1T5S
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![BU of 1t5s by Molmil](/molmil-images/mine/1t5s) | Structure of the (SR)Ca2+-ATPase Ca2-E1-AMPPCP form | Descriptor: | CALCIUM ION, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | Authors: | Sorensen, T.L.-M, Moller, J.V, Nissen, P. | Deposit date: | 2004-05-05 | Release date: | 2004-06-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Phosphoryl transfer and calcium ion occlusion in the calcium pump. Science, 304, 2004
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4RET
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![BU of 4ret by Molmil](/molmil-images/mine/4ret) | Crystal structure of the Na,K-ATPase E2P-digoxin complex with bound magnesium | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | Authors: | Gregersen, J.L, Laursen, M, Yatime, L, Nissen, P, Fedosova, N.U. | Deposit date: | 2014-09-23 | Release date: | 2015-01-28 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | Structures and characterization of digoxin- and bufalin-bound Na+,K+-ATPase compared with the ouabain-bound complex. Proc.Natl.Acad.Sci.USA, 112, 2015
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3FPS
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![BU of 3fps by Molmil](/molmil-images/mine/3fps) | The Structure of Sarcoplasmic Reticulum Ca2+-ATPase Bound To Cyclopiazonic and ADP | Descriptor: | (6AR,11AS,11BR)-10-ACETYL-9-HYDROXY-7,7-DIMETHYL-2,6,6A,7,11A,11B-HEXAHYDRO-11H-PYRROLO[1',2':2,3]ISOINDOLO[4,5,6-CD]INDOL-11-ONE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Moncoq, K, Morth, J.P, Bublitz, M, Laursen, M, Nissen, P, Young, H.S. | Deposit date: | 2009-01-06 | Release date: | 2009-04-07 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Cyclopiazonic acid is complexed to a divalent metal ion when bound to the sarcoplasmic reticulum Ca2+-ATPase. J.Biol.Chem., 284, 2009
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8OWA
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![BU of 8owa by Molmil](/molmil-images/mine/8owa) | SR Ca(2+)-ATPase in the E2 state complexed with the photoswitch-thapsigargin derivative AzTG-4 | Descriptor: | ACETYL GROUP, SODIUM ION, Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, ... | Authors: | Hjorth-Jensen, S.J, Konrad, D.B, Quistgaard, E.M.H, Hansen, L.C, Novak, A, Chu, H, Jurasek, M, Zimmermann, T, Andersen, J.L, Baran, P.S, Nissen, P, Trauner, D. | Deposit date: | 2023-04-27 | Release date: | 2023-06-21 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Photoswitchable inhibitors of the sarco(endo)plasmic calcium pump To Be Published
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3FGO
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![BU of 3fgo by Molmil](/molmil-images/mine/3fgo) | Crystal Structure of the E2 magnesium fluoride complex of the (SR) Ca2+-ATPase with bound CPA and AMPPCP | Descriptor: | (6AR,11AS,11BR)-10-ACETYL-9-HYDROXY-7,7-DIMETHYL-2,6,6A,7,11A,11B-HEXAHYDRO-11H-PYRROLO[1',2':2,3]ISOINDOLO[4,5,6-CD]INDOL-11-ONE, ACETATE ION, MAGNESIUM ION, ... | Authors: | Laursen, M, Bublitz, M, Moncoq, K, Olesen, C, Moller, J.V, Young, H.S, Nissen, P, Morth, J.P. | Deposit date: | 2008-12-08 | Release date: | 2009-04-07 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Cyclopiazonic acid is complexed to a divalent metal ion when bound to the sarcoplasmic reticulum Ca2+-ATPase. J.Biol.Chem., 2009
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3FPB
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![BU of 3fpb by Molmil](/molmil-images/mine/3fpb) | The Structure of Sarcoplasmic Reticulum Ca2+-ATPase Bound To Cyclopiazonic acid with ATP | Descriptor: | (6AR,11AS,11BR)-10-ACETYL-9-HYDROXY-7,7-DIMETHYL-2,6,6A,7,11A,11B-HEXAHYDRO-11H-PYRROLO[1',2':2,3]ISOINDOLO[4,5,6-CD]INDOL-11-ONE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Moncoq, K, Morth, J.P, Bublitz, M, Laursen, M, Nissen, P, Young, H.S. | Deposit date: | 2009-01-05 | Release date: | 2009-04-07 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Cyclopiazonic acid is complexed to a divalent metal ion when bound to the sarcoplasmic reticulum Ca2+-ATPase. J.Biol.Chem., 284, 2009
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4RES
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![BU of 4res by Molmil](/molmil-images/mine/4res) | Crystal structure of the Na,K-ATPase E2P-bufalin complex with bound potassium | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | Authors: | Laursen, M, Yatime, L, Gregersen, J.L, Nissen, P, Fedosova, N.U. | Deposit date: | 2014-09-23 | Release date: | 2015-01-28 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.408 Å) | Cite: | Structures and characterization of digoxin- and bufalin-bound Na+,K+-ATPase compared with the ouabain-bound complex. Proc.Natl.Acad.Sci.USA, 112, 2015
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6ZHH
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![BU of 6zhh by Molmil](/molmil-images/mine/6zhh) | Ca2+-ATPase from Listeria Monocytogenes with G4 insertion. | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, BERYLLIUM TRIFLUORIDE ION, Calcium-transporting ATPase, ... | Authors: | Basse Hansen, S, Dyla, M, Neumann, C, Quistgaard, E.M.H, Lauwring Andersen, J, Kjaergaard, M, Nissen, P. | Deposit date: | 2020-06-23 | Release date: | 2021-05-19 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The Crystal Structure of the Ca 2+ -ATPase 1 from Listeria monocytogenes reveals a Pump Primed for Dephosphorylation. J.Mol.Biol., 433, 2021
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6ZHF
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![BU of 6zhf by Molmil](/molmil-images/mine/6zhf) | Calcium ATPase-1 from Listeria monocytogenes in complex with BeF | Descriptor: | BERYLLIUM TRIFLUORIDE ION, Calcium-transporting ATPase, MAGNESIUM ION | Authors: | Basse Hansen, S, Dyla, M, Neumann, C, Quistgaard, E.M.H, Lauwring Andersen, J, Kjaergaard, M, Nissen, P. | Deposit date: | 2020-06-23 | Release date: | 2021-05-19 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | The Crystal Structure of the Ca 2+ -ATPase 1 from Listeria monocytogenes reveals a Pump Primed for Dephosphorylation. J.Mol.Biol., 433, 2021
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4J2T
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![BU of 4j2t by Molmil](/molmil-images/mine/4j2t) | Inhibitor-bound Ca2+ ATPase | Descriptor: | (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-3a,4-bis(butanoyloxy)-3-hydroxy-3,6,9-trimethyl-8-{[(2E)-2-methylbut-2-enoyl]oxy}-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-7-yl octanoate, PHOSPHATIDYLETHANOLAMINE, POTASSIUM ION, ... | Authors: | Paulsen, E.S, Villadsen, J, Tenori, E, Liu, H, Lie, M.A, Bonde, D.F, Bublitz, M, Olesen, C, Autzen, H.E, Dach, I, Sehgal, P, Moller, J.V, Schiott, B, Nissen, P, Christensen, S.B. | Deposit date: | 2013-02-05 | Release date: | 2013-06-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Water-mediated interactions influence the binding of thapsigargin to sarco/endoplasmic reticulum calcium adenosinetriphosphatase. J.Med.Chem., 56, 2013
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6ZHG
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![BU of 6zhg by Molmil](/molmil-images/mine/6zhg) | Ca2+-ATPase from Listeria Monocytogenes in complex with AlF | Descriptor: | Calcium-transporting ATPase, MAGNESIUM ION, TETRAFLUOROALUMINATE ION | Authors: | Basse Hansen, S, Dyla, M, Neumann, C, Quistgaard, E.M.H, Lauwring Andersen, J, Kjaergaard, M, Nissen, P. | Deposit date: | 2020-06-23 | Release date: | 2021-05-19 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | The Crystal Structure of the Ca 2+ -ATPase 1 from Listeria monocytogenes reveals a Pump Primed for Dephosphorylation. J.Mol.Biol., 433, 2021
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8K1L
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![BU of 8k1l by Molmil](/molmil-images/mine/8k1l) | Cryo-EM structure of Na+,K+-ATPase alpha2 from Artemia salina in cation-free E2P form | Descriptor: | Na+,K+-ATPase alpha2KK, Na+,K+-ATPase beta2, TETRAFLUOROALUMINATE ION | Authors: | Abe, K, Artigas, P. | Deposit date: | 2023-07-11 | Release date: | 2023-11-29 | Last modified: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (3.44 Å) | Cite: | A Na pump with reduced stoichiometry is up-regulated by brine shrimp in extreme salinities. Proc.Natl.Acad.Sci.USA, 120, 2023
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8OWL
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![BU of 8owl by Molmil](/molmil-images/mine/8owl) | SR Ca(2+)-ATPase in the E2 state complexed with the photoswitch-thapsigargin derivative AzTG-6 | Descriptor: | ACETYL GROUP, SODIUM ION, Sarcoplasmic/endoplasmic reticulum calcium ATPase 1, ... | Authors: | Hjorth-Jensen, S.J, Konrad, D.B, Quistgaard, E.M.H, Hansen, L.C, Novak, A, Chu, H, Jurasek, M, Zimmermann, T, Andersen, J.L, Baran, P.S, Nissen, P, Trauner, D. | Deposit date: | 2023-04-28 | Release date: | 2023-06-21 | Method: | X-RAY DIFFRACTION (3.02 Å) | Cite: | Photoswitchable inhibitors of the sarco(endo)plasmic calcium pump To Be Published
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1WPG
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![BU of 1wpg by Molmil](/molmil-images/mine/1wpg) | Crystal structure of the SR CA2+-ATPase with MGF4 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, OCTANOIC ACID [3S-[3ALPHA, ... | Authors: | Toyoshima, C, Nomura, H, Tsuda, T. | Deposit date: | 2004-09-02 | Release date: | 2004-10-05 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Lumenal gating mechanism revealed in calcium pump crystal structures with phosphate analogues Nature, 432, 2004
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4HYT
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![BU of 4hyt by Molmil](/molmil-images/mine/4hyt) | Na,K-ATPase in the E2P state with bound ouabain and Mg2+ in the cation-binding site | Descriptor: | 1-O-decanoyl-beta-D-tagatofuranosyl beta-D-allopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Laursen, M, Yatime, L, Nissen, P, Fedosova, N.U. | Deposit date: | 2012-11-14 | Release date: | 2013-06-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.404 Å) | Cite: | Crystal structure of the high-affinity Na+,K+-ATPase-ouabain complex with Mg2+ bound in the cation binding site. Proc.Natl.Acad.Sci.USA, 110, 2013
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4KYT
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![BU of 4kyt by Molmil](/molmil-images/mine/4kyt) | The structure of superinhibitory phospholamban bound to the calcium pump SERCA1a | Descriptor: | Cardiac phospholamban, POTASSIUM ION, SERCA1a, ... | Authors: | Hurley, T.D, Akin, B.L, Jones, L.R. | Deposit date: | 2013-05-29 | Release date: | 2013-09-04 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.833 Å) | Cite: | The structural basis for phospholamban inhibition of the calcium pump in sarcoplasmic reticulum. J.Biol.Chem., 288, 2013
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4UX2
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![BU of 4ux2 by Molmil](/molmil-images/mine/4ux2) | Cryo-EM structure of antagonist-bound E2P gastric H,K-ATPase (SCH.E2. MgF) | Descriptor: | POTASSIUM-TRANSPORTING ATPASE ALPHA CHAIN 1, POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA | Authors: | Abe, K, Tani, K, Fujiyoshi, Y. | Deposit date: | 2014-08-18 | Release date: | 2014-09-17 | Last modified: | 2014-11-12 | Method: | ELECTRON CRYSTALLOGRAPHY (7 Å) | Cite: | Systematic Comparison of Molecular Conformations of H+,K+-ATPase Reveals an Important Contribution of the A-M2 Linker for the Luminal Gating. J.Biol.Chem., 289, 2014
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2AGV
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![BU of 2agv by Molmil](/molmil-images/mine/2agv) | Crystal structure of the SR CA2+-ATPASE with BHQ and TG | Descriptor: | 2,5-DITERT-BUTYLBENZENE-1,4-DIOL, OCTANOIC ACID [3S-[3ALPHA, 3ABETA, ... | Authors: | Toyoshima, C, Obara, K, Norimatsu, Y. | Deposit date: | 2005-07-27 | Release date: | 2005-10-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Inaugural Article: Structural role of countertransport revealed in Ca2+ pump crystal structure in the absence of Ca2+. Proc.Natl.Acad.Sci.USA, 102, 2005
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1VFP
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![BU of 1vfp by Molmil](/molmil-images/mine/1vfp) | |
2BY4
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![BU of 2by4 by Molmil](/molmil-images/mine/2by4) | SR Ca(2+)-ATPase in the HnE2 state complexed with the thapsigargin derivative Boc-12ADT. | Descriptor: | (3S,3AR,4S,6S,6AR,7S,8S,9BS)-6-(ACETYLOXY)-3,3A-DIHYDROXY-3,6,9-TRIMETHYL-8-{[(2Z)-2-METHYLBUT-2-ENOYL]OXY}-7-(OCTANOYLOXY)-2-OXO-2,3,3A,4,5,6,6A,7,8,9B-DECAHYDROAZULENO[4,5-B]FURAN-4-YL 12-[(TERT-BUTOXYCARBONYL)AMINO]DODECANOATE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | Authors: | Jensen, A.L, Moller, J.V, Soehoel, H, Denmeade, S.R, Isaacs, J.T, Olsen, C.E, Christensen, S.B, Nissen, P. | Deposit date: | 2005-07-28 | Release date: | 2006-04-07 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Natural Products as Starting Materials for Development of Second-Generation Serca Inhibitors Targeted Towards Prostate Cancer Cells Bioorg.Med.Chem., 14, 2006
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1XP5
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![BU of 1xp5 by Molmil](/molmil-images/mine/1xp5) | Structure Of The (Sr)Ca2+-ATPase E2-AlF4- Form | Descriptor: | MAGNESIUM ION, OCTANOIC ACID [3S-[3ALPHA, 3ABETA, ... | Authors: | Olesen, C, Sorensen, T.L.S, Nielsen, R.C, Moller, J.V, Nissen, P. | Deposit date: | 2004-10-08 | Release date: | 2005-01-04 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Dephosphorylation of the Calcium Pump Coupled to Counterion Occlusion Science, 306, 2004
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2C9M
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![BU of 2c9m by Molmil](/molmil-images/mine/2c9m) | Structure of (SR) Calcium-ATPase in the Ca2E1 state solved in a P1 crystal form. | Descriptor: | CALCIUM ION, CHLORIDE ION, POTASSIUM ION, ... | Authors: | Lund Jensen, A.-M, Sorensen, T.L.-M, Olesen, C, Moller, J.V, Nissen, P. | Deposit date: | 2005-12-13 | Release date: | 2006-12-18 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Modulatory and Catalytic Modes of ATP Binding by the Calcium Pump Embo J., 25, 2006
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5XAA
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![BU of 5xaa by Molmil](/molmil-images/mine/5xaa) | Complete structure factors and an atomic model of the calcium pump (SERCA1A) and associated phospholipids in the E2-ALF-(TG) crystals of P21212 symmetry | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, MAGNESIUM ION, OCTANOIC ACID [3S-[3ALPHA, ... | Authors: | Norimatsu, Y, Hasegawa, K, Shimizu, N, Toyoshima, C. | Deposit date: | 2017-03-11 | Release date: | 2017-05-24 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Protein-phospholipid interplay revealed with crystals of a calcium pump. Nature, 545, 2017
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5XA8
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![BU of 5xa8 by Molmil](/molmil-images/mine/5xa8) | Complete structure factors and an atomic model of the calcium pump (SERCA1A) and associated phospholipids in the E1-ALF4-ADP-2CA2+ crystals | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, ... | Authors: | Norimatsu, Y, Hasegawa, K, Shimizu, N, Toyoshima, C. | Deposit date: | 2017-03-11 | Release date: | 2017-05-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Protein-phospholipid interplay revealed with crystals of a calcium pump. Nature, 545, 2017
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5XA9
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![BU of 5xa9 by Molmil](/molmil-images/mine/5xa9) | Complete structure factors and an atomic model of the calcium pump (SERCA1A) and associated phospholipids in the E2-ALF-(TG) crystals of C2 symmetry | Descriptor: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, MAGNESIUM ION, OCTANOIC ACID [3S-[3ALPHA, ... | Authors: | Norimatsu, Y, Hasegawa, K, Shimizu, N, Toyoshima, C. | Deposit date: | 2017-03-11 | Release date: | 2017-06-14 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Protein-phospholipid interplay revealed with crystals of a calcium pump. Nature, 545, 2017
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