3L6B
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![BU of 3l6b by Molmil](/molmil-images/mine/3l6b) | X-ray crystal structure of human serine racemase in complex with malonate a potent inhibitor | Descriptor: | MALONATE ION, MANGANESE (II) ION, PYRIDOXAL-5'-PHOSPHATE, ... | Authors: | Smith, M.A, Barker, J, Mack, V, Ebneth, A, Moraes, I, Felicetti, B, Cesura, A. | Deposit date: | 2009-12-23 | Release date: | 2010-01-26 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding. J.Biol.Chem., 285, 2010
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7NBG
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![BU of 7nbg by Molmil](/molmil-images/mine/7nbg) | Crystal structure of human serine racemase in complex with DSiP fragment Z52314092, XChem fragment screen. | Descriptor: | 1,2-ETHANEDIOL, 2-(2-METHOXYETHOXY)ETHANOL, CALCIUM ION, ... | Authors: | Koulouris, C.R, Roe, S.M. | Deposit date: | 2021-01-26 | Release date: | 2021-03-03 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase. Commun Biol, 5, 2022
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6ZSP
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![BU of 6zsp by Molmil](/molmil-images/mine/6zsp) | Human serine racemase bound to ATP and malonate. | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, GLYCEROL, ... | Authors: | Koulouris, C.R, Bax, B.D, Roe, S.M, Atack, J.R. | Deposit date: | 2020-07-16 | Release date: | 2021-03-03 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase. Commun Biol, 5, 2022
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7NBF
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![BU of 7nbf by Molmil](/molmil-images/mine/7nbf) | Crystal structure of human serine racemase in complex with DSiP fragment Z126932614, XChem fragment screen. | Descriptor: | 1,2-ETHANEDIOL, 2-[(methylsulfonyl)methyl]-1H-benzimidazole, CALCIUM ION, ... | Authors: | Koulouris, C.R, Roe, S.M. | Deposit date: | 2021-01-26 | Release date: | 2021-03-03 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase. Commun Biol, 5, 2022
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3L6R
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![BU of 3l6r by Molmil](/molmil-images/mine/3l6r) | The structure of mammalian serine racemase: Evidence for conformational changes upon inhibitor binding | Descriptor: | MALONATE ION, MANGANESE (II) ION, Serine racemase | Authors: | Smith, M.A, Mack, V, Ebneth, A, Cesura, A, Felicetti, B, Barker, J. | Deposit date: | 2009-12-24 | Release date: | 2010-01-26 | Last modified: | 2021-11-10 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The structure of mammalian serine racemase: evidence for conformational changes upon inhibitor binding. J.Biol.Chem., 285, 2010
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7NBC
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![BU of 7nbc by Molmil](/molmil-images/mine/7nbc) | Crystal structure of human serine racemase in complex with DSiP fragment Z2856434779, XChem fragment screen. | Descriptor: | 1,2-ETHANEDIOL, 2-(2-METHOXYETHOXY)ETHANOL, CALCIUM ION, ... | Authors: | Koulouris, C.R, Roe, S.M. | Deposit date: | 2021-01-26 | Release date: | 2021-03-03 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase. Commun Biol, 5, 2022
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7NBH
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![BU of 7nbh by Molmil](/molmil-images/mine/7nbh) | Crystal structure of human serine racemase in complex with DSiP fragment Z26781964, XChem fragment screen. | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, CHLORIDE ION, ... | Authors: | Koulouris, C.R, Roe, S.M. | Deposit date: | 2021-01-26 | Release date: | 2021-03-03 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase. Commun Biol, 5, 2022
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6ZUJ
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![BU of 6zuj by Molmil](/molmil-images/mine/6zuj) | Human serine racemase holoenzyme from 20% DMSO soak (XChem crystallographic fragment screen). | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, DIMETHYL SULFOXIDE, ... | Authors: | Koulouris, C.R, Bax, B.D, Roe, S.M, Atack, J.R. | Deposit date: | 2020-07-23 | Release date: | 2021-03-03 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase. Commun Biol, 5, 2022
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5X2L
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![BU of 5x2l by Molmil](/molmil-images/mine/5x2l) | Crystal Structure of Human Serine Racemase | Descriptor: | MAGNESIUM ION, PYRIDOXAL-5'-PHOSPHATE, Serine racemase | Authors: | Obita, T, Matsumoto, K, Mori, H, Toyooka, N, Mizuguchi, M. | Deposit date: | 2017-02-01 | Release date: | 2018-01-31 | Last modified: | 2021-02-24 | Method: | X-RAY DIFFRACTION (1.806 Å) | Cite: | Design, synthesis, and evaluation of novel inhibitors for wild-type human serine racemase. Bioorg. Med. Chem. Lett., 2017
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7NBD
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![BU of 7nbd by Molmil](/molmil-images/mine/7nbd) | Crystal structure of human serine racemase in complex with DSiP fragment Z235449082, XChem fragment screen. | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, GLYCEROL, ... | Authors: | Koulouris, C.R, Roe, S.M. | Deposit date: | 2021-01-26 | Release date: | 2021-03-03 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.865 Å) | Cite: | Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase. Commun Biol, 5, 2022
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6SLH
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![BU of 6slh by Molmil](/molmil-images/mine/6slh) | Conformational flexibility within the small domain of human serine racemase. | Descriptor: | MAGNESIUM ION, SODIUM ION, Serine racemase, ... | Authors: | Koulouris, C.R, Bax, B, Atack, J, Roe, S.M. | Deposit date: | 2019-08-19 | Release date: | 2020-02-12 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Conformational flexibility within the small domain of human serine racemase. Acta Crystallogr.,Sect.F, 76, 2020
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