PDB: 238582 resultsInfo pagesStatus searchChemie searchBIRD

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8AK9	Human Sirt6 in complex with ADP-ribose and fragment Isatin Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... Authors: You, W, Steegborn, C. Deposit date: 2022-07-29 Release date: 2023-08-16 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Development of novel Sirtuin 6 inhibitors and activators based on a protein crystallography-based fragment screen To Be Published
8ANC	14-3-3 sigma sirtuin-3 phospho-peptide complex Descriptor: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... Authors: Weyand, M, Steegborn, C, Debbert, L. Deposit date: 2022-08-05 Release date: 2023-08-16 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.11 Å) Cite: 14-3-3 sigma sirtuin-3 phospho-peptide complex To Be Published
4V6D	Crystal structure of the E. coli 70S ribosome in an intermediate state of ratcheting Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... Authors: Zhang, W, Dunkle, J.A, Cate, J.H.D. Deposit date: 2009-06-27 Release date: 2014-07-09 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (3.814 Å) Cite: Structures of the ribosome in intermediate States of ratcheting. Science, 325, 2009
8AHL	Cryo-EM structure of crescentin filaments (stutter mutant, C1 symmetry and large box) Descriptor: Crescentin, Crescentin-specific megabody MB13 Authors: Liu, Y, Lowe, J. Deposit date: 2022-07-22 Release date: 2023-08-16 Last modified: 2024-10-09 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Filament structure and subcellular organization of the bacterial intermediate filament-like protein crescentin. Proc.Natl.Acad.Sci.USA, 121, 2024
8AKE	Human Sirt6 in complex with ADP-ribose and fragment nicotinamide Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, NAD-dependent protein deacetylase sirtuin-6, ... Authors: You, W, Steegborn, C. Deposit date: 2022-07-29 Release date: 2023-08-16 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Development of novel Sirtuin 6 inhibitors and activators based on a protein crystallography-based fragment screen To Be Published
3CLN	STRUCTURE OF CALMODULIN REFINED AT 2.2 ANGSTROMS RESOLUTION Descriptor: CALCIUM ION, CALMODULIN Authors: Babu, Y.S, Bugg, C.E, Cook, W.J. Deposit date: 1988-05-11 Release date: 1988-07-16 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structure of calmodulin refined at 2.2 A resolution. J.Mol.Biol., 204, 1988
8AFH	Cryo-EM structure of crescentin filaments (stutter mutant, C2, symmetry and small box) Descriptor: Crescentin, Crescentus-specific megabody MB13 Authors: Liu, Y, Lowe, J. Deposit date: 2022-07-18 Release date: 2023-08-16 Last modified: 2024-11-20 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Filament structure and subcellular organization of the bacterial intermediate filament-like protein crescentin. Proc.Natl.Acad.Sci.USA, 121, 2024
4V8J	Crystal structure of the bacterial ribosome ram mutation G347U. Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... Authors: Fagan, C.E, Dunkle, J.A, Maehigashi, T, Dunham, C.M. Deposit date: 2011-12-20 Release date: 2014-07-09 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (3.9 Å) Cite: Reorganization of an intersubunit bridge induced by disparate 16S ribosomal ambiguity mutations mimics an EF-Tu-bound state. Proc.Natl.Acad.Sci.USA, 110, 2013
3CXC	The structure of an enhanced oxazolidinone inhibitor bound to the 50S ribosomal subunit of H. marismortui Descriptor: (3Z)-N-[(4E)-5-(4-{(5S)-5-[(acetylamino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2-fluorophenyl)pent-4-en-1-yl]-3-(4-methyl-2,6-dioxo-1,6-dihydropyrimidin-5(2H)-ylidene)propanamide, 23S RIBOSOMAL RNA, 5'-R(*CP*CP*A)-3', ... Authors: Ippolito, J.A, Wang, D, Kanyo, Z.F, Duffy, E.M. Deposit date: 2008-04-24 Release date: 2009-04-28 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (3 Å) Cite: Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics. Bioorg.Med.Chem.Lett., 18, 2008
8AK8	Human Sirt6 in complex with ADP-ribose and fragment 4-hydroxybenzamide Descriptor: 4-HYDROXYBENZAMIDE, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... Authors: You, W, Steegborn, C. Deposit date: 2022-07-29 Release date: 2023-08-16 Method: X-RAY DIFFRACTION (1.73 Å) Cite: Development of novel Sirtuin 6 inhibitors and activators based on a protein crystallography-based fragment screen To Be Published
4V9C	Allosteric control of the ribosome by small-molecule antibiotics Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... Authors: Cate, J.H.D, Pulk, A, Blanchard, S.C, Wang, L, Feldman, M.B, Wasserman, M.R, Altman, R. Deposit date: 2012-07-25 Release date: 2014-07-09 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Allosteric control of the ribosome by small-molecule antibiotics. Nat.Struct.Mol.Biol., 19, 2012
8AKG	Human Sirt6 in complex with ADP-ribose and fragment 4-amino-6-chlorobenzene-1,3-disulfonamide Descriptor: 1,2-ETHANEDIOL, 4-AMINO-6-CHLOROBENZENE-1,3-DISULFONAMIDE, CHLORIDE ION, ... Authors: You, W, Steegborn, C. Deposit date: 2022-07-29 Release date: 2023-08-16 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Development of novel Sirtuin 6 inhibitors and activators based on a protein crystallography-based fragment screen To Be Published
4W2F	Crystal structure of the Thermus thermophilus 70S ribosome in complex with amicoumacin, mRNA and three deacylated tRNAs in the A, P and E sites Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S10, ... Authors: Polikanov, Y.S, Osterman, I.A, Szal, T, Tashlitsky, V.N, Serebryakova, M.V, Kusochek, P, Bulkley, D, Malanicheva, I.A, Efimenko, T.A, Efremenkova, O.V, Konevega, A.L, Shaw, K.J, Bogdanov, A.A, Rodnina, M.V, Dontsova, O.A, Mankin, A.S, Steitz, T.A, Sergiev, P.V. Deposit date: 2014-09-12 Release date: 2014-10-15 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome. Mol.Cell, 56, 2014
8AK7	Human Sirt6 in complex with ADP-ribose and fragment 6-O-methylguanine Descriptor: 1,2-ETHANEDIOL, 6-O-methylguanine, CHLORIDE ION, ... Authors: You, W, Steegborn, C. Deposit date: 2022-07-29 Release date: 2023-08-16 Method: X-RAY DIFFRACTION (1.81 Å) Cite: Development of novel Sirtuin 6 inhibitors and activators based on a protein crystallography-based fragment screen To Be Published
4V6F	Elongation complex of the 70S ribosome with three tRNAs and mRNA. Descriptor: 16S ribosomal RNA, 23S RIBOSOMAL RNA, 23S RRNA, ... Authors: Jenner, L.B, Yusupova, G, Yusupov, M. Deposit date: 2009-07-09 Release date: 2014-07-09 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Structural aspects of messenger RNA reading frame maintenance by the ribosome. Nat.Struct.Mol.Biol., 17, 2010
6T37	Pseudomonas aeruginosa RmlA in complex with allosteric inhibitor Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, Glucose-1-phosphate thymidylyltransferase, ... Authors: Alphey, M.S, Xiao, G, Westwood, J.N. Deposit date: 2019-10-10 Release date: 2020-08-19 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.079 Å) Cite: Next generation Glucose-1-phosphate thymidylyltransferase (RmlA) inhibitors: An extended SAR study to direct future design. Bioorg.Med.Chem., 50, 2021
8AFM	Cryo-EM structure of crescentin filaments (wildtype, C2 symmetry and small box) Descriptor: Crescentin, Crescentin-specific megabody MB13 Authors: Liu, Y, Lowe, J. Deposit date: 2022-07-18 Release date: 2023-08-16 Last modified: 2024-11-06 Method: ELECTRON MICROSCOPY (4.8 Å) Cite: Filament structure and subcellular organization of the bacterial intermediate filament-like protein crescentin. Proc.Natl.Acad.Sci.USA, 121, 2024
9B8O	Synaptic Vesicle V-ATPase with synaptophysin and SidK, State 3, Vo Descriptor: (7R)-4,7-DIHYDROXY-N,N,N-TRIMETHYL-10-OXO-3,5,9-TRIOXA-4-PHOSPHAHEPTACOSAN-1-AMINIUM 4-OXIDE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Coupland, C.E, Rubinstein, J.L. Deposit date: 2024-03-31 Release date: 2024-06-26 Last modified: 2024-10-23 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: High-resolution electron cryomicroscopy of V-ATPase in native synaptic vesicles. Science, 385, 2024
8AKA	Human Sirt6 in complex with ADP-ribose and fragment cis-resveratrol Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... Authors: You, W, Steegborn, C. Deposit date: 2022-07-29 Release date: 2023-08-16 Method: X-RAY DIFFRACTION (1.77 Å) Cite: Development of novel Sirtuin 6 inhibitors and activators based on a protein crystallography-based fragment screen To Be Published
9BRZ	V0-only V-ATPase and synaptophysin complex in mouse brain isolated synaptic vesicles Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Wang, C, Jiang, W, Yang, K, Wang, X, Guo, Q, Brunger, A.T. Deposit date: 2024-05-12 Release date: 2024-06-19 Last modified: 2024-11-13 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Structure and topography of the synaptic V-ATPase-synaptophysin complex. Nature, 631, 2024
3SF6	Crystal structure of Glutaryl-CoA dehydrogenase from Mycobacterium smegmatis Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, ... Authors: Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2011-06-12 Release date: 2011-06-29 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015
8AFL	Cryo-EM structure of crescentin filaments (wildtype, C1 symmetry and small box) Descriptor: Crescentin, Crescentin-specific megabody MB13 Authors: Liu, Y, Lowe, J. Deposit date: 2022-07-18 Release date: 2023-08-16 Last modified: 2024-11-20 Method: ELECTRON MICROSCOPY (4.4 Å) Cite: Filament structure and subcellular organization of the bacterial intermediate filament-like protein crescentin. Proc.Natl.Acad.Sci.USA, 121, 2024
8AJB	Cryo-EM structure of crescentin filaments (stutter mutant, C2 symmetry and large box) Descriptor: Crescentin, Crescentin-specific megabody MB13 Authors: Liu, Y, Lowe, J. Deposit date: 2022-07-28 Release date: 2023-08-16 Last modified: 2024-11-20 Method: ELECTRON MICROSCOPY (4.3 Å) Cite: Filament structure and subcellular organization of the bacterial intermediate filament-like protein crescentin. Proc.Natl.Acad.Sci.USA, 121, 2024
6T7L	Crystal structure of AmpC from E.coli with Nacubactam (OP0595) Descriptor: (2S,5R)-N-(2-aminoethoxy)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Beta-lactamase, ... Authors: Lang, P.A, Leissing, T.M, Schofield, C.J, Brem, J. Deposit date: 2019-10-22 Release date: 2020-11-18 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (1.47 Å) Cite: Structural Investigations of the Inhibition of Escherichia coli AmpC beta-Lactamase by Diazabicyclooctanes. Antimicrob.Agents Chemother., 65, 2021
4V6G	Initiation complex of 70S ribosome with two tRNAs and mRNA. Descriptor: 16S RRNA (E.COLI NUMBERING), 23S ribosomal RNA, 30S RIBOSOMAL PROTEIN S10, ... Authors: Jenner, L.B, Yusupova, G, Yusupov, M. Deposit date: 2009-07-10 Release date: 2014-07-09 Last modified: 2024-12-25 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Structural aspects of messenger RNA reading frame maintenance by the ribosome. Nat.Struct.Mol.Biol., 17, 2010

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