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1O4I
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CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PAS219.
Descriptor: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, cyclohexylmethyl 2-formylphenyl hydrogen (S)-phosphate
Authors:Lange, G, Loenze, P, Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O48
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BU of 1o48 by Molmil
CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU85053.
Descriptor: 5-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-CARBOXYMETHYL-BENZOIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
Authors:Lange, G, Loenze, P, Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4O
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BU of 1o4o by Molmil
CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PHENYLPHOSPHATE.
Descriptor: PHENYL DIHYDROGEN PHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
Authors:Lange, G, Loenze, P, Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O41
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BU of 1o41 by Molmil
CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78300.
Descriptor: 2-FORMYL-6-METHOXYPHENYL DIHYDROGEN PHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
Authors:Lange, G, Loenze, P, Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O47
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BU of 1o47 by Molmil
CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU82209.
Descriptor: N-ACETYL-N-[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]-4-[DIFLUORO(PHOSPHONO)METHYL]PHENYLALANINAMIDE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
Authors:Lange, G, Loenze, P, Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1NRV
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BU of 1nrv by Molmil
Crystal structure of the SH2 domain of Grb10
Descriptor: Growth factor receptor-bound protein 10
Authors:Stein, E.G, Hubbard, S.R.
Deposit date:2003-01-25
Release date:2003-04-15
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural basis for dimerization of the Grb10 Src homology 2 domain. Implications for ligand specificity.
J.Biol.Chem., 278, 2003
1NZV
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BU of 1nzv by Molmil
Crystal Structure of Src SH2 domain bound to doubly phosphorylated peptide PQpYIpYVPA
Descriptor: CHLORIDE ION, Doubly phosphorylated peptide PQpYIpYVPA, TETRAETHYLENE GLYCOL, ...
Authors:Lubman, O.Y, Waksman, G.
Deposit date:2003-02-19
Release date:2003-04-22
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and Thermodynamic Basis for the Interaction of the Src SH2 domain with the Activated form of the PDGF beta-receptor
J.Mol.Biol., 328, 2003
1O4J
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BU of 1o4j by Molmil
CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH ISO24.
Descriptor: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, [(4-ETHYLPHENYL)AMINO]CARBONYLPHOSPHONIC ACID
Authors:Lange, G, Loenze, P, Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4D
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BU of 1o4d by Molmil
CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78262.
Descriptor: 2-FORMYLPHENYL DIHYDROGEN PHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
Authors:Lange, G, Loenze, P, Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O46
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BU of 1o46 by Molmil
CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU90395.
Descriptor: 2-{4-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-METHOXYCARBONYL-PHENYL}-2-FLUORO-MALONIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
Authors:Lange, G, Loenze, P, Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1NZL
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BU of 1nzl by Molmil
Crystal Structure of Src SH2 domain bound to doubly phosphorylated peptide PQpYEpYIPI
Descriptor: CHLORIDE ION, Doubly phosphorylated peptide ligand (PQpYEpYIPI), TETRAETHYLENE GLYCOL, ...
Authors:Lubman, O.Y, Waksman, G.
Deposit date:2003-02-18
Release date:2003-04-22
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Thermodynamic Basis for the Interaction of the Src SH2 domain with the Activated form of the PDGF beta-receptor
J.Mol.Biol., 328, 2003
1O4H
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BU of 1o4h by Molmil
CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU79072.
Descriptor: 2-CYANOQUINOLIN-8-YL DIHYDROGEN PHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
Authors:Lange, G, Loenze, P, Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4L
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BU of 1o4l by Molmil
CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH FRAGMENT2.
Descriptor: CITRIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
Authors:Lange, G, Loenze, P, Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
9BLG
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BU of 9blg by Molmil
Crystal structure of non-receptor protein tyrosine phosphatase SHP2 in complex with PF-07284892
Descriptor: (1S)-1'-{6-[(2-amino-3-chloropyridin-4-yl)sulfanyl]-1,2,4-triazin-3-yl}-1,3-dihydrospiro[indene-2,4'-piperidin]-1-amine, Tyrosine-protein phosphatase non-receptor type 11
Authors:Bester, S.M, Wu, W.-I, Mou, T.-C.
Deposit date:2024-04-30
Release date:2024-05-29
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:SHP2 Inhibition Sensitizes Diverse Oncogene-Addicted Solid Tumors to Re-treatment with Targeted Therapy.
Cancer Discov, 13, 2023
4LUD
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BU of 4lud by Molmil
Crystal Structure of HCK in complex with the fluorescent compound SKF86002
Descriptor: 6-(4-fluorophenyl)-5-(pyridin-4-yl)-2,3-dihydroimidazo[2,1-b][1,3]thiazole, CALCIUM ION, CHLORIDE ION, ...
Authors:Parker, L.J, Tanaka, A, Handa, N, Honda, K, Tomabechi, Y, Shirouzu, M, Yokoyama, S.
Deposit date:2013-07-25
Release date:2014-02-12
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002.
Acta Crystallogr.,Sect.D, 70, 2014
6PBC
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BU of 6pbc by Molmil
Structural basis for the activation of PLC-gamma isozymes by phosphorylation and cancer-associated mutations
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma,1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, CALCIUM ION, SODIUM ION
Authors:Hajicek, N, Sondek, J.
Deposit date:2019-06-13
Release date:2020-01-08
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Structural basis for the activation of PLC-gamma isozymes by phosphorylation and cancer-associated mutations.
Elife, 8, 2019
6JMF
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BU of 6jmf by Molmil
Crystal structure of human tyrosine-protein kinase Fes/Fps in complex with compound 4
Descriptor: 6-{[(1R,2S)-2-aminocyclohexyl]amino}-5-cyano-2-[(3-methylphenyl)amino]pyridine-3-carboxamide, SULFATE ION, Tyrosine-protein kinase Fes/Fps
Authors:Baba, D, Hanzawa, H.
Deposit date:2019-03-08
Release date:2019-06-12
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors with Antitumor Activity.
Acs Med.Chem.Lett., 10, 2019
5M6U
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BU of 5m6u by Molmil
HUMAN PI3KDELTA IN COMPLEX WITH LASW1579
Descriptor: 4-azanyl-6-[[(1~{S})-1-(4-oxidanylidene-3-phenyl-pyrrolo[2,1-f][1,2,4]triazin-2-yl)ethyl]amino]pyrimidine-5-carbonitrile, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Authors:Segarra, V, Hernandez, B, Lozoya, E, Blaesse, M, Hoeppner, S, Jestel, A.
Deposit date:2016-10-26
Release date:2017-02-01
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Discovery of a Potent, Selective, and Orally Available PI3K delta Inhibitor for the Treatment of Inflammatory Diseases.
ACS Med Chem Lett, 8, 2017
7T8T
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BU of 7t8t by Molmil
CryoEM structure of PLCg1
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma, CALCIUM ION
Authors:Endo-Streeter, S, Sondek, J.
Deposit date:2021-12-17
Release date:2022-12-21
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.68 Å)
Cite:CryoEM structure of PLCg1
To Be Published
8W9B
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BU of 8w9b by Molmil
CryoEM structure of human PI3K-alpha (P85/P110-H1047R) with QR-8557 binding at an allosteric site
Descriptor: 1-[(1S)-1-(5-fluoranyl-3-methyl-1-benzofuran-2-yl)-2-methyl-propyl]-3-(1-oxidanylidene-2,3-dihydroisoindol-5-yl)urea, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Authors:Huang, X, Ren, X, Zhong, W.
Deposit date:2023-09-05
Release date:2024-04-17
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Cryo-EM structures reveal two allosteric inhibition modes of PI3K alpha H1047R involving a re-shaping of the activation loop.
Structure, 2024
7O3D
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BU of 7o3d by Molmil
Cooperation between the intrinsically disordered and ordered regions of Spt6 regulates nucleosome and Pol II CTD binding, and nucleosome assembly
Descriptor: Transcription elongation factor SPT6
Authors:Kasiliauskaite, A, Kubicek, K, Klumpler, T, Zanova, M, Zapletal, D, Novacek, J, Stefl, R.
Deposit date:2021-04-01
Release date:2022-04-13
Last modified:2022-06-15
Method:ELECTRON MICROSCOPY (3.71 Å)
Cite:Cooperation between intrinsically disordered and ordered regions of Spt6 regulates nucleosome and Pol II CTD binding, and nucleosome assembly.
Nucleic Acids Res., 50, 2022
8W9A
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BU of 8w9a by Molmil
CryoEM structure of human PI3K-alpha (P85/P110-H1047R) with QR-7909 binding at an allosteric site
Descriptor: 6-chloranyl-3-[[(1R)-1-[2-(1,3-dihydropyrrolo[3,4-c]pyridin-2-yl)-3,6-dimethyl-4-oxidanylidene-quinazolin-8-yl]ethyl]amino]pyridine-2-carboxylic acid, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Authors:Huang, X, Ren, X, Zhong, W.
Deposit date:2023-09-05
Release date:2024-04-17
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Cryo-EM structures reveal two allosteric inhibition modes of PI3K alpha H1047R involving a re-shaping of the activation loop.
Structure, 2024
7O6B
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BU of 7o6b by Molmil
Cooperation between the intrinsically disordered and ordered regions of Spt6 regulates nucleosome and Pol II CTD binding, and nucleosome assembly
Descriptor: Transcription elongation factor SPT6
Authors:Kasiliauskaite, A, Kubicek, K, Klumpler, T, Zanova, M, Zapletal, D, Novacek, J, Stefl, R.
Deposit date:2021-04-09
Release date:2022-04-20
Last modified:2022-06-22
Method:ELECTRON MICROSCOPY (3.88 Å)
Cite:Cooperation between intrinsically disordered and ordered regions of Spt6 regulates nucleosome and Pol II CTD binding, and nucleosome assembly.
Nucleic Acids Res., 50, 2022
6C5X
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BU of 6c5x by Molmil
Crystal Structure of SOCS1 in complex with ElonginB and ElonginC
Descriptor: Elongin-B, Elongin-C, GP130 peptide fragment, ...
Authors:Kershaw, N.J, Laktyushin, A, Babon, J.J.
Deposit date:2018-01-17
Release date:2018-05-02
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.105 Å)
Cite:The molecular basis of JAK/STAT inhibition by SOCS1.
Nat Commun, 9, 2018
6C7Y
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BU of 6c7y by Molmil
Crystal structure of inhibitory protein SOCS1 in complex with JAK1 kinase domain
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Liau, N.P.D, Laktyushin, A, Lucet, I.S, Murphy, J.M, Yao, S, Callaghan, K, Nicola, N.A, Kershaw, N.J, Babon, J.J.
Deposit date:2018-01-23
Release date:2018-05-02
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.499 Å)
Cite:The molecular basis of JAK/STAT inhibition by SOCS1.
Nat Commun, 9, 2018

221716

数据于2024-06-26公开中

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