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6VGR	Crystal Structure of Human Dipeptidase 3 in Complex with Fab of SC-003 Descriptor: Dipeptidase 3, SC-003 Fab Heavy Chain, SC-003 Fab Light Chain Authors: Hayashi, K, Longenecker, K.L, Vivona, S. Deposit date: 2020-01-08 Release date: 2020-05-13 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.84 Å) Cite: Structure of human DPEP3 in complex with the SC-003 antibody Fab fragment reveals basis for lack of dipeptidase activity. J.Struct.Biol., 211, 2020
1I4W	THE CRYSTAL STRUCTURE OF THE TRANSCRIPTION FACTOR SC-MTTFB OFFERS INTRIGUING INSIGHTS INTO MITOCHONDRIAL TRANSCRIPTION Descriptor: MITOCHONDRIAL REPLICATION PROTEIN MTF1, XENON Authors: Schubot, F.D, Chen, C.-J, Rose, J.P, Dailey, T.A, Dailey, H.A, Wang, B.-C. Deposit date: 2001-02-23 Release date: 2001-10-03 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Crystal structure of the transcription factor sc-mtTFB offers insights into mitochondrial transcription. Protein Sci., 10, 2001
1HOV	SOLUTION STRUCTURE OF A CATALYTIC DOMAIN OF MMP-2 COMPLEXED WITH SC-74020 Descriptor: CALCIUM ION, MATRIX METALLOPROTEINASE-2, N-{4-[(1-HYDROXYCARBAMOYL-2-METHYL-PROPYL)-(2-MORPHOLIN-4-YL-ETHYL)-SULFAMOYL]-4-PENTYL-BENZAMIDE, ... Authors: Feng, Y, Likos, J.J, Zhu, L, Woodward, H, Munie, G, McDonald, J.J, Stevens, A.M, Howard, C.P, De Crescenzo, G.A, Welsch, D, Shieh, H.-S, Stallings, W.C. Deposit date: 2000-12-11 Release date: 2001-12-12 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Solution structure and backbone dynamics of the catalytic domain of matrix metalloproteinase-2 complexed with a hydroxamic acid inhibitor Biochim.Biophys.Acta, 1598, 2002
2K66	NMR solution structure of the d3'-stem closed by a GAAA tetraloop of the group II intron Sc.ai5(gamma) Descriptor: 5'-R(*GP*GP*AP*GP*UP*AP*UP*GP*UP*GP*AP*AP*AP*GP*CP*AP*UP*AP*CP*UP*CP*C)-3' Authors: Kruschel, D, Sigel, R.K.O. Deposit date: 2008-07-04 Release date: 2009-07-14 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: NMR structure of the 5' splice site in the group IIB intron Sc.ai5 gamma--conformational requirements for exon-intron recognition. Rna, 20, 2014
2M24	NMR solution structure of the d3'-hairpin including the exon binding site 1 (EBS1) of the group II intron Sc.ai5gamma Descriptor: RNA (29-MER) Authors: Kruschel, D, Skilandat, M, Sigel, R.K.O. Deposit date: 2012-12-12 Release date: 2013-12-18 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: NMR structure of the 5' splice site in the group IIB intron Sc.ai5 gamma--conformational requirements for exon-intron recognition. Rna, 20, 2014
2M23	NMR solution structure of the d3'-hairpin of the group II intron Sc.ai5gamma including EBS1 bound to IBS1 Descriptor: RNA (29-MER), RNA_(5'-R(*CP*AP*GP*UP*GP*UP*C)-3')_ Authors: Kruschel, D, Skilandat, M, Sigel, R.K.O. Deposit date: 2012-12-12 Release date: 2013-12-18 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: NMR structure of the 5' splice site in the group IIB intron Sc.ai5 gamma--conformational requirements for exon-intron recognition. Rna, 20, 2014
6VGO	Crystal Structure of Human Dipeptidase 3 Descriptor: Dipeptidase 3 Authors: Hayashi, K, Longenecker, K.L, Vivona, S. Deposit date: 2020-01-08 Release date: 2020-05-13 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Structure of human DPEP3 in complex with the SC-003 antibody Fab fragment reveals basis for lack of dipeptidase activity. J.Struct.Biol., 211, 2020
6LP1	Crystal structure of acetate:succinate CoA transferase (ASCT) from Trypanosoma brucei. Descriptor: CALCIUM ION, GLYCEROL, Succinyl-CoA:3-ketoacid-coenzyme A transferase Authors: Mochizuki, K, Inaoka, D.K, Shiba, T, Fukuda, K, Kurasawa, H, Mazet, M, Millerioux, Y, Bringaud, F, Boshart, M, Balogun, E.O, Harada, S, Hirayama, K, Kita, K. Deposit date: 2020-01-08 Release date: 2020-10-07 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.01 Å) Cite: The ASCT/SCS cycle fuels mitochondrial ATP and acetate production in Trypanosoma brucei. Biochim Biophys Acta Bioenerg, 1861, 2020
8A3K	X-ray crystal structure of a de novo designed single-chain antiparallel 4-helix coiled-coil bundle, sc-apCC-4 Descriptor: sc-apCC-4 Authors: Albanese, K.I, Mylemans, B, Naudin, E.A, Woolfson, D.N. Deposit date: 2022-06-08 Release date: 2022-10-05 Last modified: 2024-05-01 Method: X-RAY DIFFRACTION (2 Å) Cite: From peptides to proteins: coiled-coil tetramers to single-chain 4-helix bundles. Chem Sci, 13, 2022
8QAH	X-ray crystal structure of a de novo designed single-chain parallel coiled-coil alpha-helical barrel with 8 inner helices, sc-CC-8-58 Descriptor: sc-CC-8-58 Authors: Petrenas, R, Albanese, K.I, Woolfson, D.N. Deposit date: 2023-08-22 Release date: 2024-07-03 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Rationally seeded computational protein design of ɑ-helical barrels. Nat.Chem.Biol., 2024
8QAF	X-ray crystal structure of a de novo designed single-chain antiparallel 8-helix coiled-coil alpha-helical barrel, sc-apCC-8 Descriptor: sc-apCC-8 Authors: Albanese, K.I, Petrenas, R, Woolfson, D.N. Deposit date: 2023-08-22 Release date: 2024-07-03 Method: X-RAY DIFFRACTION (2 Å) Cite: Rationally seeded computational protein design of ɑ-helical barrels. Nat.Chem.Biol., 2024
6XKZ	R. capsulatus CIII2CIV tripartite super-complex, conformation B (SC-1B) Descriptor: COPPER (II) ION, Cbb3-type cytochrome c oxidase subunit CcoP,Cytochrome c-type cyt cy, Cytochrome b, ... Authors: Steimle, S, Van Eeuwen, T, Ozturk, Y, Kim, H.J, Braitbard, M, Selamoglu, N, Garcia, B.A, Schneidman-Duhovny, D, Murakami, K, Daldal, F. Deposit date: 2020-06-27 Release date: 2020-12-30 Last modified: 2021-03-03 Method: ELECTRON MICROSCOPY (7.2 Å) Cite: Cryo-EM structures of engineered active bc 1 -cbb 3 type CIII 2 CIV super-complexes and electronic communication between the complexes. Nat Commun, 12, 2021
6XKW	R. capsulatus CIII2CIV bipartite super-complex (SC-2A) with CcoH/cy Descriptor: COPPER (II) ION, Cbb3-type cytochrome c oxidase subunit CcoP, Cytochrome b, ... Authors: Steimle, S, Van Eeuwen, T, Ozturk, Y, Kim, H.J, Braitbard, M, Selamoglu, N, Garcia, B.A, Schneidman-Duhovny, D, Murakami, K, Daldal, F. Deposit date: 2020-06-27 Release date: 2020-12-30 Last modified: 2021-03-03 Method: ELECTRON MICROSCOPY (5.2 Å) Cite: Cryo-EM structures of engineered active bc 1 -cbb 3 type CIII 2 CIV super-complexes and electronic communication between the complexes. Nat Commun, 12, 2021
6XKX	R. capsulatus CIII2CIV tripartite super-complex, conformation A (SC-1A) Descriptor: COPPER (II) ION, Cbb3-type cytochrome c oxidase subunit CcoP,Cytochrome c-type cyt cy, Cytochrome b, ... Authors: Steimle, S, Van Eeuwen, T, Ozturk, Y, Kim, H.J, Braitbard, M, Selamoglu, N, Garcia, B.A, Schneidman-Duhovny, D, Murakami, K, Daldal, F. Deposit date: 2020-06-27 Release date: 2020-12-30 Last modified: 2021-03-03 Method: ELECTRON MICROSCOPY (6.1 Å) Cite: Cryo-EM structures of engineered active bc 1 -cbb 3 type CIII 2 CIV super-complexes and electronic communication between the complexes. Nat Commun, 12, 2021
3MQE	Structure of SC-75416 bound at the COX-2 active site Descriptor: (2S)-7-tert-butyl-6-chloro-2-(trifluoromethyl)-2H-chromene-3-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Wang, J.L, Limburg, D, Graneto, M.J, Springer, J, Rogier, J, Kiefer, J.R. Deposit date: 2010-04-28 Release date: 2010-10-27 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.8 Å) Cite: The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: The second clinical candidate having a shorter and favorable human half-life. Bioorg.Med.Chem.Lett., 20, 2010
6Q9B	CI Membrane Arm focused refinement from Ovine respiratory SC I+III2 Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, Acyl carrier protein, ... Authors: Letts, J.A, Sazanov, L.A. Deposit date: 2018-12-17 Release date: 2019-08-21 Last modified: 2019-12-18 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Structures of Respiratory Supercomplex I+III2Reveal Functional and Conformational Crosstalk. Mol.Cell, 75, 2019
6Q9D	CI Peripheral Arm focused refinement from Ovine respiratory SC I+III2 Descriptor: Acyl carrier protein, FE2/S2 (INORGANIC) CLUSTER, FLAVIN MONONUCLEOTIDE, ... Authors: Letts, J.A, Sazanov, L.A. Deposit date: 2018-12-18 Release date: 2019-08-21 Last modified: 2019-12-18 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Structures of Respiratory Supercomplex I+III2Reveal Functional and Conformational Crosstalk. Mol.Cell, 75, 2019
1R50	Bacillus subtilis lipase A with covalently bound Sc-IPG-phosphonate-inhibitor Descriptor: Lipase, [(4S)-2,2-DIMETHYL-1,3-DIOXOLAN-4-YL]METHYL HYDROGEN HEX-5-ENYLPHOSPHONATE Authors: Droege, M.J, Van Pouderoyen, G, Vrenken, T.E, Rueggeberg, C.J, Reetz, M.T, Dijkstra, B.W, Quax, W.J. Deposit date: 2003-10-09 Release date: 2004-10-19 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Directed Evolution of Bacillus subtilis Lipase A by Use of Enantiomeric Phosphonate Inhibitors: Crystal Structures and Phage Display Selection Chembiochem, 7, 2005
3KRY	Crystal structure of MMP-13 in complex with SC-78080 Descriptor: 1-(2-methoxyethyl)-N-oxo-4-({4-[4-(trifluoromethoxy)phenoxy]phenyl}sulfonyl)piperidine-4-carboxamide, CALCIUM ION, Collagenase 3, ... Authors: Kiefer, J.R, Williams, J.M, Becker, D.P. Deposit date: 2009-11-19 Release date: 2010-10-06 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Orally-active MMP-1 sparing alpha-tetrahydropyranyl and alpha-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease J.Med.Chem., 53, 2010
1CX2	CYCLOOXYGENASE-2 (PROSTAGLANDIN SYNTHASE-2) COMPLEXED WITH A SELECTIVE INHIBITOR, SC-558 Descriptor: 1-PHENYLSULFONAMIDE-3-TRIFLUOROMETHYL-5-PARABROMOPHENYLPYRAZOLE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CYCLOOXYGENASE-2, ... Authors: Kurumbail, R, Stallings, W. Deposit date: 1996-12-17 Release date: 1997-12-24 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (3 Å) Cite: Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents. Nature, 384, 1996
6COX	CYCLOOXYGENASE-2 (PROSTAGLANDIN SYNTHASE-2) COMPLEXED WITH A SELECTIVE INHIBITOR, SC-558 IN I222 SPACE GROUP Descriptor: 1-PHENYLSULFONAMIDE-3-TRIFLUOROMETHYL-5-PARABROMOPHENYLPYRAZOLE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CYCLOOXYGENASE-2, ... Authors: Kurumbail, R, Stallings, W. Deposit date: 1996-12-18 Release date: 1997-12-24 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents. Nature, 384, 1996
2M1V	NMR solution structure of the d3'-hairpin from the Sc.ai5gamma group II intron including the EBS1:dIBS1 RNA:DNA hybrid Descriptor: DNA_(5'-D(*CP*AP*GP*TP*GP*TP*C)-3')_, RNA (29-MER) Authors: Skilandat, M, Sigel, R.K.O. Deposit date: 2012-12-07 Release date: 2014-06-11 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: The Role of Mg(II) in DNA Cleavage Site Recognition in Group II Intron Ribozymes: SOLUTION STRUCTURE AND METAL ION BINDING SITES OF THE RNADNA COMPLEX. J.Biol.Chem., 289, 2014
8QAI	X-ray crystal structure of a de novo designed single-chain parallel coiled-coil alpha-helical barrel with 7 inner helices, sc-CC-7-LI Descriptor: DI(HYDROXYETHYL)ETHER, sc-CC-7-LI Authors: Petrenas, R, Albanese, K.I, Woolfson, D.N. Deposit date: 2023-08-22 Release date: 2024-07-03 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Rationally seeded computational protein design of ɑ-helical barrels. Nat.Chem.Biol., 2024
8QKD	X-ray crystal structure of a de novo designed single-chain parallel coiled-coil alpha-helical barrel with 5 inner helices, sc-CC-5-24 Descriptor: DI(HYDROXYETHYL)ETHER, sc-CC-5-24 Authors: Petrenas, R, Albanese, K.I, Woolfson, D.N. Deposit date: 2023-09-15 Release date: 2024-07-03 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Rationally seeded computational protein design of ɑ-helical barrels. Nat.Chem.Biol., 2024
8QAD	X-ray crystal structure of a de novo designed single-chain antiparallel 6-helix coiled-coil alpha-helical barrel, sc-apCC-6-LLIA Descriptor: DODECAETHYLENE GLYCOL, sc-apCC-6-LLIA Authors: Albanese, K.I, Petrenas, R, Woolfson, D.N. Deposit date: 2023-08-22 Release date: 2024-07-03 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Rationally seeded computational protein design of ɑ-helical barrels. Nat.Chem.Biol., 2024

 

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