7A09
 
 | | Structure of a human ABCE1-bound 43S pre-initiation complex - State III | | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | | Authors: | Kratzat, H, Mackens-Kiani, T, Ameismeier, A, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R. | | Deposit date: | 2020-08-07 | | Release date: | 2020-10-14 | | Last modified: | 2021-01-13 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | A structural inventory of native ribosomal ABCE1-43S pre-initiation complexes.
Embo J., 40, 2021
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1YAT
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1YKE
 | | Structure of the mediator MED7/MED21 subcomplex | | Descriptor: | RNA polymerase II holoenzyme component SRB7, RNA polymerase II mediator complex protein MED7 | | Authors: | Baumli, S, Hoeppner, S, Cramer, P. | | Deposit date: | 2005-01-18 | | Release date: | 2005-02-22 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | A conserved mediator hinge revealed in the structure of the MED7.MED21 (Med7.Srb7) heterodimer.
J.Biol.Chem., 280, 2005
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1YKH
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1YCR
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6TGZ
 | | IE1 from human cytomegalovirus | | Descriptor: | 55 kDa immediate-early protein 1 | | Authors: | Schweininger, J, Muller, Y.A. | | Deposit date: | 2019-11-18 | | Release date: | 2020-11-25 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Cytomegalovirus immediate-early 1 proteins form a structurally distinct protein class with adaptations determining cross-species barriers.
Plos Pathog., 17, 2021
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9BLG
 | | Crystal structure of non-receptor protein tyrosine phosphatase SHP2 in complex with PF-07284892 | | Descriptor: | (1S)-1'-{6-[(2-amino-3-chloropyridin-4-yl)sulfanyl]-1,2,4-triazin-3-yl}-1,3-dihydrospiro[indene-2,4'-piperidin]-1-amine, Tyrosine-protein phosphatase non-receptor type 11 | | Authors: | Bester, S.M, Wu, W.-I, Mou, T.-C. | | Deposit date: | 2024-04-30 | | Release date: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.06 Å) | | Cite: | SHP2 Inhibition Sensitizes Diverse Oncogene-Addicted Solid Tumors to Re-treatment with Targeted Therapy.
Cancer Discov, 13, 2023
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8FFW
 | | Cryo-EM structure of the GR-Hsp90-FKBP51 complex | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DEXAMETHASONE, Glucocorticoid receptor, ... | | Authors: | Noddings, C.M, Agard, D.A. | | Deposit date: | 2022-12-10 | | Release date: | 2023-11-01 | | Last modified: | 2023-12-20 | | Method: | ELECTRON MICROSCOPY (3.23 Å) | | Cite: | Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor.
Nat.Struct.Mol.Biol., 30, 2023
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1YCI
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8FFV
 | | Cryo-EM structure of the GR-Hsp90-FKBP52 complex | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DEXAMETHASONE, Glucocorticoid receptor, ... | | Authors: | Noddings, C.M, Agard, D.A. | | Deposit date: | 2022-12-10 | | Release date: | 2023-11-01 | | Last modified: | 2023-12-20 | | Method: | ELECTRON MICROSCOPY (3.01 Å) | | Cite: | Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor.
Nat.Struct.Mol.Biol., 30, 2023
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8A3L
 | | Structural insights into the binding of bS1 to the ribosome | | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S1, ... | | Authors: | D'Urso, G, Chat, S, Gillet, R, Giudice, E. | | Deposit date: | 2022-06-08 | | Release date: | 2023-05-10 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (3.42 Å) | | Cite: | Structural insights into the binding of bS1 to the ribosome.
Nucleic Acids Res., 51, 2023
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6ZUO
 | | Human RIO1(kd)-StHA late pre-40S particle, structural state A (pre 18S rRNA cleavage) | | Descriptor: | 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S12, ... | | Authors: | Plassart, L, Shayan, R, Plisson-Chastang, C. | | Deposit date: | 2020-07-23 | | Release date: | 2021-05-12 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | The final step of 40S ribosomal subunit maturation is controlled by a dual key lock.
Elife, 10, 2021
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6ZV6
 | | Human RIO1(kd)-StHA late pre-40S particle, structural state B (post 18S rRNA cleavage) | | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | | Authors: | Plassart, L, Shayan, R, Plisson-Chastang, C. | | Deposit date: | 2020-07-24 | | Release date: | 2021-05-12 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | The final step of 40S ribosomal subunit maturation is controlled by a dual key lock.
Elife, 10, 2021
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6I7V
 | | Ribosomal protein paralogs bL31 and bL36 | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, 1,4-DIAMINOBUTANE, ... | | Authors: | Pulk, A, Cate, J.H.D, Remme, J, Lilleorg, S, Reier, K, Peil, L, Liiv, A, Tammsalu, T. | | Deposit date: | 2018-11-19 | | Release date: | 2018-12-05 | | Last modified: | 2024-04-24 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Bacterial ribosome heterogeneity: Changes in ribosomal protein composition during transition into stationary growth phase.
Biochimie, 156, 2018
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8B0X
 | | Translating 70S ribosome in the unrotated state (P and E, tRNAs) | | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | Authors: | Fromm, S.A, O'Connor, K.M, Purdy, M, Bhatt, P.R, Loughran, G, Atkins, J.F, Jomaa, A, Mattei, S. | | Deposit date: | 2022-09-08 | | Release date: | 2022-11-30 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (1.55 Å) | | Cite: | The translating bacterial ribosome at 1.55 angstrom resolution generated by cryo-EM imaging services.
Nat Commun, 14, 2023
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7R4X
 | | Cryo-EM reconstruction of the human 40S ribosomal subunit - Full map | | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | | Authors: | Pellegrino, S, Dent, K.C, Spikes, T, Warren, A.J. | | Deposit date: | 2022-02-09 | | Release date: | 2023-02-22 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (2.15 Å) | | Cite: | Cryo-EM reconstruction of the human 40S ribosomal subunit at 2.15 angstrom resolution.
Nucleic Acids Res., 51, 2023
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6H4N
 | | Structure of a hibernating 100S ribosome reveals an inactive conformation of the ribosomal protein S1 - 70S Hibernating E. coli Ribosome | | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S1, ... | | Authors: | Beckert, B, Turk, M, Czech, A, Berninghausen, O, Beckmann, R, Ignatova, Z, Plitzko, J, Wilson, N.D. | | Deposit date: | 2018-07-22 | | Release date: | 2018-09-05 | | Last modified: | 2018-10-24 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structure of a hibernating 100S ribosome reveals an inactive conformation of the ribosomal protein S1.
Nat Microbiol, 3, 2018
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6GXM
 | | Cryo-EM structure of an E. coli 70S ribosome in complex with RF3-GDPCP, RF1(GAQ) and Pint-tRNA (State II) | | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Graf, M, Huter, P, Maracci, C, Peterek, M, Rodnina, M.V, Wilson, D.N. | | Deposit date: | 2018-06-27 | | Release date: | 2018-08-22 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Visualization of translation termination intermediates trapped by the Apidaecin 137 peptide during RF3-mediated recycling of RF1.
Nat Commun, 9, 2018
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6H58
 | | Structure of a hibernating 100S ribosome reveals an inactive conformation of the ribosomal protein S1 - Full 100S Hibernating E. coli Ribosome | | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S1, ... | | Authors: | Beckert, B, Turk, M, Czech, A, Berninghausen, O, Beckmann, R, Ignatova, Z, Plitzko, J, Wilson, D.N. | | Deposit date: | 2018-07-24 | | Release date: | 2018-09-05 | | Last modified: | 2018-10-24 | | Method: | ELECTRON MICROSCOPY (7.9 Å) | | Cite: | Structure of a hibernating 100S ribosome reveals an inactive conformation of the ribosomal protein S1.
Nat Microbiol, 3, 2018
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8B7Y
 | | Cryo-EM structure of the E.coli 70S ribosome in complex with the antibiotic Myxovalargin B. | | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | | Authors: | Koller, T.O, Graf, M, Wilson, D.N. | | Deposit date: | 2022-10-03 | | Release date: | 2023-01-25 | | Last modified: | 2023-02-01 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | The Myxobacterial Antibiotic Myxovalargin: Biosynthesis, Structural Revision, Total Synthesis, and Molecular Characterization of Ribosomal Inhibition.
J.Am.Chem.Soc., 145, 2023
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6ZMW
 | | Structure of a human 48S translational initiation complex | | Descriptor: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | | Authors: | Brito Querido, J, Sokabe, M, Kraatz, S, Gordiyenko, Y, Skehel, M, Fraser, C, Ramakrishnan, V. | | Deposit date: | 2020-07-04 | | Release date: | 2020-09-23 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structure of a human 48Stranslational initiation complex.
Science, 369, 2020
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1SC5
 | | Sigma-28(FliA)/FlgM complex | | Descriptor: | RNA polymerase sigma factor FliA, anti-sigma factor FlgM | | Authors: | Sorenson, M.K, Ray, S.S, Darst, S.A. | | Deposit date: | 2004-02-11 | | Release date: | 2004-04-06 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3.26 Å) | | Cite: | Crystal structure of the flagellar sigma/anti-sigma complex sigma(28)/FlgM reveals an intact sigma factor in an inactive conformation.
Mol.Cell, 14, 2004
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6ZXD
 | | Cryo-EM structure of a late human pre-40S ribosomal subunit - State F1 | | Descriptor: | 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S12, ... | | Authors: | Ameismeier, M, Zemp, I, van den Heuvel, J, Thoms, M, Berninghausen, O, Kutay, U, Beckmann, R. | | Deposit date: | 2020-07-29 | | Release date: | 2020-12-02 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural basis for the final steps of human 40S ribosome maturation.
Nature, 587, 2020
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6Q98
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6ZON
 | | SARS-CoV-2 Nsp1 bound to a human 43S preinitiation ribosome complex - state 1 | | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | | Authors: | Thoms, M, Buschauer, R, Ameismeier, M, Denk, T, Kratzat, H, Mackens-Kiani, T, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R. | | Deposit date: | 2020-07-07 | | Release date: | 2020-07-29 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
Science, 369, 2020
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