PDB: 6545 resultsInfo pagesStatus searchChemie searchBIRD

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5DEC	Crystal structure of the small alarmone synthetase 1 from Bacillus subtilis Descriptor: GTP pyrophosphokinase YjbM Authors: Steinchen, W, Altegoer, A, Schuhmacher, J.S, Bange, G. Deposit date: 2015-08-25 Release date: 2015-10-28 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2 Å) Cite: Catalytic mechanism and allosteric regulation of an oligomeric (p)ppGpp synthetase by an alarmone. Proc.Natl.Acad.Sci.USA, 112, 2015
5DGS	Crystal structure of human FPPS in complex with the monophosphonate compound 15 Descriptor: Farnesyl pyrophosphate synthase, {(E)-2-[6-(acetylamino)-8-(naphthalen-1-yl)quinolin-2-yl]ethenyl}phosphonic acid Authors: Rondeau, J.M, Bourgier, E, Lehmann, S. Deposit date: 2015-08-28 Release date: 2016-07-13 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.62 Å) Cite: A General Strategy for Targeting Drugs to Bone. Angew.Chem.Int.Ed.Engl., 54, 2015
8G7F	Crystal Structure of FosB from Bacillus cereus with Zinc and 1-hydroxypropylphosphonic acid Descriptor: FORMIC ACID, GLYCEROL, MAGNESIUM ION, ... Authors: Travis, S, Pang, A.H, Tsodikov, O.V, Garneau-Tsodikova, S, Thompson, M.K. Deposit date: 2023-02-16 Release date: 2023-06-14 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.04 Å) Cite: Identification and analysis of small molecule inhibitors of FosB from Staphylococcus aureus. Rsc Med Chem, 14, 2023
8G7G	Crystal Structure of FosB from Bacillus cereus with Zinc and (1-hydroxy-2-methylpropyl)phosphonic acid Descriptor: FORMIC ACID, MAGNESIUM ION, Metallothiol transferase FosB, ... Authors: Travis, S, Pang, A.H, Tsodikov, O.V, Garneau-Tsodikova, S, Thompson, M.K. Deposit date: 2023-02-16 Release date: 2023-06-14 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.23 Å) Cite: Identification and analysis of small molecule inhibitors of FosB from Staphylococcus aureus. Rsc Med Chem, 14, 2023
8GN0	Crystal structure of DCBQ-bound photosystem II complex Descriptor: (3R)-beta,beta-caroten-3-ol, 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, ... Authors: Kamada, S, Nakajima, Y, Shen, J.-R. Deposit date: 2022-08-22 Release date: 2023-07-05 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Structural insights into the action mechanisms of artificial electron acceptors in photosystem II. J.Biol.Chem., 299, 2023
8GN2	Crystal structure of PPBQ-bound photosystem II complex Descriptor: (3R)-beta,beta-caroten-3-ol, 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, ... Authors: Kamada, S, Nakajima, Y, Shen, J.-R. Deposit date: 2022-08-22 Release date: 2023-07-05 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Structural insights into the action mechanisms of artificial electron acceptors in photosystem II. J.Biol.Chem., 299, 2023
8G3F	BceAB-S nucleotide free BceS state 1 Descriptor: Bacitracin export ATP-binding protein BceA, Bacitracin export permease protein BceB, OLEIC ACID, ... Authors: George, N.L, Orlando, B.J. Deposit date: 2023-02-07 Release date: 2023-06-21 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Architecture of a complete Bce-type antimicrobial peptide resistance module. Nat Commun, 14, 2023
8G7H	Crystal Structure of FosB from Bacillus cereus with Zinc and (1-hydroxypropan-2-yl)phosphonic acid Descriptor: FORMIC ACID, GLYCEROL, MAGNESIUM ION, ... Authors: Travis, S, Pang, A.H, Tsodikov, O.V, Garneau-Tsodikova, S, Thompson, M.K. Deposit date: 2023-02-16 Release date: 2023-06-14 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.81 Å) Cite: Identification and analysis of small molecule inhibitors of FosB from Staphylococcus aureus. Rsc Med Chem, 14, 2023
8G7I	Crystal Structure of FosB from Bacillus cereus with Zinc and Sulfate Descriptor: FORMIC ACID, GLYCEROL, MAGNESIUM ION, ... Authors: Travis, S, Pang, A.H, Tsodikov, O.V, Garneau-Tsodikova, S, Thompson, M.K. Deposit date: 2023-02-16 Release date: 2023-06-14 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (1.83 Å) Cite: Identification and analysis of small molecule inhibitors of FosB from Staphylococcus aureus. Rsc Med Chem, 14, 2023
8G3B	BceAB-S nucleotide free TM state 2 Descriptor: Bacitracin export ATP-binding protein BceA, Bacitracin export permease protein BceB, OLEIC ACID, ... Authors: George, N.L, Orlando, B.J. Deposit date: 2023-02-07 Release date: 2023-06-21 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Architecture of a complete Bce-type antimicrobial peptide resistance module. Nat Commun, 14, 2023
6SDQ	Trypanosoma cruzi farnesyl diphosphate synthase in complex with fragment 2m5n Descriptor: 2-methoxy-5-nitro-phenol, Farnesyl diphosphate synthase, SULFATE ION, ... Authors: Magari, F, Heine, A, Klebe, G. Deposit date: 2019-07-29 Release date: 2020-08-26 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.68 Å) Cite: Trypanosoma cruzi farnesyl diphosphate synthase in complex with fragment 2m5n To Be Published
8GN1	Crystal structure of DBBQ-bound photosystem II complex Descriptor: (3R)-beta,beta-caroten-3-ol, 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, ... Authors: Kamada, S, Nakajima, Y, Shen, J.-R. Deposit date: 2022-08-22 Release date: 2023-07-05 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structural insights into the action mechanisms of artificial electron acceptors in photosystem II. J.Biol.Chem., 299, 2023
8G3L	BceAB-S nucleotide free BceS state 2 Descriptor: Bacitracin export ATP-binding protein BceA, Bacitracin export permease protein BceB, OLEIC ACID, ... Authors: George, N.L, Orlando, B.J. Deposit date: 2023-02-08 Release date: 2023-06-21 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Architecture of a complete Bce-type antimicrobial peptide resistance module. Nat Commun, 14, 2023
6SI5	T. cruzi FPPS in complex with 1-methyl-5-(4,5,6,7-tetrahydrothieno[3,2-c]pyridine-5-carbonyl)pyridin-2(1H)-one Descriptor: 5-(6,7-dihydro-4~{H}-thieno[3,2-c]pyridin-5-ylcarbonyl)-1-methyl-pyridin-2-one, Farnesyl diphosphate synthase, SULFATE ION Authors: Petrick, J.K, Muenzker, L, Schleberger, C, Cornaciu, I, Clavel, D, Marquez, J.A, Jahnke, W. Deposit date: 2019-08-08 Release date: 2020-08-26 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.097 Å) Cite: Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery Thesis, 2019
6SII	T. brucei FPPS in complex with 1-((1H-indol-3-yl)methyl)-N-(3-chlorobenzyl)piperidin-4-amine Descriptor: Farnesyl pyrophosphate synthase, GLYCEROL, ~{N}-[(3-chlorophenyl)methyl]-1-(1~{H}-indol-3-ylmethyl)piperidin-4-amine Authors: Muenzker, L, Petrick, J.K, Schleberger, C, Jahnke, W. Deposit date: 2019-08-09 Release date: 2020-08-26 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.33 Å) Cite: T. brucei FPPS To Be Published
8ECM	Crystal Structure Analysis of Acetyl-CoA acetyltransferase from Firmicutes bacterium Descriptor: Acetyl-CoA acetyltransferase Authors: Seo, H.S, Dhe-Paganon, S. Deposit date: 2022-09-02 Release date: 2023-05-31 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.89 Å) Cite: Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease. Nat Med, 29, 2023
5AEL	T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-597 Descriptor: FARNESYL PYROPHOSPHATE SYNTHASE, MAGNESIUM ION, {2-[3-(hex-1-yn-1-yl)pyridinium-1-yl]ethane-1,1-diyl}bis(phosphonate) Authors: Yang, G, Oldfield, E, No, J.H. Deposit date: 2014-12-26 Release date: 2015-10-28 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Inhibition of Trypanosoma Brucei Cell Growth by Lipophilic Bisphosphonates: An in Vitro and in Vivo Investigation. Antimicrob.Agents Chemother., 59, 2015
8G4C	BceABS ATPgS high res TM Descriptor: Bacitracin export ATP-binding protein BceA, Bacitracin export permease protein BceB, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... Authors: George, N.L, Orlando, B.J. Deposit date: 2023-02-09 Release date: 2023-06-21 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Architecture of a complete Bce-type antimicrobial peptide resistance module. Nat Commun, 14, 2023
8G4D	BceABS ATPgS tilted BceS Descriptor: Bacitracin export ATP-binding protein BceA, Bacitracin export permease protein BceB, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... Authors: George, N.L, Orlando, B.J. Deposit date: 2023-02-09 Release date: 2023-06-21 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Architecture of a complete Bce-type antimicrobial peptide resistance module. Nat Commun, 14, 2023
8G3A	BceAB-S nucleotide free TM state 1 Descriptor: Bacitracin export ATP-binding protein BceA, Bacitracin export permease protein BceB, OLEIC ACID, ... Authors: George, N.L, Orlando, B.J. Deposit date: 2023-02-07 Release date: 2023-06-21 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Architecture of a complete Bce-type antimicrobial peptide resistance module. Nat Commun, 14, 2023
6SWJ	The kinase domain of GanS, a histidine kinase from Geobacillus stearothermophilus (with Pt) Descriptor: Histidine kinase, PLATINUM (II) ION Authors: Lansky, S, Shiradski, M, Lavid, N, Shoham, Y, Shoham, G. Deposit date: 2019-09-22 Release date: 2020-10-14 Last modified: 2024-05-15 Method: X-RAY DIFFRACTION (1.762 Å) Cite: The kinase domain of GanS, a histidine kinase from Geobacillus stearothermophilus (with Pt) To Be Published
6SX4	Structure of C. glutamicum mycoloyltransferase A Descriptor: ACETATE ION, Protein PS1 Authors: Li de la Sierra-Gallay, I, Van tilbeurgh, H, Bayan, N. Deposit date: 2019-09-24 Release date: 2020-03-04 Last modified: 2020-07-22 Method: X-RAY DIFFRACTION (2.796 Å) Cite: The C-terminal domain of Corynebacterium glutamicum mycoloyltransferase A is composed of five repeated motifs involved in cell wall binding and stability. Mol.Microbiol., 114, 2020
6SZG	Acinetobacter baumannii undecaprenyl pyrophosphate synthase (AB-UppS) in complex with GR839 and GSK513 Descriptor: (4-chlorophenyl)-[(3~{S})-3-oxidanylpiperidin-1-yl]methanone, 4,5,6,7-tetrahydro-2~{H}-indazole-3-carboxylic acid, CALCIUM ION, ... Authors: Thorpe, J.H. Deposit date: 2019-10-02 Release date: 2020-01-22 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.84 Å) Cite: Cocktailed fragment screening by X-ray crystallography of the antibacterial target undecaprenyl pyrophosphate synthase from Acinetobacter baumannii. Acta Crystallogr.,Sect.F, 76, 2020
6R38	T. brucei FPPS in complex with 2-(2,5-dichlorobenzo[b]thiophen-3-yl)acetic acid Descriptor: 2-[2,5-bis(chloranyl)-1-benzothiophen-3-yl]ethanoic acid, DIMETHYL SULFOXIDE, Farnesyl pyrophosphate synthase Authors: Muenzker, L, Petrick, J.K, Schleberger, C, Jahnke, W. Deposit date: 2019-03-19 Release date: 2020-04-08 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.33 Å) Cite: Targeting Trypanosoma brucei FPPS by Fragment-based drug discovery Thesis, 2019
5AB7	Crystal structure of Trypanosoma brucei SCP2-thiolase like protein (TbSLP) in complex with malonyl-CoA. Descriptor: MALONYL-COENZYME A, SCP2-THIOLASE LIKE PROTEIN, SULFATE ION Authors: Harijan, R.K, Kiema, T.R, Wierenga, R.K. Deposit date: 2015-08-02 Release date: 2016-05-04 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.3 Å) Cite: The Scp2-Thiolase-Like Protein (Slp) of Trypanosoma Brucei is an Enzyme Involved in Lipid Metabolism. Proteins, 84, 2016

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