PDB: 79225 resultsInfo pagesStatus searchChemie searchBIRD

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8BHD	N-terminal domain of Plasmodium berghei glutamyl-tRNA synthetase (Tbxo4 derivative crystal structure) Descriptor: GLYCEROL, Glutamate--tRNA ligase, SULFATE ION, ... Authors: Benas, P, Jaramillo Ponce, J.R, Legrand, P, Frugier, M, Sauter, C. Deposit date: 2022-10-31 Release date: 2023-01-25 Last modified: 2024-06-19 Method: X-RAY DIFFRACTION (3.17 Å) Cite: Solution X-ray scattering highlights discrepancies in Plasmodium multi-aminoacyl-tRNA synthetase complexes. Protein Sci., 32, 2023
9QRP	Thermus thermophilus seryl-tRNA synthetase bound to tRNA(ser)(GGA) and seryl-adenylate analogue. Descriptor: 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, MANGANESE (II) ION, SULFATE ION, ... Authors: Cusack, S. Deposit date: 2025-04-04 Release date: 2025-05-14 Method: X-RAY DIFFRACTION (2.7 Å) Cite: The crystal structure of the ternary complex of T.thermophilus seryl-tRNA synthetase with tRNA(Ser) and a seryl-adenylate analogue reveals a conformational switch in the active site. EMBO J, 15, 1996
9LS8	Crystal structure of peptidyl-tRNA hydrolase from Enterococcus faecium at 1.22 A Descriptor: 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, Peptidyl-tRNA hydrolase, ... Authors: Pandey, R, Zohib, M, Arora, A. Deposit date: 2025-02-04 Release date: 2025-02-19 Method: X-RAY DIFFRACTION (1.22 Å) Cite: Characterization of structure of peptidyl-tRNA hydrolase from Enterococcus faecium and its inhibition by a pyrrolinone compound. Int J Biol Macromol, 275, 2024
8T8B	Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site formyl-MAI-tripeptidyl-tRNA analog ACCA-IAMf at 2.65A resolution Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ... Authors: Thaler, J, Syroegin, E.A, Breuker, K, Polikanov, Y.S, Micura, R. Deposit date: 2023-06-22 Release date: 2023-07-19 Last modified: 2025-03-19 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Practical Synthesis of N -Formylmethionylated Peptidyl-tRNA Mimics. Acs Chem.Biol., 18, 2023
8T8C	Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site formyl-MFI-tripeptidyl-tRNA analog ACCA-IFMf at 2.60A resolution Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ... Authors: Thaler, J, Syroegin, E.A, Breuker, K, Polikanov, Y.S, Micura, R. Deposit date: 2023-06-22 Release date: 2023-07-19 Last modified: 2025-03-19 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Practical Synthesis of N -Formylmethionylated Peptidyl-tRNA Mimics. Acs Chem.Biol., 18, 2023
8AP4	Structure of Escherischia coli heat shock protein Hsp15 in complex with ribosomal 50S subunits bearing peptidyl-tRNA Descriptor: 23S rRNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... Authors: Safdari, H.A, Wilson, D.N. Deposit date: 2022-08-09 Release date: 2022-11-16 Last modified: 2025-03-12 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structure of Escherichia coli heat shock protein Hsp15 in complex with the ribosomal 50S subunit bearing peptidyl-tRNA. Nucleic Acids Res., 50, 2022
7XPL	Crystal structure of a C/D-free RNA-guided RNA 2'-O-methyltransferase Descriptor: BMG3 RNA strand A, BMG3 RNA strand B, C/D box methylation guide ribonucleoprotein complex aNOP56 subunit, ... Authors: Wang, J, Ye, K. Deposit date: 2022-05-04 Release date: 2022-10-05 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.213 Å) Cite: Methylation guide RNAs without box C/D motifs. Rna, 28, 2022
5I8Q	S. cerevisiae Prp43 in complex with RNA and ADPNP Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43, ... Authors: He, Y, Nielsen, K.H, Andersen, G.R. Deposit date: 2016-02-19 Release date: 2017-02-01 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (4.2 Å) Cite: Structure of the DEAH/RHA ATPase Prp43p bound to RNA implicates a pair of hairpins and motif Va in translocation along RNA. RNA, 23, 2017
6D90	Mammalian 80S ribosome with a double translocated CrPV-IRES, P-site tRNA and eRF1. Descriptor: 18S rRNA, 28S rRNA, 40S ribosomal protein S12, ... Authors: Pisareva, V.P, Pisarev, A.V, Fernandez, I.S. Deposit date: 2018-04-27 Release date: 2018-06-06 Last modified: 2024-12-25 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Dual tRNA mimicry in the Cricket Paralysis Virus IRES uncovers an unexpected similarity with the Hepatitis C Virus IRES. Elife, 7, 2018
8HMY	Cryo-EM structure of the human pre-catalytic TSEN/pre-tRNA complex Descriptor: Chromosome 1 open reading frame 19, isoform CRA_a, MAGNESIUM ION, ... Authors: Zhang, X, Yang, F, Zhan, X, Shi, Y. Deposit date: 2022-12-06 Release date: 2023-04-19 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (2.94 Å) Cite: Structural basis of pre-tRNA intron removal by human tRNA splicing endonuclease. Mol.Cell, 83, 2023
8HMZ	Cryo-EM structure of the human post-catalytic TSEN/pre-tRNA complex Descriptor: Chromosome 1 open reading frame 19, isoform CRA_a, MAGNESIUM ION, ... Authors: Zhang, X, Yang, F, Zhan, X, Shi, Y. Deposit date: 2022-12-06 Release date: 2023-04-19 Last modified: 2024-05-29 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Structural basis of pre-tRNA intron removal by human tRNA splicing endonuclease. Mol.Cell, 83, 2023
6D9J	Mammalian 80S ribosome with a double translocated CrPV-IRES, P-sitetRNA and eRF1. Descriptor: 18S rRNA, 28S rRNA, 40S ribosomal protein S12, ... Authors: Pisareva, V.P, Pisarev, A.V, Fernandez, I.S. Deposit date: 2018-04-30 Release date: 2018-06-06 Last modified: 2024-12-25 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Dual tRNA mimicry in the Cricket Paralysis Virus IRES uncovers an unexpected similarity with the Hepatitis C Virus IRES. Elife, 7, 2018
3EP2	Model of Phe-tRNA(Phe) in the ribosomal pre-accommodated state revealed by cryo-EM Descriptor: 30S ribosomal protein S12, 50S ribosomal protein L11, Elongation factor Tu, ... Authors: Frank, J, Li, W, Agirrezabala, X. Deposit date: 2008-09-29 Release date: 2008-12-16 Last modified: 2024-02-21 Method: ELECTRON MICROSCOPY (9 Å) Cite: Recognition of aminoacyl-tRNA: a common molecular mechanism revealed by cryo-EM. Embo J., 27, 2008
5NEW	RNA-RNA base stacking in the crystal structure of an Hfq6:RNA dimer Descriptor: RNA (5'-R(P*AP*AP*AP*AP*AP*A)-3'), RNA (5'-R(P*UP*U)-3'), RNA-binding protein Hfq, ... Authors: Schulz, E.C, Barabas, O. Deposit date: 2017-03-12 Release date: 2017-10-04 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.511 Å) Cite: Intermolecular base stacking mediates RNA-RNA interaction in a crystal structure of the RNA chaperone Hfq. Sci Rep, 7, 2017
3J9Z	Activation of GTP Hydrolysis in mRNA-tRNA Translocation by Elongation Factor G Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... Authors: Li, W, Liu, Z, Koripella, R.K, Langlois, R, Sanyal, S, Frank, J. Deposit date: 2015-03-27 Release date: 2015-07-01 Last modified: 2024-02-21 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Activation of GTP hydrolysis in mRNA-tRNA translocation by elongation factor G. Sci Adv, 1, 2015
4UP7	Crystal structure of Entamoeba histolytica lysyl-tRNA synthetase in complex with lysyl-adenylate Descriptor: ADENOSINE-5'-[LYSYL-PHOSPHATE], LYSINE--TRNA LIGASE Authors: Bonnefond, L, Nureki, O. Deposit date: 2014-06-14 Release date: 2014-10-29 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.789 Å) Cite: Crystal Structures of Entamoeba Histolytica Lysyl-tRNA Synthetase Reveal Conformational Changes Upon Lysine Binding and a Specific Helix Bundle Domain. FEBS Lett., 588, 2014
4UP9	Crystal structure of Entamoeba histolytica lysyl-tRNA synthetase in complex with ATP Descriptor: ADENOSINE-5'-TRIPHOSPHATE, LYSINE--TRNA LIGASE Authors: Bonnefond, L, Nureki, O. Deposit date: 2014-06-14 Release date: 2014-10-29 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3.047 Å) Cite: Crystal Structures of Entamoeba Histolytica Lysyl-tRNA Synthetase Reveal Conformational Changes Upon Lysine Binding and a Specific Helix Bundle Domain. FEBS Lett., 588, 2014
2DLC	Crystal structure of the ternary complex of yeast tyrosyl-tRNA synthetase Descriptor: MAGNESIUM ION, O-(ADENOSINE-5'-O-YL)-N-(L-TYROSYL)PHOSPHORAMIDATE, T-RNA (76-MER), ... Authors: Tsunoda, M, Kusakabe, Y, Tanaka, N, Nakamura, K.T. Deposit date: 2006-04-18 Release date: 2007-06-12 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural basis for recognition of cognate tRNA by tyrosyl-tRNA synthetase from three kingdoms. Nucleic Acids Res., 35, 2007
9DRS	Crystal structure of M. tuberculosis PheRS-tRNA complex bound to inhibitor D-116 Descriptor: 1,2-ETHANEDIOL, 1H-benzimidazol-2-amine, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... Authors: Gade, P, Chang, C, Forte, B, Wower, J, Gilbert, I.H, Baragana, B, Michalska, K, Joachimiak, A, Center for Structural Biology of Infectious Diseases (CSBID) Deposit date: 2024-09-26 Release date: 2025-02-12 Last modified: 2025-02-19 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Different chemical scaffolds bind to L-phe site in Mycobacterium tuberculosis Phe-tRNA synthetase. Eur.J.Med.Chem., 287, 2025
1ASZ	THE ACTIVE SITE OF YEAST ASPARTYL-TRNA SYNTHETASE: STRUCTURAL AND FUNCTIONAL ASPECTS OF THE AMINOACYLATION REACTION Descriptor: ADENOSINE-5'-TRIPHOSPHATE, ASPARTYL-tRNA SYNTHETASE, T-RNA (75-MER) Authors: Cavarelli, J, Rees, B, Thierry, J.C, Moras, D. Deposit date: 1995-01-19 Release date: 1995-05-08 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (3 Å) Cite: The active site of yeast aspartyl-tRNA synthetase: structural and functional aspects of the aminoacylation reaction. EMBO J., 13, 1994
8C8V	Priestia megaterium mupirocin-resistant isoleucyl-tRNA synthetase 2 with a fully-resolved C-terminal tRNA-binding domain complexed with an isoleucyl-adenylate analogue Descriptor: D(-)-TARTARIC ACID, Isoleucine--tRNA ligase, N-[ISOLEUCINYL]-N'-[ADENOSYL]-DIAMINOSUFONE, ... Authors: Brkic, A, Leibundgut, M, Jablonska, J, Zanki, V, Car, Z, Petrovic Perokovic, V, Ban, N, Gruic-Sovulj, I. Deposit date: 2023-01-21 Release date: 2023-08-16 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Antibiotic hyper-resistance in a class I aminoacyl-tRNA synthetase with altered active site signature motif. Nat Commun, 14, 2023
9J4O	Crystal structure of B. subtilis Leucine tRNA with UAA anticodon Descriptor: Leucine tRNA_UAA (89-MER), SPERMINE Authors: Kim, J, Cho, G. Deposit date: 2024-08-09 Release date: 2025-07-09 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Crystal structures of free-state tRNALeu reveal conformational flexibility of Type-II tRNAs. Rna, 2025
9J4N	Crystal structure of E. coli Leucine tRNA with UAG anticodon Descriptor: Leucine tRNA_UAG (85-MER) Authors: Kim, J, Cho, G. Deposit date: 2024-08-09 Release date: 2025-07-09 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Crystal structures of free-state tRNALeu reveal conformational flexibility of Type-II tRNAs. Rna, 2025
8C9D	Priestia megaterium W130Q mutant of type 2 isoleucyl-tRNA synthetase complexed with an isoleucyl-adenylate analogue Descriptor: D(-)-TARTARIC ACID, Isoleucine--tRNA ligase, N-[ISOLEUCINYL]-N'-[ADENOSYL]-DIAMINOSUFONE, ... Authors: Brkic, A, Leibundgut, M, Jablonska, J, Zanki, V, Car, Z, Petrovic Perokovic, V, Ban, N, Gruic-Sovulj, I. Deposit date: 2023-01-21 Release date: 2023-08-16 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Antibiotic hyper-resistance in a class I aminoacyl-tRNA synthetase with altered active site signature motif. Nat Commun, 14, 2023
7RSM	Crystal structure of pyrrolysyl-tRNA synthetase (N346D/C348S/Y384F) in complex with o-Chlorophenylalanine and AMP-PNP Descriptor: 2-chloro-L-phenylalanine, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Pyrrolysine--tRNA ligase Authors: Yang, K, Liu, W. Deposit date: 2021-08-11 Release date: 2022-07-20 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.15 Å) Cite: A Designed, Highly Efficient Pyrrolysyl-tRNA Synthetase Mutant Binds o-Chlorophenylalanine Using Two Halogen Bonds. J.Mol.Biol., 434, 2022

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