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1O4B

CRYSTAL STRUCTURE OF SH2 IN COMPLEX WITH RU83876.

Summary for 1O4B
Entry DOI10.2210/pdb1o4b/pdb
DescriptorPROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC, N-ACETYL-N-[1-(1,1'-BIPHENYL-4-YLMETHYL)-2-OXOAZEPAN-3-YL]-3,4-DIPHOSPHONOPHENYLALANINAMIDE (3 entities in total)
Functional Keywordssh2 domain fragment approach, signaling protein
Biological sourceHomo sapiens (human)
Cellular locationCell membrane: P12931
Total number of polymer chains1
Total formula weight13018.52
Authors
Lange, G.,Loenze, P.,Liesum, A. (deposition date: 2003-06-15, release date: 2004-02-17, Last modification date: 2023-08-16)
Primary citationLange, G.,Lesuisse, D.,Deprez, P.,Schoot, B.,Loenze, P.,Benard, D.,Marquette, J.P.,Broto, P.,Sarubbi, E.,Mandine, E.
Requirements for specific binding of low affinity inhibitor fragments to the SH2 domain of (pp60)Src are identical to those for high affinity binding of full length inhibitors.
J.Med.Chem., 46:5184-5195, 2003
Cited by
PubMed: 14613321
DOI: 10.1021/jm020970s
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.85 Å)
Structure validation

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