6ZUJ

Human serine racemase holoenzyme from 20% DMSO soak (XChem crystallographic fragment screen).

This is a non-PDB format compatible entry.

Summary for 6ZUJ

• Entry DOI: 10.2210/pdb6zuj/pdb
• Related: 6ZSP
• Descriptor: Serine racemase, TRIETHYLENE GLYCOL, DIMETHYL SULFOXIDE, ... (9 entities in total)
• Functional Keywords: plp-dependent, d-serine, isomerase, forebrain
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 153202.92

Authors

Koulouris, C.R.,Bax, B.D.,Roe, S.M.,Atack, J.R. (deposition date: 2020-07-23, release date: 2021-03-03, Last modification date: 2024-01-31)

• Primary citation: Koulouris, C.R.,Gardiner, S.E.,Harris, T.K.,Elvers, K.T.,Mark Roe, S.,Gillespie, J.A.,Ward, S.E.,Grubisha, O.,Nicholls, R.A.,Atack, J.R.,Bax, B.D.; Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase.; Commun Biol, 5:346-346, 2022; PubMed: 35410329; DOI: 10.1038/s42003-022-03264-5

Experimental method

X-RAY DIFFRACTION (1.8 Å)