6MQG
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1S8F
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6N2J
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![BU of 6n2j by Molmil](/molmil-images/mine/6n2j) | Tetrahydropyridopyrimidines as Covalent Inhibitors of KRAS-G12C | Descriptor: | 1-{4-[7-(naphthalen-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl]piperazin-1-yl}propan-1-one, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Vigers, G.P. | Deposit date: | 2018-11-13 | Release date: | 2018-12-12 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity. ACS Med Chem Lett, 9, 2018
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2MMC
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![BU of 2mmc by Molmil](/molmil-images/mine/2mmc) | Nucleotide-free human ran gtpase | Descriptor: | GTP-binding nuclear protein Ran | Authors: | Bacot-Davis, V.R, Palmenberg, A.C. | Deposit date: | 2014-03-13 | Release date: | 2014-10-22 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Nuclear Magnetic Resonance Structure of Ran GTPase Determines C-terminal Tail Conformational Dynamics. To be Published
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2N46
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![BU of 2n46 by Molmil](/molmil-images/mine/2n46) | EC-NMR Structure of Human H-RasT35S mutant protein Determined by Combining Evolutionary Couplings (EC) and Sparse NMR Data | Descriptor: | GTPase HRas | Authors: | Tang, Y, Huang, Y.J, Hopf, T.A, Sander, C, Marks, D, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2015-06-17 | Release date: | 2015-07-01 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Protein structure determination by combining sparse NMR data with evolutionary couplings. Nat.Methods, 12, 2015
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1QG2
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![BU of 1qg2 by Molmil](/molmil-images/mine/1qg2) | CANINE GDP-RAN R76E MUTANT | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PROTEIN (RAN) | Authors: | Kent, H.M, Moore, M.S, Quimby, B.B, Baker, A.M.E, McCoy, A.J, Murphy, G.A, Corbett, A.H, Stewart, M. | Deposit date: | 1999-04-20 | Release date: | 1999-06-11 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Engineered mutants in the switch II loop of Ran define the contribution made by key residues to the interaction with nuclear transport factor 2 (NTF2) and the role of this interaction in nuclear protein import. J.Mol.Biol., 289, 1999
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2N1B
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6NAZ
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![BU of 6naz by Molmil](/molmil-images/mine/6naz) | Crystal structure of DIRAS 2/3 chimera in complex with GDP | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, GTP-binding protein Di-Ras2,GTP-binding protein Di-Ras3,GTP-binding protein Di-Ras2, ... | Authors: | Gilbert, Y.H, Reger, A, Sharma, R, Bast, J, Kim, C. | Deposit date: | 2018-12-06 | Release date: | 2019-12-18 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.081 Å) | Cite: | Crystal structure of DIRAS 2/3 chimera in complex with GDP To Be Published
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1R2Q
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![BU of 1r2q by Molmil](/molmil-images/mine/1r2q) | Crystal Structure of Human Rab5a GTPase Domain at 1.05 A resolution | Descriptor: | GLYCEROL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | Authors: | Terzyan, S, Zhu, G, Li, G, Zhang, X.C. | Deposit date: | 2003-09-29 | Release date: | 2003-12-23 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Refinement of the structure of human Rab5a GTPase domain at 1.05 A resolution. Acta Crystallogr.,Sect.D, 60, 2004
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2KB0
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![BU of 2kb0 by Molmil](/molmil-images/mine/2kb0) | Cdc42(T35A) | Descriptor: | Cell division control protein 42 homolog | Authors: | Adams, P.D, Oswald, R.E, McFeeters, R. | Deposit date: | 2008-11-18 | Release date: | 2009-12-01 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Cdc42(T35A) To be Published
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2KE5
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![BU of 2ke5 by Molmil](/molmil-images/mine/2ke5) | Solution structure and dynamics of the small GTPase Ralb in its active conformation: significance for effector protein binding | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein Ral-B | Authors: | Fenwick, R, Prasannan, S, Campbell, L.J, Nietlispach, D, Evetts, K.A, Camonis, J, Mott, H.R, Owen, D. | Deposit date: | 2009-01-23 | Release date: | 2009-02-17 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure and dynamics of the small GTPase RalB in its active conformation: significance for effector protein binding Biochemistry, 48, 2009
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1T91
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![BU of 1t91 by Molmil](/molmil-images/mine/1t91) | crystal structure of human small GTPase Rab7(GTP) | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-7 | Authors: | Song, H, Hong, W, Wu, M, Wang, T. | Deposit date: | 2004-05-14 | Release date: | 2005-05-17 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for recruitment of RILP by small GTPase Rab7. Embo J., 24, 2005
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1P2U
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![BU of 1p2u by Molmil](/molmil-images/mine/1p2u) | H-Ras in 50% isopropanol | Descriptor: | ISOPROPYL ALCOHOL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | Authors: | Buhrman, G.K, de Serrano, V, Mattos, C. | Deposit date: | 2003-04-16 | Release date: | 2003-08-05 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Organic solvents order the dynamic switch II in Ras crystals Structure, 11, 2003
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2LWI
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![BU of 2lwi by Molmil](/molmil-images/mine/2lwi) | Solution structure of H-RasT35S mutant protein in complex with Kobe2601 | Descriptor: | 2-(2,4-dinitrophenyl)-N-(4-fluorophenyl)hydrazinecarbothioamide, GTPase HRas, MAGNESIUM ION, ... | Authors: | Araki, M, Tamura, A, Shima, F, Kataoka, T. | Deposit date: | 2012-08-01 | Release date: | 2013-05-22 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proc.Natl.Acad.Sci.USA, 110, 2013
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2MMG
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![BU of 2mmg by Molmil](/molmil-images/mine/2mmg) | Structural Characterization of the Mengovirus Leader Protein Bound to Ran GTPase by Nuclear Magnetic Resonance | Descriptor: | GTP-binding nuclear protein Ran | Authors: | Bacot-Davis, V.R, Palmenberg, A.C, Cornilescu, C.C, Markley, J.L. | Deposit date: | 2014-03-15 | Release date: | 2014-10-15 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution structures of Mengovirus Leader protein, its phosphorylated derivatives, and in complex with nuclear transport regulatory protein, RanGTPase. Proc.Natl.Acad.Sci.USA, 111, 2014
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2O52
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![BU of 2o52 by Molmil](/molmil-images/mine/2o52) | Crystal structure of human RAB4B in complex with GDP | Descriptor: | BETA-MERCAPTOETHANOL, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Zhu, H, Tempel, W, Wang, J, Shen, Y, Landry, R, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2006-12-05 | Release date: | 2006-12-19 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of human RAB4B in complex with GDP To be Published
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2OIL
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![BU of 2oil by Molmil](/molmil-images/mine/2oil) | Crystal structure of human RAB25 in complex with GDP | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-25, ... | Authors: | Zhu, H, Wang, J, Shen, Y, Tempel, W, Landry, R, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2007-01-11 | Release date: | 2007-01-23 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of human RAB25 in complex with GDP To be Published
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2NZJ
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![BU of 2nzj by Molmil](/molmil-images/mine/2nzj) | The crystal structure of REM1 in complex with GDP | Descriptor: | CHLORIDE ION, GTP-binding protein REM 1, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Turnbull, A.P, Papagrigoriou, E, Ugochukwu, E, Elkins, J.M, Soundararajan, M, Yang, X, Gorrec, F, Umeano, C, Salah, E, Burgess, N, Johansson, C, Berridge, G, Gileadi, O, Bray, J, Marsden, B, Watts, S, von Delft, F, Weigelt, J, Edwards, A, Arrowsmith, C.H, Sundstrom, M, Doyle, D, Structural Genomics Consortium (SGC) | Deposit date: | 2006-11-23 | Release date: | 2006-12-12 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The crystal structure of REM1 in complex with GDP To be Published
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4LYF
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![BU of 4lyf by Molmil](/molmil-images/mine/4lyf) | Crystal Structure of small molecule vinylsulfonamide 8 covalently bound to K-Ras G12C | Descriptor: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, N-{1-[N-(4,5-dichloro-2-hydroxyphenyl)glycyl]piperidin-4-yl}ethanesulfonamide | Authors: | Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. | Deposit date: | 2013-07-31 | Release date: | 2013-11-27 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (1.568 Å) | Cite: | K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
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4M1W
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![BU of 4m1w by Molmil](/molmil-images/mine/4m1w) | Crystal Structure of small molecule vinylsulfonamide covalently bound to K-Ras G12C | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, K-Ras GTPase, MAGNESIUM ION, ... | Authors: | Ostrem, J.M, Peters, U, Sos, M.L, Wells, J.A, Shokat, K.M. | Deposit date: | 2013-08-04 | Release date: | 2013-11-27 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature, 503, 2013
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3C5C
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![BU of 3c5c by Molmil](/molmil-images/mine/3c5c) | Crystal structure of human Ras-like, family 12 protein in complex with GDP | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, RAS-like protein 12, ... | Authors: | Shen, L, Tong, Y, Tempel, W, Loppnau, P, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2008-01-31 | Release date: | 2008-02-12 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Crystal structure of human Ras-like, family 12 protein in complex with GDP. To be Published
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3CBQ
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![BU of 3cbq by Molmil](/molmil-images/mine/3cbq) | Crystal structure of the human REM2 GTPase with bound GDP | Descriptor: | 1,2-ETHANEDIOL, GTP-binding protein REM 2, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Nedyalkova, L, Shen, Y, Tong, Y, Tempel, W, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2008-02-22 | Release date: | 2008-03-04 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Crystal structure of the human REM2 GTPase with bound GDP. To be Published
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4OJK
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![BU of 4ojk by Molmil](/molmil-images/mine/4ojk) | Structure of the cGMP Dependent Protein Kinase II and Rab11b Complex | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Ras-related protein Rab-11B, cGMP-dependent protein kinase 2 | Authors: | Reger, A.S, Yang, M.P, Guo, E, Kim, C. | Deposit date: | 2014-01-21 | Release date: | 2014-08-06 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.657 Å) | Cite: | Crystal Structure of the cGMP-dependent Protein Kinase II Leucine Zipper and Rab11b Protein Complex Reveals Molecular Details of G-kinase-specific Interactions. J.Biol.Chem., 289, 2014
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3CF6
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![BU of 3cf6 by Molmil](/molmil-images/mine/3cf6) | Structure of Epac2 in complex with cyclic-AMP and Rap | Descriptor: | 6-(6-AMINO-PURIN-9-YL)-2-THIOXO-TETRAHYDRO-2-FURO[3,2-D][1,3,2]DIOXAPHOSPHININE-2,7-DIOL, Rap guanine nucleotide exchange factor (GEF) 4, Ras-related protein Rap-1b, ... | Authors: | Rehmann, H, Arias-Palomo, E, Hadders, M.A, Schwede, F, Llorca, O, Bos, J.L. | Deposit date: | 2008-03-02 | Release date: | 2008-07-29 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B Nature, 455, 2008
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3BWD
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![BU of 3bwd by Molmil](/molmil-images/mine/3bwd) | Crystal structure of the plant Rho protein ROP5 | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Rac-like GTP-binding protein ARAC6 | Authors: | Thomas, C, Berken, A. | Deposit date: | 2008-01-09 | Release date: | 2008-03-11 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | Crystal structure of the plant Rho protein ROP5 To be Published
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