6ZUJ

Human serine racemase holoenzyme from 20% DMSO soak (XChem crystallographic fragment screen).

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	AAA, BBB, CCC, DDD	Serine racemase	polymer	346	37684.0	4	UniProt (Q9GZT4) Pfam (PF00291) In PDB	Homo sapiens (Human)	D-serine ammonia-lyase,D-serine dehydratase,L-serine ammonia-lyase,L-serine dehydratase
2	CCC, AAA, DDD	TRIETHYLENE GLYCOL	non-polymer		150.2	5	Chemie (PGE)
3	AAA, DDD	DIMETHYL SULFOXIDE	non-polymer		78.1	2	Chemie (DMS)
4	AAA	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
5	DDD, AAA, BBB, CCC	CALCIUM ION	non-polymer		40.1	4	Chemie (CA)
6	DDD, AAA, BBB	SODIUM ION	non-polymer		23.0	6	Chemie (NA)
7	CCC, DDD, AAA, BBB	1,2-ETHANEDIOL	non-polymer		62.1	14	Chemie (EDO)
8	CCC, AAA	GLYCEROL	non-polymer		92.1	4	Chemie (GOL)
9		water	water		18.0	792	Chemie (HOH)

Sequence modifications

AAA, BBB, CCC, DDD: 1 - 340 (UniProt: Q9GZT4)

PDB	External Database	Details
Asp 2	Cys 2	engineered mutation
Asp 6	Cys 6	engineered mutation
His 341	-	expression tag
His 342	-	expression tag
His 343	-	expression tag
His 344	-	expression tag
His 345	-	expression tag
His 346	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	150735.9
Non-Polymers*	Number of molecules	36
	Total formula weight	2467.0
All*	Total formula weight	153202.9

*Water molecules are not included.