2BY4
SR Ca(2+)-ATPase in the HnE2 state complexed with the thapsigargin derivative Boc-12ADT.
Summary for 2BY4
Entry DOI | 10.2210/pdb2by4/pdb |
Related | 1FQU 1IWO 1KJU 1SU4 1T5S 1T5T 1VFP 1WPE 1WPG 1XP5 2AGV 2C88 2C8K 2C8L 2C9M |
Descriptor | SARCOPLASMIC/ENDOPLASMIC RETICULUM CALCIUM ATPASE 1, (3S,3AR,4S,6S,6AR,7S,8S,9BS)-6-(ACETYLOXY)-3,3A-DIHYDROXY-3,6,9-TRIMETHYL-8-{[(2Z)-2-METHYLBUT-2-ENOYL]OXY}-7-(OCTANOYLOXY)-2-OXO-2,3,3A,4,5,6,6A,7,8,9B-DECAHYDROAZULENO[4,5-B]FURAN-4-YL 12-[(TERT-BUTOXYCARBONYL)AMINO]DODECANOATE, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (5 entities in total) |
Functional Keywords | serca, p-type atpase, ca2+-atpase, thapsigargin, prostate cancer, atp-binding, calcium, calcium transport, endoplasmic reticulum, hydrolase, ion transport, magnesium, metal-binding, multigene family, nucleotide-binding, phosphorylation, sarcoplasmic reticulum, transmembrane, transport |
Biological source | ORYCTOLAGUS CUNICULUS (RABBIT) |
Cellular location | Endoplasmic reticulum membrane; Multi-pass membrane protein: P04191 |
Total number of polymer chains | 1 |
Total formula weight | 111057.48 |
Authors | Jensen, A.L.,Moller, J.V.,Soehoel, H.,Denmeade, S.R.,Isaacs, J.T.,Olsen, C.E.,Christensen, S.B.,Nissen, P. (deposition date: 2005-07-28, release date: 2006-04-07, Last modification date: 2023-12-13) |
Primary citation | Soehoel, H.,Jensen, A.L.,Moller, J.V.,Nissen, P.,Denmeade, S.R.,Isaacs, J.T.,Olsen, C.E.,Christensen, S.B. Natural Products as Starting Materials for Development of Second-Generation Serca Inhibitors Targeted Towards Prostate Cancer Cells Bioorg.Med.Chem., 14:2810-, 2006 Cited by PubMed: 16412648DOI: 10.1016/J.BMC.2005.12.001 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.3 Å) |
Structure validation
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