6ZUJ
Human serine racemase holoenzyme from 20% DMSO soak (XChem crystallographic fragment screen).
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (AAA, BBB, CCC, DDD) | Serine racemase | polymer | 346 | 37684.0 | 4 | UniProt (Q9GZT4) Pfam (PF00291) | Homo sapiens (Human) | D-serine ammonia-lyase,D-serine dehydratase,L-serine ammonia-lyase,L-serine dehydratase |
| 2 | DA, E, GA, NA, V (CCC, AAA, DDD) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 5 | Chemie (PGE) | |||
| 3 | F, HA (AAA, DDD) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) | |||
| 4 | G (AAA) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | FA, H, R, W (DDD, AAA, BBB, CCC) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 6 | EA, I, O, P, S... (DDD, AAA, BBB) | SODIUM ION | non-polymer | 23.0 | 6 | Chemie (NA) | |||
| 7 | BA, IA, J, JA, K... (CCC, DDD, AAA, BBB) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 14 | Chemie (EDO) | |||
| 8 | AA, CA, N, U (CCC, AAA) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 9 | OA, PA, QA, RA (AAA, BBB, CCC, DDD) | water | water | 18.0 | 792 | Chemie (HOH) |
Sequence modifications
AAA, BBB, CCC, DDD: 1 - 340 (UniProt: Q9GZT4)
| PDB | External Database | Details |
|---|---|---|
| Asp 2 | Cys 2 | engineered mutation |
| Asp 6 | Cys 6 | engineered mutation |
| His 341 | - | expression tag |
| His 342 | - | expression tag |
| His 343 | - | expression tag |
| His 344 | - | expression tag |
| His 345 | - | expression tag |
| His 346 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 150735.9 | |
| Non-Polymers* | Number of molecules | 36 |
| Total formula weight | 2467.0 | |
| All* | Total formula weight | 153202.9 |
