6ZUJ

Human serine racemase holoenzyme from 20% DMSO soak (XChem crystallographic fragment screen).

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0000287	molecular_function	magnesium ion binding
AAA	0003824	molecular_function	catalytic activity
AAA	0003941	molecular_function	L-serine ammonia-lyase activity
AAA	0005509	molecular_function	calcium ion binding
AAA	0005515	molecular_function	protein binding
AAA	0005524	molecular_function	ATP binding
AAA	0005737	cellular_component	cytoplasm
AAA	0005829	cellular_component	cytosol
AAA	0006520	biological_process	amino acid metabolic process
AAA	0006563	biological_process	L-serine metabolic process
AAA	0008721	molecular_function	D-serine ammonia-lyase activity
AAA	0009069	biological_process	serine family amino acid metabolic process
AAA	0009410	biological_process	response to xenobiotic stimulus
AAA	0014070	biological_process	response to organic cyclic compound
AAA	0016594	molecular_function	glycine binding
AAA	0016829	molecular_function	lyase activity
AAA	0016853	molecular_function	isomerase activity
AAA	0018114	molecular_function	threonine racemase activity
AAA	0030165	molecular_function	PDZ domain binding
AAA	0030170	molecular_function	pyridoxal phosphate binding
AAA	0030378	molecular_function	serine racemase activity
AAA	0032496	biological_process	response to lipopolysaccharide
AAA	0042802	molecular_function	identical protein binding
AAA	0042803	molecular_function	protein homodimerization activity
AAA	0042866	biological_process	pyruvate biosynthetic process
AAA	0043025	cellular_component	neuronal cell body
AAA	0045177	cellular_component	apical part of cell
AAA	0046872	molecular_function	metal ion binding
AAA	0070178	biological_process	D-serine metabolic process
AAA	0070179	biological_process	D-serine biosynthetic process
BBB	0000287	molecular_function	magnesium ion binding
BBB	0003824	molecular_function	catalytic activity
BBB	0003941	molecular_function	L-serine ammonia-lyase activity
BBB	0005509	molecular_function	calcium ion binding
BBB	0005515	molecular_function	protein binding
BBB	0005524	molecular_function	ATP binding
BBB	0005737	cellular_component	cytoplasm
BBB	0005829	cellular_component	cytosol
BBB	0006520	biological_process	amino acid metabolic process
BBB	0006563	biological_process	L-serine metabolic process
BBB	0008721	molecular_function	D-serine ammonia-lyase activity
BBB	0009069	biological_process	serine family amino acid metabolic process
BBB	0009410	biological_process	response to xenobiotic stimulus
BBB	0014070	biological_process	response to organic cyclic compound
BBB	0016594	molecular_function	glycine binding
BBB	0016829	molecular_function	lyase activity
BBB	0016853	molecular_function	isomerase activity
BBB	0018114	molecular_function	threonine racemase activity
BBB	0030165	molecular_function	PDZ domain binding
BBB	0030170	molecular_function	pyridoxal phosphate binding
BBB	0030378	molecular_function	serine racemase activity
BBB	0032496	biological_process	response to lipopolysaccharide
BBB	0042802	molecular_function	identical protein binding
BBB	0042803	molecular_function	protein homodimerization activity
BBB	0042866	biological_process	pyruvate biosynthetic process
BBB	0043025	cellular_component	neuronal cell body
BBB	0045177	cellular_component	apical part of cell
BBB	0046872	molecular_function	metal ion binding
BBB	0070178	biological_process	D-serine metabolic process
BBB	0070179	biological_process	D-serine biosynthetic process
CCC	0000287	molecular_function	magnesium ion binding
CCC	0003824	molecular_function	catalytic activity
CCC	0003941	molecular_function	L-serine ammonia-lyase activity
CCC	0005509	molecular_function	calcium ion binding
CCC	0005515	molecular_function	protein binding
CCC	0005524	molecular_function	ATP binding
CCC	0005737	cellular_component	cytoplasm
CCC	0005829	cellular_component	cytosol
CCC	0006520	biological_process	amino acid metabolic process
CCC	0006563	biological_process	L-serine metabolic process
CCC	0008721	molecular_function	D-serine ammonia-lyase activity
CCC	0009069	biological_process	serine family amino acid metabolic process
CCC	0009410	biological_process	response to xenobiotic stimulus
CCC	0014070	biological_process	response to organic cyclic compound
CCC	0016594	molecular_function	glycine binding
CCC	0016829	molecular_function	lyase activity
CCC	0016853	molecular_function	isomerase activity
CCC	0018114	molecular_function	threonine racemase activity
CCC	0030165	molecular_function	PDZ domain binding
CCC	0030170	molecular_function	pyridoxal phosphate binding
CCC	0030378	molecular_function	serine racemase activity
CCC	0032496	biological_process	response to lipopolysaccharide
CCC	0042802	molecular_function	identical protein binding
CCC	0042803	molecular_function	protein homodimerization activity
CCC	0042866	biological_process	pyruvate biosynthetic process
CCC	0043025	cellular_component	neuronal cell body
CCC	0045177	cellular_component	apical part of cell
CCC	0046872	molecular_function	metal ion binding
CCC	0070178	biological_process	D-serine metabolic process
CCC	0070179	biological_process	D-serine biosynthetic process
DDD	0000287	molecular_function	magnesium ion binding
DDD	0003824	molecular_function	catalytic activity
DDD	0003941	molecular_function	L-serine ammonia-lyase activity
DDD	0005509	molecular_function	calcium ion binding
DDD	0005515	molecular_function	protein binding
DDD	0005524	molecular_function	ATP binding
DDD	0005737	cellular_component	cytoplasm
DDD	0005829	cellular_component	cytosol
DDD	0006520	biological_process	amino acid metabolic process
DDD	0006563	biological_process	L-serine metabolic process
DDD	0008721	molecular_function	D-serine ammonia-lyase activity
DDD	0009069	biological_process	serine family amino acid metabolic process
DDD	0009410	biological_process	response to xenobiotic stimulus
DDD	0014070	biological_process	response to organic cyclic compound
DDD	0016594	molecular_function	glycine binding
DDD	0016829	molecular_function	lyase activity
DDD	0016853	molecular_function	isomerase activity
DDD	0018114	molecular_function	threonine racemase activity
DDD	0030165	molecular_function	PDZ domain binding
DDD	0030170	molecular_function	pyridoxal phosphate binding
DDD	0030378	molecular_function	serine racemase activity
DDD	0032496	biological_process	response to lipopolysaccharide
DDD	0042802	molecular_function	identical protein binding
DDD	0042803	molecular_function	protein homodimerization activity
DDD	0042866	biological_process	pyruvate biosynthetic process
DDD	0043025	cellular_component	neuronal cell body
DDD	0045177	cellular_component	apical part of cell
DDD	0046872	molecular_function	metal ion binding
DDD	0070178	biological_process	D-serine metabolic process
DDD	0070179	biological_process	D-serine biosynthetic process

Functional Information from PROSITE/UniProt

site_id	PS00165
Number of Residues	14
Details	DEHYDRATASE_SER_THR Serine/threonine dehydratases pyridoxal-phosphate attachment site. Elfqk.TGSFKIRGA

Chain	Residue	Details
AAA	GLU47-ALA60

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:O59791

Chain	Residue	Details
AAA	LLP56
AAA	SER84
BBB	LLP56
BBB	SER84
CCC	LLP56
CCC	SER84
DDD	LLP56
DDD	SER84

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:35410329, ECO:0007744|PDB:7NBH

Chain	Residue	Details
AAA	GLU13
BBB	GLU13
CCC	GLU13
DDD	GLU13

---

site_id	SWS_FT_FI3
Number of Residues	36
Details	BINDING: BINDING => ECO:0000269|PubMed:35410329, ECO:0007744|PDB:6ZSP

Chain	Residue	Details
AAA	SER31
BBB	SER31
BBB	SER32
BBB	ILE33
BBB	LYS51
BBB	THR52
BBB	GLN89
BBB	TYR121
BBB	LYS279
BBB	ASN316
CCC	SER31
AAA	SER32
CCC	SER32
CCC	ILE33
CCC	LYS51
CCC	THR52
CCC	GLN89
CCC	TYR121
CCC	LYS279
CCC	ASN316
DDD	SER31
DDD	SER32
AAA	ILE33
DDD	ILE33
DDD	LYS51
DDD	THR52
DDD	GLN89
DDD	TYR121
DDD	LYS279
DDD	ASN316
AAA	LYS51
AAA	THR52
AAA	GLN89
AAA	TYR121
AAA	LYS279
AAA	ASN316

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:35410329, ECO:0007744|PDB:7NBC, ECO:0007744|PDB:7NBF

Chain	Residue	Details
AAA	PRO69
BBB	PRO69
CCC	PRO69
DDD	PRO69

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:35410329, ECO:0007744|PDB:7NBD

Chain	Residue	Details
AAA	THR81
BBB	THR81
CCC	THR81
DDD	THR81

---

site_id	SWS_FT_FI6
Number of Residues	28
Details	BINDING: BINDING => ECO:0000269|PubMed:20106978, ECO:0000269|PubMed:29277459, ECO:0000269|PubMed:35410329, ECO:0007744|PDB:3L6B, ECO:0007744|PDB:5X2L, ECO:0007744|PDB:7NBC, ECO:0007744|PDB:7NBD, ECO:0007744|PDB:7NBF, ECO:0007744|PDB:7NBG

Chain	Residue	Details
AAA	ASN86
BBB	GLY186
BBB	GLY187
BBB	GLY188
BBB	MET189
BBB	SER313
CCC	ASN86
CCC	GLY185
CCC	GLY186
CCC	GLY187
CCC	GLY188
AAA	GLY185
CCC	MET189
CCC	SER313
DDD	ASN86
DDD	GLY185
DDD	GLY186
DDD	GLY187
DDD	GLY188
DDD	MET189
DDD	SER313
AAA	GLY186
AAA	GLY187
AAA	GLY188
AAA	MET189
AAA	SER313
BBB	ASN86
BBB	GLY185

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q76EQ0

Chain	Residue	Details
AAA	ASN154
BBB	ASN154
CCC	ASN154
DDD	ASN154

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:32039887, ECO:0000269|PubMed:35410329, ECO:0007744|PDB:6SLH, ECO:0007744|PDB:6ZUJ, ECO:0007744|PDB:7NBD

Chain	Residue	Details
AAA	ASP178
BBB	ASP178
CCC	ASP178
DDD	ASP178

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:20106978, ECO:0000269|PubMed:35410329, ECO:0007744|PDB:3L6B, ECO:0007744|PDB:3L6R

Chain	Residue	Details
AAA	GLU210
BBB	GLU210
CCC	GLU210
DDD	GLU210

---

site_id	SWS_FT_FI10
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:20106978, ECO:0007744|PDB:3L6B, ECO:0007744|PDB:3L6R

Chain	Residue	Details
AAA	ALA214
AAA	ASP216
BBB	ALA214
BBB	ASP216
CCC	ALA214
CCC	ASP216
DDD	ALA214
DDD	ASP216

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:35410329, ECO:0007744|PDB:7NBC, ECO:0007744|PDB:7NBD, ECO:0007744|PDB:7NBF, ECO:0007744|PDB:7NBG, ECO:0007744|PDB:7NBH

Chain	Residue	Details
AAA	ASN247
BBB	ASN247
CCC	ASN247
DDD	ASN247

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:20106978, ECO:0000269|PubMed:29277459, ECO:0000269|PubMed:35410329, ECO:0007744|PDB:3L6B, ECO:0007744|PDB:5X2L, ECO:0007744|PDB:7NBC, ECO:0007744|PDB:7NBD, ECO:0007744|PDB:7NBF, ECO:0007744|PDB:7NBG

Chain	Residue	Details
AAA	LLP56
BBB	LLP56
CCC	LLP56
DDD	LLP56

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	MOD_RES: S-nitrosocysteine => ECO:0000250|UniProtKB:Q9QZX7

Chain	Residue	Details
AAA	CYS113
BBB	CYS113
CCC	CYS113
DDD	CYS113

---