PDB: 243531 resultsInfo pagesStatus searchChemie searchBIRD

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8VCG	Mutant Src SH2 domain in complex with phosphotyrosine Descriptor: Isoform 3 of Proto-oncogene tyrosine-protein kinase Src, O-PHOSPHOTYROSINE Authors: Hashem, A, Nyovanie, S, Oltean, N, Patskovska, L, Patskovsky, Y, Krogsgaard, M. Deposit date: 2023-12-14 Release date: 2025-01-29 Method: X-RAY DIFFRACTION (1.61 Å) Cite: Engineered Mutant Src Sh2 Domain To Be Published
5VDS	Human cyclic GMP-AMP synthase (cGAS) in complex with 3',3'-cdUMP Descriptor: 3',3'-cdUMP, Cyclic GMP-AMP synthase, ZINC ION Authors: Byrnes, L.J, Hall, J.D. Deposit date: 2017-04-03 Release date: 2017-09-27 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.766 Å) Cite: The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition. Protein Sci., 26, 2017
8VW3	Structure of the non-symmetric capsomer of the Drosophila retrotransposon Copia capsid Descriptor: Copia VLP protein Authors: Liu, Y, Kelch, B.A. Deposit date: 2024-01-31 Release date: 2025-02-12 Last modified: 2025-04-09 Method: ELECTRON MICROSCOPY (3.47 Å) Cite: Capsid transfer of the retrotransposon Copia controls structural synaptic plasticity in Drosophila. Plos Biol., 23, 2025
5I9I	Crystal structure of LP_PLA2 in complex with Darapladib Descriptor: N-[2-(diethylamino)ethyl]-2-{2-[(4-fluorobenzyl)sulfanyl]-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl}-N-{[ 4'-(trifluoromethyl)biphenyl-4-yl]methyl}acetamide, Platelet-activating factor acetylhydrolase, SULFATE ION Authors: Liu, Q.F, Xu, Y.C. Deposit date: 2016-02-20 Release date: 2016-06-15 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural and Thermodynamic Characterization of Protein-Ligand Interactions Formed between Lipoprotein-Associated Phospholipase A2 and Inhibitors J.Med.Chem., 59, 2016
8W3Q	Crystal structure of prefusion-stabilized hMPV F protein UFCM1-P2-iSS Descriptor: prefusion-stabilized hMPV F protein UFCM1-P2-iSS Authors: Lee, Y.Z, Stanfield, R.L, Wilson, I.A, Zhu, J. Deposit date: 2024-02-22 Release date: 2025-01-15 Method: X-RAY DIFFRACTION (5.99 Å) Cite: Rational design of uncleaved prefusion-closed trimer vaccines for human respiratory syncytial virus and metapneumovirus. Nat Commun, 15, 2024
7MAP	Drug Resistant HIV-1 Protease (L10I, V32I, L33F, K45I, M46I, I50V, A71V, V82I, I84V) in Complex with DRV Descriptor: (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, Protease Authors: Lockbaum, G.J, Schiffer, C.A. Deposit date: 2021-03-31 Release date: 2022-11-09 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.951 Å) Cite: Drug Resistant HIV-1 Protease (L10I, V32I, L33F, K45I, M46I, I50V, A71V, V82I, I84V) in Complex with DRV To Be Published
8VHG	Structure of the BMAL1/HIF2A heterodimer in Complex with DNA Descriptor: Basic helix-loop-helix ARNT-like protein 1, Endothelial PAS domain-containing protein 1, Forward strand DNA containing HRE motif, ... Authors: Li, T, Tsai, K.L. Deposit date: 2024-01-01 Release date: 2025-02-12 Last modified: 2025-06-04 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: BMAL1-HIF2A heterodimer modulates circadian variations of myocardial injury. Nature, 641, 2025
8VTH	DUF2169 domain-containing protein from Vibrio xiamenensis Descriptor: 1,2-ETHANEDIOL, DUF2169 domain-containing protein Authors: Sachar, K, Whitney, J.C, Prehna, G, Kim, Y. Deposit date: 2024-01-26 Release date: 2025-02-12 Last modified: 2025-06-18 Method: X-RAY DIFFRACTION (1.85 Å) Cite: A conserved chaperone protein is required for the formation of a noncanonical type VI secretion system spike tip complex. J.Biol.Chem., 301, 2025
5VYP	Crystal structure of the Plant Defensin NsD7 bound to PIP2 Descriptor: Defensin NsD7, GLYCEROL, SULFATE ION, ... Authors: Jarva, M, Lay, F.T, Hulett, M, Kvansakul, M. Deposit date: 2017-05-25 Release date: 2017-08-02 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structure of the defensin NsD7 in complex with PIP2 reveals that defensin : lipid oligomer topologies are dependent on lipid type. FEBS Lett., 591, 2017
8VWG	Structure of the Drosophila retrotransposon Copia capsid Descriptor: Copia VLP protein Authors: Liu, Y, Kelch, B.A. Deposit date: 2024-02-01 Release date: 2025-02-12 Last modified: 2025-04-09 Method: ELECTRON MICROSCOPY (4.17 Å) Cite: Capsid transfer of the retrotransposon Copia controls structural synaptic plasticity in Drosophila. Plos Biol., 23, 2025
5IGE	Crystal structure of Staphylococcal nuclease variant Delta+PHS T62H/V99D at cryogenic temperature Descriptor: CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease Authors: Robinson, A.C, Schlessman, J.L, Garcia-Moreno E, B. Deposit date: 2016-02-27 Release date: 2016-03-09 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure of Staphylococcal nuclease variant Delta+PHS T62H/V99D at cryogenic temperature To be Published
6VUE	wild-type choline TMA lyase in complex with 1-methyl-1,2,3,6-tetrahydropyridin-3-ol Descriptor: (3S)-1-methyl-1,2,3,6-tetrahydropyridin-3-ol, Choline trimethylamine-lyase, SODIUM ION Authors: Ortega, M.A, Drennan, C.L. Deposit date: 2020-02-15 Release date: 2020-11-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Discovery of a Cyclic Choline Analog That Inhibits Anaerobic Choline Metabolism by Human Gut Bacteria. Acs Med.Chem.Lett., 11, 2020
7MBH	Structure of Human Enolase 2 in complex with phosphoserine Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Gamma-enolase, ... Authors: Leonard, P.G, Hicks, K.G, Rutter, J. Deposit date: 2021-03-31 Release date: 2022-11-09 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase. Science, 379, 2023
6W8L	Crystal structure of JAK1 kinase with compound 10 Descriptor: N-[(1S,5R)-3-(5-fluoro-2-{[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]amino}pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-1-yl]cyclopropanecarboxamide, Tyrosine-protein kinase JAK1 Authors: Vajdos, F.F. Deposit date: 2020-03-20 Release date: 2020-04-08 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.11 Å) Cite: Design and optimization of a series of 4-(3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-2-amines: Dual inhibitors of TYK2 and JAK1. Bioorg.Med.Chem., 28, 2020
8VVZ	Structure of the three-fold capsomer of the Drosophila retrotransposon Copia capsid Descriptor: Copia VLP protein Authors: Liu, Y, Kelch, B.A. Deposit date: 2024-01-31 Release date: 2025-02-12 Last modified: 2025-04-09 Method: ELECTRON MICROSCOPY (3.41 Å) Cite: Capsid transfer of the retrotransposon Copia controls structural synaptic plasticity in Drosophila. Plos Biol., 23, 2025
7MAQ	Drug Resistant HIV-1 Protease (L10F, V32I, L33F, K45I, A71V, V82I, I84V) in Complex with DRV Descriptor: (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, Protease, SULFATE ION Authors: Lockbaum, G.J, Schiffer, C.A. Deposit date: 2021-03-31 Release date: 2022-11-09 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.93 Å) Cite: Drug Resistant HIV-1 Protease (L10F, V32I, L33F, K45I, A71V, V82I, I84V) in Complex with DRV To Be Published
8VVW	Structure of the five-fold capsomer of the Drosophila retrotransposon Copia capsid Descriptor: Copia VLP protein Authors: Liu, Y, Kelch, B.A. Deposit date: 2024-01-31 Release date: 2025-02-12 Last modified: 2025-05-14 Method: ELECTRON MICROSCOPY (3.29 Å) Cite: Capsid transfer of the retrotransposon Copia controls structural synaptic plasticity in Drosophila. Plos Biol., 23, 2025
5IGP	Macrolide 2'-phosphotransferase type I - complex with GDP and erythromycin Descriptor: ERYTHROMYCIN A, GUANOSINE-5'-DIPHOSPHATE, ISOPROPYL ALCOHOL, ... Authors: Berghuis, A.M, Fong, D.H. Deposit date: 2016-02-28 Release date: 2017-04-26 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural Basis for Kinase-Mediated Macrolide Antibiotic Resistance. Structure, 25, 2017
5VZJ	STRUCTURE OF A TWELVE COMPONENT MPP6-NUCLEAR RNA EXOSOME COMPLEX BOUND TO RNA Descriptor: Exosome complex component CSL4, Exosome complex component MTR3, Exosome complex component RRP4, ... Authors: Lima, C.D, Wasmuth, E.V. Deposit date: 2017-05-28 Release date: 2017-08-02 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Structure and reconstitution of yeast Mpp6-nuclear exosome complexes reveals that Mpp6 stimulates RNA decay and recruits the Mtr4 helicase. Elife, 6, 2017
8VZ6	PbAbiF dimer bound to ncRNA Descriptor: Abi family protein, AbiF ncRNA Authors: Wilkinson, M.E, Zilberzwige-Tal, S, Altae-Tran, H, Zhang, F. Deposit date: 2024-02-10 Release date: 2025-02-12 Method: ELECTRON MICROSCOPY (3.56 Å) Cite: Emergence of a CRISPR RNA-guiding mechanism from a type III toxin-antitoxin system To Be Published
6WBD	Crystal Structure of Lysyl-tRNA synthetase from Stenotrophomonas maltophilia with bound L-lysine Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, LYSINE, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2020-03-26 Release date: 2020-04-08 Last modified: 2025-10-22 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Crystal Structure of Lysyl-tRNA synthetase from Stenotrophomonas maltophilia with bound L-lysine to be published
5IGZ	Macrolide 2'-phosphotransferase type II - complex with GDP and spiramycin Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Macrolide 2'-phosphotransferase II, ... Authors: Berghuis, A.M, Fong, D.H. Deposit date: 2016-02-28 Release date: 2017-04-26 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural Basis for Kinase-Mediated Macrolide Antibiotic Resistance. Structure, 25, 2017
5IAV	Mechanistic and Structural Analysis of Substrate Recognition and Cofactor Binding by an Unusual Bacterial Prolyl Hydroxylase - Co-BaP4H-MLI Descriptor: COBALT (II) ION, MALONATE ION, Procollagen-Proline Dioxygenase Authors: Schnicker, N.J, Dey, M. Deposit date: 2016-02-21 Release date: 2016-04-27 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Bacillus anthracis Prolyl 4-Hydroxylase Modifies Collagen-like Substrates in Asymmetric Patterns. J.Biol.Chem., 291, 2016
5W0M	Structure of human TUT7 catalytic module (CM) in complex with U5 RNA Descriptor: IODIDE ION, SULFATE ION, Terminal uridylyltransferase 7, ... Authors: Faehnle, C.R, Walleshauser, J, Joshua-Tor, L. Deposit date: 2017-05-31 Release date: 2017-06-28 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.298 Å) Cite: Multi-domain utilization by TUT4 and TUT7 in control of let-7 biogenesis. Nat. Struct. Mol. Biol., 24, 2017
7MA5	HIV-1 Protease (I84V) in Complex with UMass4 Descriptor: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-3-{(1,3-benzodioxol-5-ylsulfonyl)[(2S)-2-methylbutyl]amino}-1-benzyl-2-hydroxypropyl]carbamate, Protease, SULFATE ION Authors: Lockbaum, G.J, Schiffer, C.A. Deposit date: 2021-03-31 Release date: 2022-11-09 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.977 Å) Cite: HIV-1 Protease (I84V) in Complex with UMass4 To Be Published

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