition of aminoacyl-tRNA: a common molecular mechanism revealed by cryo-EM.
Embo J., 27, 2008
5NEW
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BU of 5new by Molmil
RNA-RNA base stacking in the crystal structure of an Hfq6:RNA dimer
Descriptor: RNA (5'-R(P*AP*AP*AP*AP*AP*A)-3'), RNA (5'-R(P*UP*U)-3'), RNA-binding protein Hfq, ...
Authors:Schulz, E.C, Barabas, O.
Deposit date:2017-03-12
Release date:2017-10-04
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.511 Å)
Cite:Intermolecular base stacking mediates RNA-RNA interaction in a crystal structure of the RNA chaperone Hfq.
Sci Rep, 7, 2017
3J9Z
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BU of 3j9z by Molmil
Activation of GTP Hydrolysis in mRNA-tRNA Translocation by Elongation Factor G
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Li, W, Liu, Z, Koripella, R.K, Langlois, R, Sanyal, S, Frank, J.
Deposit date:2015-03-27
Release date:2015-07-01
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Activation of GTP hydrolysis in mRNA-tRNA translocation by elongation factor G.
Sci Adv, 1, 2015
4UP7
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BU of 4up7 by Molmil
Crystal structure of Entamoeba histolytica lysyl-tRNA synthetase in complex with lysyl-adenylate
Descriptor: ADENOSINE-5'-[LYSYL-PHOSPHATE], LYSINE--TRNA LIGASE
Authors:Bonnefond, L, Nureki, O.
Deposit date:2014-06-14
Release date:2014-10-29
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.789 Å)
Cite:Crystal Structures of Entamoeba Histolytica Lysyl-tRNA Synthetase Reveal Conformational Changes Upon Lysine Binding and a Specific Helix Bundle Domain.
FEBS Lett., 588, 2014
4UP9
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BU of 4up9 by Molmil
Crystal structure of Entamoeba histolytica lysyl-tRNA synthetase in complex with ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, LYSINE--TRNA LIGASE
Authors:Bonnefond, L, Nureki, O.
Deposit date:2014-06-14
Release date:2014-10-29
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.047 Å)
Cite:Crystal Structures of Entamoeba Histolytica Lysyl-tRNA Synthetase Reveal Conformational Changes Upon Lysine Binding and a Specific Helix Bundle Domain.
FEBS Lett., 588, 2014
2DLC
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BU of 2dlc by Molmil
Crystal structure of the ternary complex of yeast tyrosyl-tRNA synthetase
Descriptor: MAGNESIUM ION, O-(ADENOSINE-5'-O-YL)-N-(L-TYROSYL)PHOSPHORAMIDATE, T-RNA (76-MER), ...
Authors:Tsunoda, M, Kusakabe, Y, Tanaka, N, Nakamura, K.T.
Deposit date:2006-04-18
Release date:2007-06-12
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for recognition of cognate tRNA by tyrosyl-tRNA synthetase from three kingdoms.
Nucleic Acids Res., 35, 2007
9DRS
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BU of 9drs by Molmil
Crystal structure of M. tuberculosis PheRS-tRNA complex bound to inhibitor D-116
Descriptor: 1,2-ETHANEDIOL, 1H-benzimidazol-2-amine, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Gade, P, Chang, C, Forte, B, Wower, J, Gilbert, I.H, Baragana, B, Michalska, K, Joachimiak, A, Center for Structural Biology of Infectious Diseases (CSBID)
Deposit date:2024-09-26
Release date:2025-02-12
Last modified:2025-02-19
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Different chemical scaffolds bind to L-phe site in Mycobacterium tuberculosis Phe-tRNA synthetase.
Eur.J.Med.Chem., 287, 2025
1ASZ
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BU of 1asz by Molmil
THE ACTIVE SITE OF YEAST ASPARTYL-TRNA SYNTHETASE: STRUCTURAL AND FUNCTIONAL ASPECTS OF THE AMINOACYLATION REACTION
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, ASPARTYL-tRNA SYNTHETASE, T-RNA (75-MER)
Authors:Cavarelli, J, Rees, B, Thierry, J.C, Moras, D.
Deposit date:1995-01-19
Release date:1995-05-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:The active site of yeast aspartyl-tRNA synthetase: structural and functional aspects of the aminoacylation reaction.
EMBO J., 13, 1994
8C8V
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BU of 8c8v by Molmil
Priestia megaterium mupirocin-resistant isoleucyl-tRNA synthetase 2 with a fully-resolved C-terminal tRNA-binding domain complexed with an isoleucyl-adenylate analogue
Descriptor: D(-)-TARTARIC ACID, Isoleucine--tRNA ligase, N-[ISOLEUCINYL]-N'-[ADENOSYL]-DIAMINOSUFONE, ...
Authors:Brkic, A, Leibundgut, M, Jablonska, J, Zanki, V, Car, Z, Petrovic Perokovic, V, Ban, N, Gruic-Sovulj, I.
Deposit date:2023-01-21
Release date:2023-08-16
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Antibiotic hyper-resistance in a class I aminoacyl-tRNA synthetase with altered active site signature motif.
Nat Commun, 14, 2023
9J4O
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BU of 9j4o by Molmil
Crystal structure of B. subtilis Leucine tRNA with UAA anticodon
Descriptor: Leucine tRNA_UAA (89-MER), SPERMINE
Authors:Kim, J, Cho, G.
Deposit date:2024-08-09
Release date:2025-07-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of free-state tRNALeu reveal conformational flexibility of Type-II tRNAs.
Rna, 2025
9J4N
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BU of 9j4n by Molmil
Crystal structure of E. coli Leucine tRNA with UAG anticodon
Descriptor: Leucine tRNA_UAG (85-MER)
Authors:Kim, J, Cho, G.
Deposit date:2024-08-09
Release date:2025-07-09
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structures of free-state tRNALeu reveal conformational flexibility of Type-II tRNAs.
Rna, 2025
8C9D
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BU of 8c9d by Molmil
Priestia megaterium W130Q mutant of type 2 isoleucyl-tRNA synthetase complexed with an isoleucyl-adenylate analogue
Descriptor: D(-)-TARTARIC ACID, Isoleucine--tRNA ligase, N-[ISOLEUCINYL]-N'-[ADENOSYL]-DIAMINOSUFONE, ...
Authors:Brkic, A, Leibundgut, M, Jablonska, J, Zanki, V, Car, Z, Petrovic Perokovic, V, Ban, N, Gruic-Sovulj, I.
Deposit date:2023-01-21
Release date:2023-08-16
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Antibiotic hyper-resistance in a class I aminoacyl-tRNA synthetase with altered active site signature motif.
Nat Commun, 14, 2023
7RSM
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BU of 7rsm by Molmil
Crystal structure of pyrrolysyl-tRNA synthetase (N346D/C348S/Y384F) in complex with o-Chlorophenylalanine and AMP-PNP
Descriptor: 2-chloro-L-phenylalanine, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Pyrrolysine--tRNA ligase
Authors:Yang, K, Liu, W.
Deposit date:2021-08-11
Release date:2022-07-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:A Designed, Highly Efficient Pyrrolysyl-tRNA Synthetase Mutant Binds o-Chlorophenylalanine Using Two Halogen Bonds.
J.Mol.Biol., 434, 2022

238582

数据于2025-07-09公开中

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