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9AVS
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BU of 9avs by Molmil
Human alpha-galactosidase A in complex with saposin B
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-galactosidase A, ...
Authors:Sawyer, T.K, Garman, S.C.
Deposit date:2024-03-04
Release date:2024-04-17
Last modified:2024-04-24
Method:X-RAY DIFFRACTION (3.53 Å)
Cite:Human Saposin B Ligand Binding and Presentation to alpha-Galactosidase A.
Biorxiv, 2024
9AVQ
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BU of 9avq by Molmil
Crystal structure of SARS-CoV-2 main protease A191T mutant in complex with an inhibitor Nirmatrelvir
Descriptor: (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5, DI(HYDROXYETHYL)ETHER
Authors:Bulut, H, Hattori, S, Hayashi, H, Hasegawa, K, Li, M, Wlodawer, A, Tamamura, H, Mitsuya, H.
Deposit date:2024-03-04
Release date:2024-04-24
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Structural and virologic mechanism of emergence of main protease inhibitor-resistance in SARS-CoV-2 as selected with main protease inhibitors
To Be Published
9AVL
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BU of 9avl by Molmil
Structure of human calcium-sensing receptor in complex with Gi3 protein in nanodiscs
Descriptor: (19R,22S,25R)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zuo, H, Park, J, Frangaj, A, Ye, J, Lu, G, Manning, J.J, Asher, W.B, Lu, Z, Hu, G, Wang, L, Mendez, J, Eng, E, Zhang, Z, Lin, X, Grasucci, R, Hendrickson, W.A, Clarke, O.B, Javitch, J.A, Conigrave, A.D, Fan, Q.R.
Deposit date:2024-03-04
Release date:2024-04-17
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Promiscuous G-protein activation by the calcium-sensing receptor.
Nature, 629, 2024
9AVK
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Structure of long Rib domain from Limosilactobacillus reuteri
Descriptor: SODIUM ION, THIOCYANATE ION, YSIRK signal domain/LPXTG anchor domain surface protein
Authors:Xue, Y, Kang, X.
Deposit date:2024-03-04
Release date:2024-05-08
Last modified:2024-06-12
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Crystal structure of the long Rib domain of the LPXTG-anchored surface protein from Limosilactobacillus reuteri.
Acta Crystallogr.,Sect.F, 80, 2024
9AVG
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BU of 9avg by Molmil
Structure of human calcium-sensing receptor in complex with chimeric Gs (miniGis) protein in nanodiscs
Descriptor: (19R,22S,25R)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zuo, H, Park, J, Frangaj, A, Ye, J, Lu, G, Manning, J.J, Asher, W.B, Lu, Z, Hu, G, Wang, L, Mendez, J, Eng, E, Zhang, Z, Lin, X, Grasucci, R, Hendrickson, W.A, Clarke, O.B, Javitch, J.A, Conigrave, A.D, Fan, Q.R.
Deposit date:2024-03-02
Release date:2024-04-17
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Promiscuous G-protein activation by the calcium-sensing receptor.
Nature, 629, 2024
9AVA
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BU of 9ava by Molmil
Co-crystal structure of human TREX1 in complex with an inhibitor
Descriptor: (2R)-2-[(5R,6S,8R,9aS)-8-amino-1-oxo-5-(2-phenylethyl)hexahydro-1H-pyrrolo[1,2-a][1,4]diazepin-2(3H)-yl]-N-[(3,4-dichlorophenyl)methyl]-4-methylpentanamide, POTASSIUM ION, Three-prime repair exonuclease 1, ...
Authors:Dehghani-Tafti, S, Dong, A, Li, Y, Xu, J, Ackloo, S, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC)
Deposit date:2024-03-01
Release date:2024-05-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Co-crystal structure of human TREX1 in complex with an inhibitor
To be published
9AV7
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BU of 9av7 by Molmil
Crystal structure of CMGC family protein kinase from Trichomonas vaginalis (AMP-PNP)
Descriptor: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, non-specific serine/threonine protein kinase
Authors:Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2024-03-01
Release date:2024-03-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of CMGC family protein kinase from Trichomonas vaginalis (AMP-PNP)
To be published
9AV6
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BU of 9av6 by Molmil
Crystal structure of CMGC family protein kinase from Trichomonas vaginalis (Apo)
Descriptor: SULFATE ION, non-specific serine/threonine protein kinase
Authors:Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2024-03-01
Release date:2024-03-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of CMGC family protein kinase from Trichomonas vaginalis (Apo)
To be published
9AUC
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BU of 9auc by Molmil
Human Amylin1 Receptor in Complex with Gs and human Calcitonin Gene-Related Peptide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Calcitonin gene-related peptide 1, ...
Authors:Cao, J, Belousoff, M.J, Wootten, D.L, Sexton, P.M.
Deposit date:2024-02-28
Release date:2024-04-24
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Cryo-EM Structure of the Human Amylin 1 Receptor in Complex with CGRP and Gs Protein.
Biochemistry, 63, 2024
9ATX
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BU of 9atx by Molmil
AcpB protein from Bacillus anthracis, N-terminal part
Descriptor: Capsule synthesis positive regulator AcpB
Authors:Osipiuk, J, Koehler, T.M, Joachimiak, A, Center for Structural Biology of Infectious Diseases (CSBID)
Deposit date:2024-02-27
Release date:2024-03-06
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:AcpB protein from Bacillus anthracis, N-terminal part
To Be Published
9ATU
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BU of 9atu by Molmil
Bifunctional Inhibition of Neutrophil Elastase by Eap4 from S. aureus
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Extracellular Adherence Protein, Neutrophil elastase, ...
Authors:Mishra, N.B, Herdendorf, T.J, Geisbrecht, B.V.
Deposit date:2024-02-27
Release date:2024-06-12
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Bifunctional Inhibition of Neutrophil Elastase by Eap4 from S. aureus
To Be Published
9ATN
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BU of 9atn by Molmil
NMR structure of the MLL4 PHD2/3 fingers in complex with ASXL2
Descriptor: Histone-lysine N-methyltransferase 2D, Polycomb group protein ASXL2, ZINC ION
Authors:Zhang, Y, Zandian, M, Kutateladze, T.
Deposit date:2024-02-27
Release date:2024-06-19
Method:SOLUTION NMR
Cite:ASXLs binding to the PHD2/3 fingers of MLL4 provides a mechanism for the recruitment of BAP1 to active enhancers.
Nat Commun, 15, 2024
9ATK
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BU of 9atk by Molmil
BIFUNCTIONAL INHIBITION OF NEUTROPHIL ELASTASE AND CATHEPSIN G by Eap4 of S. aureus
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Cathepsin-G, ...
Authors:Mishra, N.B, Herdendorf, T.J, Geisbrecht, B.V.
Deposit date:2024-02-27
Release date:2024-06-12
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Bifunctional Inhibition of Neutrophil Elastase and Cathepsin-G by Eap4 from S. aureus
To Be Published
9ATC
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BU of 9atc by Molmil
ATCASE Y165F MUTANT
Descriptor: ASPARTATE TRANSCARBAMOYLASE, ZINC ION
Authors:Ha, Y, Allewell, N.M.
Deposit date:1998-06-26
Release date:1999-07-26
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Intersubunit hydrogen bond acts as a global molecular switch in Escherichia coli aspartate transcarbamoylase.
Proteins, 33, 1998
9ASX
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BU of 9asx by Molmil
BIFUNCTIONAL INHIBITION OF NEUTROPHIL ELASTASE AND CATHEPSIN G by Eap3 of S. aureus
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Cathepsin-G, ...
Authors:Mishra, N.B, Herdendorf, T.J, Geisbrecht, B.V.
Deposit date:2024-02-26
Release date:2024-06-12
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Bifunctional Inhibition of Neutrophil Elastase and Cathepsin-G by Eap4 from S. aureus
To Be Published
9ASS
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BU of 9ass by Molmil
Crystal Structure of Neutrophil Elastase Inhibited by Eap4 from S. aureus
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Extracellular Adherence Protein, Neutrophil elastase, ...
Authors:Mishra, N.B, Geisbrecht, B.V.
Deposit date:2024-02-26
Release date:2024-06-12
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Bifunctional Inhibition of Neutrophil Elastase and Cathepsin-G by Eap4 from S. aureus
To Be Published
9ASL
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BU of 9asl by Molmil
Human DNA polymerase theta helicase domain tetramer, apo-form
Descriptor: DNA polymerase theta
Authors:Ito, F, Li, Z, Chen, X.S.
Deposit date:2024-02-26
Release date:2024-06-26
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural Basis for Pol theta-Helicase DNA Binding and Microhomology-Mediated End-Joining.
Biorxiv, 2024
9ASK
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BU of 9ask by Molmil
Human DNA polymerase theta helicase domain dimer, apo-form
Descriptor: DNA polymerase theta
Authors:Ito, F, Li, Z, Chen, X.S.
Deposit date:2024-02-26
Release date:2024-06-26
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural Basis for Pol theta-Helicase DNA Binding and Microhomology-Mediated End-Joining.
Biorxiv, 2024
9ASJ
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BU of 9asj by Molmil
Human DNA polymerase theta helicase domain in complex with AMP-PNP, dimer form
Descriptor: DNA polymerase theta, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Ito, F, Li, Z, Chen, X.S.
Deposit date:2024-02-26
Release date:2024-06-26
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural Basis for Pol theta-Helicase DNA Binding and Microhomology-Mediated End-Joining.
Biorxiv, 2024
9ASB
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BU of 9asb by Molmil
Structure of human calcium-sensing receptor in complex with chimeric Gq (miniGisq) protein in nanodiscs
Descriptor: (19R,22S,25R)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zuo, H, Park, J, Frangaj, A, Ye, J, Lu, G, Manning, J.J, Asher, W.B, Lu, Z, Hu, G, Wang, L, Mendez, J, Eng, E, Zhang, Z, Lin, X, Grasucci, R, Hendrickson, W.A, Clarke, O.B, Javitch, J.A, Conigrave, A.D, Fan, Q.R.
Deposit date:2024-02-24
Release date:2024-04-17
Last modified:2024-05-22
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Promiscuous G-protein activation by the calcium-sensing receptor.
Nature, 629, 2024
9ART
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BU of 9art by Molmil
Crystal structure of SARS-CoV-2 main protease A191T mutant in complex with an inhibitor 5h
Descriptor: 3C-like proteinase nsp5, N-[(2S)-1-({(1S,2S)-1-(1,3-benzothiazol-2-yl)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}amino)-4-methyl-1-oxopentan-2-yl]-4-methoxy-1H-indole-2-carboxamide
Authors:Bulut, H, Hattori, S, Hayashi, H, Hasegawa, K, Li, M, Wlodawer, A, Tamamura, H, Mitsuya, H.
Deposit date:2024-02-23
Release date:2024-04-24
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Structural and virologic mechanism of emergence of main protease inhibitor-resistance in SARS-CoV-2 as selected with main protease inhibitors
To Be Published
9ARS
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BU of 9ars by Molmil
Crystal structure of SARS-CoV-2 main protease E166V mutant in complex with an inhibitor TKB-245
Descriptor: (1R,2S,5S)-N-{(1S,2S)-1-(4-fluoro-1,3-benzothiazol-2-yl)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5
Authors:Bulut, H, Hattori, S, Hayashi, H, Hasegawa, K, Li, M, Wlodawer, A, Misumi, S, Tamamura, H, Mitsuya, H.
Deposit date:2024-02-23
Release date:2024-04-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural and virologic mechanism of emergence of main protease inhibitor-resistance in SARS-CoV-2 as selected with main protease inhibitors
To Be Published
9ARQ
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BU of 9arq by Molmil
Crystal structure of SARS-CoV-2 main protease (authentic protein) in complex with an inhibitor TKB-245
Descriptor: (1R,2S,5S)-N-{(1S,2S)-1-(4-fluoro-1,3-benzothiazol-2-yl)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5
Authors:Bulut, H, Hattori, S, Hayashi, H, Hasegawa, K, Li, M, Wlodawer, A, Tamamura, H, Mitsuya, H.
Deposit date:2024-02-23
Release date:2024-04-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and virologic mechanism of emergence of main protease inhibitor-resistance in SARS-CoV-2 as selected with main protease inhibitors
To Be Published
9ARD
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BU of 9ard by Molmil
Structure of Pycsar EcPycC cyclase immunoglobulin-like AGS-C domain
Descriptor: Cytidylate cyclase
Authors:Richmond-Buccola, D, Kranzusch, P.J.
Deposit date:2024-02-23
Release date:2024-06-19
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:A large-scale Type I CBASS antiphage screen identifies the phage prohead protease as a key determinant of immune activation and evasion
To Be Published
9API
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BU of 9api by Molmil
THE S VARIANT OF HUMAN ALPHA1-ANTITRYPSIN, STRUCTURE AND IMPLICATIONS FOR FUNCTION AND METABOLISM
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ALPHA 1-ANTITRYPSIN, ...
Authors:Loebermann, H, Tokuoka, R, Deisenhofer, J, Huber, R.
Deposit date:1988-09-08
Release date:1990-10-15
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:The S variant of human alpha 1-antitrypsin, structure and implications for function and metabolism.
Protein Eng., 2, 1989

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数据于2024-06-26公开中

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