8BHD
 
 | N-terminal domain of Plasmodium berghei glutamyl-tRNA synthetase (Tbxo4 derivative crystal structure) | Descriptor: | GLYCEROL, Glutamate--tRNA ligase, SULFATE ION, ... | Authors: | Benas, P, Jaramillo Ponce, J.R, Legrand, P, Frugier, M, Sauter, C. | Deposit date: | 2022-10-31 | Release date: | 2023-01-25 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (3.17 Å) | Cite: | Solution X-ray scattering highlights discrepancies in Plasmodium multi-aminoacyl-tRNA synthetase complexes. Protein Sci., 32, 2023
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9QRP
 
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9LS8
 
 | Crystal structure of peptidyl-tRNA hydrolase from Enterococcus faecium at 1.22 A | Descriptor: | 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, Peptidyl-tRNA hydrolase, ... | Authors: | Pandey, R, Zohib, M, Arora, A. | Deposit date: | 2025-02-04 | Release date: | 2025-02-19 | Method: | X-RAY DIFFRACTION (1.22 Å) | Cite: | Characterization of structure of peptidyl-tRNA hydrolase from Enterococcus faecium and its inhibition by a pyrrolinone compound. Int J Biol Macromol, 275, 2024
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8T8B
 
 | Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site formyl-MAI-tripeptidyl-tRNA analog ACCA-IAMf at 2.65A resolution | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ... | Authors: | Thaler, J, Syroegin, E.A, Breuker, K, Polikanov, Y.S, Micura, R. | Deposit date: | 2023-06-22 | Release date: | 2023-07-19 | Last modified: | 2025-03-19 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Practical Synthesis of N -Formylmethionylated Peptidyl-tRNA Mimics. Acs Chem.Biol., 18, 2023
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8T8C
 
 | Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site aminoacyl-tRNA analog ACC-PMN, and P-site formyl-MFI-tripeptidyl-tRNA analog ACCA-IFMf at 2.60A resolution | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ... | Authors: | Thaler, J, Syroegin, E.A, Breuker, K, Polikanov, Y.S, Micura, R. | Deposit date: | 2023-06-22 | Release date: | 2023-07-19 | Last modified: | 2025-03-19 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Practical Synthesis of N -Formylmethionylated Peptidyl-tRNA Mimics. Acs Chem.Biol., 18, 2023
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8AP4
 
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7XPL
 
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5I8Q
 
 | S. cerevisiae Prp43 in complex with RNA and ADPNP | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43, ... | Authors: | He, Y, Nielsen, K.H, Andersen, G.R. | Deposit date: | 2016-02-19 | Release date: | 2017-02-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (4.2 Å) | Cite: | Structure of the DEAH/RHA ATPase Prp43p bound to RNA implicates a pair of hairpins and motif Va in translocation along RNA. RNA, 23, 2017
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6D90
 
 | Mammalian 80S ribosome with a double translocated CrPV-IRES, P-site tRNA and eRF1. | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S12, ... | Authors: | Pisareva, V.P, Pisarev, A.V, Fernandez, I.S. | Deposit date: | 2018-04-27 | Release date: | 2018-06-06 | Last modified: | 2024-12-25 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Dual tRNA mimicry in the Cricket Paralysis Virus IRES uncovers an unexpected similarity with the Hepatitis C Virus IRES. Elife, 7, 2018
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8HMY
 
 | Cryo-EM structure of the human pre-catalytic TSEN/pre-tRNA complex | Descriptor: | Chromosome 1 open reading frame 19, isoform CRA_a, MAGNESIUM ION, ... | Authors: | Zhang, X, Yang, F, Zhan, X, Shi, Y. | Deposit date: | 2022-12-06 | Release date: | 2023-04-19 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.94 Å) | Cite: | Structural basis of pre-tRNA intron removal by human tRNA splicing endonuclease. Mol.Cell, 83, 2023
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8HMZ
 
 | Cryo-EM structure of the human post-catalytic TSEN/pre-tRNA complex | Descriptor: | Chromosome 1 open reading frame 19, isoform CRA_a, MAGNESIUM ION, ... | Authors: | Zhang, X, Yang, F, Zhan, X, Shi, Y. | Deposit date: | 2022-12-06 | Release date: | 2023-04-19 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural basis of pre-tRNA intron removal by human tRNA splicing endonuclease. Mol.Cell, 83, 2023
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6D9J
 
 | Mammalian 80S ribosome with a double translocated CrPV-IRES, P-sitetRNA and eRF1. | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S12, ... | Authors: | Pisareva, V.P, Pisarev, A.V, Fernandez, I.S. | Deposit date: | 2018-04-30 | Release date: | 2018-06-06 | Last modified: | 2024-12-25 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Dual tRNA mimicry in the Cricket Paralysis Virus IRES uncovers an unexpected similarity with the Hepatitis C Virus IRES. Elife, 7, 2018
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3EP2
 
 | Model of Phe-tRNA(Phe) in the ribosomal pre-accommodated state revealed by cryo-EM | Descriptor: | 30S ribosomal protein S12, 50S ribosomal protein L11, Elongation factor Tu, ... | Authors: | Frank, J, Li, W, Agirrezabala, X. | Deposit date: | 2008-09-29 | Release date: | 2008-12-16 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (9 Å) | Cite: | Recognition of aminoacyl-tRNA: a common molecular mechanism revealed by cryo-EM. Embo J., 27, 2008
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5NEW
 
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3J9Z
 
 | Activation of GTP Hydrolysis in mRNA-tRNA Translocation by Elongation Factor G | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Li, W, Liu, Z, Koripella, R.K, Langlois, R, Sanyal, S, Frank, J. | Deposit date: | 2015-03-27 | Release date: | 2015-07-01 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Activation of GTP hydrolysis in mRNA-tRNA translocation by elongation factor G. Sci Adv, 1, 2015
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4UP7
 
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4UP9
 
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2DLC
 
 | Crystal structure of the ternary complex of yeast tyrosyl-tRNA synthetase | Descriptor: | MAGNESIUM ION, O-(ADENOSINE-5'-O-YL)-N-(L-TYROSYL)PHOSPHORAMIDATE, T-RNA (76-MER), ... | Authors: | Tsunoda, M, Kusakabe, Y, Tanaka, N, Nakamura, K.T. | Deposit date: | 2006-04-18 | Release date: | 2007-06-12 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for recognition of cognate tRNA by tyrosyl-tRNA synthetase from three kingdoms. Nucleic Acids Res., 35, 2007
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9DRS
 
 | Crystal structure of M. tuberculosis PheRS-tRNA complex bound to inhibitor D-116 | Descriptor: | 1,2-ETHANEDIOL, 1H-benzimidazol-2-amine, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | Authors: | Gade, P, Chang, C, Forte, B, Wower, J, Gilbert, I.H, Baragana, B, Michalska, K, Joachimiak, A, Center for Structural Biology of Infectious Diseases (CSBID) | Deposit date: | 2024-09-26 | Release date: | 2025-02-12 | Last modified: | 2025-02-19 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Different chemical scaffolds bind to L-phe site in Mycobacterium tuberculosis Phe-tRNA synthetase. Eur.J.Med.Chem., 287, 2025
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1ASZ
 
 | THE ACTIVE SITE OF YEAST ASPARTYL-TRNA SYNTHETASE: STRUCTURAL AND FUNCTIONAL ASPECTS OF THE AMINOACYLATION REACTION | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ASPARTYL-tRNA SYNTHETASE, T-RNA (75-MER) | Authors: | Cavarelli, J, Rees, B, Thierry, J.C, Moras, D. | Deposit date: | 1995-01-19 | Release date: | 1995-05-08 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The active site of yeast aspartyl-tRNA synthetase: structural and functional aspects of the aminoacylation reaction. EMBO J., 13, 1994
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8C8V
 
 | Priestia megaterium mupirocin-resistant isoleucyl-tRNA synthetase 2 with a fully-resolved C-terminal tRNA-binding domain complexed with an isoleucyl-adenylate analogue | Descriptor: | D(-)-TARTARIC ACID, Isoleucine--tRNA ligase, N-[ISOLEUCINYL]-N'-[ADENOSYL]-DIAMINOSUFONE, ... | Authors: | Brkic, A, Leibundgut, M, Jablonska, J, Zanki, V, Car, Z, Petrovic Perokovic, V, Ban, N, Gruic-Sovulj, I. | Deposit date: | 2023-01-21 | Release date: | 2023-08-16 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Antibiotic hyper-resistance in a class I aminoacyl-tRNA synthetase with altered active site signature motif. Nat Commun, 14, 2023
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9J4O
 
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9J4N
 
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8C9D
 
 | Priestia megaterium W130Q mutant of type 2 isoleucyl-tRNA synthetase complexed with an isoleucyl-adenylate analogue | Descriptor: | D(-)-TARTARIC ACID, Isoleucine--tRNA ligase, N-[ISOLEUCINYL]-N'-[ADENOSYL]-DIAMINOSUFONE, ... | Authors: | Brkic, A, Leibundgut, M, Jablonska, J, Zanki, V, Car, Z, Petrovic Perokovic, V, Ban, N, Gruic-Sovulj, I. | Deposit date: | 2023-01-21 | Release date: | 2023-08-16 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Antibiotic hyper-resistance in a class I aminoacyl-tRNA synthetase with altered active site signature motif. Nat Commun, 14, 2023
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7RSM
 
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