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1O44
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BU of 1o44 by Molmil
Crystal structure of sh2 in complex with ru85052
Descriptor: 2-{4-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-CARBOXY-PHENYL}-MALONIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
Authors:Lange, G, Loenze, P, Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4C
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BU of 1o4c by Molmil
CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PHOSPHATE.
Descriptor: PHOSPHATE ION, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
Authors:Lange, G, Loenze, P, Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4I
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BU of 1o4i by Molmil
CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PAS219.
Descriptor: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, cyclohexylmethyl 2-formylphenyl hydrogen (S)-phosphate
Authors:Lange, G, Loenze, P, Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O48
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BU of 1o48 by Molmil
CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU85053.
Descriptor: 5-[2-ACETYLAMINO-2-(1-BIPHENYL-4-YLMETHYL-2-OXO-AZEPAN-3-YLCARBAMOYL)-ETHYL]-2-CARBOXYMETHYL-BENZOIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
Authors:Lange, G, Loenze, P, Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4O
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BU of 1o4o by Molmil
CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH PHENYLPHOSPHATE.
Descriptor: PHENYL DIHYDROGEN PHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
Authors:Lange, G, Loenze, P, Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1P13
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BU of 1p13 by Molmil
Crystal Structure of the Src SH2 Domain Complexed with Peptide (SDpYANFK)
Descriptor: CACODYLATE ION, Peptide, Proto-oncogene tyrosine-protein kinase Src
Authors:Sonnenburg, E.D, Bilwes, A, Hunter, T, Noel, J.P.
Deposit date:2003-04-11
Release date:2003-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:The structure of the membrane distal phosphatase domain of RPTPalpha reveals interdomain flexibility and an SH2 domain interaction region.
Biochemistry, 42, 2003
1O4Q
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BU of 1o4q by Molmil
CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU79256.
Descriptor: PHENYL(SULFO)ACETIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
Authors:Lange, G, Loenze, P, Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1NRV
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BU of 1nrv by Molmil
Crystal structure of the SH2 domain of Grb10
Descriptor: Growth factor receptor-bound protein 10
Authors:Stein, E.G, Hubbard, S.R.
Deposit date:2003-01-25
Release date:2003-04-15
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural basis for dimerization of the Grb10 Src homology 2 domain. Implications for ligand specificity.
J.Biol.Chem., 278, 2003
1NZV
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BU of 1nzv by Molmil
Crystal Structure of Src SH2 domain bound to doubly phosphorylated peptide PQpYIpYVPA
Descriptor: CHLORIDE ION, Doubly phosphorylated peptide PQpYIpYVPA, TETRAETHYLENE GLYCOL, ...
Authors:Lubman, O.Y, Waksman, G.
Deposit date:2003-02-19
Release date:2003-04-22
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and Thermodynamic Basis for the Interaction of the Src SH2 domain with the Activated form of the PDGF beta-receptor
J.Mol.Biol., 328, 2003
1O4N
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BU of 1o4n by Molmil
CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH OXALIC ACID.
Descriptor: OXALIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
Authors:Lange, G, Loenze, P, Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1O4D
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BU of 1o4d by Molmil
CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU78262.
Descriptor: 2-FORMYLPHENYL DIHYDROGEN PHOSPHATE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC
Authors:Lange, G, Loenze, P, Liesum, A.
Deposit date:2003-06-15
Release date:2004-02-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46, 2003
1R1Q
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BU of 1r1q by Molmil
Structural Basis for Differential Recognition of Tyrosine Phosphorylated Sites in the Linker for Activation of T cells (LAT) by the Adaptor Protein Gads
Descriptor: GRB2-related adaptor protein 2, LAT pY191 peptide, SULFATE ION
Authors:Cho, S, Mariuzza, R.A.
Deposit date:2003-09-24
Release date:2004-09-28
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for differential recognition of tyrosine-phosphorylated sites in the linker for activation of T cells (LAT) by the adaptor Gads.
Embo J., 23, 2004
1R1S
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BU of 1r1s by Molmil
Structural Basis for Differential Recognition of Tyrosine Phosphorylated Sites in the Linker for Activation of T cells (LAT) by the Adaptor Protein Gads
Descriptor: GRB2-related adaptor protein 2, LAT pY226 peptide, SULFATE ION
Authors:Cho, S, Mariuzza, R.A.
Deposit date:2003-09-24
Release date:2004-09-28
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for differential recognition of tyrosine-phosphorylated sites in the linker for activation of T cells (LAT) by the adaptor Gads.
Embo J., 23, 2004
6WU8
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BU of 6wu8 by Molmil
Structure of human SHP2 in complex with inhibitor IACS-13909
Descriptor: 1-[3-(2,3-dichlorophenyl)-1H-pyrazolo[3,4-b]pyrazin-6-yl]-4-methylpiperidin-4-amine, Tyrosine-protein phosphatase non-receptor type 11
Authors:Leonard, P.G, Joseph, S, Rodenberger, A.
Deposit date:2020-05-04
Release date:2021-03-17
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib.
Cancer Res., 80, 2020
7Z3J
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BU of 7z3j by Molmil
Structure of crystallisable rat Phospholipase C gamma 1 in complex with inositol 1,4,5-trisphosphate
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, CALCIUM ION, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, ...
Authors:Pinotsis, N, Bunney, T.D, Katan, M.
Deposit date:2022-03-02
Release date:2022-07-20
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Characterization of the membrane interactions of phospholipase C gamma reveals key features of the active enzyme.
Sci Adv, 8, 2022
1X27
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BU of 1x27 by Molmil
Crystal Structure of Lck SH2-SH3 with SH2 binding site of p130Cas
Descriptor: CRK-associated substrate, Proto-oncogene tyrosine-protein kinase LCK, SODIUM ION
Authors:Nasertorabi, F, Tars, K, Becherer, K, Kodandapani, R, Liljas, L, Vuori, K, Ely, K.R.
Deposit date:2005-04-20
Release date:2006-02-07
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Molecular basis for regulation of Src by the docking protein p130Cas
J.MOL.RECOG., 19, 2006
8CBH
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BU of 8cbh by Molmil
SHP2 in complex with a novel allosteric inhibitor
Descriptor: Tyrosine-protein phosphatase non-receptor type 11, [(1~{S},6~{R},7~{S})-3-[3-[2,3-bis(chloranyl)phenyl]-2~{H}-pyrazolo[3,4-b]pyrazin-6-yl]-7-(4-methyl-1,3-thiazol-2-yl)-3-azabicyclo[4.1.0]heptan-7-yl]methanamine
Authors:di Fabio, R, Petrocchi, A.
Deposit date:2023-01-25
Release date:2023-04-26
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Discovery of a Novel Series of Imidazopyrazine Derivatives as Potent SHP2 Allosteric Inhibitors.
Acs Med.Chem.Lett., 14, 2023
3UF4
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BU of 3uf4 by Molmil
Crystal structure of a SH3 and SH2 domains of FYN protein (Proto-concogene Tyrosine-protein kinase Fyn) from Mus musculus at 1.98 A resolution
Descriptor: CHLORIDE ION, GLYCEROL, SODIUM ION, ...
Authors:Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL)
Deposit date:2011-10-31
Release date:2011-12-07
Last modified:2023-02-01
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Crystal structure of a SH3 and SH2 domains of FYN protein (Proto-concogene Tyrosine-protein kinase Fyn) from Mus musculus at 1.98 A resolution
To be published
8XN8
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BU of 8xn8 by Molmil
The Crystal Structure of SRC from Biortus.
Descriptor: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ...
Authors:Wang, F, Cheng, W, Yuan, Z, Lin, D, Bao, C.
Deposit date:2023-12-29
Release date:2024-01-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The Crystal Structure of SRC from Biortus.
To Be Published
2FO0
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BU of 2fo0 by Molmil
Organization of the SH3-SH2 Unit in Active and Inactive Forms of the c-Abl Tyrosine Kinase
Descriptor: 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, GLYCEROL, MYRISTIC ACID, ...
Authors:Nagar, B, Hantschel, O, Seeliger, M, Davies, J.M, Weis, W.I, Superti-Furga, G, Kuriyan, J.
Deposit date:2006-01-12
Release date:2006-03-21
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase.
Mol.Cell, 21, 2006
9BLG
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BU of 9blg by Molmil
Crystal structure of non-receptor protein tyrosine phosphatase SHP2 in complex with PF-07284892
Descriptor: (1S)-1'-{6-[(2-amino-3-chloropyridin-4-yl)sulfanyl]-1,2,4-triazin-3-yl}-1,3-dihydrospiro[indene-2,4'-piperidin]-1-amine, Tyrosine-protein phosphatase non-receptor type 11
Authors:Bester, S.M, Wu, W.-I, Mou, T.-C.
Deposit date:2024-04-30
Release date:2024-05-29
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:SHP2 Inhibition Sensitizes Diverse Oncogene-Addicted Solid Tumors to Re-treatment with Targeted Therapy.
Cancer Discov, 13, 2023
5XGI
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BU of 5xgi by Molmil
Crystal structure of PI3K complex with an inhibitor
Descriptor: 3-azanyl-5-(4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phenol, GLYCEROL, HEXAETHYLENE GLYCOL, ...
Authors:Song, K, Yang, X, Zhao, Y, Jian, Z.
Deposit date:2017-04-13
Release date:2018-04-25
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Crystal structure of PI3K complex with an inhibitor
To Be Published
5XZR
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BU of 5xzr by Molmil
The atomic structure of SHP2 E76A mutant in complex with allosteric inhibitor 9b
Descriptor: 4-(3-phenylphenyl)-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3-thiazol-2-amine, Tyrosine-protein phosphatase non-receptor type 11
Authors:Li, D, Xie, J, Zhu, J, Liu, C.
Deposit date:2017-07-13
Release date:2017-12-13
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Allosteric Inhibitors of SHP2 with Therapeutic Potential for Cancer Treatment.
J. Med. Chem., 60, 2017
7JVN
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BU of 7jvn by Molmil
Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor Compound 24
Descriptor: 6-(4-amino-4-methylpiperidin-1-yl)-3-[(2,3-dichlorophenyl)sulfanyl]pyrazin-2-amine, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 11
Authors:Fodor, M, Stams, T.
Deposit date:2020-08-21
Release date:2020-09-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.917 Å)
Cite:Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer.
J.Med.Chem., 63, 2020
7EMN
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BU of 7emn by Molmil
The atomic structure of SHP2 E76A mutant
Descriptor: Tyrosine-protein phosphatase non-receptor type 11
Authors:Luo, F, Xie, J.J, Zhu, J.D, Liu, C.
Deposit date:2021-04-14
Release date:2021-05-05
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:A novel partially open state of SHP2 points to a "multiple gear" regulation mechanism.
J.Biol.Chem., 296, 2021

221051

数据于2024-06-12公开中

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